Search Results - "Pagel, Michael A."

Using Acetaminophen's Toxicity Mechanism to Enhance Cisplatin Efficacy in Hepatocarcinoma and Hepatoblastoma Cell Lines by Neuwelt, Alexander J., Wu, Y. Jeffrey, Knap, Narcyz, Losin, Marcin, Neuwelt, Edward A., Pagel, Michael A., Warmann, Steven, Fuchs, Joerg, Czauderna, Piotr, Wozniak, Michal

“…Background/Aims: Acetaminophen overdose causes hepatotoxicity mediated by toxic metabolites generated through the cytochrome P450 enzyme. The objective of this…”
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Blood–brain barrier opening by intracarotid artery hyperosmolar mannitol induces sterile inflammatory and innate immune responses by Burks, Scott R., Kersch, Cymon N., Witko, Jaclyn A., Pagel, Michael A., Sundby, Maggie, Muldoon, Leslie L., Neuwelt, Edward A., Frank, Joseph A.

“…Intracarotid arterial hyperosmolar mannitol (ICAHM) blood–brain barrier disruption (BBBD) is effective and safe for delivery of therapeutics for central…”
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Bone marrow chemoprotection without compromise of chemotherapy efficacy in a rat brain tumor model by Neuwelt, Edward A, Pagel, Michael A, Kraemer, Dale F, Peterson, Darryl R, Muldoon, Leslie L

“…Thiol chemoprotective agents can reduce chemotherapy side effects, but clinical use is limited due to concerns of impaired chemotherapeutic efficacy. We…”
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High αv Integrin Level of Cancer Cells Is Associated with Development of Brain Metastasis in Athymic Rats by Wu, Yingjen Jeffrey, Pagel, Michael A, Muldoon, Leslie L, Fu, Rongwei, Neuwelt, Edward A

“…Brain metastases commonly occur in patients with malignant skin, lung and breast cancers resulting in high morbidity and poor prognosis. Integrins containing…”
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N-acetylcysteine chemoprotection without decreased cisplatin antitumor efficacy in pediatric tumor models by Muldoon, Leslie L., Wu, Y. Jeffrey, Pagel, Michael A., Neuwelt, Edward A.

“…Decreasing oxidative damage with the antioxidant agent N-acetylcysteine (NAC) can block the side effects of chemotherapy, but may diminish anti-tumor efficacy…”
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Intra-arterial administration improves temozolomide delivery and efficacy in a model of intracerebral metastasis, but has unexpected brain toxicity by Muldoon, Leslie L., Pagel, Michael A., Netto, Joao Prola, Neuwelt, Edward A.

“…We tested the hypothesis that intra-arterial (IA) infusion of temozolomide into the internal carotid artery would safely improve drug delivery to brain and…”
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Vascular endothelial growth factor blockade alters magnetic resonance imaging biomarkers of vascular function and decreases barrier permeability in a rat model of lung cancer brain metastasis by Pishko, Gregory L, Muldoon, Leslie L, Pagel, Michael A, Schwartz, Daniel L, Neuwelt, Edward A

“…Blockade of vascular endothelial growth factor (VEGF) to promote vascular normalization and inhibit angiogenesis has been proposed for the treatment of brain…”
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Imaging and Therapy with Rituximab Anti-CD20 Immunotherapy in an Animal Model of Central Nervous System Lymphoma by MULDOON, Leslie L, LEWIN, Seth J, DOSA, Edit, KRAEMER, Dale F, PAGEL, Michael A, DOOLITTLE, Nancy D, NEUWELT, Edward A

“…To evaluate the effect of rituximab monoclonal antibody (mAb) on MRI tumor volumetrics and efficacy in a rat model of central nervous system (CNS) lymphoma…”
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Delayed Administration of Sodium Thiosulfate in Animal Models Reduces Platinum Ototoxicity without Reduction of Antitumor Activity by MULDOON, L. L, PAGEL, M. A, KROLL, R. A, BRUMMETT, R. E, DOOLITTLE, N. D, ZUHOWSKI, E. G, EGORIN, M. J, NEUWELT, E. A

“…Platinum-based chemotherapeutic agents, such as carboplatin and cisplatin, are effective against many human tumors, but their use may be limited by a high…”
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Therapeutic efficacy of aortic administration of N-acetylcysteine as a chemoprotectant against bone marrow toxicity after intracarotid administration of alkylators, with or without glutathione depletion in a rat model by NEUWELT, Edward A, PAGEL, Michael A, HASLER, Brant P, DELOUGHERY, Thomas G, MULDOON, Leslie L

“…Modulation of thiol levels may alter both the efficacy and toxicity of chemotherapeutic agents. We investigated cytoenhancement, using…”
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First evidence of otoprotection against carboplatin-induced hearing loss with a two-compartment system in patients with central nervous system malignancy using sodium thiosulfate by Neuwelt, E A, Brummett, R E, Doolittle, N D, Muldoon, L L, Kroll, R A, Pagel, M A, Dojan, R, Church, V, Remsen, L G, Bubalo, J S

“…Sodium thiosulfate (STS) provides protection against carboplatin-induced ototoxicity in an animal model. The purpose of this study was to determine the STS…”
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A Physiological Barrier Distal to the Anatomic Blood-Brain Barrier in a Model of Transvascular Delivery by Muldoon, Leslie L, Pagel, Michael A, Kroll, Robert A, Roman-Goldstein, Simon, Jones, Russell S, Neuwelt, Edward A

“…Osmotic disruption of the blood-brain barrier (BBB) provides a method for transvascular delivery of therapeutic agents to the brain. The apparent global…”
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Delivery of Herpesvirus and Adenovirus to Nude Rat Intracerebral Tumors After Osmotic Blood-Brain Barrier Disruption by Nilaver, Gajanan, Muldoon, Leslie L., Kroll, Robert A., Pagel, Michael A., Breakefield, Xandra O., Davidson, Beverly L., Neuwelt, Edward A.

“…The delivery of viral vectors to the brain for treatment of intracerebral tumors is most commonly accomplished by stereotaxic inoculation directly into the…”
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In vitro and animal studies of sodium thiosulfate as a potential chemoprotectant against carboplatin-induced ototoxicity by Neuwelt, E A, Brummett, R E, Remsen, L G, Kroll, R A, Pagel, M A, McCormick, C I, Guitjens, S, Muldoon, L L

“…When carboplatin (cis-diammine-1,1-cyclobutane-dicarboxylato-platinum) delivery to brain tumors is optimized with osmotic blood-brain barrier disruption…”
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Abstract 4477: Safety and efficacy of intracarotid administration of temozolomide in a rat model of intracerebral metastasis by Muldoon, Leslie L., Pagel, Michael A., Neuwelt, Edward A.

“…Abstract Purpose: Temozolomide (Temodar; Merck) is an alkylating chemotherapeutic agent used to treat glioblastoma and other brain malignancies. After oral…”
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Abstract 839: N-acetylcysteine chemoprotection without decreased cisplatin antitumor efficacy in pediatric tumor models by Muldoon, Leslie L., Wu, Y. Jeffrey, Pagel, Michael A., Beeson, Kathleen A., Neuwelt, Edward A.

“…Abstract PURPOSE. Cisplatin chemotherapy is used in the treatment of many pediatric cancers, but has significant toxicities that impact patient quality of…”
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Abstract 5529: Imaging and therapy with rituximab anti-CD20 immunotherapy in an animal model of central nervous system lymphoma by Muldoon, Leslie L., Lewin, Seth J., Dosa, Edit, Pagel, Michael A., Doolittle, Nancy D., Neuwelt, Edward A.

“…Abstract Purpose: To evaluate monoclonal antibody (mAb) delivery, tumor volumetrics on magnetic resonance imaging (MRI), and efficacy in a rat model of central…”
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Using Acetaminophen's Toxicity Mechanism to Enhance Cisplatin Efficacy in Hepatocarcinoma and Hepatoblastoma Cell Lines1 by Neuwelt, Alexander J, Wu, Y Jeffrey, Knap, Narcyz, Losin, Marcin, Neuwelt, Edward A, Pagel, Michael A, Warmann, Steven, Fuchs, Joerg, Czauderna, Piotr, Wozniak, Michal

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The Influence of Anesthetic Choice, PaCO2, and Other Factors on Osmotic Blood-Brain Barrier Disruption in Rats with Brain Tumor Xenografts by Remsen, Laura G., Pagel, Michael A., McCormick, Christopher I., Fiamengo, Steven A., Sexton, Gary, Neuwelt, Edward A.

“…Increasing the delivery of therapeutic drugs to the brain improves outcome for patients with brain tumors.Osmotic opening of the blood-brain barrier (BBB) can…”
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Improving drug delivery to intracerebral tumor and surrounding brain in a rodent model: a comparison of osmotic versus bradykinin modification of the blood-brain and/or blood-tumor barriers by Kroll, R A, Pagel, M A, Muldoon, L L, Roman-Goldstein, S, Fiamengo, S A, Neuwelt, E A

“…To compare transient blood-brain barrier disruption (BBBD) by hypertonic mannitol with pharmacological modification of the blood-tumor barrier by the…”
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