Search Results - "Padi, Sathish K R"

The long noncoding RNA H19 regulates tumor plasticity in neuroendocrine prostate cancer by Singh, Neha, Ramnarine, Varune R., Song, Jin H., Pandey, Ritu, Padi, Sathish K. R., Nouri, Mannan, Olive, Virginie, Kobelev, Maxim, Okumura, Koichi, McCarthy, David, Hanna, Michelle M., Mukherjee, Piali, Sun, Belinda, Lee, Benjamin R., Parker, J. Brandon, Chakravarti, Debabrata, Warfel, Noel A., Zhou, Muhan, Bearss, Jeremiah J., Gibb, Ewan A., Alshalalfa, Mohammed, Karnes, R. Jefferey, Small, Eric J., Aggarwal, Rahul, Feng, Felix, Wang, Yuzhuo, Buttyan, Ralph, Zoubeidi, Amina, Rubin, Mark, Gleave, Martin, Slack, Frank J., Davicioni, Elai, Beltran, Himisha, Collins, Colin, Kraft, Andrew S.

“…Neuroendocrine (NE) prostate cancer (NEPC) is a lethal subtype of castration-resistant prostate cancer (PCa) arising either de novo or from transdifferentiated…”
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MMP‑9 Responsive PEG Cleavable Nanovesicles for Efficient Delivery of Chemotherapeutics to Pancreatic Cancer by Kulkarni, Prajakta S, Haldar, Manas K, Nahire, Rahul R, Katti, Preeya, Ambre, Avinash H, Muhonen, Wallace W, Shabb, John B, Padi, Sathish K. R, Singh, Raushan K, Borowicz, Pawel P, Shrivastava, D. K, Katti, Kalpana S, Reindl, Katie, Guo, Bin, Mallik, Sanku

“…Significant differences in biochemical parameters between normal and tumor tissues offer an opportunity to chemically design drug carriers which respond to…”
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PIM protein kinases regulate the level of the long noncoding RNA H19 to control stem cell gene transcription and modulate tumor growth by Singh, Neha, Padi, Sathish K. R., Bearss, Jeremiah J., Pandey, Ritu, Okumura, Koichi, Beltran, Himisha, Song, Jin H., Kraft, Andrew S., Olive, Virginie

“…The proviral integration site for Moloney murine leukemia virus (PIM) serine/threonine kinases have an oncogenic and prosurvival role in hematological and…”
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EDC3 phosphorylation regulates growth and invasion through controlling P-body formation and dynamics by Bearss, Jeremiah J, Padi, Sathish KR, Singh, Neha, Cardo-Vila, Marina, Song, Jin H, Mouneimne, Ghassan, Fernandes, Nikita, Li, Yang, Harter, Matthew R, Gard, Jaime MC, Cress, Anne E, Peti, Wolfgang, Nelson, Andrew DL, Buchan, J Ross, Kraft, Andrew S, Okumura, Koichi

“…Regulation of mRNA stability and translation plays a critical role in determining protein abundance within cells. Processing bodies (P-bodies) are critical…”
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“Root”ing for successful T-ALL treatment by Padi, Sathish K.R., Kraft, Andrew S.

“…In this issue of Blood , Anand et al 1 provide compelling evidence that resistance to Notch inhibitor therapy in early T-cell precursor acute lymphoblastic…”
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Cryo-EM structures of PP2A:B55–FAM122A and PP2A:B55–ARPP19 by Padi, Sathish K. R., Vos, Margaret R., Godek, Rachel J., Fuller, James R., Kruse, Thomas, Hein, Jamin B., Nilsson, Jakob, Kelker, Matthew S., Page, Rebecca, Peti, Wolfgang

“…Progression through the cell cycle is controlled by regulated and abrupt changes in phosphorylation 1 . Mitotic entry is initiated by increased phosphorylation…”
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MicroRNA-627 Mediates the Epigenetic Mechanisms of Vitamin D to Suppress Proliferation of Human Colorectal Cancer Cells and Growth of Xenograft Tumors in Mice by Padi, Sathish K.R, Zhang, Qunshu, Rustum, Youcef M, Morrison, Carl, Guo, Bin

“…Background & Aims Vitamin D protects against colorectal cancer through unclear mechanisms. We investigated the effects of calcitriol (1α,25-dihydroxyvitamin D3…”
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Phosphorylation of DEPDC5, a component of the GATOR1 complex, releases inhibition of mTORC1 and promotes tumor growth by Padi, Sathish K. R., Singh, Neha, Bearss, Jeremiah J., Olive, Virginie, Song, Jin H., Cardó-Vila, Marina, Kraft, Andrew S., Okumura, Koichi

“…The Pim and AKT serine/threonine protein kinases are implicated as drivers of cancer. Their regulation of tumor growth is closely tied to the ability of these…”
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PIM Kinase Inhibitors Block the Growth of Primary T-cell Acute Lymphoblastic Leukemia: Resistance Pathways Identified by Network Modeling Analysis by Lim, James T, Singh, Neha, Leuvano, Libia A, Calvert, Valerie S, Petricoin, Emanuel F, Teachey, David T, Lock, Richard B, Padi, Megha, Kraft, Andrew S, Padi, Sathish K R

“…Despite significant progress in understanding the genetic landscape of T-cell acute lymphoblastic leukemia (T-ALL), the discovery of novel therapeutic targets…”
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Targeting the PIM protein kinases for the treatment of a T-cell acute lymphoblastic leukemia subset by Padi, Sathish K R, Luevano, Libia A, An, Ningfei, Pandey, Ritu, Singh, Neha, Song, Jin H, Aster, Jon C, Yu, Xue-Zhong, Mehrotra, Shikhar, Kraft, Andrew S

“…New approaches are needed for the treatment of patients with T-cell acute lymphoblastic leukemia (T-ALL) who fail to achieve remission with chemotherapy…”
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Insulin receptor substrate 1 is a substrate of the Pim protein kinases by Song, Jin H, Padi, Sathish K R, Luevano, Libia A, Minden, Mark D, DeAngelo, Daniel J, Hardiman, Gary, Ball, Lauren E, Warfel, Noel A, Kraft, Andrew S

“…The Pim family of serine/threonine protein kinases (Pim 1, 2, and 3) contribute to cellular transformation by regulating glucose metabolism, protein synthesis,…”
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High-resolution structures of two phosphatase-inhibitor complexes

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Mechanisms Behind Resistance to PI3K Inhibitor Treatment Induced by the PIM Kinase by Song, Jin H, Singh, Neha, Luevano, Libia A, Padi, Sathish K R, Okumura, Koichi, Olive, Virginie, Black, Stephen M, Warfel, Noel A, Goodrich, David W, Kraft, Andrew S

“…Cancer resistance to PI3K inhibitor therapy can be in part mediated by increases in the PIM1 kinase. However, the exact mechanism by which PIM kinase promotes…”
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