Histological analysis of the repair of dural lesions with silicone mesh in rats subjected to experimental lesions

To evaluate inflammatory reaction, fibrosis and neovascularization in dural repairs in Wistar rats using four techniques: simple suture, bovine collagen membrane, silicon mesh and silicon mesh with suture. Thirty Wistar rats were randomized in five groups: the first was the control group, submitted...

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Bibliographic Details
Published in:	Einstein (São Paulo, Brazil) Vol. 13; no. 4; pp. 567 - 573
Main Authors:	Rosa, Fernando William Figueiredo da, Pohl, Pedro Henrique Isoldi, Mader, Ana Maria Amaral Antônio, Paiva, Carla Peluso de, Santos, Aline Amaro dos, Bianco, Bianca, Rodrigues, Luciano Miller Reis
Format:	Journal Article
Language:	English
Published:	Brazil Instituto Israelita de Ensino e Pesquisa Albert Einstein 01-10-2015
Subjects:	Animals Cattle Cirurgia torácica Disease Models, Animal Dura Mater - blood supply Dura Mater - injuries Dura Mater - pathology Dura Mater - surgery Dura-Máter Fibrosis Male MEDICINE, GENERAL & INTERNAL Meninges Modelos animais Neovascularization, Physiologic - drug effects Non-Fibrillar Collagens - therapeutic use Original Procedimentos cirúrgicos operatórios Random Allocation Rats, Wistar Silicones - pharmacology Silicones - therapeutic use Silício Surgical Mesh Suture Techniques - statistics & numerical data Wound Healing - drug effects Thoracic surgery Silício Models, animal Procedimentos cirúrgicos operatórios Modelos animais Surgical procedures, operative Meninges Silicon Dura-Máter Cirurgia torácica Dura Mater
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Summary:	To evaluate inflammatory reaction, fibrosis and neovascularization in dural repairs in Wistar rats using four techniques: simple suture, bovine collagen membrane, silicon mesh and silicon mesh with suture. Thirty Wistar rats were randomized in five groups: the first was the control group, submitted to dural tear only. The others underwent durotomy and simple suture, bovine collagen membrane, silicon mesh and silicon mesh with suture. Animals were euthanized and the spine was submitted to histological evaluation with a score system (ranging from zero to 3) for inflammation, neovascularization and fibrosis. Fibrosis was significantly different between simple suture and silicon mesh (p=0.005) and between simple suture and mesh with suture (p=0.015), showing that fibrosis is more intense when a foreign body is used in the repair. Bovine membrane was significantly different from mesh plus suture (p=0.011) regarding vascularization. Inflammation was significantly different between simple suture and bovine collagen membrane. Silicon mesh, compared to other commercial products available, is a possible alternative for dural repair. More studies are necessary to confirm these findings.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Conflict of interest: none.
ISSN:	1679-4508 2317-6385 2317-6385 1679-4508
DOI:	10.1590/S1679-45082015AO3378