Search Results - "Page, Malcolm GP"

Preacinetobactin not acinetobactin is essential for iron uptake by the BauA transporter of the pathogen Acinetobacter baumannii by Moynié, Lucile, Serra, Ilaria, Scorciapino, Mariano A, Oueis, Emilia, Page, Malcolm Gp, Ceccarelli, Matteo, Naismith, James H

“…New strategies are urgently required to develop antibiotics. The siderophore uptake system has attracted considerable attention, but rational design of…”
Get full text

Prospects for the next anti- Pseudomonas drug by Page, Malcolm GP, Heim, Jutta

“…Pseudomonas aeruginosa is one of the most dreaded Gram-negative bacterial pathogens in hospitals. Not only it is among the most frequently isolated…”
Get full text

Siderophore conjugates by Page, Malcolm G. P.

“…There has been considerable effort expended in the investigation of the potential of siderophore conjugates of antibiotics to circumvent the permeability…”
Get full text

Discovery and development of new antibacterial agents targeting Gram-negative bacteria in the era of pandrug resistance: is the future promising? by Page, Malcolm GP, Bush, Karen

“…Highlights • Agents targeting resistant Gram-negative bacteria are in the antibacterial pipeline. • Both broad and narrow spectrum agents are in clinical…”
Get full text

Structure and Function of the PiuA and PirA Siderophore-Drug Receptors from Pseudomonas aeruginosa and Acinetobacter baumannii by Moynié, Lucile, Luscher, Alexandre, Rolo, Dora, Pletzer, Daniel, Tortajada, Antoni, Weingart, Helge, Braun, Yvonne, Page, Malcolm G P, Naismith, James H, Köhler, Thilo

“…The outer membrane of Gram-negative bacteria presents an efficient barrier to the permeation of antimicrobial molecules. One strategy pursued to circumvent…”
Get full text

What we may expect from novel antibacterial agents in the pipeline with respect to resistance and pharmacodynamic principles by Bush, Karen, Page, Malcolm G. P.

“…There are some 43 small molecules in the antibiotic development pipeline from late preclinical stage (7 compounds) through Phase 1 (11 molecules), Phase 2 (13…”
Get full text

Penicillin-binding proteins: evergreen drug targets by Frère, Jean-Marie, Page, Malcolm GP

“…Highlights • Structures of sensitive and resistant variants of essential penicillin-binding proteins (PBPs). • Spectroscopic studies of the reaction of…”
Get full text

The Pseudomonas aeruginosa PA14 ABC Transporter NppA1A2BCD Is Required for Uptake of Peptidyl Nucleoside Antibiotics by Pletzer, Daniel, Braun, Yvonne, Dubiley, Svetlana, Lafon, Corinne, Köhler, Thilo, Page, Malcolm G P, Mourez, Michael, Severinov, Konstantin, Weingart, Helge

“…Analysis of the genome sequence of Pseudomonas aeruginosa PA14 revealed the presence of an operon encoding an ABC-type transporter (NppA1A2BCD) showing…”
Get full text

Stemming the tide? by Page, Malcolm GP, Kellenberger, Laurenz

Get full text

Involvement of Fe Uptake Systems and AmpC β-Lactamase in Susceptibility to the Siderophore Monosulfactam BAL30072 in Pseudomonas aeruginosa by van Delden, Christian, Page, Malcolm G P, Köhler, Thilo

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Binding of Ceftobiprole and Comparators to the Penicillin-Binding Proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae by DAVIES, Todd A, PAGE, Malcolm G. P, WENCHI SHANG, ANDREW, Ted, KANIA, Malgosia, BUSH, Karen

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

In vitro activity of the siderophore monosulfactam BAL30072 against meropenem-non-susceptible Acinetobacter baumannii by HIGGINS, Paul G, STEFANIK, Danuta, PAGE, Malcolm G. P, HACKEL, Meredith, SEIFERT, Harald

“…The activity of BAL30072 was compared with that of anti-Acinetobacter reference drugs against meropenem-non-susceptible Acinetobacter baumannii isolates…”
Get full text

In vivo and in vitro activity of the siderophore monosulfactam BAL30072 against Acinetobacter baumannii by RUSSO, Thomas A, PAGE, Malcolm G. P, BEANAN, Janet M, OLSON, Ruth, HUJER, Andrea M, HUJER, Kristine M, JACOBS, Michael, BAJAKSOUZIAN, Saralee, ENDIMIANI, Andrea, BONOMO, Robert A

“…New antibiotics that are active against multidrug-resistant (MDR) Acinetobacter baumannii are urgently needed. BAL30072, a siderophore monosulfactam antibiotic…”
Get full text

Bead diffusion assay for discovering antimicrobial cyclic peptides by Fluxà, Viviana S, Maillard, Noélie, Page, Malcolm G P, Reymond, Jean-Louis

“…A combinatorial library of 15,536 cyclic decapeptide analogues of tyrocidine A and gramicidin S was prepared on photocleavable TentaGel beads. The beads were…”
Get more information

In Vitro and In Vivo Properties of BAL30376, a β-Lactam and Dual β-Lactamase Inhibitor Combination with Enhanced Activity against Gram-Negative Bacilli That Express Multiple β-Lactamases by PAGE, Malcolm G. P, DANTIER, Clothilde, DESARBRE, Eric, GAUCHER, Bérangère, GEBHARDT, Klaus, SCHMITT-HOFFMANN, Anne

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Stemming the tide?: Advances in antibiotic discovery and development in the face of emerging resistance and financial constraint by Page, Malcolm GP, Kellenberger, Laurenz

Get full text

In vitro activity of isavuconazole against 140 reference fungal strains and 165 clinically isolated yeasts from Japan by Yamazaki, Toshikazu, Inagaki, Yukiko, Fujii, Toshihiko, Ohwada, Jun, Tsukazaki, Masao, Umeda, Isao, Kobayashi, Kazuko, Shimma, Nobuo, Page, Malcolm G.P, Arisawa, Mikio

“…Abstract The in vitro susceptibilities of 140 laboratory reference strains of fungi, including type strains, and 165 clinical yeast isolates from Japan towards…”
Get full text

Crystallographic and Biophysical Analysis of a Bacterial Signal Peptidase in Complex with a Lipopeptide-based Inhibitor by Paetzel, Mark, Goodall, Jonathon J, Kania, Malgosia, Dalbey, Ross E, Page, Malcolm G P

“…We report here the crystallographic and biophysical analysis of a soluble, catalytically active fragment of the Escherichia coli type I signal peptidase (SPase…”
Get full text

Impact of Specific pbp5 Mutations on Expression of β-Lactam Resistance in Enterococcus faecium by RICE, Louis B, BELLAIS, Samuel, CARIAS, Lenore L, HUTTON-THOMAS, Rebecca, BONOMO, Robert A, CASPERS, Patrick, PAGE, Malcolm G. P, GUTMANN, Laurent

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

A kinetic analysis of the inhibition of FOX-4  -lactamase, a plasmid-mediated AmpC cephalosporinase, by monocyclic  -lactams and carbapenems by Papp-Wallace, K. M., Mallo, S., Bethel, C. R., Taracila, M. A., Hujer, A. M., Fernandez, A., Gatta, J. A., Smith, K. M., Xu, Y., Page, M. G. P., Desarbre, E., Bou, G., Bonomo, R. A.

“…Class C β-lactamases are prevalent among Enterobacteriaceae; however, these enzymes are resistant to inactivation by commercially available β-lactamase…”
Get full text