Search Results - "Pai, Manjunath P"

Reappraisal of Linezolid Dosing in Renal Impairment To Improve Safety by Crass, Ryan L, Cojutti, Pier Giorgio, Pai, Manjunath P, Pea, Federico

“…Linezolid is administered as a fixed dose to all patients despite evidence of increased exposure and myelosuppression in renal impairment. The objectives of…”
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Therapeutic Monitoring of Vancomycin for Serious Methicillin-resistant Staphylococcus aureus Infections: A Revised Consensus Guideline and Review by the American Society of Health-system Pharmacists, the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the Society of Infectious Diseases Pharmacists by Rybak, Michael J, Le, Jennifer, Lodise, Thomas P, Levine, Donald P, Bradley, John S, Liu, Catherine, Mueller, Bruce A, Pai, Manjunath P, Wong-Beringer, Annie, Rotschafer, John C, Rodvold, Keith A, Maples, Holly D, Lomaestro, Benjamin

“…Abstract Recent clinical data on vancomycin pharmacokinetics and pharmacodynamics suggest a reevaluation of current dosing and monitoring recommendations. The…”
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Innovative approaches to optimizing the delivery of vancomycin in individual patients by Pai, Manjunath P., Neely, Michael, Rodvold, Keith A., Lodise, Thomas P.

“…The delivery of personalized antimicrobial therapy is a critical component in the treatment of patients with invasive infections. Vancomycin, the drug of…”
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Pharmacokinetics of Tedizolid in Morbidly Obese and Covariate-Matched Nonobese Adults by Pai, Manjunath P

“…Tedizolid is a novel oxazolidinone antimicrobial administered in its prodrug form, tedizolid phosphate, as a fixed once-daily dose. The pharmacokinetics of…”
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Population Pharmacokinetics and Dosing Considerations for the Use of Linezolid in Overweight and Obese Adult Patients by Cojutti, Piergiorgio, Pai, Manjunath P., Pea, Federico

“…Background Linezolid is an anti-Gram-positive antimicrobial agent used at a fixed dose of 600 mg every 12 h. Objectives The objective of this study was to…”
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Volumetric Absorptive Microsampling to Enhance the Therapeutic Drug Monitoring of Tacrolimus and Mycophenolic Acid: A Systematic Review and Critical Assessment by Leino, Abbie D., Takyi-Williams, John, Pai, Manjunath P.

“…Volumetric absorptive microsampling (VAMS) is an emerging technique that may support multisample collection to enhance therapeutic drug monitoring in solid…”
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Reconsideration of the current models of estimated kidney function-based drug dose adjustment in older adults: The role of biological age by Alikhani, Radin, Pai, Manjunath P

“…Human lifespan has increased from a median of 46.5 years in 1950 to 71.7 years in 2022. As people age, one of the inevitable consequences is a decline in…”
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Time to Initiation of Fluconazole Therapy Impacts Mortality in Patients with Candidemia: A Multi-Institutional Study by Garey, Kevin W., Rege, Milind, Pai, Manjunath P., Mingo, Dana E., Suda, Katie J., Turpin, Robin S., Bearden, David T.

“…Background. Inadequate antimicrobial treatment is an independent determinant of hospital mortality, and fungal bloodstream infections are among the types of…”
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Estimated glomerular filtration rate with and without race for drug dosing: Cystatin C vs. serum creatinine by Yun, Hyun Gi, Smith, Andrew J. F., DeBacker, Kenneth C., Pai, Manjunath P.

“…The goal of this study was to use a model kidney function clearance‐dependent drug (vancomycin) to understand the gain or loss of precision in dosing with use…”
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Executive Summary: Therapeutic Monitoring of Vancomycin for Serious Methicillin‐Resistant Staphylococcus aureus Infections: A Revised Consensus Guideline and Review of the American Society of Health‐System Pharmacists, the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the Society of Infectious Diseases Pharmacists by Rybak, Michael J., Le, Jennifer, Lodise, Thomas P., Levine, Donald P., Bradley, John S., Liu, Catherine, Mueller, Bruce A., Pai, Manjunath P., Wong‐Beringer, Annie, Rotschafer, John C., Rodvold, Keith A., Maples, Holly D., Lomaestro, Benjamin M.

“…Background Recent vancomycin PK/PD and toxicodynamic studies enable a reassessment of the current dosing and monitoring guideline in an attempt to further…”
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Panobinostat penetrates the blood–brain barrier and achieves effective brain concentrations in a murine model by Homan, Morgan J., Franson, Andrea, Ravi, Karthik, Roberts, Holly, Pai, Manjunath P., Liu, Cai, He, Miao, Matvekas, Aleksas, Koschmann, Carl, Marini, Bernard L.

“…Purpose Panobinostat, an orally bioavailable pan-HDAC inhibitor, has demonstrated potent activity in multiple malignancies, including pediatric brain tumors…”
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Individualized Vancomycin Dosing in Obese Patients: A Two-Sample Measurement Approach Improves Target Attainment by Hong, Joseph, Krop, Lynne C., Johns, Tracy, Pai, Manjunath P.

“…Study Objective To compare the likelihood of vancomycin target trough concentration attainment based on infectious diagnosis and/or minimum inhibitory…”
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Paclitaxel Plasma Concentration after the First Infusion Predicts Treatment-Limiting Peripheral Neuropathy by Hertz, Daniel L, Kidwell, Kelley M, Vangipuram, Kiran, Li, Feng, Pai, Manjunath P, Burness, Monika, Griggs, Jennifer J, Schott, Anne F, Van Poznak, Catherine, Hayes, Daniel F, Lavoie Smith, Ellen M, Henry, N Lynn

“…Paclitaxel exposure, specifically the maximum concentration ( ) and amount of time the concentration remains above 0.05 μmol/L ( ), has been associated with…”
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In Vivo Dissolution and Systemic Absorption of Immediate Release Ibuprofen in Human Gastrointestinal Tract under Fed and Fasted Conditions by Koenigsknecht, Mark J, Baker, Jason R, Wen, Bo, Frances, Ann, Zhang, Huixia, Yu, Alex, Zhao, Ting, Tsume, Yasuhiro, Pai, Manjunath P, Bleske, Barry E, Zhang, Xinyuan, Lionberger, Robert, Lee, Allen, Amidon, Gordon L, Hasler, William L, Sun, Duxin

“…In vivo drug dissolution in the gastrointestinal (GI) tract is largely unmeasured. The purpose of this clinical study was to evaluate the in vivo drug…”
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Estimation of creatinine clearance in morbidly obese patients by Demirovic, Jasmina A, Pai, Amy Barton, Pai, Manjunath P

“…Estimates of creatinine clearance (CL(cr)) based on equations and various body-size descriptors were compared with 24-hour measured CL(cr) values in morbidly…”
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Steady-State Plasma Pharmacokinetics of Oral Voriconazole in Obese Adults by PAI, Manjunath P, LODISE, Thomas P

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Characterization of genetic changes associated with daptomycin nonsusceptibility in Staphylococcus aureus by Ma, Zhuo, Lasek-Nesselquist, Erica, Lu, Jackson, Schneider, Ryan, Shah, Riddhi, Oliva, George, Pata, Janice, McDonough, Kathleen, Pai, Manjunath P, Rose, Warren E, Sakoulas, George, Malik, Meenakshi

“…The extensive use of daptomycin (DAP) for treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections in the last decade has led to the…”
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Simplified Estimation of Aminoglycoside Pharmacokinetics in Underweight and Obese Adult Patients by PAI, Manjunath P, NAFZIGER, Anne N, BERTINO, Joseph S

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Use of Oral Tetracyclines in the Treatment of Adult Patients with Community-Acquired Bacterial Pneumonia: A Literature Review on the Often-Overlooked Antibiotic Class by Bidell, Monique R, Pai, Manjunath Amit P, Lodise, Thomas P

“…Oral tetracyclines have been used in clinical practice for over 60 years. Overall, one of the most common indications for use of oral tetracyclines is for…”
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Association of Fluconazole Area under the Concentration-Time Curve/MIC and Dose/MIC Ratios with Mortality in Nonneutropenic Patients with Candidemia by PAI, Manjunath P, TURPIN, Robin S, GAREY, Kevin W

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