Search Results - "Paiva, Artur"

Pharmacokinetics-pharmacodynamics issues relevant for the clinical use of beta-lactam antibiotics in critically ill patients by Veiga, Rui Pedro, Paiva, José-Artur

“…Antimicrobials are among the most important and commonly prescribed drugs in the management of critically ill patients and beta-lactams are the most common…”
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International ERS/ESICM/ESCMID/ALAT guidelines for the management of hospital-acquired pneumonia and ventilator-associated pneumonia by Torres, Antoni, Niederman, Michael S, Chastre Jean, Ewig Santiago, Fernandez-Vandellos, Patricia, Hanberger Hakan, Marin, Kollef, Li Bassi Gianluigi, Luna, Carlos M, Martin-Loeches, Ignacio, Artur, Paiva J, Read, Robert C, Rigau, David, Timsit Jean Francois, Welte, Tobias, Wunderink, Richard

“…The most recent European guidelines and task force reports on hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) were published almost…”
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Antimicrobial therapeutic drug monitoring in critically ill adult patients: a Position Paper by Abdul-Aziz, Mohd H., Alffenaar, Jan-Willem C., Bassetti, Matteo, Bracht, Hendrik, Dimopoulos, George, Marriott, Deborah, Neely, Michael N., Paiva, Jose-Artur, Pea, Federico, Sjovall, Fredrik, Timsit, Jean F., Udy, Andrew A., Wicha, Sebastian G., Zeitlinger, Markus, De Waele, Jan J., Roberts, Jason A.

“…Purpose This Position Paper aims to review and discuss the available data on therapeutic drug monitoring (TDM) of antibacterials, antifungals and antivirals in…”
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Epidemiology of invasive aspergillosis in critically ill patients: clinical presentation, underlying conditions, and outcomes by Taccone, Fabio Silvio, Van den Abeele, Anne-Marie, Bulpa, Pierre, Misset, Benoit, Meersseman, Wouter, Cardoso, Teresa, Paiva, José-Artur, Blasco-Navalpotro, Miguel, De Laere, Emmanuel, Dimopoulos, George, Rello, Jordi, Vogelaers, Dirk, Blot, Stijn I

“…Invasive aspergillosis (IA) is a fungal infection that particularly affects immunocompromised hosts. Recently, several studies have indicated a high incidence…”
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Antimicrobial de-escalation in critically ill patients: a position statement from a task force of the European Society of Intensive Care Medicine (ESICM) and European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Critically Ill Patients Study Group (ESGCIP) by Tabah, Alexis, Bassetti, Matteo, Kollef, Marin H., Zahar, Jean-Ralph, Paiva, José-Artur, Timsit, Jean-Francois, Roberts, Jason A., Schouten, Jeroen, Giamarellou, Helen, Rello, Jordi, De Waele, Jan, Shorr, Andrew F., Leone, Marc, Poulakou, Garyphallia, Depuydt, Pieter, Garnacho-Montero, Jose

“…Background Antimicrobial de-escalation (ADE) is a strategy of antimicrobial stewardship, aiming at preventing the emergence of antimicrobial resistance (AMR)…”
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Infections in the critically ill patient: new challenges of an old problem by Paiva, José-Artur

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High impact of COVID-19 in long-term care facilities, suggestion for monitoring in the EU/EEA, May 2020 by Danis, Kostas, Fonteneau, Laure, Georges, Scarlett, Daniau, Côme, Bernard-Stoecklin, Sibylle, Domegan, Lisa, O'Donnell, Joan, Hauge, Siri Helene, Dequeker, Sara, Vandael, Eline, Van der Heyden, Johan, Renard, Françoise, Sierra, Natalia Bustos, Ricchizzi, Enrico, Schweickert, Birgitta, Schmidt, Nicole, Abu Sin, Muna, Eckmanns, Tim, Paiva, José-Artur, Schneider, Elke

“…Residents in long-term care facilities (LTCF) are a vulnerable population group. Coronavirus disease (COVID-19)-related deaths in LTCF residents represent…”
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Antimicrobial resistance and antibiotic stewardship programs in the ICU: insistence and persistence in the fight against resistance. A position statement from ESICM/ESCMID/WAAAR round table on multi-drug resistance by De Waele, Jan J., Akova, Murat, Antonelli, Massimo, Canton, Rafael, Carlet, Jean, De Backer, Daniel, Dimopoulos, George, Garnacho-Montero, José, Kesecioglu, Jozef, Lipman, Jeffrey, Mer, Mervyn, Paiva, José-Artur, Poljak, Mario, Roberts, Jason A., Rodriguez Bano, Jesus, Timsit, Jean-François, Zahar, Jean-Ralph, Bassetti, Matteo

“…Antimicrobial resistance (AMR) is a clear and present danger to patients in any intensive care unit (ICU) around the world. Whereas AMR may affect any patient…”
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Aptamer-based Targeted Delivery of a G-quadruplex Ligand in Cervical Cancer Cells by Carvalho, Josué, Paiva, Artur, Cabral Campello, Maria Paula, Paulo, António, Mergny, Jean-Louis, Salgado, Gilmar F., Queiroz, João A., Cruz, Carla

“…AS1411 is a G-rich DNA oligonucleotide that functions as an aptamer of the protein nucleolin, found at high levels on the surface of cancer cells but not on…”
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Remdesivir plus standard of care versus standard of care alone for the treatment of patients admitted to hospital with COVID-19 (DisCoVeRy): a phase 3, randomised, controlled, open-label trial by Hites, Maya, Peiffer-Smadja, Nathan, Poissy, Julien, Lê, Minh-Patrick, Peytavin, Gilles, Staub, Thérèse, Greil, Richard, Costagliola, Dominique, Yazdanpanah, Yazdan, Mentré, France, Egle, Alexander, Greil, Richard, Belkhir, Leila, Verschelden, Gil, Aboab, Jérôme, Ait-Oufella, Hafid, Andrejak, Claire, Argaud, Laurent, Bani-Sadr, Firouzé, Benezit, François, Blot, Mathieu, Bougon, David, Bounes-Vardon, Fanny, Boutoille, David, Bruel, Cédric, Chirouze, Catherine, Clere-Jehl, Raphaël, Courjon, Johan, Crockett, Flora, Danion, François, Dellamonica, Jean, Duvignaud, Alexandre, Epaulard, Olivier, Epelboin, Loïc, Fartoukh, Murielle, Ferry, Tristan, Gaci, Rostane, Gagneux-Brunon, Amandine, Geri, Guillaume, Gibot, Sébastien, Goehringer, François, Hansmann, Yves, Hinschberger, Olivier, Jeanmichel, Vanessa, Kerneis, Solen, Lachâtre, Marie, Lacombe, Karine, Laine, Fabrice, Lanoix, Jean-Philippe, Le Pavec, Jérôme, Le Turnier, Paul, Lebeaux, David, Lefevre, Benjamin, Lessire, Henry, Leveau, Benjamin, Loubet, Paul, Makinson, Alain, Malvy, Denis, Martin-Blondel, Guillaume, Mekontso-Dessap, Armand, Meziani, Ferhat, Mira, Jean-Paul, Molina, Jean-Michel, Monnet, Xavier, Mourvillier, Bruno, Murris-Espin, Marlène, Navellou, Jean-Christophe, Nseir, Saad, Peiffer-Smadja, Nathan, Perpoint, Thomas, Pialoux, Gilles, Piriou, Vincent, Poissy, Julien, Pourcher, Valérie, Quenot, Jean-Pierre, Reignier, Jean, Riu-Poulenc, Béatrice, Robert, Céline, Roger, Pierre-Alexandre, Roger, Claire, Rouveix-Nordon, Elisabeth, Sotto, Albert, Tacquard, Charles, Terzi, Nicolas, Turmel, Jean-Marie, Wattecamps, Guilhem, Berna, Marc, Reuter, Jean, Staub, Thérèse, Braz, Sandra, Ferreira Ribeiro, Joao-Miguel, Paiva, José-Artur, Bouscambert-Duchamp, Maude, Gaymard, Alexandre, Lê, Minh-Patrick, Lina, Bruno, Tubiana, Sarah, Belhadi, Drifa, Mentré, France, Velou, Priyanka

“…The antiviral efficacy of remdesivir against SARS-CoV-2 is still controversial. We aimed to evaluate the clinical efficacy of remdesivir plus standard of care…”
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Rationalizing antimicrobial therapy in the ICU: a narrative review by Timsit, Jean-François, Bassetti, Matteo, Cremer, Olaf, Daikos, George, de Waele, Jan, Kallil, Andre, Kipnis, Eric, Kollef, Marin, Laupland, Kevin, Paiva, Jose-Artur, Rodríguez-Baño, Jesús, Ruppé, Étienne, Salluh, Jorge, Taccone, Fabio Silvio, Weiss, Emmanuel, Barbier, François

“…The massive consumption of antibiotics in the ICU is responsible for substantial ecological side effects that promote the dissemination of multidrug-resistant…”
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Treatment of invasive candidiasis in the era of Candida resistance by Paiva, José-Artur, Pereira, José Manuel

“…The increasing incidence of drug-resistant Candida brings a new challenge to the treatment of invasive candidiasis. Although cross-resistance among azoles and…”
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The Use of Procalcitonin (PCT) for Diagnosis of Sepsis in Burn Patients: A Meta-Analysis by Cabral, Luís, Afreixo, Vera, Almeida, Luís, Paiva, José Artur

“…The continuous development of resuscitation techniques and intensive care reduced the mortality rate induced by the initial shock in burn patients and,…”
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Characteristics and risk factors for 28-day mortality of hospital acquired fungemias in ICUs: data from the EUROBACT study by Paiva, José-Artur, Pereira, José Manuel, Tabah, Alexis, Mikstacki, Adam, de Carvalho, Frederico Bruzzi, Koulenti, Despoina, Ruckly, Stéphane, Çakar, Nahit, Misset, Benoit, Dimopoulos, George, Antonelli, Massimo, Rello, Jordi, Ma, Xiaochun, Tamowicz, Barbara, Timsit, Jean-François

“…To characterize and identify prognostic factors for 28-day mortality among patients with hospital-acquired fungemia (HAF) in the Intensive Care Unit (ICU). A…”
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Characteristics and determinants of outcome of hospital-acquired bloodstream infections in intensive care units: the EUROBACT International Cohort Study by Tabah, Alexis, Koulenti, Despoina, Laupland, Kevin, Misset, Benoit, Valles, Jordi, Bruzzi de Carvalho, Frederico, Paiva, José Artur, Çakar, Nahit, Ma, Xiaochun, Eggimann, Philippe, Antonelli, Massimo, Bonten, Marc J. M., Csomos, Akos, Krueger, Wolfgang A., Mikstacki, Adam, Lipman, Jeffrey, Depuydt, Pieter, Vesin, Aurélien, Garrouste-Orgeas, Maité, Zahar, Jean-Ralph, Blot, Stijn, Carlet, Jean, Brun-Buisson, Christian, Martin, Claude, Rello, Jordi, Dimopoulos, Georges, Timsit, Jean-François

“…Purpose The recent increase in drug-resistant micro-organisms complicates the management of hospital-acquired bloodstream infections (HA-BSIs). We investigated…”
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Adjuvant therapies in critical care: steroids to treat infectious diseases by Pereira, José Manuel, Lisboa, Thiago, Paiva, José-Artur

“…We present a synthesis of the role of corticosteroidsin severe infectious situations treated in intensive caredepartments, discussing, as the title implies,…”
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Therapeutic implications of an enriched cancer stem-like cell population in a human osteosarcoma cell line by Martins-Neves, Sara R, Lopes, Áurio O, do Carmo, Anália, Paiva, Artur A, Simões, Paulo C, Abrunhosa, Antero J, Gomes, Célia M F

“…Osteosarcoma is a bone-forming tumor of mesenchymal origin that presents a clinical pattern that is consistent with the cancer stem cell model. Cells with…”
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Effect of remdesivir on viral dynamics in COVID-19 hospitalized patients: a modelling analysis of the randomized, controlled, open-label DisCoVeRy trial by Lingas, Guillaume, Néant, Nadège, Gaymard, Alexandre, Belhadi, Drifa, Peytavin, Gilles, Hites, Maya, Staub, Thérèse, Greil, Richard, Paiva, Jose-Artur, Poissy, Julien, Peiffer-Smadja, Nathan, Costagliola, Dominique, Yazdanpanah, Yazdan, Wallet, Florent, Gagneux-Brunon, Amandine, Mentré, France, Ader, Florence, Burdet, Charles, Guedj, Jérémie, Bouscambert-Duchamp, Maude

“…Abstract Background The antiviral efficacy of remdesivir in COVID-19 hospitalized patients remains controversial. Objectives To estimate the effect of…”
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Ventilator-associated pneumonia prevention: one good turn does not always deserve another by Póvoa, Pedro, Lisboa, Thiago, Paiva, José-Artur

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Biomarker-guided antifungal therapy in patients with suspected invasive candidiasis: Ready for prime time? by Paiva, José-Artur, Charles, Pierre-Emmanuel

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