Search Results - "Pain, V M"

Translation initiation factor modifications and the regulation of protein synthesis in apoptotic cells by Clemens, M J, Bushell, M, Jeffrey, I W, Pain, V M, Morley, S J

“…The rate of protein synthesis is rapidly down-regulated in mammalian cells following the induction of apoptosis. Inhibition occurs at the level of polypeptide…”
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C-terminal domain of eukaryotic protein synthesis initiation factor (eIF) 4G is sufficient to support cap-independent translation in the absence of eIF4E by Ohlmann, T, Rau, M, Pain, V.M, Morley, S.J

“…The foot and mouth disease virus, a picornavirus, encodes two forms of a cysteine proteinase (leader or L protease) that bisects the eIF4G polypeptide of the…”
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Initiation of protein synthesis in mammalian cells by Pain, V M

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Effect of diabetes on the rates of synthesis and degradation of ribosomes in rat muscle and liver in vivo by Ashford, A J, Pain, V M

“…An important component of the decrease in protein synthesis in muscle of diabetic animals is a fall in the ribosome content. Therefore, we have investigated…”
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Translational control during amino acid starvation by Pain, V M

“…Amino acid starvation of mammalian cells results in a pronounced fall in the overall rate of protein synthesis. This is associated with increased…”
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Protein metabolism in skeletal muscle, diaphragm, and heart of diabetic rats by Pain, V M, Albertse, E C, Garlick, P J

“…Rates of protein synthesis were measured in several muscle types in young streptozotocin-diabetic rats at different times after withdrawal of insulin therapy…”
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eIF4G: translation's mystery factor begins to yield its secrets by Morley, S J, Curtis, P S, Pain, V M

“…Translational control is now recognized as a major contributor to the regulation of gene expression in eukaryotes. Within this process, most of the regulatory…”
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Initiation of Protein Synthesis in Eukaryotic Cells by Pain, Virginia M.

“…It is becoming increasingly apparent that translational control plays an important role in the regulation of gene expression in eukaryotic cells. Most of the…”
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Insulin stimulation of growth in diabetic rats. Synthesis and degradation of ribosomes and total tissue protein in skeletal muscle and heart by Ashford, A J, Pain, V M

“…Skeletal muscle and heart of diabetic rats show a substantial decline in the rate of protein synthesis associated with decreases in both the number and…”
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Effect of starvation and diabetes on the activity of the eukaryotic initiation factor eIF-2 in rat skeletal muscle by Jeffrey, I W, Kelly, F J, Duncan, R, Hershey, J W, Pain, V M

“…The ability of the initiation factor eIF-2 in skeletal muscle extracts to form ternary initiation complexes ([Met-tRNA(f).eIF-2.GDP]) is decreased by either…”
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Disruption of the Interaction of Mammalian Protein Synthesis Eukaryotic Initiation Factor 4B with the Poly(A)-binding Protein by Caspase- and Viral Protease-mediated Cleavages by Bushell, Martin, Wood, Wendy, Carpenter, Gillian, Pain, Virginia M., Morley, Simon J., Clemens, Michael J.

“…Eukaryotic initiation factor (eIF) 4B interacts with several components of the initiation pathway and is targeted for cleavage during apoptosis. In a cell-free…”
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Protein metabolism in the mouse during pregnancy and lactation by Millican, P E, Vernon, R G, Pain, V M

“…Protein synthesis was measured in vivo in the whole body and in a number of individual tissues in mice at various stages of pregnancy and lactation. The…”
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Stimulation by insulin of protein synthesis in cultured chick embryo fibroblasts by Jeffrey, I W, Pain, V M

“…Insulin stimulates protein synthesis in skeletal muscle of young animals and has been reported to exert similar effects on a variety of mammalian cell types in…”
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Effect of cleavage of the p220 subunit of eukaryotic translation initiation factor eIF-4F on protein synthesis in vitro by Ohlmann, T, Rau, M, Morley, S, Pain, V M

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A Reevaluation of the Cap-binding Protein, eIF4E, as a Rate-limiting Factor for Initiation of Translation in Reticulocyte Lysate (∗) by Rau, Michael, Ohlmann, Theophile, Morley, Simon J., Pain, Virginia M.

“…The cap-binding eukaryotic initiation factor, eIF4E, is a key target for the regulation of translation in mammalian cells and is widely thought to be present…”
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Translation initiation factor 4E by McKendrick, Linda, Pain, Virginia M., Morley, Simon J.

“…Translation initiation factor 4E (eIF4E) binds the 7-methylguanosine cap structure of mRNA and mediates recruitment of mRNA to ribosomes, with the potential of…”
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Increased phosphorylation of eukaryotic initiation factor 4α during early activation of T lymphocytes correlates with increased initiation factor 4F complex formation by Morley, Simon J., RAU, Michael, KAY, John E., PAIN, Virginia M.

“…Mature porcine peripheral blood mononuclear cells (PPBMCs) exist in a resting state both in vivo and when maintained in culture, with low translation rates…”
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The effects of amino acid starvation on regulation of polypeptide chain initiation in Ehrlich ascites tumor cells by Pain, V M, Lewis, J A, Huvos, P, Henshaw, E C, Clemens, M J

“…The ratio of initiation of protein synthesis in Ehrlich ascites tumor cells in culture is reduced by over 60% in the absence of a single essential amino acid…”
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Protein metabolism in the tumour-bearing mouse. Rates of protein synthesis in host tissues and in an Ehrlich ascites tumour at different stages in tumour growth by Lopes, M N, Black, P, Ashford, A J, Pain, V M

“…We have investigated the time course of the changes in protein metabolism in skeletal muscle and liver in mice during the progression of growth of an Ehrlich…”
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The Association of Initiation Factor 4F with Poly(A)-binding Protein Is Enhanced in Serum-stimulated Xenopus Kidney Cells by Fraser, Christopher S., Pain, Virginia M., Morley, Simon J.

“…Serum stimulation of cultured Xenopuskidney cells results in enhanced phosphorylation of the translational initiation factor (eIF) 4E and promotes a 2.8-fold…”
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