Search Results - "Pagotto, Anna"
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Autophagy inhibition reduces chemoresistance and tumorigenic potential of human ovarian cancer stem cells
Published in Cell death & disease (20-07-2017)“…Epithelial ovarian cancer (EOC) is one of the most malignant gynecological tumors with a high mortality rate owing to tumor relapse after anticancer therapies…”
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2
Staphylococcus aureus iron-regulated surface determinant B (IsdB) protein interacts with von Willebrand factor and promotes adherence to endothelial cells
Published in Scientific reports (23-11-2021)“…Staphylococcus aureus is the cause of a spectrum of diseases in humans and animals. The molecular basis of this pathogenicity lies in the expression of a…”
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3
A juxtacrine/paracrine loop between C-Kit and stem cell factor promotes cancer stem cell survival in epithelial ovarian cancer
Published in Cell death & disease (28-05-2019)“…Receptors tyrosine kinase (RTK) enable normal and tumor cells to perceive and adapt to stimuli present in the microenvironment. These stimuli, also known as…”
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Exogenous human α-Synuclein acts in vitro as a mild platelet antiaggregant inhibiting α-thrombin-induced platelet activation
Published in Scientific reports (14-06-2022)“…α-Synuclein (αSyn) is a small disordered protein, highly conserved in vertebrates and involved in the pathogenesis of Parkinson’s disease (PD). Indeed, αSyn…”
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5
Targeted review of IL36RN mutations in patients with generalised pustular psoriasis
Published in Skin health and disease (01-04-2024)“…Background Generalised pustular psoriasis (GPP) is a rare and chronic skin disease historically treated with therapies that were originally intended to treat…”
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Inhibitor of apoptosis-stimulating protein of p53 (iASPP) prevents senescence and is required for epithelial stratification
Published in Proceedings of the National Academy of Sciences - PNAS (04-10-2011)“…Inhibitor of apoptosis-stimulating protein of p53 (iASPP) is the most ancient member of the ASPP family of proteins and an evolutionary conserved inhibitor of…”
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ASPP2 suppresses squamous cell carcinoma via RelA/p65–mediated repression of p63
Published in Proceedings of the National Academy of Sciences - PNAS (29-10-2013)“…Squamous cell carcinoma (SCC) is highly malignant and refractory to therapy. The majority of existing mouse SCC models involve multiple gene mutations. Very…”
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Centrosomal localisation of the cancer/testis (CT) antigens NY-ESO-1 and MAGE-C1 is regulated by proteasome activity in tumour cells
Published in PloS one (10-12-2013)“…The Cancer/Testis (CT) antigen family of genes are transcriptionally repressed in most human tissues but are atypically re-expressed in many malignant tumour…”
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9
Frequent MAGE mutations in human melanoma
Published in PloS one (16-09-2010)“…Cancer/testis (CT) genes are expressed only in the germ line and certain tumors and are most frequently located on the X-chromosome (the CT-X genes). Amongst…”
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Mechanistic basis of activation and inhibition of protein disulfide isomerase by allosteric antithrombotic compounds
Published in Journal of thrombosis and haemostasis (23-10-2024)“…Protein disulfide isomerase (PDI) is a promising target for combating thrombosis. Extensive research over the past decade has identified numerous PDI-targeting…”
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From haemadin to haemanorm: Synthesis and characterization of full‐length haemadin from the leech Haemadipsa sylvestris and of a novel bivalent, highly potent thrombin inhibitor (haemanorm)
Published in Protein science (01-12-2023)“…Hirudin from Hirudo medicinalis is a bivalent α‐Thrombin (αT) inhibitor, targeting the enzyme active site and exosite‐I, and is currently used in anticoagulant…”
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12
Invasive candidiasis: current clinical challenges and unmet needs in adult populations
Published in Journal of antimicrobial chemotherapy (05-07-2023)“…Abstract Invasive candidiasis (IC) is a serious infection caused by several Candida species, and the most common fungal disease in hospitals in high-income…”
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Resistance to glucose starvation as metabolic trait of platinum-resistant human epithelial ovarian cancer cells
Published in Oncotarget (24-01-2017)“…Deregulated glucose metabolism is observed in cancer but whether this metabolic trait influences response to or is modulated by cytotoxic drugs is unknown. We…”
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ASPP2 suppresses squamous cell carcinoma via ReIA/p65–mediated repression of p63
Published in Proceedings of the National Academy of Sciences - PNAS (29-10-2013)“…Squamous cell carcinoma (SCC) is highly malignant and refractory to therapy. The majority of existing mouse SCC models involve multiple gene mutations. Very…”
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15
Correction: Frequent MAGE Mutations in Human Melanoma
Published in PloS one (18-11-2010)Get full text
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16
Centrosomal Localisation of the Cancer/Testis (CT) Antigens NY-ESO-1 and MAGE-C1 Is Regulated by Proteasome Activity in Tumour Cells: e83212
Published in PloS one (01-12-2013)“…The Cancer/Testis (CT) antigen family of genes are transcriptionally repressed in most human tissues but are atypically re-expressed in many malignant tumour…”
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17
Correction: Frequent Mutations in Human Melanoma
Published in PloS one (01-01-2010)Get full text
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