Search Results - "Padiolleau‐Lefevre, Severine"

Do proteolytic antibodies complete the panoply of the autoimmune response in acquired haemophilia A? by Mahendra, Ankit, Padiolleau-Lefevre, Séverine, Kaveri, Srinivas V., Lacroix-Desmazes, Sébastien

“…Summary Acquired haemophilia A (AHA) is a rare bleeding disorder characterized by the sudden generation of autoantibodies against factor VIII (FVIII) in…”
Get full text

Structural and Functional Mise en Abyme by Avalle, Bérangère, Padiolleau-Lefevre, Séverine, Friboulet, Alain

Get full text

Genetic background and immunological status influence B cell repertoire diversity in mice by Chaaya, Nancy, Shahsavarian, Melody A., Maffucci, Irene, Friboulet, Alain, Offmann, Bernard, Léger, Jean-Benoist, Rousseau, Sylvain, Avalle, Bérangère, Padiolleau-Lefèvre, Séverine

“…The relationship between the immune repertoire and the physiopathological status of individuals is essential to apprehend the genesis and the evolution of…”
Get full text

The functionality of a therapeutic antibody candidate restored by a single mutation from proline to threonine in the variable region by Hautiere, Marie, Maffucci, Irene, Costa, Narciso, Herbet, Amaury, Essono, Sosthene, Padiolleau-Lefevre, Séverine, Boquet, Didier

“…mAbs play an essential role in the therapeutic arsenal. Our laboratory has patented the Rendomab-B49 mAb targeting the endothelin B receptor (ET ). This G…”
Get full text

Novel peptide inhibiting both TEM‐1 β‐lactamase and penicillin‐binding proteins by Phichith, Denis, Bun, Sylvie, Padiolleau‐Lefevre, Severine, Guellier, Adeline, Banh, Soun, Galleni, Moreno, Frere, Jean‐Marie, Thomas, Daniel, Friboulet, Alain, Avalle, Berangere

“…9G4H9, a catalytic antibody displaying β‐lactamase‐like activity, has been developed by the anti‐idiotypic approach using β‐lactamase as the first antigen…”
Get full text

Mutational and inhibitory analysis of a catalytic antibody. Implication for drug discovery by Phichith, Denis, Bun, Sylvie, Padiolleau-Lefèvre, Séverine, Banh, Soun, Thomas, Daniel, Friboulet, Alain, Avalle, Bérangère

“…Data on catalytic antibodies (abzymes) having critical roles in pathologies, for example in some auto-immune diseases accumulate at overwhelming pace…”
Get full text

IVIg treatment reduces catalytic antibody titers of renal transplanted patients by Mahendra, Ankit, Peyron, Ivan, Dollinger, Cécile, Gilardin, Laurent, Sharma, Meenu, Wootla, Bharath, Padiolleau-Lefevre, Séverine, Friboulet, Alain, Boquet, Didier, Legendre, Christophe, Kaveri, Srinivas V, Thaunat, Olivier, Lacroix-Desmazes, Sébastien

“…Catalytic antibodies are immunoglobulins endowed with enzymatic activity. Catalytic IgG has been reported in several human autoimmune and inflammatory…”
Get full text

Comparative Study of Single-stranded Oligonucleotides Secondary Structure Prediction Tools by Binet, Thomas, Padiolleau-Lefèvre, Séverine, Octave, Stéphane, Avalle, Bérangère, Maffucci, Irene

“…Single-stranded nucleic acids (ssNAs) have important biological roles and a high biotechnological potential linked to their ability to bind to numerous…”
Get full text

Lyme borreliosis diagnosis: state of the art of improvements and innovations by Guérin, Mickaël, Shawky, Marc, Zedan, Ahed, Octave, Stéphane, Avalle, Bérangère, Maffucci, Irene, Padiolleau-Lefèvre, Séverine

“…With almost 700 000 estimated cases each year in the United States and Europe, Lyme borreliosis (LB), also called Lyme disease, is the most common tick-borne…”
Get full text

Generation of Catalytic Antibodies Is an Intrinsic Property of an Individual's Immune System: A Study on a Large Cohort of Renal Transplant Patients by Mahendra, Ankit, Peyron, Ivan, Thaunat, Olivier, Dollinger, Cécile, Gilardin, Laurent, Sharma, Meenu, Wootla, Bharath, Rao, Desirazu N, Padiolleau-Lefevre, Séverine, Boquet, Didier, More, Abhijit, Varadarajan, Navin, Kaveri, Srini V, Legendre, Christophe, Lacroix-Desmazes, Sébastien

“…Renal transplant is the treatment of choice for patients with terminal end-stage renal disease. We have previously identified low levels of catalytic IgG as a…”
Get full text

Multitarget selection of catalytic antibodies with β‐lactamase activity using phage display by Shahsavarian, Melody A., Chaaya, Nancy, Costa, Narciso, Boquet, Didier, Atkinson, Alexandre, Offmann, Bernard, Kaveri, Srini V., Lacroix‐Desmazes, Sébastien, Friboulet, Alain, Avalle, Bérangère, Padiolleau‐Lefèvre, Séverine

“…β‐lactamase enzymes responsible for bacterial resistance to antibiotics are among the most important health threats to the human population today…”
Get full text

Production, purification, and quality assessment of borrelial proteins CspZ from Borrelia burgdorferi and FhbA from Borrelia hermsii by Guérin, Mickaël, Vandevenne, Marylène, Brans, Alain, Matagne, André, Marquant, Rodrigue, Prost, Elise, Octave, Stéphane, Avalle, Bérangère, Maffucci, Irene, Padiolleau-Lefèvre, Séverine

“…Borrelia , spirochetes transmitted by ticks, are the etiological agents of numerous multisystemic diseases, such as Lyme borreliosis (LB) and tick-borne…”
Get full text

Expression and detection strategies for an scFv fragment retaining the same high affinity than Fab and whole antibody: Implications for therapeutic use in prion diseases by Padiolleau-Lefevre, Séverine, Alexandrenne, Coralie, Dkhissi, Fatima, Clement, Gilles, Essono, Sosthène, Blache, Céline, Couraud, Jean-Yves, Wijkhuisen, Anne, Boquet, Didier

“…Since antibodies currently constitute the most rapidly growing class of human therapeutics, the high-yield production of recombinant antibodies and antibody…”
Get full text

Novel peptide inhibiting both TEM-1 [beta]-lactamase and penicillin-binding proteins by Phichith, Denis, Bun, Sylvie, Padiolleau-Lefevre, Severine, Guellier, Adeline, Banh, Soun, Galleni, Moreno, Frere, Jean-Marie, Thomas, Daniel, Friboulet, Alain, Avalle, Berangere

“…9G4H9, a catalytic antibody displaying [beta]-lactamase-like activity, has been developed by the anti-idiotypic approach using [beta]-lactamase as the first…”
Get full text

Exploitation of rolling circle amplification for the construction of large phage-display antibody libraries by Shahsavarian, Melody A., Le Minoux, Damien, Matti, Kalyankumar M., Kaveri, Srini, Lacroix-Desmazes, Sébastien, Boquet, Didier, Friboulet, Alain, Avalle, Bérangère, Padiolleau-Lefèvre, Séverine

“…Phage display antibody libraries have proven to have a significant role in the discovery of therapeutic antibodies and polypeptides with desired biological and…”
Get full text

Catalytic antibodies and their applications in biotechnology: state of the art by Padiolleau-Lefèvre, Séverine, Naya, Raouia Ben, Shahsavarian, Melody A, Friboulet, Alain, Avalle, Bérangère

“…Catalytic antibodies are immunoglobulins endowed with enzymatic properties. Discovered in the second part of the 1980s, the enthusiasm they initially aroused…”
Get full text

Peptide mass-assisted antibody cloning strategy for accurate characterization of potential therapeutic monoclonal antibodies against neurodegenerative diseases by Essono, Sosthene, Clément, Gilles, Padiolleau-Lefevre, Severine, Créminon, Christophe, Grassi, Jacques, Boquet, Didier

“…The development of therapeutic recombinant antibodies involves accurate characterization of immunoglobulin variable light (VL) and heavy (VH) chains. However,…”
Get full text

Efficient refolding of a recombinant abzyme: Structural and catalytic characterizations by Ben Naya, Raouia, Matti, Kalyankumar, Guellier, Adeline, Matagne, André, Boquet, Didier, Thomas, Daniel, Friboulet, Alain, Avalle, Bérangère, Padiolleau-Lefèvre, Séverine

“…Catalytic antibodies are currently being investigated in order to understand their role under physio-pathological situations. To this end, the knowledge of…”
Get full text

A novel molecular analysis of genes encoding catalytic antibodies by Le Minoux, Damien, Mahendra, Ankit, Kaveri, Srini, Limnios, Nikolaos, Friboulet, Alain, Avalle, Bérangère, Boquet, Didier, Lacroix-Desmazes, Sébastien, Padiolleau-Lefèvre, Séverine

“…► We analyze the somatic hypermutations of catalytic antibodies displaying an amidase activity by comparison to the closest germline genes using the IMGT…”
Get full text

Multitarget selection of catalytic antibodies with [beta]-lactamase activity using phage display by Shahsavarian, Melody A, Chaaya, Nancy, Costa, Narciso, Boquet, Didier, Atkinson, Alexandre, Offmann, Bernard, Kaveri, Srini V, Lacroix-Desmazes, Sébastien, Friboulet, Alain, Avalle, Bérangère, Padiolleau-Lefevre, Séverine

“…[beta]-lactamase enzymes responsible for bacterial resistance to antibiotics are among the most important health threats to the human population today…”
Get full text