Single-dose Universal Hepatitis A Immunization in One-year-old Children in Argentina: High Prevalence of Protective Antibodies up to 9 Years After Vaccination

BACKGROUND:Single-dose hepatitis A virus (HAV) vaccination was implemented in all Argentinean children 12 months of age in 2005. Previous studies demonstrated high prevalence of protective antibody response 4 years after single-dose vaccination. This study assessed long-term seroprotection against H...

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Published in:	The Pediatric infectious disease journal Vol. 35; no. 12; pp. 1339 - 1342
Main Authors:	Urueña, Analía, González, Jorge E, Rearte, Analía, Pérez Carrega, María E, Calli, Rogelio, Pagani, María F, Uboldi, Andrea, Vicentín, Rosalía, Caglio, Patricia, Cañero-Velasco, María C, Gentile, Angela, Ramonet, Margarita, Vizzotti, Carla
Format:	Journal Article
Language:	English
Published:	United States Copyright Wolters Kluwer Health, Inc. All rights reserved 01-12-2016
Subjects:	Argentina Child Female Follow-Up Studies Hepatitis A - prevention & control Hepatitis A Antibodies - blood Hepatitis A Vaccines - administration & dosage Hepatitis A Vaccines - immunology Hepatitis A virus - immunology Humans Infant Male Prevalence
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Summary:	BACKGROUND:Single-dose hepatitis A virus (HAV) vaccination was implemented in all Argentinean children 12 months of age in 2005. Previous studies demonstrated high prevalence of protective antibody response 4 years after single-dose vaccination. This study assessed long-term seroprotection against HAV after vaccination. METHODS:Children who received 1 dose of HAV vaccine at 1 year of age at least 6 years before enrollment were included at 5 centers in Argentina between 2013 and 2014. Demographic and socioeconomic characteristics were collected through a questionnaire. Blood samples were tested for anti-HAV antibodies. Antibody values ≥10 mIU/mL were considered seroprotective. Logistic regression analysis was performed to evaluate the association between demographic and socioeconomic variables and seroprotection. RESULTS:A total of 1088 children were included, with a median postvaccination interval of 7.7 years (range 6.3–9.2 years). Of these children, 97.4% (95% confidence interval96.3%–98.3%) had protective antibodies against HAV. No association between demographic or socioeconomic variables and seroprotection was found. Geometric mean concentration of antibody levels against HAV was 170.5 mUI/mL (95% confidence interval163.2–178.2 mUI/mL). CONCLUSIONS:Single-dose universal hepatitis A immunization in 1-year-old children resulted in sustained immunologic protection for up to 9 years in Argentina. These findings, along with the low current disease burden, confirm the success of the intervention.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0891-3668 1532-0987
DOI:	10.1097/INF.0000000000001322