Search Results - "Pajares, María J"

Epigenetic Regulation of microRNAs in Cancer: Shortening the Distance from Bench to Bedside by Pajares, María J., Alemany-Cosme, Ester, Goñi, Saioa, Bandres, Eva, Palanca-Ballester, Cora, Sandoval, Juan

“…Cancer is a complex disease involving alterations of multiple processes, with both genetic and epigenetic features contributing as core factors to the disease…”
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A Combined PD-1/C5a Blockade Synergistically Protects against Lung Cancer Growth and Metastasis by Ajona, Daniel, Ortiz-Espinosa, Sergio, Moreno, Haritz, Lozano, Teresa, Pajares, María J, Agorreta, Jackeline, Bértolo, Cristina, Lasarte, Juan J, Vicent, Silvestre, Hoehlig, Kai, Vater, Axel, Lecanda, Fernando, Montuenga, Luis M, Pio, Ruben

“…Disruption of the programmed cell death protein 1 (PD-1) pathway with immune checkpoint inhibitors represents a major breakthrough in the treatment of…”
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Methods for analysis of specific DNA methylation status by Pajares, María J., Palanca-Ballester, Cora, Urtasun, Raquel, Alemany-Cosme, Ester, Lahoz, Agustin, Sandoval, Juan

“…•DNA methylation techniques unravel underlying molecular mechanisms related to disease.•Epigenetics has been applied to study cancer, obesity and…”
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Investigation of Complement Activation Product C4d as a Diagnostic and Prognostic Biomarker for Lung Cancer by AJONA, Daniel, PAJARES, María J, CAMPS, Carlos, ZULUETA, Javier J, MONTUENGA, Luis M, PIO, Ruben, CORRALES, Leticia, PEREZ-GRACIA, Jose L, AGORRETA, Jackeline, LOZANO, Maria D, TORRE, Wenceslao, MASSION, Pierre P, DE-TORRES, Juan P, JANTUS-LEWINTRE, Eloisa

“…There is a medical need for diagnostic biomarkers in lung cancer. We evaluated the diagnostic performance of complement activation fragments. We assessed…”
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Inhibition of Collagen Receptor Discoidin Domain Receptor-1 (DDR1) Reduces Cell Survival, Homing, and Colonization in Lung Cancer Bone Metastasis by VALENCIA, Karmele, ORMAZABAL, Cristina, LECANDA, Fernando, ZANDUETA, Carolina, LUIS-RAVELO, Diego, ANTON, Iker, PAJARES, Maria J, AGORRETA, Jackeline, MONTUENGA, Luis M, MARTINEZ-CANARIAS, Susana, LEITINGER, Birgit

“…We investigated the role of the collagen-binding receptor discoidin domain receptor-1 (DDR1) in the initiation and development of bone metastasis. We conducted…”
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Blockade of the Complement C5a/C5aR1 Axis Impairs Lung Cancer Bone Metastasis by CXCL16-mediated Effects by Ajona, Daniel, Zandueta, Carolina, Corrales, Leticia, Moreno, Haritz, Pajares, María J, Ortiz-Espinosa, Sergio, Martínez-Terroba, Elena, Perurena, Naiara, de Miguel, Fernando J, Jantus-Lewintre, Eloisa, Camps, Carlos, Vicent, Silvestre, Agorreta, Jackeline, Montuenga, Luis M, Pio, Ruben, Lecanda, Fernando

“…C5aR1 (CD88), a receptor for complement anaphylatoxin C5a, is a potent immune mediator. Its impact on malignant growth and dissemination of non-small cell lung…”
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Alternative splicing: an emerging topic in molecular and clinical oncology by Pajares, María J, PhD, Ezponda, Teresa, MSc, Catena, Raúl, MSc, Calvo, Alfonso, PhD, Pio, Ruben, Prof, Montuenga, Luis M, Prof

“…Summary Alternative pre-mRNA splicing is a key molecular event that allows for protein diversity. Through this process, a single gene increases its coding…”
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Expression of sirtuin 1 and 2 is associated with poor prognosis in non-small cell lung cancer patients by Grbesa, Ivana, Pajares, María J, Martínez-Terroba, Elena, Agorreta, Jackeline, Mikecin, Ana-Matea, Larráyoz, Marta, Idoate, Miguel A, Gall-Troselj, Koraljka, Pio, Ruben, Montuenga, Luis M

“…Sirtuin 1 (SIRT1) and sirtuin 2 (SIRT2) are NAD+-dependent protein deacetylases involved in the regulation of key cancer-associated genes. In this study we…”
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YES1 Drives Lung Cancer Growth and Progression and Predicts Sensitivity to Dasatinib by Garmendia, Irati, Pajares, María J, Hermida-Prado, Francisco, Ajona, Daniel, Bértolo, Cristina, Sainz, Cristina, Lavín, Amaya, Remírez, Ana B, Valencia, Karmele, Moreno, Haritz, Ferrer, Irene, Behrens, Carmen, Cuadrado, Myriam, Paz-Ares, Luis, Bustelo, Xosé R, Gil-Bazo, Ignacio, Alameda, Daniel, Lecanda, Fernando, Calvo, Alfonso, Felip, Enriqueta, Sánchez-Céspedes, Montse, Wistuba, Ignacio I, Granda-Diaz, Rocio, Rodrigo, Juan Pablo, García-Pedrero, Juana María, Pio, Ruben, Montuenga, Luis M, Agorreta, Jackeline

“…The characterization of new genetic alterations is essential to assign effective personalized therapies in non-small cell lung cancer (NSCLC). Furthermore,…”
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Lactiplantibacillus plantarum DSM20174 Attenuates the Progression of Non-Alcoholic Fatty Liver Disease by Modulating Gut Microbiota, Improving Metabolic Risk Factors, and Attenuating Adipose Inflammation by Riezu-Boj, José I, Barajas, Miguel, Pérez-Sánchez, Tania, Pajares, María J, Araña, Miriam, Milagro, Fermín I, Urtasun, Raquel

“…Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease, reaching epidemic proportions worldwide. Targeting the gut-adipose…”
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The oncogenic RNA-binding protein SRSF1 regulates LIG1 in non-small cell lung cancer by Martínez-Terroba, Elena, Ezponda, Teresa, Bértolo, Cristina, Sainz, Cristina, Remírez, Ana, Agorreta, Jackeline, Garmendia, Irati, Behrens, Carmen, Pio, Ruben, Wistuba, Ignacio I., Montuenga, Luis M., Pajares, María J.

“…In recent years, the relevance of RNA metabolism has been increasingly recognized in a variety of diseases. Modifications in the levels of RNA-binding proteins…”
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A large-scale analysis of alternative splicing reveals a key role of QKI in lung cancer by de Miguel, Fernando J., Pajares, María J., Martínez-Terroba, Elena, Ajona, Daniel, Morales, Xabier, Sharma, Ravi D., Pardo, Francisco J., Rouzaut, Ana, Rubio, Angel, Montuenga, Luis M., Pio, Ruben

“…Increasing interest has been devoted in recent years to the understanding of alternative splicing in cancer. In this study, we performed a genome-wide analysis…”
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Telomere shortening and accelerated aging in COPD: findings from the BODE cohort by Córdoba-Lanús, Elizabeth, Cazorla-Rivero, Sara, Espinoza-Jiménez, Adriana, de-Torres, Juan P, Pajares, María J, Aguirre-Jaime, Armando, Celli, Bartolomé, Casanova, Ciro

“…Chronic Obstructive Pulmonary Disease (COPD) may be associated with accelerated aging. Telomere shortening is a biomarker of aging. Cross-sectional studies…”
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Strategies to design clinical studies to identify predictive biomarkers in cancer research by Luis Perez-Gracia, Jose, Sanmamed, Miguel F, Bosch, Ana, Patiño-Garcia, Ana, Schalper, Kurt A, Segura, Victor, Bellmunt, Joaquim, Tabernero, Josep, Sweeney, Christopher J, Choueiri, Toni K, Martín, Miguel, Pablo Fusco, Juan, Esperanza Rodriguez-Ruiz, Maria, Calvo, Alfonso, Prior, Celia, Paz-Ares, Luis, Pio, Ruben, Gonzalez Billalabeitia, Enrique, Gonzalez Hernandez, Alvaro, Páez, David, María Piulats, Jose, Gurpide, Alfonso, Andueza, Mapi, de Velasco, Guillermo, Pazo, Roberto, Grande, Enrique, Nicolas, Pilar, Abad-Santos, Francisco, Garcia-Donas, Jesus, Castellano, Daniel, Pajares, María J, Suarez, Cristina, Colomer, Ramon, Montuenga, Luis M, Melero, Ignacio

“…Highlights • Predictive biomarkers are essential to improve the efficacy of anticancer drugs. • Biomarker identification requires well-designed studies that…”
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TRAP1 regulates proliferation, mitochondrial function, and has prognostic significance in NSCLC by Agorreta, Jackeline, Hu, Jianting, Liu, Dongxia, Delia, Domenico, Turley, Helen, Ferguson, David J P, Iborra, Francisco, Pajares, María J, Larrayoz, Marta, Zudaire, Isabel, Pio, Ruben, Montuenga, Luis M, Harris, Adrian L, Gatter, Kevin, Pezzella, Francesco

“…The TNF receptor-associated protein 1 (TRAP1) is a mitochondrial HSP that has been related to drug resistance and protection from apoptosis in colorectal and…”
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Phosphorylated tubulin adaptor protein CRMP‐2 as prognostic marker and candidate therapeutic target for NSCLC by Oliemuller, Erik, Peláez, Rafael, Garasa, Saray, Pajares, María J., Agorreta, Jackeline, Pío, Rubén, Montuenga, Luis M., Teijeira, Alvaro, Llanos, Susana, Rouzaut, Ana

“…Collapsin response mediator protein‐2 (CRMP‐2) is the first described and most studied member of a family of proteins that mediate the addition of tubulin…”
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A novel protein‐based prognostic signature improves risk stratification to guide clinical management in early‐stage lung adenocarcinoma patients by Martínez‐Terroba, Elena, Behrens, Carmen, de Miguel, Fernando J, Agorreta, Jackeline, Monsó, Eduard, Millares, Laura, Sainz, Cristina, Mesa‐Guzman, Miguel, Pérez‐Gracia, José Luis, Lozano, María Dolores, Zulueta, Javier J, Pio, Ruben, Wistuba, Ignacio I, Montuenga, Luis M, Pajares, María J

“…Each of the pathological stages (I–IIIa) of surgically resected non‐small‐cell lung cancer has hidden biological heterogeneity, manifested as heterogeneous…”
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Expression of Tumor-Derived Vascular Endothelial Growth Factor and Its Receptors Is Associated With Outcome in Early Squamous Cell Carcinoma of the Lung by PAJARES, María J, AGORRETA, Jackeline, WISTUBA, Ignacio I, BEHRENS, Carmen, TIMSIT, Jean-Francois, PIO, Ruben, FIELD, John K, MONTUENGA, Luis M, LARRAYOZ, Marta, VESIN, Aurelien, EZPONDA, Teresa, ZUDAIRE, Isabel, TORRE, Wenceslao, LOZANO, María D, BRAMBILLA, Elisabeth, BRAMBILLA, Christian

“…Antiangiogenic therapies targeting the vascular endothelial growth factor (VEGF) pathway have yielded more modest clinical benefit to patients with…”
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The Oncoprotein SF2/ASF Promotes Non-Small Cell Lung Cancer Survival by Enhancing Survivin Expression by EZPONDA, Teresa, PAJARES, Maria J, AGORRETA, Jackeline, ECHEVESTE, José I, LOPEZ-PICAZO, José M, TORRE, Wenceslao, PIO, Ruben, MONTUENGA, Luis M

“…SF2/ASF is a splicing factor recently described as an oncoprotein. In the present work, we examined the role of SF2/ASF in human non-small cell lung cancer…”
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Pediococcus acidilactici pA1c ® Improves the Beneficial Effects of Metformin Treatment in Type 2 Diabetes by Controlling Glycaemia and Modulating Intestinal Microbiota by Cabello-Olmo, Miriam, Oneca, María, Urtasun, Raquel, Pajares, María J, Goñi, Saioa, Riezu-Boj, José I, Milagro, Fermín I, Ayo, Josune, Encio, Ignacio J, Barajas, Miguel, Araña, Miriam

“…Type 2 diabetes (T2D) is a complex metabolic disease, which involves maintained hyperglycemia, mainly due to the development of an insulin resistance process…”
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