Search Results - "Painter, Ronald E."

A small-molecule inhibitor of BamA impervious to efflux and the outer membrane permeability barrier by Hart, Elizabeth M., Mitchell, Angela M., Konovalova, Anna, Grabowicz, Marcin, Sheng, Jessica, Han, Xiaoqing, Rodriguez-Rivera, Frances P., Schwaid, Adam G., Malinverni, Juliana C., Balibar, Carl J., Bodea, Smaranda, Si, Qian, Wang, Hao, Homsher, Michelle F., Painter, Ronald E., Ogawa, Anthony K., Sutterlin, Holly, Roemer, Terry, Black, Todd A., Rothman, Deborah M., Walker, Scott S., Silhavy, Thomas J.

“…The development of new antimicrobial drugs is a priority to combat the increasing spread of multidrug-resistant bacteria. This development is especially…”
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In vitro studies evaluating the activity of imipenem in combination with relebactam against Pseudomonas aeruginosa by Young, Katherine, Painter, Ronald E, Raghoobar, Susan L, Hairston, Nichelle N, Racine, Fred, Wisniewski, Douglas, Balibar, Carl J, Villafania, Artjohn, Zhang, Rumin, Sahm, Daniel F, Blizzard, Timothy, Murgolo, Nicholas, Hammond, Milton L, Motyl, Mary R

“…The prevalence of antibiotic resistance is increasing, and multidrug-resistant Pseudomonas aeruginosa has been identified as a serious threat to human health…”
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Outbreak of Klebsiella pneumoniae Producing a New Carbapenem-Hydrolyzing Class A β-Lactamase, KPC-3, in a New York Medical Center by WOODFORD, Neil, TIERNO, Philip M, INGLIMA, Kenneth, KORNBLUM, John, LIVERMORE, David M, YOUNG, Katherine, TYSALL, Luke, PALEPOU, Marie-France I, WARD, Elaina, PAINTER, Ronald E, SUBER, Deborah F, SHUNGU, Daniel, SILVER, Lynn L

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Broadening the Spectrum of β-Lactam Antibiotics through Inhibition of Signal Peptidase Type I by THERIEN, Alex G, HUBER, Joann L, XIN GU, KEVIN, Nancy J, LAFLEUR, Josiane, LEAVITT, Penny S, LEBEAU-JACOB, Christian, LEE, Suzy S, LIN, Molly M, MICHELS, Anna A, OGAWA, Aimie M, PAINTER, Ronald E, WILSON, Kenneth E, PARISH, Craig A, PARK, Young-Whan, BENTON-PERDOMO, Liliana, PETCU, Mihai, PHILLIPS, John W, POWLES, Mary Ann, SKOREY, Kathryn I, TAM, John, TAN, Christopher M, YOUNG, Katherine, BEAULIEU, Patrick, WONG, Simon, WADDELL, Sherman T, MIESEL, Lynn, CARON, Alexandre, CLAVEAU, David, DESCHAMPS, Kathleen, DONALD, Robert G. K, GALGOCI, Andrew M, GALLANT, Michel

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Antibacterial small molecules targeting the conserved TOPRIM domain of DNA gyrase by Walker, Scott S, Labroli, Marc, Painter, Ronald E, Wiltsie, Judyann, Sherborne, Brad, Murgolo, Nicholas, Sher, Xinwei, Mann, Paul, Zuck, Paul, Garlisi, Charles G, Su, Jing, Kargman, Stacia, Xiao, Li, Scapin, Giovanna, Salowe, Scott, Devito, Kristine, Sheth, Payal, Buist, Nichole, Tan, Christopher M, Black, Todd A, Roemer, Terry

“…To combat the threat of antibiotic-resistant Gram-negative bacteria, novel agents that circumvent established resistance mechanisms are urgently needed. Our…”
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Selective small-molecule inhibition of an RNA structural element by Howe, John A., Wang, Hao, Fischmann, Thierry O., Balibar, Carl J., Xiao, Li, Galgoci, Andrew M., Malinverni, Juliana C., Mayhood, Todd, Villafania, Artjohn, Nahvi, Ali, Murgolo, Nicholas, Barbieri, Christopher M., Mann, Paul A., Carr, Donna, Xia, Ellen, Zuck, Paul, Riley, Dan, Painter, Ronald E., Walker, Scott S., Sherborne, Brad, de Jesus, Reynalda, Pan, Weidong, Plotkin, Michael A., Wu, Jin, Rindgen, Diane, Cummings, John, Garlisi, Charles G., Zhang, Rumin, Sheth, Payal R., Gill, Charles J., Tang, Haifeng, Roemer, Terry

“…Riboswitches are non-coding RNA structures located in messenger RNAs that bind endogenous ligands, such as a specific metabolite or ion, to regulate gene…”
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Discovery of MK-7655, a β-lactamase inhibitor for combination with Primaxin by Blizzard, Timothy A., Chen, Helen, Kim, Seongkon, Wu, Jane, Bodner, Rena, Gude, Candido, Imbriglio, Jason, Young, Katherine, Park, Young-Whan, Ogawa, Aimie, Raghoobar, Susan, Hairston, Nichelle, Painter, Ronald E., Wisniewski, Doug, Scapin, Giovanna, Fitzgerald, Paula, Sharma, Nandini, Lu, Jun, Ha, Sookhee, Hermes, Jeff, Hammond, Milton L.

“…β-Lactamase inhibitors with a bicyclic urea core and a variety of heterocyclic side chains were prepared and evaluated as potential partners for combination…”
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Discovery of sulfone containing metallo-β-lactamase inhibitors with reduced bacterial cell efflux and histamine release issues by Bennett, Frank, Huang, Yuhua, Dong, Shuzhi, Jiang, Jinlong, Hunter, David, Zhao, Zhiqiang, Gu, Xin, Scott, Jack D., Tang, Haiqun, Yang, Dexi, Xiao, Li, Scapin, Giovanna, Fischmann, Thierry, Mirza, Asra, Dayananth, Priya, Painter, Ronald E., Villafania, Artjohn, Garlisi, Charles G., Zhang, Rumin, Mayhood, Todd W., Si, Qian, Li, Nianyu, Amin, Rupesh P., Chen, Feifei, Bhatt, Bhavana, Regan, Christopher P., Regan, Hilary, Lin, Xinjie, Wu, Jin, Leithead, Andrew, Young, Katherine, Pasternak, Alexander

“…[Display omitted] •Gram-Negative Bacterial Coverage.•Anti-bacterial Resistance.•Sulfone Containing Drug.•Histamine Release.•Enzyme-Inhibitor X- Ray…”
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Imipenem/Relebactam Resistance in Clinical Isolates of Extensively Drug Resistant Pseudomonas aeruginosa: Inhibitor-Resistant β-Lactamases and Their Increasing Importance by Hujer, Andrea M, Bethel, Christopher R, Taracila, Magdalena A, Marshall, Steven H, Rojas, Laura J, Winkler, Marisa L, Painter, Ronald E, Domitrovic, T Nicholas, Watkins, Richard R, Abdelhamed, Ayman M, D'Souza, Roshan, Mack, Andrew R, White, Richard C, Clarke, Thomas, Fouts, Derrick E, Jacobs, Michael R, Young, Katherine, Bonomo, Robert A

“…Multidrug-resistant (MDR) Pseudomonas aeruginosa infections are a major clinical challenge. Many isolates are carbapenem resistant, which severely limits…”
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Cerastecin Inhibition of the Lipooligosaccharide Transporter MsbA to Combat Acinetobacter baumannii : From Screening Impurity to In Vivo Efficacy by Skudlarek, Jason W, Cooke, Andrew J, Mitchell, Helen J, Babaoglu, Kerim, Shaw, Anthony W, Tong, Ling, Nomland, Ashley B, Labroli, Marc, Sha, Deyou, Mulhearn, James J, Wu, Chengwei, Li, Sarah W, Beshore, Douglas C, Hughes, Jonathan M E, Jouffroy, Matthieu, Wang, Hao, Balibar, Carl J, Painter, Ronald E, Shen, Pamela, Lange, Henry S, Ishchenko, Andrii, Chen, Yun-Ting, Klein, Daniel J, Tracy, Rodger W, Miller, Randy R, Cabalu, Tamara D, Wu, Zhe, Leithead, Andrew, Scapin, Giovanna, Hruza, Alan W, Dzhekieva, Liudmila, Bukhtiyarova, Marina, Homsher, Michelle F, Xu, Min, Bahnck-Teets, Carolyn, McKenney, David, Buevich, Alexei V, Liu, Jian, Zhang, Li-Kang, Meng, Tao, Kelly, Terri, DiNunzio, Edward, Soisson, Stephen, Cheng, Robert K Y, Hennig, Michael, Raheem, Izzat, Walker, Scott S

“…, a commonly multidrug-resistant Gram-negative bacterium responsible for large numbers of bloodstream and lung infections worldwide, is increasingly difficult…”
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Discovery of Kibdelomycin, A Potent New Class of Bacterial Type II Topoisomerase Inhibitor by Chemical-Genetic Profiling in Staphylococcus aureus by Phillips, John W., Goetz, Michael A., Smith, Scott K., Zink, Deborah L., Polishook, Jon, Onishi, Russell, Salowe, Scott, Wiltsie, Judyann, Allocco, John, Sigmund, Janet, Dorso, Karen, Lee, Suzy, Skwish, Stephen, de la Cruz, Mercedes, Martín, Jesús, Vicente, Francisca, Genilloud, Olga, Lu, Jun, Painter, Ronald E., Young, Katherine, Overbye, Karen, Donald, Robert G.K., Singh, Sheo B.

“…Bacterial resistance to known therapeutics has led to an urgent need for new chemical classes of antibacterial agents. To address this we have applied a…”
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Affinity Selection–Mass Spectrometry Identifies a Novel Antibacterial RNA Polymerase Inhibitor by Walker, Scott S, Degen, David, Nickbarg, Elliott, Carr, Donna, Soriano, Aileen, Mandal, Mihir, Painter, Ronald E, Sheth, Payal, Xiao, Li, Sher, Xinwei, Murgolo, Nicholas, Su, Jing, Olsen, David B, Ebright, Richard H, Young, Katherine

“…The growing prevalence of drug resistant bacteria is a significant global threat to human health. The antibacterial drug rifampin, which functions by…”
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Inhibitor of intramembrane protease RseP blocks the σE response causing lethal accumulation of unfolded outer membrane proteins by Konovalova, Anna, Grabowicz, Marcin, Balibar, Carl J., Malinverni, Juliana C., Painter, Ronald E., Riley, Daniel, Mann, Paul A., Wang, Hao, Garlisi, Charles G., Sherborne, Brad, Rigel, Nathan W., Ricci, Dante P., Black, Todd A., Roemer, Terry, Silhavy, Thomas J., Walker, Scott S.

“…The outer membrane (OM) of Gram-negative bacteria forms a robust permeability barrier that blocks entry of toxins and antibiotics. Most OM proteins (OMPs)…”
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Cerastecins inhibit membrane lipooligosaccharide transport in drug-resistant Acinetobacter baumannii by Wang, Hao, Ishchenko, Andrii, Skudlarek, Jason, Shen, Pamela, Dzhekieva, Liudmila, Painter, Ronald E., Chen, Yun-Ting, Bukhtiyarova, Marina, Leithead, Andrew, Tracy, Rodger, Babaoglu, Kerim, Bahnck-Teets, Carolyn, Buevich, Alexei, Cabalu, Tamara D., Labroli, Marc, Lange, Henry, Lei, Ying, Li, Wei, Liu, Jian, Mann, Paul A., Meng, Tao, Mitchell, Helen J., Mulhearn, James, Scapin, Giovanna, Sha, Deyou, Shaw, Anthony W., Si, Qian, Tong, Ling, Wu, Chengwei, Wu, Zhe, Xiao, Jing Chen, Xu, Min, Zhang, Li-Kang, McKenney, David, Miller, Randy R., Black, Todd A., Cooke, Andrew, Balibar, Carl J., Klein, Daniel J., Raheem, Izzat, Walker, Scott S.

“…Carbapenem-resistant Acinetobacter baumannii infections have limited treatment options. Synthesis, transport and placement of lipopolysaccharide or…”
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4,7-Dichloro benzothien-2-yl sulfonylaminomethyl boronic acid: First boronic acid-derived beta-lactamase inhibitor with class A, C, and D activity by Tan, Qiang, Ogawa, Aimie M., Painter, Ronald E., Park, Young-Whan, Young, Katherine, DiNinno, Frank P.

“…4,7-Dichloro-1-benzothien-2-yl sulfonylaminomethyl boronic acid (DSABA) is reported as the first boronic acid-based class D beta-lactamase inhibitor, also with…”
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Side chain SAR of bicyclic β-lactamase inhibitors (BLIs). 2. N-Alkylated and open chain analogs of MK-8712 by Chen, Helen, Blizzard, Timothy A., Kim, Seongkon, Wu, Jane, Young, Katherine, Park, Young-Whan, Ogawa, Aimie M., Raghoobar, Susan, Painter, Ronald E., Wisniewski, Doug, Hairston, Nichelle, Fitzgerald, Paula, Sharma, Nandini, Scapin, Giovanna, Lu, Jun, Hermes, Jeff, Hammond, Milton L.

“…The bridged monobactam β-lactamase inhibitor MK-8712 ( 1) effectively inhibits class C β-lactamases. Side chain N-alkylated and ring-opened analogs of 1 were…”
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Side chain SAR of bicyclic β-lactamase inhibitors (BLIs). 1. Discovery of a class C BLI for combination with imipinem by Blizzard, Timothy A., Chen, Helen, Kim, Seongkon, Wu, Jane, Young, Katherine, Park, Young-Whan, Ogawa, Amy, Raghoobar, Susan, Painter, Ronald E., Hairston, Nichelle, Lee, Sang Ho, Misura, Andrew, Felcetto, Tom, Fitzgerald, Paula, Sharma, Nandini, Lu, Jun, Ha, Sookhee, Hickey, Emily, Hermes, Jeff, Hammond, Milton L.

“…Bridged monobactam β-lactamase inhibitors were prepared and evaluated as potential partners for combination with imipenem to overcome class C β-lactamase…”
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Elucidation of DnaE as the Antibacterial Target of the Natural Product, Nargenicin by Painter, Ronald E., Adam, Gregory C., Arocho, Marta, DiNunzio, Edward, Donald, Robert G.K., Dorso, Karen, Genilloud, Olga, Gill, Charles, Goetz, Michael, Hairston, Nichelle N., Murgolo, Nicholas, Nare, Bakela, Olsen, David B., Powles, Maryann, Racine, Fred, Su, Jing, Vicente, Francisca, Wisniewski, Douglas, Xiao, Li, Hammond, Milton, Young, Katherine

“…Resistance to existing classes of antibiotics drives the need for discovery of novel compounds with unique mechanisms of action. Nargenicin A1, a natural…”
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Design and synthesis of novel antibacterial agents with inhibitory activity against DNA polymerase III by Ali, Amjad, Aster, Susan D, Graham, Donald W, Patel, Gool F, Taylor, Gayle E, Tolman, Richard L, Painter, Ronald E, Silver, Lynn L, Young, Katherine, Ellsworth, Kenneth, Geissler, Wayne, Harris, Georgianna S

“…4-Substituted 2-amino-6-(anilino)pyrimidines have been found to be selective inhibitors of DNA polymerase III, a replicative enzyme known to be essential in…”
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Inhibitor of intramembrane protease RseP blocks the sE response causing lethal accumulation of unfolded outer membrane proteins by Konovalova, Anna, Grabowicz, Marcin, Balibar, Carl J, Malinverni, Juliana C, Painter, Ronald E, Riley, Daniel, Mann, Paul A, Wang, Hao, Garlisi, Charles G, Sherborne, Brad, Rigel, Nathan W, Ricci, Dante P, Black, Todd A, Roemer, Terry, Silhavy, Thomas J, Walker, Scott S

“…The outer membrane (OM) of Gram-negative bacteria forms a robust permeability barrier that blocks entry of toxins and antibiotics. Most OM proteins (OMPs)…”
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