Evaluation of Home Polysomnography Findings, Quality of Sleep, and Fatigue in Inflammatory Bowel Disease: A Case Series

Evaluation of Home Polysomnography Findings, Quality of Sleep, and Fatigue in Inflammatory Bowel Disease: A Case Series

The pathogenesis of inflammatory bowel disease (IBD) is not well understood, and sleep disorders may be potential triggers for IBD. Thus, an evaluation of the sleep characteristics, fatigue symptoms, and cytokine levels was performed in patients with IBD during periods of active disease and remissio...

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Published in:Journal of clinical sleep medicine Vol. 15; no. 1; pp. 39 - 45
Main Authors: Paixão, Deise Lun, Poyares, Dalva, de Paula, Marta Sevilh, Duarte, Joselmo Willamy, Castelo, Paula Midor, Ambrogini-Júnior, Orlando, Miszputen, Sender Jankie, Oshima, Celina Tizuko Fujiyam, Chagas, Jair Ribeir, Paiotti, Ana Paula Ribeir
Format: Journal Article
Language:English
Published: United States American Academy of Sleep Medicine 15-01-2019
Subjects:
Adult
Fatigue - complications
Female
Humans
Inflammatory Bowel Diseases - complications
Male
Middle Aged
Polysomnography - methods
Scientific Investigations
Sleep Wake Disorders - complications
Sleep Wake Disorders - diagnosis
Surveys and Questionnaires
fatigue
sleep disorders
polysomnography
inflammatory bowel disease
interleukins
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Summary:The pathogenesis of inflammatory bowel disease (IBD) is not well understood, and sleep disorders may be potential triggers for IBD. Thus, an evaluation of the sleep characteristics, fatigue symptoms, and cytokine levels was performed in patients with IBD during periods of active disease and remission. A total of 20 participants presenting with Crohn's disease or ulcerative colitis, with active disease (n = 7) or in remission (n = 13), underwent home polysomnography (H-PSG). Pittsburgh Sleep Quality Index (PSQI) and Modified Fatigue Impact Scale (MFIS) were applied, in addition to the evaluation of interleukin (IL)-6, IL-10, and tumor necrosis factor alpha (TNF-α) serum levels. Exploratory analysis, test and Mann-Whitney test were used. The mean sleep latency in patients with active disease was 133.07 minutes and 106.79 minutes in those in remission. The sleep efficiency and sleep fragmentation in patients with active disease and those in remission were 80.90% and 84.20% (median), and 76.36/min and 69.82/min (mean), respectively, although the H-PSG parameters did not differ between the groups. The PSQI scores indicated poor sleep quality (global score above 5) in all participants with IBD, and the participants with active disease presented more symptoms of fatigue ( = .032). IL-6 and TNF-α average levels were higher in the participants with disease remission, although with a larger dispersion of the data. No significant difference in the H-PSG characteristics was observed between the patients with IBD with active disease and those in remission; however, the perception of the participants with IBD showed significant effect on the sleep quality and fatigue symptoms.
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ISSN:1550-9389
1550-9397
DOI:10.5664/jcsm.7566