Search Results - "Pais, Daniela"

Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy by Siddiqui, Imran, Schaeuble, Karin, Chennupati, Vijaykumar, Fuertes Marraco, Silvia A., Calderon-Copete, Sandra, Pais Ferreira, Daniela, Carmona, Santiago J., Scarpellino, Leonardo, Gfeller, David, Pradervand, Sylvain, Luther, Sanjiv A., Speiser, Daniel E., Held, Werner

“…Checkpoint blockade mediates a proliferative response of tumor-infiltrating CD8+ T lymphocytes (TILs). The origin of this response has remained elusive because…”
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Optimized antiangiogenic reprogramming of the tumor microenvironment potentiates CD40 immunotherapy by Kashyap, Abhishek S., Schmittnaegel, Martina, Rigamonti, Nicolò, Pais-Ferreira, Daniela, Mueller, Philipp, Buchi, Melanie, Ooi, Chia-Huey, Kreuzaler, Matthias, Hirschmann, Petra, Guichard, Alan, Rieder, Natascha, Bill, Ruben, Herting, Frank, Kienast, Yvonne, Dirnhofer, Stefan, Klein, Christian, Hoves, Sabine, Ries, Carola H., Corse, Emily, De Palma, Michele, Zippelius, Alfred

“…Cancer immunotherapies are increasingly combined with targeted therapies to improve therapeutic outcomes. We show that combination of agonistic anti-CD40 with…”
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Lymphoepithelioma-Like Gastric Carcinoma and Gastric Involvement of Chronic Lymphocytic Leukemia: Two Rare Identities Coexisting in One Patient by Guimaraes, Narcisa, Bolais Monica, Ines, Oliveira, Simone, Pato Pais, Daniela, Andrade, Sara, Bertao Colaco, Ines, Vila Nova, Carlos, Vieira, Vera, Azenha, Nuno, Fonseca Pinho, Joao, Guedes, Fatima, Conceicao, Lucilia, Valente Cecilio, Jose

“…Lymphoepithelioma-like gastric carcinoma (LELGC) constitutes 1-4% of all gastric carcinomas and gastrointestinal involvement in leukemia can be present in up…”
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Central memory CD8 + T cells derive from stem-like Tcf7 hi effector cells in the absence of cytotoxic differentiation by Pais Ferreira, Daniela, Silva, Joana Gomes, Wyss, Tania, Fuertes Marraco, Silvia A, Scarpellino, Léonardo, Charmoy, Mélanie, Maas, Roeltje, Siddiqui, Imran, Tang, Li, Joyce, Johanna A, Delorenzi, Mauro, Luther, Sanjiv A, Speiser, Daniel E, Held, Werner

“…Central memory CD8 T cells (Tcm) control systemic secondary infections and can protect from chronic infection and cancer as a result of their stem-cell-like…”
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Hemoperitoneum secondary to mesenteric laceration after abdominal trauma - Case report by Ferreira, Marta M., Guimarães, Narcisa, Mónica, Inês Bolais, Oliveira, Simone, Pais, Daniela, Andrade, Sara, Fonseca, Alice, Couceiro, Ana, Borges, Isabel, Cecílio, José Valente

“…Mesenteric laceration is an uncommon cause of hemoperitoneum, with nonspecific signs and symptoms and frequently is camouflaged by the signs of other traumatic…”
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Emergence and fate of stem cell-like Tcf7 + CD8 + T cells during a primary immune response to viral infection by Silva, Joana Gomes, Pais Ferreira, Daniela, Dumez, Alexandre, Wyss, Tania, Veber, Romain, Danilo, Maxime, Pinschewer, Daniel D, Charmoy, Mélanie, Held, Werner

“…In response to infection, naïve CD8 T (T ) cells yield a large pool of short-lived terminal effector (T ) cells that eliminate infected host cells. In…”
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T Cell Factor 1-Expressing Memory-like CD8+ T Cells Sustain the Immune Response to Chronic Viral Infections by Utzschneider, Daniel T., Charmoy, Mélanie, Chennupati, Vijaykumar, Pousse, Laurène, Ferreira, Daniela Pais, Calderon-Copete, Sandra, Danilo, Maxime, Alfei, Francesca, Hofmann, Maike, Wieland, Dominik, Pradervand, Sylvain, Thimme, Robert, Zehn, Dietmar, Held, Werner

“…Chronic infections promote the terminal differentiation (or “exhaustion”) of T cells and are thought to preclude the formation of memory T cells. In contrast,…”
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The role of surgery in the multidisciplinary approach to non-HIV Kaposi’s sarcoma by Marques, Sónia, Pais, Daniela, Martins, Pedro, Videira, José, Guimarães, Jorge, Moreira, Augusto, Sousa, Abreu

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Integrated Preclinical Data Analysis of ISB 2001 Enables Optimal Starting Dose Selection for a First-in-Class Trispecific T Cell Engager Phase1 Study in Multiple Myeloma by Drake, Adam, Pihlgren, Maria, Menon, Vinu, Pais, Daniela, Carretero-Iglesia, Laura, Berret, Jeremy, Hall, Olivia, Macoin, Julie, Gruber, Isabelle, Stainnack, Elodie, Estoppey, Carole, Dreyfus, Cyrille, Gudi, Girish, Matsuura, Tomomi, van der Graft, Piet H, Dyson, Michael, Konto, Cyril, Pacaud, Lida, Srivastava, Ankita, Zhukovsky, Eugene, Perro, Mario

“…Despite significant clinical benefit achieved by targeted immunotherapies in recent years, durable responses are still limited in multiple myeloma (MM) 1,2…”
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Gastric Schwannoma: A Rare Cause of Gastric Bleeding by Pais, Daniela Pato, Andrade, Sara, Colaco, Ines Bertao, Luis, Margarida, Azenha, Nuno, Couceiro, Ana, Cecilio, Jose Valente

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ISB 2001, a First-in-Class Trispecific BCMA and CD38 T Cell Engager Designed to Overcome Mechanisms of Escape from Treatments for Multiple Myeloma By Targeting Two Antigens by Pihlgren, Maria, Hall, Olivia, Carretero, Laura, Estoppey, Carole, Drake, Adam, Pais, Daniela, Loyau, Jeremy, Berret, Jeremy, Gruber, Isabelle, Suere, Perrine, Schnorhk, Vincent, Nallet, Emilie, Pouleau, Blandine, Chimen, Myriam, Macoin, Julie, Stainnack, Elodie, Monney, Thierry, Delachat, Aurore, Dreyfus, Cyrille, Matthes, Thomas, Konto, Cyril, Dyson, Michael, Blein, Stanislas, Mbow, Lamine, Wood, Rebecca, Srivastava, Ankita, Zhukovsky, Eugene, Perro, Mario

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Sudoku Solver Based on Human Strategies an Application in VBA by Pais, Daniela Marques

“…O Sudoku é um puzzle popularmente conhecido, com aplicações em diversas áreas que se estendem desde a Criptografia à Medicina. Por ser um problema NP-completo,…”
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Abstract 1238: ISB 2001, a BCMA and CD38 dual targeting T cell engager, demonstrates superior cytotoxicity relative to teclistamab in the samples of patient relapsing from CD38 and BCMA targeted immunotherapies by Carretero-Iglesia, Laura, Pihlgren, Maria, Berret, Jeremy, Drake, Adam, Pais, Daniela, Dreyfus, Cyrille, Menon, Vinu, Matthes, Thomas, Edwards, Claire, Edwards, James, Pellat-Deceunynck, Catherine, Moreau, Philippe, Touzeau, Cyrille, Matsuura, Tomomi, van der Graaf, Piet, Pacaud, Lida, Konto, Cyril, Zhukovsky, Eugene, Perro, Mario

“…Abstract Immune therapies targeting single tumor associated antigens (TAA) demonstrated efficacy against multiple myeloma (MM). However, durable responses are…”
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Transvaginal Resection of a Rectal Gastrointestinal Stromal Tumor: A Case Report by Ferreira, Marta M., Guimaraes, Narcisa, Monica, Ines Bolais, Oliveira, Simone, Pais, Daniela Pato, Andrade, Sara, Azenha, Nuno, Dias, Raquel, Borges, Isabel, Cecilio, Jose Valente

“…Gastrointestinal stromal tumors (GISTs) are a type of mesenchymal tumors. They are rare in rectum. This location is a surgical challenge due to the high…”
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Abstract 2970: Overcoming mechanisms of escape from treatments for multiple myeloma with ISB 2001, a potential first-in-class trispecific BCMA and CD38 targeted T cell engager by Pihlgren, Maria, Carretero, Laura, Berret, Jeremy, Hall, Olivia, Estoppey, Carole, Drake, Adam, Pais, Daniela, Macoin, Julie, Chimen, Myriam, Suere, Perrine, Nallet, Emily, Pouleau, Blandine, Stainnack, Elodie, Loyau, Jeremy, Monney, Thierry, Delachat, Aurore, Dreyfus, Cyrille, Blein, Stan, Kaya, Zeynep, Matthes, Thomas, Croasdale-wood, Rebecca, Edwards, James, Edwards, Claire, Mbow, Lamine, Dyson, Michael, Konto, Cyril, Srivastava, Ankita, Zhukovshy, Eugene, Perro, Mario

“…Abstract Immune therapies targeting a single tumor associated antigen (TAA) have demonstrated their efficacy against multiple myeloma (MM) in recent years…”
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ISB 2001 trispecific T cell engager shows strong tumor cytotoxicity and overcomes immune escape mechanisms of multiple myeloma cells by Carretero-Iglesia, Laura, Hall, Olivia J., Berret, Jérémy, Pais, Daniela, Estoppey, Carole, Chimen, Myriam, Monney, Thierry, Loyau, Jeremy, Dreyfus, Cyrille, Macoin, Julie, Perez, Cynthia, Menon, Vinu, Gruber, Isabelle, Laurendon, Amélie, Caro, Lydia N., Gudi, Girish S., Matsuura, Tomomi, van der Graaf, Piet H., Blein, Stanislas, Mbow, M. Lamine, Croasdale-Wood, Rebecca, Srivastava, Ankita, Dyson, Michael R., Matthes, Thomas, Kaya, Zeynep, Edwards, Claire M., Edwards, James R., Maiga, Sophie, Pellat-Deceunynck, Catherine, Touzeau, Cyrille, Moreau, Philippe, Konto, Cyril, Drake, Adam, Zhukovsky, Eugene A., Perro, Mario, Pihlgren, Maria

“…Despite recent advances in immunotherapies targeting single tumor-associated antigens, patients with multiple myeloma eventually relapse. ISB 2001 is a CD3 + T…”
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Overcoming the Small Dataset Challenge in Healthcare by Pais, Daniela, Bras, Susana, Sebastiao, Raquel

“…Obtaining large datasets for training and evaluating models remains a challenge in the medical and healthcare fields due to patient privacy, organizational and…”
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Estudo Sobre o Consumo de Estimulantes Pelos Alunos da Universidade da Beira Interior: Experiência Profissionalizante na Vertente de Farmácia Comunitária, Hospitalar e Investigação by Costa, Filipa Daniela Pais

“…O presente documento, elaborado no âmbito da unidade curricular Estágio, incluído no plano de estudos do Mestrado Integrado em Ciências Farmacêuticas,…”
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Preclinical characterization of ISB 1342, a CD38 × CD3 T-cell engager for relapsed/refractory multiple myeloma by Pouleau, Blandine, Estoppey, Carole, Suere, Perrine, Nallet, Emilie, Laurendon, Amélie, Monney, Thierry, Pais Ferreira, Daniela, Drake, Adam, Carretero-Iglesia, Laura, Macoin, Julie, Berret, Jérémy, Pihlgren, Maria, Doucey, Marie-Agnès, Gudi, Girish S., Menon, Vinu, Udupa, Venkatesha, Maiti, Abhishek, Borthakur, Gautam, Srivastava, Ankita, Blein, Stanislas, Mbow, M. Lamine, Matthes, Thomas, Kaya, Zeynep, Edwards, Claire M., Edwards, James R., Menoret, Emmanuelle, Kervoëlen, Charlotte, Pellat-Deceunynck, Catherine, Moreau, Philippe, Zhukovsky, Eugene, Perro, Mario, Chimen, Myriam

“…•ISB 1342 exhibits potent killing of primary MM cells and MM cell lines with low sensitivity to daratumumab.•ISB 1342 induced complete MM tumor eradication in…”
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Requalificação do Património Industrial como Dinamizador do Sistema Urbano : Fábrica de Fiação e Tecidos Sá by Pais, Daniela Cristina Gomes

“…Nesta dissertação pretende-se explorar a temática da requalificação do património industrial como elemento dinamizador do sistema urbano. Questões atuais que…”
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