Search Results - "Pajares, Marta"

Inflammation in Parkinson's Disease: Mechanisms and Therapeutic Implications by Pajares, Marta, I Rojo, Ana, Manda, Gina, Boscá, Lisardo, Cuadrado, Antonio

“…Parkinson's disease (PD) is a common neurodegenerative disorder primarily characterized by the death of dopaminergic neurons that project from the substantia…”
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Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases by Pajares, Marta, Cuadrado, Antonio, Rojo, Ana I.

“…Neurodegenerative diseases are linked to the accumulation of specific protein aggregates, suggesting an intimate connection between injured brain and loss of…”
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Transcription factor NFE2L2/NRF2 modulates chaperone-mediated autophagy through the regulation of LAMP2A by Pajares, Marta, Rojo, Ana I, Arias, Esperanza, Díaz-Carretero, Antonio, Cuervo, Ana María, Cuadrado, Antonio

“…Chaperone-mediated autophagy (CMA) is a selective degradative process for cytosolic proteins that contributes to the maintenance of proteostasis. The signaling…”
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Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes by Pajares, Marta, Jiménez-Moreno, Natalia, García-Yagüe, Ángel J., Escoll, Maribel, de Ceballos, María L., Van Leuven, Fred, Rábano, Alberto, Yamamoto, Masayuki, Rojo, Ana I., Cuadrado, Antonio

“…Autophagy is a highly coordinated process that is controlled at several levels including transcriptional regulation. Here, we identify the transcription factor…”
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NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology by Rojo, Ana I., Pajares, Marta, Rada, Patricia, Nuñez, Angel, Nevado-Holgado, Alejo J., Killik, Richard, Van Leuven, Fred, Ribe, Elena, Lovestone, Simon, Yamamoto, Masayuki, Cuadrado, Antonio

“…Failure to translate successful neuroprotective preclinical data to a clinical setting in Alzheimer's disease (AD) indicates that amyloidopathy and tauopathy…”
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Deficiency in the transcription factor NRF2 worsens inflammatory parameters in a mouse model with combined tauopathy and amyloidopathy by Rojo, Ana I., Pajares, Marta, García-Yagüe, Angel J., Buendia, Izaskun, Van Leuven, Fred, Yamamoto, Masayuki, López, Manuela G., Cuadrado, Antonio

“…Chronic neuroinflammation is a hallmark of the onset and progression of brain proteinopathies such as Alzheimer disease (AD) and it is suspected to participate…”
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Repurposing Zileuton as a Depression Drug Using an AI and In Vitro Approach by Kubick, Norwin, Pajares, Marta, Enache, Ioana, Manda, Gina, Mickael, Michel-Edwar

“…Repurposing drugs to target M1 macrophages inflammatory response in depression constitutes a bright alternative for commonly used antidepressants. Depression…”
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Preclinical Test of Dacomitinib, an Irreversible EGFR Inhibitor, Confirms Its Effectiveness for Glioblastoma by Zahonero, Cristina, Aguilera, Pilar, Ramírez-Castillejo, Carmen, Pajares, Marta, Bolós, Maria Victoria, Cantero, Diana, Perez-Nuñez, Angel, Hernández-Laín, Aurelio, Sánchez-Gómez, Pilar, Sepúlveda, Juan Manuel

“…Glioblastomas (GBM) are devastating tumors in which there has been little clinical improvement in the last decades. New molecularly directed therapies are…”
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Computer-assisted cognitive remediation therapy: Cognition, self-esteem and quality of life in schizophrenia by Garrido, Gemma, Barrios, Maite, Penadés, Rafael, Enríquez, Maria, Garolera, Maite, Aragay, Núria, Pajares, Marta, Vallès, Vicenç, Delgado, Luis, Alberni, Joan, Faixa, Carlota, Vendrell, Josep M

“…Abstract Background Quality of life (QoL) is an important outcome in the treatment of schizophrenia. Cognitive deficits have an impact on functional outcomes…”
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Transcription factor NRF2 uses the Hippo pathway effector TAZ to induce tumorigenesis in glioblastomas by Escoll, Maribel, Lastra, Diego, Pajares, Marta, Robledinos-Antón, Natalia, Rojo, Ana I., Fernández-Ginés, Raquel, Mendiola, Marta, Martínez-Marín, Virginia, Esteban, Isabel, López-Larrubia, Pilar, Gargini, Ricardo, Cuadrado, Antonio

“…Transcription factor NRF2 orchestrates a cellular defense against oxidative stress and, so far, has been involved in tumor progression by providing a metabolic…”
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Can Activation of NRF2 Be a Strategy against COVID-19? by Cuadrado, Antonio, Pajares, Marta, Benito, Cristina, Jiménez-Villegas, José, Escoll, Maribel, Fernández-Ginés, Raquel, Garcia Yagüe, Angel J., Lastra, Diego, Manda, Gina, Rojo, Ana I., Dinkova-Kostova, Albena T.

“…Acute respiratory distress syndrome (ARDS) caused by SARS-CoV-2 is largely the result of a dysregulated host response, followed by damage to alveolar cells and…”
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Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach by Cuadrado, Antonio, Manda, Gina, Hassan, Ahmed, Alcaraz, María José, Barbas, Coral, Daiber, Andreas, Ghezzi, Pietro, León, Rafael, López, Manuela G, Oliva, Baldo, Pajares, Marta, Rojo, Ana I, Robledinos-Antón, Natalia, Valverde, Angela M, Guney, Emre, Schmidt, Harald H H W

“…Systems medicine has a mechanism-based rather than a symptom- or organ-based approach to disease and identifies therapeutic targets in a nonhypothesis-driven…”
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Transcription factor NRF2 regulates the permeability of the blood brain barrier at the level of ANGPT1/2-TIE2 signaling by Cazalla, Eduardo, García-Yagüe, Angel J., Pajares, Marta, Jiménez-Villegas, Jose, Cuadrado, Antonio

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P 087 - NRF2 controls proteostasis through the transcriptional regulation of autophagy by Pajares, Marta, Rojo, Ana I, Cuadrado, Antonio

“…Cells control the abundance and quality of the proteome through a wide network that integrates signaling pathways, gene expression and protein degradation…”
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NRF2 controls proteostasis through the transcriptional regulation of autophagy by Pajares, Marta, Rojo, Ana I, Cuadrado, Antonio

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Redox control of protein degradation by Pajares, Marta, Jiménez-Moreno, Natalia, Dias, Irundika H K, Debelec, Bilge, Vucetic, Milica, Fladmark, Kari E, Basaga, Huveyda, Ribaric, Samo, Milisav, Irina, Cuadrado, Antonio

“…Intracellular proteolysis is critical to maintain timely degradation of altered proteins including oxidized proteins. This review attempts to summarize the…”
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YO-3 - Transcription factor NRF2 modulates chaperone mediated autophagy through the regulation of LAMP2A by Pajares, Marta, Rojo, Ana I., Arias, Esperanza, Diaz-Carretero, Antonio, Cuervo, Ana Maria, Cuadrado, Antonio

“…Chaperone mediated autophagy (CMA) is a selective degradative pathway in which soluble proteins are translocated into lysosomes and degraded. The regulatory…”
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Transcription factor NRF2 modulates chaperone mediated autophagy through the regulation of LAMP2A by Pajares, Marta, Rojo, Ana I., Arias, Esperanza, Diaz-Carretero, Antonio, Cuervo, Ana Maria, Cuadrado, Antonio

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Impact of the transcription factor NRF2 in the modulation of autophagy on TAU and β-amyloid pathology in a combined mouse model of Alzheimer’s disease by Pajares, Marta, Rojo, Ana I, Jiménez, Natalia, Cuadrado, Antonio

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OP3 - Impact of the transcription factor NRF2 in the modulation of autophagy on TAU and β-amyloid pathology in a combined mouse model of Alzheimer’s disease by Pajares, Marta, Rojo, Ana I, Jiménez, Natalia, Cuadrado, Antonio

“…NRF2 might orchestrate a defensive response against proteinopa­thies such as Alzheimer’s disease (AD). Indeed, a bioinformatics analysis allowed us to identify…”
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