Search Results - "Page, Angustias"

Role of NF-κB in Ageing and Age-Related Diseases: Lessons from Genetically Modified Mouse Models by García-García, Verónica A., Alameda, Josefa P., Page, Angustias, Casanova, María Llanos

“…Ageing is a complex process, induced by multifaceted interaction of genetic, epigenetic, and environmental factors. It is manifested by a decline in the…”
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A Transposon-based Analysis Reveals RASA1 Is Involved in Triple-Negative Breast Cancer by Suárez-Cabrera, Cristian, Quintana, Rita M, Bravo, Ana, Casanova, M Llanos, Page, Angustias, Alameda, Josefa P, Paramio, Jesús M, Maroto, Alicia, Salamanca, Javier, Dupuy, Adam J, Ramírez, Angel, Navarro, Manuel

“…RAS genes are mutated in 20% of human tumors, but these mutations are very rare in breast cancer. Here, we used a mouse model to generate tumors upon…”
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IKKα Induces Epithelial-Mesenchymal Changes in Mouse Skin Carcinoma Cells That Can Be Partially Reversed by Apigenin by García-García, Verónica A, Alameda, Josefa P, Page, Angustias, Mérida-García, Antonio, Navarro, Manuel, Tejero, Adrián, Paramio, Jesús M, García-Fernández, Rosa A, Casanova, M Llanos

“…NMSC (non-melanoma skin cancer) is a common tumor in the Caucasian population, accounting for 90% of skin cancers. Among them, squamous cell carcinomas (SCCs)…”
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CYLD Inhibits the Development of Skin Squamous Cell Tumors in Immunocompetent Mice by Alameda, Josefa P, García-García, Verónica A, López, Silvia, Hernando, Ana, Page, Angustias, Navarro, Manuel, Moreno-Maldonado, Rodolfo, Paramio, Jesús M, Ramírez, Ángel, García-Fernández, Rosa A, Casanova, María Llanos

“…Cylindromatosis (CYLD) is a deubiquitinase (DUB) enzyme that was initially characterized as a tumor suppressor of adnexal skin tumors in patients with CYLD…”
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IKKβ-Mediated Resistance to Skin Cancer Development Is Ink4a/Arf- Dependent by Page, Angustias, Bravo, Ana, Suarez-Cabrera, Cristian, Alameda, Josefa P, Casanova, M Llanos, Lorz, Corina, Segrelles, Carmen, Segovia, José C, Paramio, Jesús M, Navarro, Manuel, Ramirez, Angel

“…IKKβ (encoded by ) is a protein kinase that regulates the activity of numerous proteins important in several signaling pathways, such as the NF-κB pathway…”
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IKKβ overexpression together with a lack of tumour suppressor genes causes ameloblastic odontomas in mice by Page, Angustias, Bravo, Ana, Suarez-Cabrera, Cristian, Sanchez-Baltasar, Raquel, Oteo, Marta, Morcillo, Miguel Angel, Casanova, M. Llanos, Segovia, Jose C., Navarro, Manuel, Ramirez, Angel

“…Odontogenic tumours are a heterogeneous group of lesions that develop in the oral cavity region and are characterized by the formation of tumoural structures…”
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Protective role of p53 in skin cancer: Carcinogenesis studies in mice lacking epidermal p53 by Page, Angustias, Navarro, Manuel, Suarez-Cabrera, Cristian, Alameda, Josefa P, Casanova, M Llanos, Paramio, Jesús M, Bravo, Ana, Ramirez, Angel

“…p53 is a protein that causes cell cycle arrest, apoptosis or senescence, being crucial in the process of tumor suppression in several cell types. Different in…”
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A keratin K5Cre transgenic line appropriate for tissue-specific or generalized cre-mediated recombination by Ramirez, Angel, Page, Angustias, Gandarillas, Alberto, Zanet, Jennifer, Pibre, Sophie, Vidal, Miguel, Tusell, Laura, Genesca, Anna, Whitaker, Duncan A., Melton, David W., Jorcano, Jose L.

“…We describe here a mouse line bearing a bovine keratin K5Cre recombinase transgene. These mice showed a dual pattern of Cre‐mediated recombination, depending…”
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IKKα Promotes the Progression and Metastasis of Non-Small Cell Lung Cancer Independently of its Subcellular Localization by Page, Angustias, Ortega, Alba, Alameda, Josefa P., Navarro, Manuel, Paramio, Jesús M., Saiz-Pardo, Melchor, Almeida, Edilia I., Hernández, Pilar, Fernández-Aceñero, M. Jesús, García-Fernández, Rosa A., Casanova, M. Llanos

“…Lung cancer is the leading worldwide cause of cancer mortality, however, neither curative treatments nor substantial prolonged survival has been achieved,…”
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Increased IKKα expression in the basal layer of the epidermis of transgenic mice enhances the malignant potential of skin tumors by Alameda, Josefa P, Moreno-Maldonado, Rodolfo, Fernández-Aceñero, M Jesús, Navarro, Manuel, Page, Angustias, Jorcano, José L, Bravo, Ana, Ramírez, Ángel, Casanova, M Llanos

“…Non-melanoma skin cancer is the most frequent type of cancer in humans. In this study we demonstrate that elevated IKKα expression in murine epidermis…”
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IKKα enhances human keratinocyte differentiation and determines the histological variant of epidermal squamous cell carcinomas by Moreno-Maldonado, Rodolfo, Ramírez, Angel, Navarro, Manuel, Fernández-Aceñero, M. Jesús, Villanueva, Concepción, Page, Angustias, Jorcano, José L., Bravo, Ana, Casanova, M. Llanos

“…Squamous cell carcinomas (SCCs) of the skin display different clinical features according to their epithelial differentiation grade and histological variant…”
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RNAi-Mediated Knockdown of IKK1 in Transgenic Mice Using a Transgenic Construct Containing the Human H1 Promoter by Casanova, M. Llanos, Bravo, Ana, Alameda, Josefa P., Suarez-Cabrera, Cristian, Page, Angustias, Navarro, Manuel, Murillas, Rodolfo, Moreno-Maldonado, Rodolfo, Ramirez, Angel

“…Inhibition of gene expression through siRNAs is a tool increasingly used for the study of gene function in model systems, including transgenic mice. To achieve…”
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Targeted Overexpression of Leptin to Keratinocytes in Transgenic Mice Results in Lack of Skin Phenotype but Induction of Early Leptin Resistance by Rico, Laura, Del Rio, Marcela, Bravo, Ana, Ramirez, Angel, Jorcano, José L, Page, M. Angustias, Larcher, Fernando

“…The epidermis has a great potential as a bioreactor to produce proteins with systemic action. However, the consequences of ectopic epidermal protein…”
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Tumor formation in mice with conditional inactivation of Brca1 in epithelial tissues by BERTON, Thomas R, MATSUMOTO, Takashi, PAGE, Angustias, CONTI, Claudio J, DENG, Chu-Xia, JORCANO, José L, JOHNSON, David G

“…The BRCA1 tumor-suppressor protein has been implicated in the regulation of transcription, DNA repair, proliferation, and apoptosis. BRCA1 is expressed in many…”
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Nuclear versus cytoplasmic IKKα signaling in keratinocytes leads to opposite skin phenotypes and inflammatory responses, and a different predisposition to cancer by García-García, Verónica A., Alameda, Josefa P., Fernández-Aceñero, M. Jesús, Navarro, Manuel, García-Escudero, Ramón, Page, Angustias, Mateo-Gallego, Raúl, Paramio, Jesús M., Ramírez, Ángel, García-Fernández, Rosa A., Bravo, Ana, Casanova, M. Llanos

“…IKKα is known as an essential protein for skin homeostasis. However, the lack of suitable models to investigate its functions in the skin has led to IKKα being…”
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Development of a mouse model for spontaneous oral squamous cell carcinoma in Fanconi anemia by Errazquin, Ricardo, Page, Angustias, Suñol, Anna, Segrelles, Carmen, Carrasco, Estela, Peral, Jorge, Garrido-Aranda, Alicia, Del Marro, Sonia, Ortiz, Jessica, Lorz, Corina, Minguillon, Jordi, Surralles, Jordi, Belendez, Cristina, Alvarez, Martina, Balmaña, Judith, Bravo, Ana, Ramirez, Angel, Garcia-Escudero, Ramon

“…•Most oral squamous cell carcinomas from Fanconi anemia patients display FANCA and TP53 genes mutations.•Fanca-/- mutant mice display premalignant lesions in…”
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Role of phosphorylated p50-NF-?B in the ultraviolet response of mouse skin by P rez, Paloma, Page, Angustias, Jorcano, Jos L.

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Context-Dependent Role of IKKβ in Cancer by Page, Angustias, Navarro, Manuel, Suárez-Cabrera, Cristian, Bravo, Ana, Ramirez, Angel

“…Inhibitor of nuclear factor kappa-B kinase subunit beta (IKKβ) is a kinase principally known as a positive regulator of the ubiquitous transcription factor…”
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ERAS, a Member of the Ras Superfamily, Acts as an Oncoprotein in the Mammary Gland by Suarez-Cabrera, Cristian, Ojeda-Perez, Isabel, Sanchez-Baltasar, Raquel, Page, Angustias, Bravo, Ana, Navarro, Manuel, Ramirez, Angel

“…ERAS is a relatively uncharacterized gene of the Ras superfamily. It is expressed in ES cells and in the first stages of embryonic development; later on, it is…”
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Overactivation of the NF‐κB pathway impairs molar enamel formation by Yamada, Akane, Kawasaki, Maiko, Miake, Yasuo, Yamada, Yurie, Blackburn, James, Kawasaki, Katsushige, Trakanant, Supaluk, Nagai, Takahiro, Nihara, Jun, Kudo, Takehisa, Meguro, Fumiya, Schmidt‐Ullrich, Ruth, Liu, Bigang, Hu, Yinling, Page, Angustias, Ramírez, Ángel, Sharpe, Paul T., Maeda, Takeyasu, Takagi, Ritsuo, Ohazama, Atsushi

“…Objective Hypohidrotic ectodermal dysplasia (HED) is a hereditary disorder characterized by abnormal structures and functions of the ectoderm‐derived organs,…”
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