Search Results - "Paesen, Guido C."

Multifunctional human monoclonal antibody combination mediates protection against Rift Valley fever virus at low doses by Chapman, Nathaniel S., Hulswit, Ruben J. G., Westover, Jonna L. B., Stass, Robert, Paesen, Guido C., Binshtein, Elad, Reidy, Joseph X., Engdahl, Taylor B., Handal, Laura S., Flores, Alejandra, Gowen, Brian B., Bowden, Thomas A., Crowe, James E.

“…The zoonotic Rift Valley fever virus (RVFV) can cause severe disease in humans and has pandemic potential, yet no approved vaccine or therapy exists. Here we…”
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Nucleocapsid assembly in pneumoviruses is regulated by conformational switching of the N protein by Renner, Max, Bertinelli, Mattia, Leyrat, Cédric, Paesen, Guido C, Saraiva de Oliveira, Laura Freitas, Huiskonen, Juha T, Grimes, Jonathan M

“…Non-segmented, (-)RNA viruses cause serious human diseases. Human metapneumovirus (HMPV), an emerging pathogen of this order of viruses (Mononegavirales) is…”
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Contrasting Modes of New World Arenavirus Neutralization by Immunization-Elicited Monoclonal Antibodies by Ng, Weng M, Sahin, Mehmet, Krumm, Stefanie A, Seow, Jeffrey, Zeltina, Antra, Harlos, Karl, Paesen, Guido C, Pinschewer, Daniel D, Doores, Katie J, Bowden, Thomas A

“…Transmission of the New World hemorrhagic fever arenaviruses Junín virus (JUNV) and Machupo virus (MACV) to humans is facilitated, in part, by the interaction…”
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Molecular rationale for antibody-mediated targeting of the hantavirus fusion glycoprotein by Rissanen, Ilona, Stass, Robert, Krumm, Stefanie A, Seow, Jeffrey, Hulswit, Ruben Jg, Paesen, Guido C, Hepojoki, Jussi, Vapalahti, Olli, Lundkvist, Åke, Reynard, Olivier, Volchkov, Viktor, Doores, Katie J, Huiskonen, Juha T, Bowden, Thomas A

“…The intricate lattice of Gn and Gc glycoprotein spike complexes on the hantavirus envelope facilitates host-cell entry and is the primary target of the…”
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Novel immunomodulators from hard ticks selectively reprogramme human dendritic cell responses by Preston, Stephen G, Majtán, Juraj, Kouremenou, Chrisoula, Rysnik, Oliwia, Burger, Lena F, Cabezas Cruz, Alejandro, Chiong Guzman, Maylin, Nunn, Miles A, Paesen, Guido C, Nuttall, Patricia A, Austyn, Jonathan M

“…Hard ticks subvert the immune responses of their vertebrate hosts in order to feed for much longer periods than other blood-feeding ectoparasites; this may be…”
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Crystal structure and functional characterization of an immunomodulatory salivary cystatin from the soft tick Ornithodoros moubata by Salát, Jirí, Paesen, Guido C, Rezácová, Pavlína, Kotsyfakis, Michalis, Kovárová, Zuzana, Sanda, Miloslav, Majtán, Juraj, Grunclová, Lenka, Horká, Helena, Andersen, John F, Brynda, Jirí, Horn, Martin, Nunn, Miles A, Kopácek, Petr, Kopecký, Jan, Mares, Michael

“…The saliva of blood-feeding parasites is a rich source of peptidase inhibitors that help to overcome the host's defence during host-parasite interactions…”
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Comparison of Entropic Contributions to Binding in a “Hydrophilic” versus “Hydrophobic” Ligand−Protein Interaction by Syme, Neil R, Dennis, Caitriona, Bronowska, Agnieszka, Paesen, Guido C, Homans, Steve W

“…In the present study we characterize the thermodynamics of binding of histamine to recombinant histamine-binding protein (rRaHBP2), a member of the lipocalin…”
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Recent Advances in Bunyavirus Glycoprotein Research: Precursor Processing, Receptor Binding and Structure by Hulswit, Ruben J G, Paesen, Guido C, Bowden, Thomas A, Shi, Xiaohong

“…The order accommodates related viruses (bunyaviruses) with segmented, linear, single-stranded, negative- or ambi-sense RNA genomes. Their glycoproteins form…”
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Complement Inhibitor of C5 Activation from the Soft Tick Ornithodoros moubata by Nunn, Miles A, Sharma, Ankit, Paesen, Guido C, Adamson, Sharon, Lissina, Olga, Willis, Anthony C, Nuttall, Patricia A

“…Blood-feeding ticks must control C activation or be damaged by the host inflammatory response. We report the characterization and expression of a novel,…”
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VelcroVax: a "Bolt-On" Vaccine Platform for Glycoprotein Display by Kingston, Natalie J, Grehan, Keith, Snowden, Joseph S, Hassall, Mark, Alzahrani, Jehad, Paesen, Guido C, Sherry, Lee, Hayward, Connor, Roe, Amy, Stephen, Sam, Tomlinson, Darren, Zeltina, Antra, Doores, Katie J, Ranson, Neil A, Stacey, Martin, Page, Mark, Rose, Nicola J, Bowden, Thomas A, Rowlands, David J, Stonehouse, Nicola J

“…Having varied approaches to the design and manufacture of vaccines is critical in being able to respond to worldwide needs and newly emerging pathogens…”
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Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera by Zhou, Daming, Dejnirattisai, Wanwisa, Supasa, Piyada, Liu, Chang, Mentzer, Alexander J., Ginn, Helen M., Zhao, Yuguang, Duyvesteyn, Helen M.E., Tuekprakhon, Aekkachai, Nutalai, Rungtiwa, Wang, Beibei, Paesen, Guido C., Lopez-Camacho, Cesar, Slon-Campos, Jose, Hallis, Bassam, Coombes, Naomi, Bewley, Kevin, Charlton, Sue, Walter, Thomas S., Skelly, Donal, Lumley, Sheila F., Dold, Christina, Levin, Robert, Dong, Tao, Pollard, Andrew J., Knight, Julian C., Crook, Derrick, Lambe, Teresa, Clutterbuck, Elizabeth, Bibi, Sagida, Flaxman, Amy, Bittaye, Mustapha, Belij-Rammerstorfer, Sandra, Gilbert, Sarah, James, William, Carroll, Miles W., Klenerman, Paul, Barnes, Eleanor, Dunachie, Susanna J., Fry, Elizabeth E., Mongkolsapaya, Juthathip, Ren, Jingshan, Stuart, David I., Screaton, Gavin R.

“…The race to produce vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began when the first sequence was published, and this forms…”
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An Ion-channel Modulator from the Saliva of the Brown Ear Tick has a Highly Modified Kunitz/BPTI Structure by Paesen, Guido C., Siebold, Christian, Dallas, Mark L., Peers, Chris, Harlos, Karl, Nuttall, Patricia A., Nunn, Miles A., Stuart, David I., Esnouf, Robert M.

“…Ra-KLP, a 75 amino acid protein secreted by the salivary gland of the brown ear tick Rhipicephalus appendiculatus has a sequence resembling those of…”
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The methyltransferase domain of the Sudan ebolavirus L protein specifically targets internal adenosines of RNA substrates, in addition to the cap structure by Martin, Baptiste, Coutard, Bruno, Guez, Théo, Paesen, Guido C, Canard, Bruno, Debart, Françoise, Vasseur, Jean-Jacques, Grimes, Jonathan M, Decroly, Etienne

“…Abstract Mononegaviruses, such as Ebola virus, encode an L (large) protein that bears all the catalytic activities for replication/transcription and RNA…”
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Central tolerance shapes the neutralizing B cell repertoire against a persisting virus in its natural host by Florova, Marianna, Abreu-Mota, Tiago, Paesen, Guido C, Beetschen, Anna Sophia, Cornille, Karen, Marx, Anna-Friederike, Narr, Kerstin, Sahin, Mehmet, Dimitrova, Mirela, Swarnalekha, Nivedya, Beil-Wagner, Jane, Savic, Natasa, Pelczar, Pawel, Buch, Thorsten, King, Carolyn G, Bowden, Thomas A, Pinschewer, Daniel D

“…Viral mimicry of host cell structures has been postulated to curtail the B cell receptor (BCR) repertoire against persisting viruses through tolerance…”
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X-ray structure and activities of an essential Mononegavirales L-protein domain by Paesen, Guido C., Collet, Axelle, Sallamand, Corinne, Debart, Françoise, Vasseur, Jean-Jacques, Canard, Bruno, Decroly, Etienne, Grimes, Jonathan M.

“…The L protein of mononegaviruses harbours all catalytic activities for genome replication and transcription. It contains six conserved domains (CR-I to -VI;…”
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Structural insights into the human metapneumovirus glycoprotein ectodomain by Leyrat, Cedric, Paesen, Guido C, Charleston, James, Renner, Max, Grimes, Jonathan M

“…Human metapneumovirus is a major cause of respiratory tract infections worldwide. Previous reports have shown that the viral attachment glycoprotein (G)…”
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Structural dissection of human metapneumovirus phosphoprotein using small angle x-ray scattering by Renner, Max, Paesen, Guido C., Grison, Claire M., Granier, Sébastien, Grimes, Jonathan M., Leyrat, Cédric

“…The phosphoprotein (P) is the main and essential cofactor of the RNA polymerase (L) of non-segmented, negative‐strand RNA viruses. P positions the viral…”
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Structural basis of cholesterol binding by a novel clade of dendritic cell modulators from ticks by Roversi, Pietro, Johnson, Steven, Preston, Stephen G., Nunn, Miles A., Paesen, Guido C., Austyn, Jonathan M., Nuttall, Patricia A., Lea, Susan M.

“…Two crystal structures of Japanin, an 18 kDa immune-modulatory lipocalin from the Brown Ear Tick ( Rhipicephalus appendiculatus ), have been determined at 2.2…”
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Bifunctional Lipocalin Ameliorates Murine Immune Complex-induced Acute Lung Injury by Roversi, Pietro, Ryffel, Bernhard, Togbe, Dieudonnée, Maillet, Isabelle, Teixeira, Mauro, Ahmat, Nurfilza, Paesen, Guido C., Lissina, Olga, Boland, Wilhelm, Ploss, Kerstin, Caesar, Joseph J.E., Leonhartsberger, Susanne, Lea, Susan M., Nunn, Miles A.

“…Molecules that simultaneously inhibit independent or co-dependent proinflammatory pathways may have advantages over conventional monotherapeutics. OmCI is a…”
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High-resolution crystal structure of arthropod Eiger TNF suggests a mode of receptor engagement and altered surface charge within endosomes by Bertinelli, Mattia, Paesen, Guido C., Grimes, Jonathan M., Renner, Max

“…The tumour necrosis factor alpha (TNFα) superfamily of proteins are critical in numerous biological processes, such as in development and immunity. Eiger is…”
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