Search Results - "Pajarinen, J."

NF-κB as a Therapeutic Target in Inflammatory-Associated Bone Diseases by Lin, T-H, Pajarinen, J, Lu, L, Nabeshima, A, Cordova, L A, Yao, Z, Goodman, S B

“…Inflammation is a defensive mechanism for pathogen clearance and maintaining tissue homeostasis. In the skeletal system, inflammation is closely associated…”
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Novel biological strategies for treatment of wear particle-induced periprosthetic osteolysis of orthopaedic implants for joint replacement by Goodman, S. B., Gibon, E., Pajarinen, J., Lin, T.-H., Keeney, M., Ren, P.-G., Nich, C., Yao, Z., Egashira, K., Yang, F., Konttinen, Y. T.

“…Wear particles and by-products from joint replacements and other orthopaedic implants may result in a local chronic inflammatory and foreign body reaction…”
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Sintered S53P4 bioactive glass scaffolds have anti-inflammatory properties and stimulate osteogenesis in vitro by Björkenheim, R, Jämsen, E, Eriksson, E, Uppstu, P, Aalto-Setälä, L, Hupa, L, Eklund, K K, Ainola, M, Lindfors, N C, Pajarinen, J

“…Bioactive glasses (BAG) are used as bone-graft substitutes in orthopaedic surgery. A specific BAG scaffold was developed by sintering BAG-S53P4 granules. It is…”
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Polymer-coated bioactive glass S53P4 increases VEGF and TNF expression in an induced membrane model in vivo by Björkenheim, R., Strömberg, G., Pajarinen, J., Ainola, M., Uppstu, P., Hupa, L., Böhling, T. O., Lindfors, N. C.

“…The two-stage induced-membrane technique for treatment of large bone defects has become popular among orthopedic surgeons. In the first operation, the bone…”
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Aging Affects Bone Marrow Macrophage Polarization: Relevance to Bone Healing by Gibon, E, Loi, F, Córdova, Luis A, Pajarinen, J, Lin, T, Lu, L, Nabeshima, A, Yao, Z, Goodman, Stuart B

“…Macrophages are an important component of the inflammatory cascade by initiating and modulating the processes leading to tissue regeneration and bone healing…”
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S53P4 bioactive glass scaffolds induce BMP expression and integrative bone formation in a critical-sized diaphysis defect treated with a single-staged induced membrane technique by Eriksson, E., Björkenheim, R., Strömberg, G., Ainola, M., Uppstu, P., Aalto-Setälä, L., Leino, V-M., Hupa, L., Pajarinen, J., Lindfors, N.C.

“…Critical-sized diaphysis defects are complicated by inherent sub-optimal healing conditions. The two-staged induced membrane technique has been used to treat…”
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RANKL in the osteolysis of AES total ankle replacement implants by Koivu, H, Mackiewicz, Z, Takakubo, Y, Trokovic, N, Pajarinen, J, Konttinen, Y.T

“…Abstract Peri-implant tissue reactions in failed total ankle replacement (TAR) are characterized by early developing peri-implant osteolysis. The hypothesis of…”
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Operative treatment of type C intercondylar fractures of the distal humerus: Results after a mean follow-up of 2 years in a series of 18 patients by Pajarinen, Jarkko, Björkenheim, Jan-Magnus

“…We reviewed the results of internal fixation in a series of 18 patients (mean age, 44.4 years; SD, 19.1 years; range, 16-81 years) with type C intraarticular…”
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Accidental Falls Related to Shovelling Snow from Rooftops: Analysis of Injuries in an Extraordinary Epidemic in Southern Finland by Aulanko, M., Handolin, L., Söderlund, T., Pajarinen, J.

“…Background and Aims: Exceptional amount of snow led to snow removal attempts from the rooftops resulting in a relative unique and extraordinary epidemic of…”
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Femoral shaft medialisation and neck-shaft angle in unstable pertrochanteric femoral fractures by Pajarinen, J, Lindahl, J, Savolainen, V, Michelsson, O, Hirvensalo, E

“…We analysed the time-dependent mean changes in the femoral neck length, neck-shaft angle and hip offset in a randomised study comprising 48 patients who were…”
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Receptor activator of nuclear factor kappa B ligand in an experimental intervertebral disc degeneration by MACKIEWICZ, Z, SALO, J, KONTTINEN, Y. T, KAIGLE HOLM, A, INDAHL, A, PAJARINEN, J, HOLM, S

“…This study was designed to clarify the role of the receptor activator of nuclear factor kappa B ligand (RANKL) in the process of discus degeneration and…”
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Sling Compared With Plate Osteosynthesis for Treatment of Displaced Midshaft Clavicular Fractures: A Randomized Clinical Trial by VIRTANEN, K. J, REMES, V, PAJARINEN, J, SAVOLAINEN, V, BJÖRKENHEIM, J.-M, PAAVOLA, M

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Pertrochanteric femoral fractures treated with a dynamic hip screw or a proximal femoral nail : A randomised study comparing post-operative rehabilitation by PAJARINEN, J, LINDAHL, J, MICHELSSON, O, SAVOLAINEN, V, HIRVENSALO, E

“…We treated 108 patients with a pertrochanteric femoral fracture using either the dynamic hip screw or the proximal femoral nail in this prospective, randomised…”
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No Long-Term Effects of Ultrasound Therapy on Bioabsorbable Screw-Fixed Lateral Malleolar Fracture by Handolin, L., Kiljunen, V., Arnala, I., Kiuru, M. J., Pajarinen, J., Partio, E. K., Rokkanen, P.

“…Background and Aims: The present study was initiated to evaluate the long-term effects of low-intensity ultrasound therapy on bioabsorbable screw-fixed lateral…”
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Dose dependent but non-linear effects of alcohol on the left and right ventricle by Kajander, O A, Kupari, M, Laippala, P, Savolainen, V, Pajarinen, J, Penttilä, A, Karhunen, P J

“…OBJECTIVE To assess how left (LV) and right ventricular (RV) size, wall thickness, and mass depend on daily alcohol consumption. Among alcoholics, most common…”
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Engineered protein coatings to improve the osseointegration of dental and orthopaedic implants by Raphel, Jordan, Karlsson, Johan, Galli, Silvia, Wennerberg, Ann, Lindsay, Christopher, Haugh, Matthew G, Pajarinen, Jukka, Goodman, Stuart B, Jimbo, Ryo, Andersson, Martin, Heilshorn, Sarah C

“…Abstract Here we present the design of an engineered, elastin-like protein (ELP) that is chemically modified to enable stable coatings on the surfaces of…”
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Incidence of disorders of spermatogenesis in middle aged Finnish men, 1981-91: two necropsy series by Pajarinen, Jarkko, Laippala, Pekka, Penttila, Antti, Karhunen, Pekka J

“…Abstract Objective: To investigate if the incidence of disorders of spermatogenesis and testicular tissue morphology have changed in middle aged Finnish men…”
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Macrophages-Key cells in the response to wear debris from joint replacements by Nich, Christophe, Takakubo, Yuya, Pajarinen, Jukka, Ainola, Mari, Salem, Abdelhakim, Sillat, Tarvo, Rao, Allison J., Raska, Milan, Tamaki, Yasunobu, Takagi, Michiaki, Konttinen, Yrjö T., Goodman, Stuart B., Gallo, Jiri

“…The generation of wear debris is an inevitable result of normal usage of joint replacements. Wear debris particles stimulate local and systemic biological…”
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The GPIIIa Pl A polymorphism in the progression of abdominal aortic atherosclerosis by Mikkelsson, J., Perola, M., Laippala, P., Savolainen, V., Pajarinen, J., Penttilä, A., Karhunen, P.J., Kauppila, L.I.

“…Glycoprotein IIIa is expressed in platelets as part of the fibrinogen receptor and also in vascular endothelium where it mediates smooth muscle cell…”
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Glutathione-S-transferase GST M1 "null" genotype and the risk of alcoholic liver disease by Savolainen, V T, Pjarinen, J, Perola, M, Penttilä, A, Karhunen, P J

“…The present study was conducted to investigate possible association between the occurrence of glutathione-S-transferase GST M1 "null" genotype and alcoholic…”
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