Search Results - "Pai, Sudhir"

T cell-inducing vaccine durably prevents mucosal SHIV infection even with lower neutralizing antibody titers by Arunachalam, Prabhu S., Charles, Tysheena P., Joag, Vineet, Bollimpelli, Venkata S., Scott, Madeleine K. D., Wimmers, Florian, Burton, Samantha L., Labranche, Celia C., Petitdemange, Caroline, Gangadhara, Sailaja, Styles, Tiffany M., Quarnstrom, Clare F., Walter, Korey A., Ketas, Thomas J., Legere, Traci, Jagadeesh Reddy, Pradeep Babu, Kasturi, Sudhir Pai, Tsai, Anthony, Yeung, Bertrand Z., Gupta, Shakti, Tomai, Mark, Vasilakos, John, Shaw, George M., Kang, Chil-Yong, Moore, John P., Subramaniam, Shankar, Khatri, Purvesh, Montefiori, David, Kozlowski, Pamela A., Derdeyn, Cynthia A., Hunter, Eric, Masopust, David, Amara, Rama R., Pulendran, Bali

“…Recent efforts toward an HIV vaccine focus on inducing broadly neutralizing antibodies, but eliciting both neutralizing antibodies (nAbs) and cellular…”
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CXCL13 is a plasma biomarker of germinal center activity by Havenar-Daughton, Colin, Lindqvist, Madelene, Heit, Antje, Wu, Jennifer E., Reiss, Samantha M., Kendric, Kayla, Bélanger, Simon, Kasturi, Sudhir Pai, Landais, Elise, Akondy, Rama S., McGuire, Helen M., Bothwell, Marcella, Vagefi, Parsia A., Scully, Eileen, Tomarasm, Georgia D., Davis, Mark M., Poignard, Pascal, Ahmed, Rafi, Walker, Bruce D., Pulendran, Bali, McElrath, M. Juliana, Kaufmann, Daniel E., Crotty, Shane

“…Significantly higher levels of plasma CXCL13 [chemokine (C-X-C motif) ligand 13] were associated with the generation of broadly neutralizing antibodies (bnAbs)…”
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Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway by Murthy, Niren, Pulendran, Bali, Kasturi, Sudhir Pai, Cao, Weiping, Tang, Hua, Pirani, Ali, Manicassamy, Santhakumar

“…The mammalian target of rapamycin pathway regulates many essential cellular responses. Pulendran and colleagues show that this pathway is required for…”
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Programming the magnitude and persistence of antibody responses with innate immunity by Kasturi, Sudhir Pai, Skountzou, Ioanna, Albrecht, Randy A., Koutsonanos, Dimitrios, Hua, Tang, Nakaya, Helder I., Ravindran, Rajesh, Stewart, Shelley, Alam, Munir, Kwissa, Marcin, Villinger, Francois, Murthy, Niren, Steel, John, Jacob, Joshy, Hogan, Robert J., García-Sastre, Adolfo, Compans, Richard, Pulendran, Bali

“…Vaccines given a boost A feature of many successful vaccines is the induction of memory B cells and long-lived plasma cells that can secrete neutralizing…”
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Alexia Without Agraphia: Can Write But Not Read by Bhat, Dhananjaya I, Santosh Kumar, S A, Pai, Sudhir S, Chandramouli, B A

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Essential Regression: A generalizable framework for inferring causal latent factors from multi-omic datasets by Bing, Xin, Lovelace, Tyler, Bunea, Florentina, Wegkamp, Marten, Kasturi, Sudhir Pai, Singh, Harinder, Benos, Panayiotis V., Das, Jishnu

“…High-dimensional cellular and molecular profiling of biological samples highlights the need for analytical approaches that can integrate multi-omic datasets to…”
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Cross-presentation: avoiding trafficking chaos? by Kasturi, Sudhir Pai, Pulendran, Bali

“…Cross-presentation of antigens is essential for the responses of cytotoxic T cells to tumors and viruses. Two new papers offer insights into the subcellular…”
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The science of adjuvants by Kwissa, Marcin, Kasturi, Sudhir Pai, Pulendran, Bali

“…Adjuvants are substances that boost the immunogenicity of vaccines. However, most successful vaccines have been derived empirically and are capable of inducing…”
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Traumatic Rupture of Posterior Tibial Tendon Following Closed Supination-Adduction Ankle Fracture: A Case Report by Krishna, Sathya Vamsi, Pilar, Anoop, Pai, Sudhir N., Issac, Thomas

“…A 25-year-old man with no known comorbidities presented with pain and swelling of the left ankle following a twisting injury that had occurred during a road…”
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Prophylactic anti-tumor effects in a B cell lymphoma model with DNA vaccines delivered on polyethylenimine (PEI) functionalized PLGA microparticles by Pai Kasturi, Sudhir, Qin, Hong, Thomson, Kassandra S., El-Bereir, Shihab, Cha, Soung-chul, Neelapu, Sattva, Kwak, Larry W., Roy, Krishnendu

“…Idiotypic sequences, specific to the hypervariable regions of immunoglobulins expressed by malignant B cells offer a therapeutic target in B cell lymphoma…”
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N6-Methyladenosine Modification Controls Circular RNA Immunity by Chen, Y. Grace, Chen, Robert, Ahmad, Sadeem, Verma, Rohit, Kasturi, Sudhir Pai, Amaya, Laura, Broughton, James P., Kim, Jeewon, Cadena, Cristhian, Pulendran, Bali, Hur, Sun, Chang, Howard Y.

“…Circular RNAs (circRNAs) are prevalent in eukaryotic cells and viral genomes. Mammalian cells possess innate immunity to detect foreign circRNAs, but the…”
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The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling by Nakaya, Helder I, Murthy, Niren, Pulendran, Bali, Kepler, Thomas B, Kasturi, Sudhir Pai, Tang, Hua, Cao, Weiping, Malissen, Bernard, Ravindran, Rajesh, Kundu, Kousik

“…The mechanisms that initiate T helper type 2 responses are poorly understood. Pulendran and colleagues now show that such responses to cysteine proteases…”
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Cytokine-Independent Detection of Antigen-Specific Germinal Center T Follicular Helper Cells in Immunized Nonhuman Primates Using a Live Cell Activation-Induced Marker Technique by Havenar-Daughton, Colin, Reiss, Samantha M, Carnathan, Diane G, Wu, Jennifer E, Kendric, Kayla, Torrents de la Peña, Alba, Kasturi, Sudhir Pai, Dan, Jennifer M, Bothwell, Marcella, Sanders, Rogier W, Pulendran, Bali, Silvestri, Guido, Crotty, Shane

“…A range of current candidate AIDS vaccine regimens are focused on generating protective HIV-neutralizing Ab responses. Many of these efforts rely on the rhesus…”
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Toll-like receptor 2-dependent induction of vitamin A-metabolizing enzymes in dendritic cells promotes T regulatory responses and inhibits autoimmunity by Pulendran, Bali, Manicassamy, Santhakumar, Ravindran, Rajesh, Deng, Jiusheng, Oluoch, Herold, Denning, Timothy L, Kasturi, Sudhir Pai, Rosenthal, Kristen M, Evavold, Brian D

“…Bali Pulendran and his colleagues explore ways that signaling through different pathogen receptors can program dendritic cells (DCs) to orchestrate…”
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Adjuvanting a Simian Immunodeficiency Virus Vaccine with Toll-Like Receptor Ligands Encapsulated in Nanoparticles Induces Persistent Antibody Responses and Enhanced Protection in TRIM5α Restrictive Macaques by Kasturi, Sudhir Pai, Kozlowski, Pamela A, Nakaya, Helder I, Burger, Matheus C, Russo, Pedro, Pham, Mathew, Kovalenkov, Yevgeniy, Silveira, Eduardo L V, Havenar-Daughton, Colin, Burton, Samantha L, Kilgore, Katie M, Johnson, Mathew J, Nabi, Rafiq, Legere, Traci, Sher, Zarpheen Jinnah, Chen, Xuemin, Amara, Rama R, Hunter, Eric, Bosinger, Steven E, Spearman, Paul, Crotty, Shane, Villinger, Francois, Derdeyn, Cynthia A, Wrammert, Jens, Pulendran, Bali

“…Our previous work has shown that antigens adjuvanted with ligands specific for Toll-like receptor 4 (TLR4) and TLR7/8 encapsulated in poly(lactic-co-glycolic)…”
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3M-052, a synthetic TLR-7/8 agonist, induces durable HIV-1 envelope-specific plasma cells and humoral immunity in nonhuman primates by Kasturi, Sudhir Pai, Rasheed, Mohammed Ata Ur, Havenar-Daughton, Colin, Pham, Mathew, Legere, Traci, Sher, Zarpheen Jinnah, Kovalenkov, Yevgeny, Gumber, Sanjeev, Huang, Jessica Y, Gottardo, Raphael, Fulp, William, Sato, Alicia, Sawant, Sheetal, Stanfield-Oakley, Sherry, Yates, Nicole, LaBranche, Celia, Alam, S Munir, Tomaras, Georgia, Ferrari, Guido, Montefiori, David, Wrammert, Jens, Villinger, Francois, Tomai, Mark, Vasilakos, John, Fox, Christopher B, Reed, Steven G, Haynes, Barton F, Crotty, Shane, Ahmed, Rafi, Pulendran, Bali

“…A fundamental challenge in vaccinology is learning how to induce durable antibody responses. Live viral vaccines induce antibody responses that last a…”
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Mapping cetacean sounds using a passive acoustic monitoring system towed by an autonomous Wave Glider in the Southwestern Atlantic Ocean by Bittencourt, Lis, Soares-Filho, William, de Lima, Isabela Maria Seabra, Pai, Sudhir, Lailson-Brito, Jose, Barreira, Leonardo Martins, Azevedo, Alexandre Freitas, Guerra, Luiz Alexandre A.

“…Passive acoustic monitoring techniques provide a useful alternative to visual surveys for monitoring of marine mammals since they are less affected by adverse…”
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Clade C HIV-1 Envelope Vaccination Regimens Differ in Their Ability To Elicit Antibodies with Moderate Neutralization Breadth against Genetically Diverse Tier 2 HIV-1 Envelope Variants by Burton, Samantha, Spicer, Lori M, Charles, Tysheena P, Gangadhara, Sailaja, Reddy, Pradeep B J, Styles, Tiffany M, Velu, Vijayakumar, Kasturi, Sudhir Pai, Legere, Traci, Hunter, Eric, Pulendran, Bali, Amara, Rama, Hraber, Peter, Derdeyn, Cynthia A

“…The goals of preclinical HIV vaccine studies in nonhuman primates are to develop and test different approaches for their ability to generate protective…”
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A yeast expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates by Pino, Maria, Abid, Talha, Pereira Ribeiro, Susan, Edara, Venkata Viswanadh, Floyd, Katharine, Smith, Justin C, Latif, Muhammad Bilal, Pacheco-Sanchez, Gabriela, Dutta, Debashis, Wang, Shelly, Gumber, Sanjeev, Kirejczyk, Shannon, Cohen, Joyce, Stammen, Rachelle L, Jean, Sherrie M, Wood, Jennifer S, Connor-Stroud, Fawn, Pollet, Jeroen, Chen, Wen-Hsiang, Wei, Junfei, Zhan, Bin, Lee, Jungsoon, Liu, Zhuyun, Strych, Ulrich, Shenvi, Neeta, Easley, Kirk, Weiskopf, Daniela, Sette, Alessandro, Pollara, Justin, Mielke, Dieter, Gao, Hongmei, Eisel, Nathan, LaBranche, Celia C, Shen, Xiaoying, Ferrari, Guido, Tomaras, Georgia D, Montefiori, David C, Sekaly, Rafick P, Vanderford, Thomas H, Tomai, Mark A, Fox, Christopher B, Suthar, Mehul S, Kozlowski, Pamela A, Hotez, Peter J, Paiardini, Mirko, Bottazzi, Maria Elena, Kasturi, Sudhir Pai

“…Ongoing SARS-CoV-2 vaccine development is focused on identifying stable, cost-effective, and accessible candidates for global use, specifically in low and…”
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Signatures in Simian Immunodeficiency Virus SIVsmE660 Envelope gp120 Are Associated with Mucosal Transmission but Not Vaccination Breakthrough in Rhesus Macaques by Smith, S Abigail, Kilgore, Katie M, Kasturi, Sudhir Pai, Pulendran, Bali, Hunter, Eric, Amara, Rama R, Derdeyn, Cynthia A

“…Mucosal surfaces are vulnerable to human immunodeficiency virus (HIV)/simian immunodeficiency virus (SIV) infection and thus are key sites for eliciting…”
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