Search Results - "Pal, Srabani"

Chronic inflammation and cancer: potential chemoprevention through nuclear factor kappa B and p53 mutual antagonism by Pal, Srabani, Bhattacharjee, Ashish, Ali, Asif, Mandal, Narayan C, Mandal, Subhash C, Pal, Mahadeb

“…Activation of nuclear factor-kappa B (NF- κB) as a mechanism of host defense against infection and stress is the central mediator of inflammatory responses. A…”
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Hck Is a Key Regulator of Gene Expression in Alternatively Activated Human Monocytes by Bhattacharjee, Ashish, Pal, Srabani, Feldman, Gerald M., Cathcart, Martha K.

“…IL-13 is a Th2 cytokine that promotes alternative activation (M2 polarization) in primary human monocytes. Our studies have characterized the functional IL-13…”
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Signaling through TLR5 mitigates lethal radiation damage by neutrophil-dependent release of MMP-9 by Brackett, Craig M., Greene, Kellee F., Aldrich, Alyssa R., Trageser, Nicholas H., Pal, Srabani, Molodtsov, Ivan, Kandar, Bojidar M., Burdelya, Lyudmila G., Abrams, Scott I., Gudkov, Andrei V.

“…Acute radiation syndrome (ARS) is a major cause of lethality following radiation disasters. A TLR5 agonist, entolimod, is among the most powerful experimental…”
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Induction and mode of action of the viral stress-inducible murine proteins, P56 and P54 by Terenzi, Fulvia, Pal, Srabani, Sen, Ganes C.

“…Mammalian cells respond to virus infection or other viral stresses, such as double-stranded (ds) RNA and interferons (IFN), by robust and rapid induction of…”
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Tissue-Specific and Inducer-Specific Differential Induction of ISG56 and ISG54 in Mice by TERENZI, Fulvia, WHITE, Christine, PAL, Srabani, WILLIAMS, Bryan R. G, SEN, Ganes C

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A PKCβ-LYN-PYK2 Signaling Axis Is Critical for MCP-1-Dependent Migration and Adhesion of Monocytes by Das, Pradip, Pal, Srabani, Oldfield, Claudine M, Thillai, Kowsalya, Bala, Sinjini, Carnevale, Kevin A, Cathcart, Martha K, Bhattacharjee, Ashish

“…MCP-1-induced monocyte chemotaxis is a crucial event in inflammation and atherogenesis. Identifying the important signal transduction pathways that control…”
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Induction of monoamine oxidase A-mediated oxidative stress and impairment of NRF2-antioxidant defence response by polyphenol-rich fraction of Bergenia ligulata sensitizes prostate cancer cells in vitro and in vivo by Ghosh, Suvranil, Dutta, Naibedya, Banerjee, Pinaki, Gajbhiye, Rahul L., Sareng, Hossainoor Rahaman, Kapse, Prachi, Pal, Srabani, Burdelya, Lyudmila, Mandal, Narayan C., Ravichandiran, Velyutham, Bhattacharjee, Ashish, Kundu, Gopal C., Gudkov, Andrei V., Pal, Mahadeb

“…Prostate cancer (PCa) is a major cause of mortality and morbidity in men. Available therapies yield limited outcome. We explored anti-PCa activity in a…”
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A Toll-like Receptor 5 agonist entolimod mitigates radiation damage through a neutrophil-dependent mechanism by Brackett, Craig M, Greene, Kellee, Kandar, Bojidar, Trageser, Nicholas, Kandefer, Rachel, Pal, Srabani, Burdelya, Lyudmila, Gudkov, Andrei

“…Abstract The increased risk of exposure to life-threating nuclear and radiation emergencies warrants the development of FDA-approved medical radiation…”
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Curaxins: anticancer compounds that simultaneously suppress NF-κB and activate p53 by targeting FACT by Gasparian, Alexander V, Burkhart, Catherine A, Purmal, Andrei A, Brodsky, Leonid, Pal, Mahadeb, Saranadasa, Madhi, Bosykh, Dmitry A, Commane, Mairead, Guryanova, Olga A, Pal, Srabani, Safina, Alfiya, Sviridov, Sergey, Koman, Igor E, Veith, Jean, Komar, Anton A, Gudkov, Andrei V, Gurova, Katerina V

“…Effective eradication of cancer requires treatment directed against multiple targets. The p53 and nuclear factor κB (NF-κB) pathways are dysregulated in nearly…”
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Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling by Sen, Ganes C, Sarkar, Saumendra N, Peters, Kristi L, Elco, Christopher P, Sakamoto, Shuji, Pal, Srabani

“…Double-stranded RNA (dsRNA), a frequent byproduct of virus infection, is recognized by Toll-like receptor 3 (TLR3) to mediate innate immune response to virus…”
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Monocyte 15-lipoxygenase gene expression requires ERK1/2 MAPK activity by Bhattacharjee, Ashish, Mulya, Anny, Pal, Srabani, Roy, Biswajit, Feldman, Gerald M, Cathcart, Martha K

“…IL-13 induces profound expression of 15-lipoxygenase (15-LO) in primary human monocytes. Our studies have defined the functional IL-13R complex, association of…”
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Targeting FACT complex suppresses mammary tumorigenesis in Her2/neu transgenic mice by Koman, Igor E, Commane, Mairead, Paszkiewicz, Geraldine, Hoonjan, Bhupinder, Pal, Srabani, Safina, Alfiya, Toshkov, Ilya, Purmal, Andrei A, Wang, Dan, Liu, Song, Morrison, Carl, Gudkov, Andrei V, Gurova, Katerina V

“…Development of safe and effective tumor-preventive treatments for high-risk patient populations and therapies for early-stage cancer remains a critical need in…”
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Extracellular regulatory kinase (ERK1/2) regulates 15‐lipoxygenase Expression in Primary Human Monocytes by Bhattacharjee, Ashish, Pal, Srabani, Feldman, Gerald M, Cathcart, Martha K

“…Abstract only Interleukin‐13 (IL‐13) induces the expression of the lipid‐oxidizing enzyme 15‐lipoxygenase (15‐LO) in primary human monocytes. 15‐LO catalyzes…”
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Crisscross Enzymatic Reaction between the Two Molecules in the Active Dimeric P69 Form of the 2′-5′ Oligodenylate Synthetase by Saumendra N. Sarkar, Srabani Pal, Ganes C. Sen

“…2′-5′ oligoadenylate (2–5 (A)) synthetases are major components of the antiviral pathways induced by interferons. In the presence of double-stranded RNA,…”
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Natural Mutations in a 2‘−5‘ Oligoadenylate Synthetase Transgene Revealed Residues Essential for Enzyme Activity by Sarkar, Saumendra N, Kessler, Sean P, Rowe, Theresa M, Pandey, Mitali, Ghosh, Arundhati, Elco, Christopher P, Hartmann, Rune, Pal, Srabani, Sen, Ganes C

“…Unlike other RNA polymerases, 2‘−5‘ oligoadenylate synthetases, a family of interferon-induced enzymes, catalyze the formation of 2‘−5‘, not 3‘−5‘,…”
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Crisscross enzymatic reaction between the two molecules in the active dimeric P69 form of the 2'-5' oligodenylate synthetase by Sarkar, Saumendra N, Pal, Srabani, Sen, Ganes C

“…2'-5' oligoadenylate (2-5 (A)) synthetases are major components of the antiviral pathways induced by interferons. In the presence of double-stranded RNA, they…”
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