Search Results - "Pagliassotti, M J"

Insulin Protects Liver Cells from Saturated Fatty Acid-Induced Apoptosis via Inhibition of c-Jun NH2 Terminal Kinase Activity by Pagliassotti, M. J, Wei, Y, Wang, D

“…Hepatocyte apoptosis is increased in patients with nonalcoholic steatohepatitis and correlates with disease severity. Long-chain saturated fatty acids, such as…”
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Inhibition of adipose tissue PPARγ prevents increased adipocyte expansion after lipectomy and exacerbates a glucose‐intolerant phenotype by Booth, A. D., Magnuson, A. M., Cox‐York, K. A., Wei, Y., Wang, D., Pagliassotti, M. J., Foster, M. T.

“…Objectives Adipose tissue plays a fundamental role in glucose homeostasis. For example, fat removal (lipectomy, LipX) in lean mice, resulting in a compensatory…”
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Chemical induction of the unfolded protein response in the liver increases glucose production and is activated during insulin-induced hypoglycaemia in rats by Gonzales, J. C, Gentile, C. L, Pfaffenbach, K. T, Wei, Y, Wang, D, Pagliassotti, M. J

“…Aims/hypothesis Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) can regulate insulin secretion, insulin action and in vitro…”
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Fuel metabolism in men and women during and after long-duration exercise by Horton, Tracy J, Pagliassotti, Michael J, Hobbs, Karen, Hill, James O

“…Center for Human Nutrition, Department of Pediatrics, Universityof Colorado Health Sciences Center, Denver, Colorado 80262 This study aimed to determine…”
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Changes in insulin action, triglycerides, and lipid composition during sucrose feeding in rats by Pagliassotti, M.J. (University of Colorado, Denver, CO.), Prach, P.A, Koppenhafer, T.A, Pan, D.A

“…In the present study, the time course of change in sucrose-induced insulin resistance, triglyceride (TG) concentration, and liver fatty acid composition was…”
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The role of visceral and subcutaneous adipose tissue fatty acid composition in liver pathophysiology associated with NAFLD by Gentile, CL, Weir, TL, Cox-York, KA, Wei, Y, Wang, D, Reese, L, Moran, G, Estrada, A, Mulligan, C, Pagliassotti, MJ, Foster, MT

“…Visceral adiposity is associated with type-2-diabetes, inflammation, dyslipidemia and non-alcoholic fatty liver disease (NAFLD), whereas subcutaneous adiposity…”
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Lower body adipose tissue removal decreases glucose tolerance and insulin sensitivity in mice with exposure to high fat diet by Cox-York, K, Wei, Y, Wang, D, Pagliassotti, MJ, Foster, MT

“…It has been postulated that the protective effects of lower body subcutaneous adipose tissue (LBSAT) occur via its ability to sequester surplus lipid and thus…”
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Hyperthermia impairs liver mitochondrial function in vitro by Willis, W T, Jackman, M R, Bizeau, M E, Pagliassotti, M J, Hazel, J R

“…The effects of temperature on the relationships among the rates of pyruvate carboxylation, O(2) uptake (J(o)), oxidative phosphorylation (J(p)), and the free…”
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Quantity of sucrose alters the tissue pattern and time course of insulin resistance in young rats by Pagliassotti, M J, Prach, P A

“…To determine the effects of the amount of sucrose in the diet on insulin-stimulated glucose metabolism, euglycemic hyperinsulinemic clamps were performed on…”
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Subcutaneous adipose tissue accumulation protects systemic glucose tolerance and muscle metabolism by Booth, A.D., Magnuson, A.M., Fouts, J., Wei, Y., Wang, D., Pagliassotti, M.J., Foster, M.T.

“…The protective effects of lower body subcutaneous adiposity are linked to the depot functioning as a "metabolic sink" receiving and sequestering excess lipid…”
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Involvement of liver and skeletal muscle in sucrose-induced insulin resistance: dose-response studies by Pagliassotti, M J, Shahrokhi, K A, Moscarello, M

“…The ability of dietary sucrose to induce insulin resistance independent of changes in body weight is controversial. In the present study male rats were fed a…”
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Comparison of the time courses of insulin and the portal signal on hepatic glucose and glycogen metabolism in the conscious dog by Pagliassotti, M J, Holste, L C, Moore, M C, Neal, D W, Cherrington, A D

“…To investigate the temporal response of the liver to insulin and portal glucose delivery, somatostatin was infused into four groups of 42-h-fasted, conscious…”
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Female rats do not develop sucrose-induced insulin resistance by Horton, T.J. (University of Colorado Health Sciences Center, Denver, CO.), Gayles, E.C, Prach, P.A, Koppenhafer, T.A, Pagliassotti, M.J

“…In male rats, 2 wk of high-sucrose feeding results in insulin resistance and hypertriglyceridemia [Pagliassotti, M. J., P. A. Prach, T. A. Koppenhafer, and D…”
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Regulation of net hepatic glucose uptake in vivo by PAGLIASSOTTI, M. J, CHERRINGTON, A. D

“…Increases in the glucose level in the absence of the portal signal or changes in insulin elicits little if any glucose uptake by the liver. NHGU is augmented…”
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Effects of vagal blockade on the counterregulatory response to insulin-induced hypoglycemia in the dog by Jackson, P A, Pagliassotti, M J, Shiota, M, Neal, D W, Cardin, S, Cherrington, A D

“…Our aim was to determine whether vagal transmission is required for the hormonal response to insulin-induced hypoglycemia in 18-h-fasted conscious dogs. Hollow…”
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Contribution of energy intake and tissue enzymatic profile to body weight gain in high-fat-fed rats by Gayles, E. (University of Colorado Health Sciences Center, Denver, CO.), Gliassotti, M.J, Prach, P.A, Koppenhafer, T.A, Hill, J.A

“…The purpose of the current study was to examine the enzymatic profile [phosphofructokinase (PFK), beta-hydroxyacyl-CoA dehydrogenase (HADH), and citrate…”
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Time course of adaptation to a high-fat diet in obesity-resistant and obesity-prone rats by Pagliassotti, M J, Knobel, S M, Shahrokhi, K A, Manzo, A M, Hill, J O

“…The purpose of the present study was to characterize the time course of adaptation (i.e., circulating metabolites and hormones, fat pad mass, lipoprotein…”
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Increased net hepatic glucose output from gluconeogenic precursors after high-sucrose diet feeding in male rats by Pagliassotti, M.J, Prach, P.A

“…A high-sucrose diet reduces the ability of insulin to suppress hepatic glucose production (hepatic insulin resistance) in rats. The purpose of the present…”
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Neural and pancreatic influences on net hepatic glucose uptake and glycogen synthesis by Moore, M C, Rossetti, L, Pagliassotti, M J, Monahan, M, Venable, C, Neal, D, Cherrington, A D

“…The role of the liver nerves in the disposition of peripherally administered glucose was examined in seven hepatic innervated (HI) and nine hepatic denervated…”
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Enhanced efficiency of lactate removal after endurance training by Donovan, C M, Pagliassotti, M J

“…The effects of endurance training (running 1 h/day at 40 m/min, 10% grade) on net lactate removal at various lactate concentrations were assessed in resting…”
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