Search Results - "Padilla, Maria"

Chromatin dynamics in the regulation of cell fate allocation during early embryogenesis by Burton, Adam, Torres-Padilla, Maria-Elena

“…Key Points Major epigenetic reprogramming occurs during pre-implantation development. The precise functions of these changes in cell fate allocation remain to…”
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The molecular and cellular features of 2-cell-like cells: a reference guide by Genet, Marion, Torres-Padilla, Maria-Elena

“…Currently, two main cell culture models predominate pluripotent stem cell research: embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs)…”
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TFs for TEs: the transcription factor repertoire of mammalian transposable elements by Hermant, Clara, Torres-Padilla, Maria-Elena

“…Transposable elements (TEs) are genetic elements capable of changing position within the genome. Although their mobilization can constitute a threat to genome…”
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Transcription factor heterogeneity in pluripotent stem cells: a stochastic advantage by Torres-Padilla, Maria-Elena, Chambers, Ian

“…When pluripotent cells are exposed to a uniform culture environment they routinely display heterogeneous gene expression. Aspects of this heterogeneity, such…”
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Hyperosmotic stress induces 2‐cell‐like cells through ROS and ATR signaling by Canat, Antoine, Atilla, Derya, Torres‐Padilla, Maria‐Elena

“…Mouse embryonic stem cells (ESCs) display pluripotency features characteristic of the inner cell mass of the blastocyst. Mouse embryonic stem cell cultures are…”
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A cell in hand is worth two in the embryo: recent advances in 2-cell like cell reprogramming by Iturbide, Ane, Torres-Padilla, Maria-Elena

“…Multicellular organisms develop from a single cell, the zygote. This feature is referred to as totipotency. In the mouse, only the zygote and the 2-cell stage…”
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Dynamics of nuclear architecture during early embryonic development and lessons from liveimaging by Pecori, Federico, Torres-Padilla, Maria-Elena

“…Nuclear organization has emerged as a potential key regulator of genome function. During development, the deployment of transcriptional programs must be…”
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Control of ground-state pluripotency by allelic regulation of Nanog by Miyanari, Yusuke, Torres-Padilla, Maria-Elena

“…Tight regulation of Nanog dose at the chromosome level is important for the acquisition of pluripotency during development. Nanog under tight rein in stem…”
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A molecular roadmap for the emergence of early-embryonic-like cells in culture by Rodriguez-Terrones, Diego, Gaume, Xavier, Ishiuchi, Takashi, Weiss, Amélie, Kopp, Arnaud, Kruse, Kai, Penning, Audrey, Vaquerizas, Juan M., Brino, Laurent, Torres-Padilla, Maria-Elena

“…Unlike pluripotent cells, which generate only embryonic tissues, totipotent cells can generate a full organism, including extra-embryonic tissues. A rare…”
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On transposons and totipotency by Torres-Padilla, Maria-Elena

“…Our perception of the role of the previously considered 'selfish' or 'junk' DNA has been dramatically altered in the past 20 years or so. A large proportion of…”
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Regulation of mammalian totipotency: a molecular perspective from in vivo and in vitro studies by Nakatani, Tsunetoshi, Torres-Padilla, Maria-Elena

“…In mammals, cells acquire totipotency at fertilization. Embryonic genome activation (EGA), which occurs at the 2-cell stage in the mouse and 4- to 8-cell stage…”
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Live visualization of chromatin dynamics with fluorescent TALEs by Miyanari, Yusuke, Ziegler-Birling, Céline, Torres-Padilla, Maria-Elena

“…It has been challenging to label endogenous genomic sequences in living cells, and this has limited attempts to study the dynamics of nuclear architecture in…”
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Nimble and Ready to Mingle: Transposon Outbursts of Early Development by Rodriguez-Terrones, Diego, Torres-Padilla, Maria-Elena

“…Transposable elements are the largest individual constituent of mammalian genomes. These elements are highly diverse, a consequence of the multiplicity of…”
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Totipotency, development, and chromatin by Torres-Padilla, Maria-Elena

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LINE-1 activation after fertilization regulates global chromatin accessibility in the early mouse embryo by Jachowicz, Joanna W, Bing, Xinyang, Pontabry, Julien, Bošković, Ana, Rando, Oliver J, Torres-Padilla, Maria-Elena

“…Maria-Elena Torres-Padilla and colleagues use a targeted epigenomic approach to investigate the role of LINE-1 retroelements during early mouse development…”
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SUMO Safeguards Somatic and Pluripotent Cell Identities by Enforcing Distinct Chromatin States by Cossec, Jack-Christophe, Theurillat, Ilan, Chica, Claudia, Búa Aguín, Sabela, Gaume, Xavier, Andrieux, Alexandra, Iturbide, Ane, Jouvion, Gregory, Li, Han, Bossis, Guillaume, Seeler, Jacob-Sebastian, Torres-Padilla, Maria-Elena, Dejean, Anne

“…Understanding general principles that safeguard cellular identity should reveal critical insights into common mechanisms underlying specification of varied…”
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Expression and phase separation potential of heterochromatin proteins during early mouse development by Guthmann, Manuel, Burton, Adam, Torres‐Padilla, Maria‐Elena

“…In most eukaryotes, constitutive heterochromatin is associated with H3K9me3 and HP1α. The latter has been shown to play a role in heterochromatin formation…”
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Chromatin signatures and retrotransposon profiling in mouse embryos reveal regulation of LINE-1 by RNA by Fadloun, Anas, Le Gras, Stéphanie, Jost, Bernard, Ziegler-Birling, Céline, Takahashi, Hazuki, Gorab, Eduardo, Carninci, Piero, Torres-Padilla, Maria-Elena

“…Repetitive elements in differentiated cells are usually silenced. Genome-wide analyses in early mouse development show that repetitive-element expression…”
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Deconfining heterochromatin for expression by Burton, Adam, Torres-Padilla, Maria-Elena

“…Lineage-specific gene expression programs in multicellular organisms are controlled by balanced ON and OFF signals, amongst which heterochromatin regulates…”
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Nitric oxide buffering and conditional nitric oxide release in stress response by Begara-Morales, Juan C, Chaki, Mounira, Valderrama, Raquel, Sánchez-Calvo, Beatriz, Mata-Pérez, Capilla, Padilla, María N, Corpas, Francisco J, Barroso, Juan B

“…Overview of the GSNO turnover mechanisms and especially the role of GSNO as a modulator of NO-dependent signalling under physiological and stress conditions in…”
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