Search Results - "Paine, MF"

The role of hepatic and extrahepatic UDP-glucuronosyltransferases in human drug metabolism by Fisher, Michael B., Paine, Mary F., Strelevitz, Timothy J., Wrighton, Steven A.

“…At present, the methods and enzymology of the UDP-glucuronosyltransferases (UGTs) lag behind that of the cytochromes P450 (CYPs). About 15 human UGTs have been…”
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DO MEN AND WOMEN DIFFER IN PROXIMAL SMALL INTESTINAL CYP3A OR P-GLYCOPROTEIN EXPRESSION? by PAINE, Mary F, LUDINGTON, Shana S, CHEN, Mei-Ling, STEWART, Paul W, HUANG, Shiew-Mei, WATKINS, Paul B

“…The higher systemic clearance of some CYP3A4 [whether also P-glycoprotein (P-gp)] drug substrates in women versus men is attributed in part to a higher hepatic…”
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Fentanyl Metabolism by Human Hepatic and Intestinal Cytochrome P450 3A4: Implications for Interindividual Variability in Disposition, Efficacy, and Drug Interactions by LABROO, R. B, PAINE, M. F, THUMMEL, K. E, KHARASCH, E. D

“…The synthetic opioid fentanyl undergoes extensive metabolism in humans. Systemic elimination occurs primarily by hepatic metabolism. When administered as a…”
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Comparison of CYP2D6 content and metoprolol oxidation between microsomes isolated from human livers and small intestines by MADANI, S, PAINE, M. F, LEWIS, L, THUMMEL, K. E, SHEN, D. D

“…To assess the role of intestinal CYP2D6 in oral first-pass drug clearance by comparing the enzyme content and catalytic activity of a prototype CYP2D6…”
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Therapeutic disasters that hastened safety testing of new drugs by Paine, MF

“…New drugs were not required to undergo premarket safety testing in the United States until 1938, when a therapeutic disaster—the Elixir Sulfanilamide…”
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Is quinine a suitable probe to assess the hepatic drug‐metabolizing enzyme CYP3A4? by Wanwimolruk, Sompon, Paine, Mary F., Pusek, Susan N., Watkins, Paul B.

“…Aims To evaluate the antimalarial agent quinine as a potential in vivo probe for hepatic cytochrome P450 (CYP) 3A4 activity. Methods Ten healthy adult…”
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The human intestinal cytochrome P450 pie by PAINE, Mary F, HART, Heather L, LUDINGTON, Shana S, HAINING, Robert L, RETTIE, Allan E, ZELDIN, Darryl C

“…Cytochromes P450 (P450s) 3A, 2C, and 1A2 constitute the major "pieces" of the human liver P450 "pie" and account, on average, for 40, 25, and 18%,…”
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Altered morphine glucuronide and bile acid disposition in patients with nonalcoholic steatohepatitis by Ferslew, BC, Johnston, CK, Tsakalozou, E, Bridges, AS, Paine, MF, Jia, W, Stewart, PW, Barritt IV, AS, Brouwer, KLR

“…The functional impact of altered drug transport protein expression on the systemic pharmacokinetics of morphine, hepatically derived morphine glucuronide…”
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P-Glycoprotein increases from proximal to distal regions of human small intestine by MOULY, Stéphane, PAINE, Mary F

“…The contribution of the efflux transporter P-glycoprotein (P-gp) as a barrier to drug absorption may depend on its level of expression at the site of…”
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Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea ( Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation by Tian, Dan-Dan, Kellogg, Joshua J, Okut, Neşe, Oberlies, Nicholas H, Cech, Nadja B, Shen, Danny D, McCune, Jeannine S, Paine, Mary F

“…Green tea ( ) is a popular beverage worldwide, raising concern for adverse interactions when co-consumed with conventional drugs. Like many botanical natural…”
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Movember Is Mustache Month by Paine, MF, Smith, BP

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Two major grapefruit juice components differ in time to onset of intestinal CYP3A4 inhibition by Paine, Mary F, Criss, Anne B, Watkins, Paul B

“…Grapefruit juice elevates blood levels of some drugs taken orally, primarily by inhibiting intestinal CYP3A4-mediated first-pass metabolism. Two prominent…”
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TWO MAJOR GRAPEFRUIT JUICE COMPONENTS DIFFER IN INTESTINAL CYP3A4 INHIBITION KINETIC AND BINDING PROPERTIES by PAINE, Mary F, CRISS, Anne B, WATKINS, Paul B

“…Bergamottin (BG) and 6′,7′-dihydroxybergamottin (DHB) are the most abundant furanocoumarins present in grapefruit juice and have been proposed as major…”
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Comparison of a New Intranasal Naloxone Formulation to Intramuscular Naloxone: Results from Hypothesis‐generating Small Clinical Studies by Gufford, BT, Ainslie, GR, White, JR, Layton, ME, Padowski, JM, Pollack, GM, Paine, MF

“…Easy‐to‐use naloxone formulations are needed to help address the opioid overdose epidemic. The pharmacokinetics of i.v., i.m., and a new i.n. naloxone…”
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Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism by Paine, M F, Khalighi, M, Fisher, J M, Shen, D D, Kunze, K L, Marsh, C L, Perkins, J D, Thummel, K E

“…Cytochrome P450 3A (CYP3A) metabolizes a diverse array of clinically important drugs. For some of these (e.g., cyclosporine, verapamil, midazolam), CYP3A in…”
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6'7'-Dihydroxybergamottin contributes to the grapefruit juice effect by Kakar, Shefali M, Paine, Mary F, Stewart, Paul W, Watkins, Paul B

“…Our objective was to assess the contribution of 6',7'-dihydroxybergamottin (DHB) to the inhibitory effect of grapefruit juice toward intestinal cytochrome P450…”
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Seville orange juice-felodipine interaction: Comparison with dilute grapefruit juice and involvement of furocoumarins by Malhotra, Shefali, Bailey, David G., Paine, Mary F., Watkins, Paul B.

“…Objective Our objective was to determine whether Seville orange juice produces a grapefruit juice–like interaction with felodipine and whether bergamottin,…”
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Variation in oral clearance of saquinavir is predicted by CYP3A51 genotype but not by enterocyte content of cytochrome P450 3A5 by Mouly, Stéphane J, Matheny, Chris, Paine, Mary F, Smith, Glenn, Lamba, Jatinder, Lamba, Vishal, Pusek, Susan N, Schuetz, Erin G, Stewart, Paul W, Watkins, Paul B

“…Objective Saquinavir, a widely prescribed human immunodeficiency virus 1 protease inhibitor, has a low and variable oral bioavailability that has been…”
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Quantitative prediction and clinical evaluation of an unexplored herb–drug interaction mechanism in healthy volunteers by Gufford, BT, Barr, JT, González‐Pérez, V, Layton, ME, White, JR, Oberlies, NH, Paine, MF

“…Quantitative prediction of herb–drug interaction risk remains challenging. A quantitative framework to assess a potential interaction was used to evaluate a…”
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Physiologically Based Pharmacokinetic Modeling Framework for Quantitative Prediction of an Herb–Drug Interaction by Brantley, SJ, Gufford, BT, Dua, R, Fediuk, DJ, Graf, TN, Scarlett, YV, Frederick, KS, Fisher, MB, Oberlies, NH, Paine, MF

“…Herb–drug interaction predictions remain challenging. Physiologically based pharmacokinetic (PBPK) modeling was used to improve prediction accuracy of…”
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