Search Results - "Palaniappan, Chockalingam"

Performance evaluation of commercial short-oligonucleotide microarrays and the impact of noise in making cross-platform correlations by Shippy, Richard, Sendera, Timothy J, Lockner, Randall, Palaniappan, Chockalingam, Kaysser-Kranich, Tamma, Watts, George, Alsobrook, John

“…Despite the widespread use of microarrays, much ambiguity regarding data analysis, interpretation and correlation of the different technologies exists. There…”
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Robust dysregulation of gene expression in substantia nigra and striatum in Parkinson's disease by Miller, Renee M., Kiser, Gretchen L., Kaysser-Kranich, T.M., Lockner, Randall J., Palaniappan, Chockalingam, Federoff, Howard J.

“…Large-scale genomics approaches are now widely utilized to study a myriad of human diseases. These powerful techniques, when combined with data analysis tools,…”
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The P236L Delavirdine-Resistant Human Immunodeficiency Virus Type 1 Mutant Is Replication Defective and Demonstrates Alterations in both RNA 5′-End- and DNA 3′-End-Directed RNase H Activities by Gerondelis, P, Archer, R H, Palaniappan, C, Reichman, R C, Fay, P J, Bambara, R A, Demeter, L M

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The Sequential Mechanism of HIV Reverse Transcriptase RNase H by Wisniewski, Michele, Balakrishnan, Mini, Palaniappan, Chockalingam, Fay, Philip J., Bambara, Robert A.

“…Synthesis of the minus strand of viral DNA by human immunodeficiency virus, type 1 (HIV-1) reverse transcriptase is accompanied by RNase H degradation of the…”
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Evidence for a Unique Mechanism of Strand Transfer from the Transactivation Response Region of HIV-1 by Kim, Jin Kyung, Palaniappan, Chockalingam, Wu, Weimin, Fay, Philip J., Bambara, Robert A.

“…We previously found that strand transfer by human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) is promoted at sites where RT pauses during…”
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Mutations within the Primer Grip Region of HIV-1 Reverse Transcriptase Result in Loss of RNase H Function by Palaniappan, C, Wisniewski, M, Jacques, P S, Le Grice, S F, Fay, P J, Bambara, R A

“…Human immunodeficiency virus (HIV) DNA synthesis is accompanied by degradation of genomic RNA by the RNase H of reverse transcriptase (RT). Two different modes…”
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Mutations in the Primer Grip Region of HIV Reverse Transcriptase Can Increase Replication Fidelity by Wisniewski, Michele, Palaniappan, Chockalingam, Fu, Ziping, Le Grice, Stuart F.J., Fay, Philip, Bambara, Robert A.

“…Mutations in the primer grip region of human immunodeficiency virus reverse transcriptase (HIV-RT) affect its replication fidelity. The primer grip region…”
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Helix Structure and Ends of RNA/DNA Hybrids Direct the Cleavage Specificity of HIV-1 Reverse Transcriptase RNase H by Palaniappan, C, Fuentes, G M, Rodríguez-Rodríguez, L, Fay, P J, Bambara, R A

“…RNA/DNA hybrids in human immunodeficiency virus (HIV) replication are cleaved by HIV-1 reverse transcriptase (RT) RNase H in locations determined by hybrid…”
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Nevirapine Alters the Cleavage Specificity of Ribonuclease H of Human Immunodeficiency Virus 1 Reverse Transcriptase (∗) by Palaniappan, Chockalingam, Fay, Philip J., Bambara, Robert A.

“…The action of the dipyridodiazepinone nevirapine (BI-RG-587) on polymerization and RNase H activities of human immunodeficiency virus reverse transcriptase…”
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Substrate Requirements for Secondary Cleavage by HIV-1 Reverse Transcriptase RNase H by Wisniewski, Michele, Chen, Yan, Balakrishnan, Mini, Palaniappan, Chockalingam, Roques, Bernard P, Fay, Philip J, Bambara, Robert A

“…During and after minus-strand DNA synthesis, human immunodeficiency virus 1 (HIV-1) reverse transcriptase (RT) degrades the RNA genome. To remove RNA left…”
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Control of Initiation of Viral Plus Strand DNA Synthesis by HIV Reverse Transcriptase by Palaniappan, C, Kim, J K, Wisniewski, M, Fay, P J, Bambara, R A

“…Human immunodeficiency virus reverse transcribes its single-stranded RNA genome making a DNA copy. As synthesis proceeds, the RNA is simultaneously degraded to…”
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Strand Displacement Synthesis of the Long Terminal Repeats by HIV Reverse Transcriptase by Fuentes, G M, Rodríguez-Rodríguez, L, Palaniappan, C, Fay, P J, Bambara, R A

“…According to the current model for retroviral replication, strand displacement of the long terminal repeat (LTR) is a necessary step during plus strand DNA…”
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Misincorporation by HIV-1 Reverse Transcriptase Promotes Recombination via Strand Transfer Synthesis by Palaniappan, C, Wisniewski, M, Wu, W, Fay, P J, Bambara, R A

“…Genome heterogeneity in retroviruses derives from poor fidelity of the reverse transcriptase (RT) and recombination via RT-catalyzed strand transfer synthesis…”
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Strand Displacement Synthesis in the Central Polypurine Tract Region of HIV-1 Promotes DNA to DNA Strand Transfer Recombination by Fuentes, Gloria M., Palaniappan, Chockalingam, Fay, Philip J., Bambara, Robert A.

“…Two distinct plus strand initiation sites have been identified in human immunodeficiency virus (HIV), the central polypurine tract (cPPT) and the polypurine…”
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Inhibition of HIV-1 Replication Using a Mutated tRNALys-3 Primer by Lu, Y, Planelles, V, Li, X, Palaniappan, C, Day, B, Challita-Eid, P, Amado, R, Stephens, D, Kohn, D B, Bakker, A, Fay, P, Bambara, R A, Rosenblatt, J D

“…Cellular tRNA Lys-3 serves as the primer for reverse transcription of human immunodeficiency virus, type 1 (HIV-1). tRNA Lys-3 interacts directly with HIV-1…”
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Dysregulation of Gene Expression in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Lesioned Mouse Substantia Nigra by Miller, Renee M, Callahan, Linda M, Casaceli, Cindy, Chen, Linlin, Kiser, Gretchen L, Chui, Buena, Kaysser-Kranich, Tamma M, Sendera, Timothy J, Palaniappan, Chockalingam, Federoff, Howard J

“…Parkinson's disease pathogenesis proceeds through several phases, culminating in the loss of dopaminergic neurons of the substantia nigra (SN). Although the…”
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Differences in Mutagenesis During Minus Strand, Plus Strand and Strand Transfer (Recombination) Synthesis of the Hiv-1 Nef Gene in Vitro by Wu, Weimin, Palaniappan, Chockalingam, Bambara, Robert A., Fay, Philip J.

“…We have developed an HIV nef-Escherichia coli lacZ fusion system in vitro that allows the detection of low frequency mutations, including frameshifts,…”
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