Search Results - "Pak, Helen"

Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair by Yu, Helen, Pak, Helen, Hammond-Martel, Ian, Ghram, Mehdi, Rodrigue, Amélie, Daou, Salima, Barbour, Haithem, Corbeil, Luc, Hébert, Josée, Drobetsky, Elliot, Masson, Jean Yves, Noia, Javier M. Di, El Bachir Affar

“…The cellular response to highly genotoxic DNA double-strand breaks (DSBs) involves the exquisite coordination of multiple signaling and repair factors. Here,…”
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IKAROS is required for the measured response of NOTCH target genes upon external NOTCH signaling by Lemarié, Maud, Bottardi, Stefania, Mavoungou, Lionel, Pak, Helen, Milot, Eric

“…The tumor suppressor IKAROS binds and represses multiple NOTCH target genes. For their induction upon NOTCH signaling, IKAROS is removed and replaced by NOTCH…”
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The BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and Is Disrupted in Cancer by Daou, Salima, Hammond-Martel, Ian, Mashtalir, Nazar, Barbour, Haithem, Gagnon, Jessica, Iannantuono, NicholasV.G., Nkwe, Nadine Sen, Motorina, Alena, Pak, Helen, Yu, Helen, Wurtele, Hugo, Milot, Eric, Mallette, Frédérick A., Carbone, Michele, Affar, El Bachir

“…The deubiquitinase (DUB) and tumor suppressor BAP1 catalyzes ubiquitin removal from histone H2A Lys-119 and coordinates cell proliferation, but how BAP1…”
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NPM and NPM-MLF1 interact with chromatin remodeling complexes and influence their recruitment to specific genes by Darracq, Anaïs, Pak, Helen, Bourgoin, Vincent, Zmiri, Farah, Dellaire, Graham, Affar, El Bachir, Milot, Eric

“…Nucleophosmin (NPM1) is frequently mutated or subjected to chromosomal translocation in acute myeloid leukemia (AML). NPM protein is primarily located in the…”
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The IKAROS interaction with a complex including chromatin remodeling and transcription elongation activities is required for hematopoiesis by Bottardi, Stefania, Mavoungou, Lionel, Pak, Helen, Daou, Salima, Bourgoin, Vincent, Lakehal, Yahia A, Affar, El Bachir, Milot, Eric

“…IKAROS is a critical regulator of hematopoietic cell fate and its dynamic expression pattern is required for proper hematopoiesis. In collaboration with the…”
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Crosstalk between O-GlcNAcylation and proteolytic cleavage regulates the host cell factor-1 maturation pathway by Daou, Salima, Mashtalir, Nazar, Hammond-Martel, Ian, Pak, Helen, Yu, Helen, Sui, Guangchao, Vogel, Jodi L, Kristie, Thomas M, Affar, El Bachir

“…Host Cell Factor 1 (HCF-1) plays critical roles in regulating gene expression in a plethora of physiological processes. HCF-1 is first synthesized as a…”
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PI 3 kinase related kinases-independent proteolysis of BRCA1 regulates Rad51 recruitment during genotoxic stress in human cells by Hammond-Martel, Ian, Pak, Helen, Yu, Helen, Rouget, Raphael, Horwitz, Andrew A, Parvin, Jeffrey D, Drobetsky, Elliot A, Affar, El Bachir

“…The function of BRCA1 in response to ionizing radiation, which directly generates DNA double strand breaks, has been extensively characterized. However…”
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The Experiences of Caretaking and Financial Stress among Social Workers during the COVID-19 Pandemic by Cederbaum, Julie A, Zerden, Lisa de Saxe, Ross, Abigail M, Zelnick, Jennifer R, Pak, Hee-Eun Helen, Ruth, Betty J

“…Social workers have engaged in promotive, preventive, and intervention work throughout the COVID-19 pandemic. Given that social workers are disproportionately…”
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The IKAROS Interaction with a Complex Including Chromatin Remodeling and Transcription Elongation Activities Is Required for Hematopoiesis: e1004827 by Bottardi, Stefania, Mavoungou, Lionel, Pak, Helen, Daou, Salima, Bourgoin, Vincent, Lakehal, Yahia A, Affar, El Bachir, Milot, Eric

“…IKAROS is a critical regulator of hematopoietic cell fate and its dynamic expression pattern is required for proper hematopoiesis. In collaboration with the…”
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The transcription elongation control by IKAROS and NuRD is required for normal hematopoiesis by Bottardi, Stefania, Mavoungou, Lionel, Pak, Helen, Lakehal, Yahia A, Milot, Eric

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CHO vs. CH:CH2 competition in radical cyclizations: is the 5-hexenyl radical really supreme? by Tsang, Ray, Dickson, John K, Pak, Helen, Walton, Richard, Fraser-Reid, Bert

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Annulation of monosaccharides via serial free radical cyclization: A total synthesis of (-)-alpha-pipitzol by Pak, Helen

“…In this study, carboyhdrates were used as chiral templates to generate all the necessary stereocenters in the preparation of "annulated pyranosides" via tandem…”
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Carbohydrates to carbocycles: a synthesis of (-)-.alpha.-pipitzol by Pak, Helen, Iriepa Canalda, Isabel, Fraser-Reid, Bert

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Localization and characterization of two propranolol resistant (-) [125I]cyanopindolol binding sites in rat skeletal muscle by Molenaar, P, Roberts, S J, Kim, Y S, Pak, H S, Sainz, R D, Summers, R J

“…Autoradiographic studies were performed in sections of rat gastrocnemius, plantaris and soleus muscle bundles with (-)-[125I]cyanopindolol (59-69 pM) in the…”
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Serial radical cyclization of branched carbohydrates. Part 2. Claisen rearrangement routes to multiply substituted pyranoside diquinanes [Erratum to document cited in CA111(21):195269k] by Pak, Helen, Dickson, John K, Fraser-Reid, Bert

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Serial radical cyclization of branched carbohydrates. Part 2. Claisen rearrangement routes to multiply substituted pyranoside diquinanes by Pak, Helen, Dickson, John K, Fraser-Reid, Bert

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Localization of (-)-[125I]cyanopindolol binding in guinea-pig heart: characteristics of non-beta-adrenoceptor related binding in cardiac pacemaker and conducting regions by Molenaar, P, Kompa, A R, Roberts, S J, Pak, H S, Summers, R J

“…Receptor autoradiography was used in guinea-pig heart to locate binding sites for the beta-adrenoceptor ligand (-)[125I]cyanopindolol (CYP) resistant to…”
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