Search Results - "Pal Kalia, Nitin"

Synthesis of Oxaspirocyclohexadienones via Lewis‐Acid Catalyzed [2+3]‐Annulations of p‐Quinone Methides and Iodonium Ylides by Mujahid, Mohd, Kumar, Sanjeev, Pal Kalia, Nitin, Kanchupalli, Vinaykumar

“…Herein, we report a mild method for the synthesis of oxaspirocyclohexadienones by using a combination of Lewis acid‐HFIP mediated [2+3]‐annulation of p‐quinone…”
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Tweaking host immune responses for novel therapeutic approaches against Mycobacterium tuberculosis by Roy, Arnab, Kumari Agnivesh, Puja, Sau, Shashikanta, Kumar, Sunil, Pal Kalia, Nitin

“…•IL-12, TNF, IFN-γ and CD4+ T cells are crucial in the immunopathogenesis of TB.•Manipulating inflammatory responses reduce mycobacterial burden and…”
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Editorial: Approaches to Address Resistance, Drug Discovery, and Vaccine Development in Mycobacterium tuberculosis : Challenges and Opportunities by Sharma, Sandeep, Sharma, Divakar, Kalia, Nitin Pal

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Capsaicin, a novel inhibitor of the NorA efflux pump, reduces the intracellular invasion of Staphylococcus aureus by NITIN PAL KALIA, MAHAJAN, Priya, MEHRA, Rukmankesh, NARGOTRA, Amit, JAI PARKASH SHARMA, KOUL, Surrinder, INSHAD ALI KHAN

“…To delineate the role of capsaicin (8-methyl-N-vanillyl-6-nonenamide) as an inhibitor of the NorA efflux pump and its impact on invasion of macrophages by…”
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Targeting the Mycobacterium ulcerans cytochrome bc 1 :aa 3 for the treatment of Buruli ulcer by Scherr, Nicole, Bieri, Raphael, Thomas, Sangeeta S, Chauffour, Aurélie, Nitin Pal Kalia, Schneide, Paul, Ruf, Marie-Thérèse, Lamelas, Araceli, Manimekalai, Malathy S S, Grüber, Gerhard, Ishii, Norihisa, Suzuki, Koichi, Tanner, Marcel, Moraski, Garrett C, Miller, Marvin J, Witschel, Matthias, Jarlier, Vincent, Pluschke, Gerd, Pethe, Kevin

“…Mycobacterium ulcerans is the causative agent of Buruli ulcer (BU). Existing anti-tubercular drugs have been used to treat the condition with varying success…”
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Discovery of a Novel Mycobacterial F‐ATP Synthase Inhibitor and its Potency in Combination with Diarylquinolines by Hotra, Adam, Ragunathan, Priya, Ng, Pearly Shuyi, Seankongsuk, Pattarakiat, Harikishore, Amaravadhi, Sarathy, Jickky Palmae, Saw, Wuan‐Geok, Lakshmanan, Umayal, Sae‐Lao, Patcharaporn, Kalia, Nitin Pal, Shin, Joon, Kalyanasundaram, Revathy, Anbarasu, Sivaraj, Parthasarathy, Krupakar, Pradeep, Chaudhari Namrata, Makhija, Harshyaa, Dröge, Peter, Poulsen, Anders, Tan, Jocelyn Hui Ling, Pethe, Kevin, Dick, Thomas, Bates, Roderick W., Grüber, Gerhard

“…The F1FO‐ATP synthase is required for growth and viability of Mycobacterium tuberculosis and is a validated clinical target. A mycobacterium‐specific loop of…”
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Exploring rhodanine linked enamine–carbohydrazide derivatives as mycobacterial carbonic anhydrase inhibitors: Design, synthesis, biological evaluation, and molecular docking studies by Maddipatla, Sarvan, Bakchi, Bulti, Gadhave, Rutuja Rama, Ammara, Andrea, Sau, Shashikanta, Rani, Bandela, Nanduri, Srinivas, Kalia, Nitin Pal, Supuran, Claudiu T., Yaddanapudi, Venkata Madhavi

“…With the rise of multidrug‐resistant tuberculosis, the imperative for an alternative and superior treatment regimen, incorporating novel mechanisms of action,…”
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M. tuberculosis relies on trace oxygen to maintain energy homeostasis and survive in hypoxic environments by Kalia, Nitin Pal, Singh, Samsher, Hards, Kiel, Cheung, Chen-Yi, Sviriaeva, Ekaterina, Banaei-Esfahani, Amir, Aebersold, Ruedi, Berney, Michael, Cook, Gregory M., Pethe, Kevin

“…The bioenergetic mechanisms by which Mycobacterium tuberculosis survives hypoxia are poorly understood. Current models assume that the bacterium shifts to an…”
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Piperine as an inhibitor of the MdeA efflux pump of Staphylococcus aureus by ZAHID MEHMOOD MIRZA, KUMAR, Ashwani, NITIN PAL KALIA, ZARGAR, Afzal, INSHAD ALI KHAN

“…Piperine, a trans-trans-isomer of 1-piperoyl-piperidine, was tested in combination with mupirocin for antimicrobial activity against Staphylococcus aureus…”
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Exploration of 3‐aryl pyrazole‐tethered sulfamoyl carboxamides as carbonic anhydrase inhibitors by Ommi, Ojaswitha, Paoletti, Niccolò, Bonardi, Alessandro, Gratteri, Paola, Bhalerao, Harshada Anil, Sau, Shashikanta, Nanduri, Srinivas, Mohammed, Arifuddin, Kalia, Nitin Pal, Sonti, Rajesh, Supuran, Claudiu T., Yaddanapudi, Venkata Madhavi

“…Herein, we report the design and synthesis of two series of pyrazole‐tethered sulfamoyl phenyl acetamides and pyrazole‐tethered sulfamoyl phenyl benzamides…”
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Synthesis and pharmacological evaluation of 1,3-diaryl substituted pyrazole based (thio)urea derivatives as potent antimicrobial agents against multi-drug resistant Staphylococcus aureus and Mycobacterium tuberculosis by Ommi, Ojaswitha, Naiyaz Ahmad, Mohammad, Gajula, Siva Nageswara Rao, Wanjari, Parita, Sau, Shashikanta, Agnivesh, Puja Kumari, Sahoo, Santosh Kumar, Kalia, Nitin Pal, Sonti, Rajesh, Nanduri, Srinivas, Dasgupta, Arunava, Chopra, Sidharth, Yaddanapudi, Venkata Madhavi

“…The urgent development of newer alternatives has been deemed a panacea for tackling emerging antimicrobial resistance effectively. Herein, we report the…”
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Benzyl/phenyl‐1,2,3‐Triazole Tethered 3‐Acetyl Coumarins as Potential Drug‐Resistant Antitubercular Agents: Synthesis, Biology, and in Silico Investigations as Mtb DNA Gyrase Inhibitors by Bakchi, Bulti, Maddipatla, Sarvan, Gottemukkala, Seshamma, Raut, Shital, Naiyaz Ahmad, Mohammad, Imran, Mohmmad, Saxena, Deepanshi, Maitra, Rahul, Kumari Agnivesh, Puja, Pal Kalia, Nitin, Nanduri, Srinivas, Dasgupta, Arunava, Chopra, Sidharth, Madhavi Yaddanapudi, Venkata

“…Owing to the emergence of multi‐drug resistant tuberculosis, there is a need for the exploration of new antitubercular agents. In this context, new…”
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GaMF1.39's antibiotic efficacy and its enhanced antitubercular activity in combination with clofazimine, Telacebec, ND-011992, or TBAJ-876 by Ragunathan, Priya, Shuyi Ng, Pearly, Singh, Samsher, Poh, Wee Han, Litty, Dennis, Kalia, Nitin Pal, Larsson, Simon, Harikishore, Amaravadhi, Rice, Scott A, Ingham, Philip W, Müller, Volker, Moraski, Garrett, Miller, Marvin J, Dick, Thomas, Pethe, Kevin, Grüber, Gerhard

“…New drugs are needed to combat multidrug-resistant tuberculosis. The electron transport chain (ETC) maintains the electrochemical potential across the…”
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Discovery of a Novel Mycobacterial F‐ATP Synthase Inhibitor and its Potency in Combination with Diarylquinolines by Hotra, Adam, Ragunathan, Priya, Ng, Pearly Shuyi, Seankongsuk, Pattarakiat, Harikishore, Amaravadhi, Sarathy, Jickky Palmae, Saw, Wuan‐Geok, Lakshmanan, Umayal, Sae‐Lao, Patcharaporn, Kalia, Nitin Pal, Shin, Joon, Kalyanasundaram, Revathy, Anbarasu, Sivaraj, Parthasarathy, Krupakar, Pradeep, Chaudhari Namrata, Makhija, Harshyaa, Dröge, Peter, Poulsen, Anders, Tan, Jocelyn Hui Ling, Pethe, Kevin, Dick, Thomas, Bates, Roderick W., Grüber, Gerhard

“…The F1FO‐ATP synthase is required for growth and viability of Mycobacterium tuberculosis and is a validated clinical target. A mycobacterium‐specific loop of…”
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Synthesis and Antitubercular Activity of Berberine Derivatives by Mahapatra, Anita, Maheswari, Vijay, Kalia, Nitin Pal, Rajput, Vikrant S, Khan, Inshad Ali

“…The isoquinoline alkaloid berberine (1) was isolated from the roots of Berberis aristata and its new, 13-benzyl (3–6), 13-allyl (7, 8), 8-(2-oxopropyl) (2),…”
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P-glycoprotein inhibitors as an adjunct therapy for TB by Parida, Kishan Kumar, Lahiri, Monali, Ghosh, Mainak, Dalal, Aman, Kalia, Nitin Pal

“…•The action of the efflux pump contributes to MDR-TB cases.•P-glycoprotein reduces the bioavailability of anti-TB drugs.•Upregulation of angiogenic factors and…”
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Turbidity-Based MIC Assay and Characterization of Spontaneous Drug Resistant Mutants in Mycobacterium ulcerans by Thomas, Sangeeta Susan, Kalia, Nitin Pal, Pethe, Kevin

“…Generation and characterization of drug resistant mutants is a powerful tool in antimicrobial drug discovery for identification of the molecular target of an…”
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Role of transcription termination factor Rho in anti-tuberculosis drug discovery by Kumar, Sunil, Sau, Shashikanta, Agnivesh, Puja Kumari, Roy, Arnab, Kalia, Nitin Pal

“…•Long treatment of mycobacterial infections and emergence of resistance to the existing therapy has raised the demand for the identification of new drug…”
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Exploring and exploiting the host cell autophagy during Mycobacterium tuberculosis infection by Nagdev, Pavan Kumar, Agnivesh, Puja Kumari, Roy, Arnab, Sau, Shashikanta, Kalia, Nitin Pal

“…Tuberculosis, caused by Mycobacterium tuberculosis , is a fatal infectious disease that prevails to be the second leading cause of death from a single…”
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Advancements and challenges in tuberculosis drug discovery: A comprehensive overview by Agnivesh, Puja Kumari, Roy, Arnab, Sau, Shashikanta, Kumar, Sunil, Kalia, Nitin Pal

“…Tuberculosis continues to pose a health challenge causing the loss of millions of lives despite the existence of multiple drugs, for treatment. The emergence…”
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