Search Results - "Paes, Marciano"
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The pathology of severe dengue in multiple organs of human fatal cases: histopathology, ultrastructure and virus replication
Published in PloS one (01-04-2014)“…Dengue is a public health problem, with several gaps in understanding its pathogenesis. Studies based on human fatal cases are extremely important and may…”
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Evaluating Dengue Virus Pathogenesis in Mice and Humans by Histological and Immunohistochemistry Approaches
Published in Methods in molecular biology (Clifton, N.J.) (2022)“…The analysis of dengue virus (DENV) infected tissues in mice experimental model and in human biopsies/autopsies may support the pathogenesis studies. Through…”
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Dengue virus nonstructural 3 protein interacts directly with human glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and reduces its glycolytic activity
Published in Scientific reports (25-02-2019)“…Dengue is an important mosquito-borne disease and a global public health problem. The disease is caused by dengue virus (DENV), which is a member of the…”
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and glial cells: Insights and perspectives
Published in Brain, behavior, & immunity. Health (01-08-2020)“…In December 2019, a pneumonia outbreak was reported in Wuhan, Hubei province, China. Since then, the World Health Organization declared a public health…”
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Increased circulating levels of High Mobility Group Box 1 (HMGB1) in acute-phase Chikungunya virus infection: Potential disease biomarker
Published in Journal of clinical virology (01-01-2022)“…•HMGB1 serum levels are increased during CHIKV infections.•HMGB1 serum levels keeps increased all over the acute-phase of the disease.•HMGB1 serum levels…”
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Placental Inflammation and Fetal Injury in a Rare Zika Case Associated With Guillain-Barré Syndrome and Abortion
Published in Frontiers in microbiology (16-05-2018)“…Zika virus (ZIKV) is an emerging virus involved in recent outbreaks in Brazil. The association between the virus and Guillain-Barré syndrome (GBS) or…”
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Peripheral Organs of Dengue Fatal Cases Present Strong Pro-Inflammatory Response with Participation of IFN-Gamma-, TNF-Alpha- and RANTES-Producing Cells
Published in PloS one (22-12-2016)“…Dengue disease is an acute viral illness caused by dengue virus (DENV) that can progress to hemorrhagic stages leading to about 20000 deaths every year…”
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SARS-CoV-2 Is Persistent in Placenta and Causes Macroscopic, Histopathological, and Ultrastructural Changes
Published in Viruses (26-08-2022)“…SARS-CoV-2 is a virus that belongs to the Betacoronavirus genus of the Coronaviridae family. Other coronaviruses, such as SARS-CoV and MERS-CoV, were…”
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Cooperation between CD4+ T Cells and Humoral Immunity Is Critical for Protection against Dengue Using a DNA Vaccine Based on the NS1 Antigen
Published in PLoS neglected tropical diseases (01-12-2015)“…Dengue virus (DENV) is spread through most tropical and subtropical areas of the world and represents a serious public health problem. At present, the control…”
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Correction: Peripheral Organs of Dengue Fatal Cases Present Strong Pro-Inflammatory Response with Participation of IFN-Gamma-, TNF-Alpha- and RANTES-Producing Cells
Published in PloS one (26-03-2018)“…[This corrects the article DOI: 10.1371/journal.pone.0168973.]…”
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Dengue fatal cases present virus-specific HMGB1 response in peripheral organs
Published in Scientific reports (22-11-2017)“…Dengue is an important infectious disease that presents high incidence and yields a relevant number of fatal cases (about 20,000) every year worldwide. Despite…”
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Histopathological and immunological characteristics of placentas infected with chikungunya virus
Published in Frontiers in microbiology (17-11-2022)“…Although vertical transmission of CHIKV has been reported, little is known about the role of placenta in the transmission of this virus and the effects of…”
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Zika virus found in brain tissue of a multiple sclerosis patient undergoing an acute disseminated encephalomyelitis-like episode
Published in Multiple sclerosis (01-03-2019)“…Background: A range of different neurological manifestations has been reported in fetuses and adults after Zika virus (ZIKV) infection. Objective: We describe…”
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A Stillborn Multiple Organs' Investigation from a Maternal DENV-4 Infection: Histopathological and Inflammatory Mediators Characterization
Published in Viruses (02-04-2019)“…Dengue virus (DENV) is an emerging virus involved in outbreaks in Brazil. The association between the virus and vertical transmission, with disorders in the…”
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Spontaneous Abortion and Chikungunya Infection: Pathological Findings
Published in Viruses (25-03-2021)“…Intrauterine transmission of the Chikungunya virus (CHIKV) during early pregnancy has rarely been reported, although vertical transmission has been observed in…”
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Fatal Dengue Cases Reveal Brain Injury and Viral Replication in Brain-Resident Cells Associated with the Local Production of Pro-Inflammatory Mediators
Published in Viruses (31-05-2020)“…Dengue is an arboviral disease caused by dengue virus (DENV), which is transmitted to humans by mosquitoes. Infection by DENV most commonly results in a mild…”
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BALB/c mice infected with DENV-2 strain 66985 by the intravenous route display injury in the central nervous system
Published in Scientific reports (27-06-2018)“…Dengue is a mild flu-like arboviral illness caused by dengue virus (DENV) that occurs in tropical and subtropical countries. An increasing number of reports…”
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Hepatic damage associated with dengue-2 virus replication in liver cells of BALB/c mice
Published in Laboratory investigation (01-10-2009)“…One difficulty in studying dengue virus (DENV) is the lack of an experimental model that reproduces the human disease. In a previous work, we have shown that…”
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Placental Alterations in a Chikungunya-Virus-Infected Pregnant Woman: A Case Report
Published in Microorganisms (Basel) (22-04-2022)“…Chikungunya virus (CHIKV) is an arthropod-borne virus first isolated in Tanzania, Africa. The virus has spread to Asia as well as South and Central America…”
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Zika Induces Human Placental Damage and Inflammation
Published in Frontiers in immunology (01-09-2020)“…In Brazil, an epidemic of Zika virus (ZIKV) infections was declared in 2015 that coincided with alarming reports of microcephaly in newborns associated with…”
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