Search Results - "Padgett, A"

New connections between splicing and human disease by Padgett, Richard A

“…The removal by splicing of introns from the primary transcripts of most mammalian genes is an essential step in gene expression. Splicing is performed by…”
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Rates of in situ transcription and splicing in large human genes by Padgett, Richard A, Singh, Jarnail

“…Rates of in vivo transcription have proven hard to pin down, especially across long mammalian genes that can contain lengthy introns. Using DRB inhibition…”
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Lyme disease ecology in a changing world: consensus, uncertainty and critical gaps for improving control by Kilpatrick, A. Marm, Dobson, Andrew D. M., Levi, Taal, Salkeld, Daniel J., Swei, Andrea, Ginsberg, Howard S., Kjemtrup, Anne, Padgett, Kerry A., Jensen, Per M., Fish, Durland, Ogden, Nick H., Diuk-Wasser, Maria A.

“…Lyme disease is the most common tick-borne disease in temperate regions of North America, Europe and Asia, and the number of reported cases has increased in…”
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Biased Chromatin Signatures around Polyadenylation Sites and Exons by Spies, Noah, Nielsen, Cydney B., Padgett, Richard A., Burge, Christopher B.

“…Core RNA-processing reactions in eukaryotic cells occur cotranscriptionally in a chromatin context, but the relationship between chromatin structure and…”
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Germline DDX41 mutations cause ineffective hematopoiesis and myelodysplasia by Chlon, Timothy M., Stepanchick, Emily, Hershberger, Courtney E., Daniels, Noah J., Hueneman, Kathleen M., Kuenzi Davis, Ashley, Choi, Kwangmin, Zheng, Yi, Gurnari, Carmelo, Haferlach, Torsten, Padgett, Richard A., Maciejewski, Jaroslaw P., Starczynowski, Daniel T.

“…DDX41 mutations are the most common germline alterations in adult myelodysplastic syndromes (MDSs). The majority of affected individuals harbor germline…”
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Projected climate and land use change alter western blacklegged tick phenology, seasonal host‐seeking suitability and human encounter risk in California by MacDonald, Andrew J., McComb, Sofie, O’Neill, Craig, Padgett, Kerry A., Larsen, Ashley E.

“…Global environmental change is having profound effects on the ecology of infectious disease systems, which are widely anticipated to become more pronounced…”
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Comprehensive database and evolutionary dynamics of U12-type introns by Moyer, Devlin C, Larue, Graham E, Hershberger, Courtney E, Roy, Scott W, Padgett, Richard A

“…Abstract During nuclear maturation of most eukaryotic pre-messenger RNAs and long non-coding RNAs, introns are removed through the process of RNA splicing…”
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Mutations in the spliceosome machinery, a novel and ubiquitous pathway in leukemogenesis by Makishima, Hideki, Visconte, Valeria, Sakaguchi, Hirotoshi, Jankowska, Anna M., Abu Kar, Sarah, Jerez, Andres, Przychodzen, Bartlomiej, Bupathi, Manoj, Guinta, Kathryn, Afable, Manuel G., Sekeres, Mikkael A., Padgett, Richard A., Tiu, Ramon V., Maciejewski, Jaroslaw P.

“…Myelodysplastic syndromes (MDSs) are chronic and often progressive myeloid neoplasms associated with remarkable heterogeneity in the histomorphology and…”
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Fermi surface in the absence of a Fermi liquid in the Kondo insulator SmB6 by Hartstein, M., Toews, W. H., Hsu, Y.-T., Zeng, B., Chen, X., Hatnean, M. Ciomaga, Zhang, Q. R., Nakamura, S., Padgett, A. S., Rodway-Gant, G., Berk, J., Kingston, M. K., Zhang, G. H., Chan, M. K., Yamashita, S., Sakakibara, T., Takano, Y., Park, J.-H., Balicas, L., Harrison, N., Shitsevalova, N., Balakrishnan, G., Lonzarich, G. G., Hill, R. W., Sutherland, M., Sebastian, Suchitra E.

“…The search for a Fermi surface in the absence of a conventional Fermi liquid has thus far yielded very few potential candidates. Among promising materials are…”
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Defects in spliceosomal machinery: a new pathway of leukaemogenesis by Maciejewski, Jaroslaw P., Padgett, Richard A.

“…Summary Proper splicing of pre‐mRNA is required for protein synthesis and therefore is a fundamental cellular function. The discovery of a variety of somatic…”
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Complex landscape of alternative splicing in myeloid neoplasms by Hershberger, Courtney E., Moyer, Devlin C., Adema, Vera, Kerr, Cassandra M., Walter, Wencke, Hutter, Stephan, Meggendorfer, Manja, Baer, Constance, Kern, Wolfgang, Nadarajah, Niroshan, Twardziok, Sven, Sekeres, Mikkael A., Haferlach, Claudia, Haferlach, Torsten, Maciejewski, Jaroslaw P., Padgett, Richard A.

“…Myeloid neoplasms are characterized by frequent mutations in at least seven components of the spliceosome that have distinct roles in the process of pre-mRNA…”
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A pilot study of improved psychological distress with art therapy in patients with cancer undergoing chemotherapy by Elimimian, E B, Elson, L, Stone, E, Butler, R S, Doll, M, Roshon, S, Kondaki, C, Padgett, A, Nahleh, Z A

“…Art therapy may improve the physical, mental, and emotional wellbeing of individuals for a variety of purposes. It remains understudied and underutilized in…”
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Functional analyses of human LUC7-like proteins involved in splicing regulation and myeloid neoplasms by Daniels, Noah J., Hershberger, Courtney E., Gu, Xiaorong, Schueger, Caroline, DiPasquale, William M., Brick, Jonathan, Saunthararajah, Yogen, Maciejewski, Jaroslaw P., Padgett, Richard A.

“…Vertebrates have evolved three paralogs, termed LUC7L, LUC7L2, and LUC7L3, of the essential yeast U1 small nuclear RNA (snRNA)-associated splicing factor…”
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Mutations in U4atac snRNA, a Component of the Minor Spliceosome, in the Developmental Disorder MOPD I by He, Huiling, Liyanarachchi, Sandya, Akagi, Keiko, Nagy, Rebecca, Li, Jingfeng, Dietrich, Rosemary C., Li, Wei, Sebastian, Nikhil, Wen, Bernard, Xin, Baozhong, Singh, Jarnail, Yan, Pearlly, Alder, Hansjuerg, Haan, Eric, Wieczorek, Dagmar, Albrecht, Beate, Puffenberger, Erik, Wang, Heng, Westman, Judith A., Padgett, Richard A., Symer, David E., de la Chapelle, Albert

“…Small nuclear RNAs (snRNAs) are essential factors in messenger RNA splicing. By means of homozygosity mapping and deep sequencing, we show that a gene encoding…”
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SF3B1 haploinsufficiency leads to formation of ring sideroblasts in myelodysplastic syndromes by Visconte, Valeria, Rogers, Heesun J., Singh, Jarnail, Barnard, John, Bupathi, Manoj, Traina, Fabiola, McMahon, James, Makishima, Hideki, Szpurka, Hadrian, Jankowska, Anna, Jerez, Andres, Sekeres, Mikkael A., Saunthararajah, Yogen, Advani, Anjali S., Copelan, Edward, Koseki, Haruhiko, Isono, Kyoichi, Padgett, Richard A., Osman, Sami, Koide, Kazunori, O'Keefe, Christine, Maciejewski, Jaroslaw P., Tiu, Ramon V.

“…Whole exome/genome sequencing has been fundamental in the identification of somatic mutations in the spliceosome machinery in myelodysplastic syndromes (MDSs)…”
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Newly Recognized Spotted Fever Group Rickettsia as Cause of Severe Rocky Mountain Spotted Fever-Like Illness, Northern California, USA by Probert, Will S, Haw, Monica P, Nichol, Aran C, Glaser, Carol A, Park, Sarah Y, Campbell, Laura E, Trivedi, Kavita K, Romo, Hannah, Saunders, Megan E M, Kjemtrup, Anne M, Padgett, Kerry A, Hacker, Jill K

“…The incidence of spotted fever group (SFG) rickettsioses in the United States has tripled since 2010. Rocky Mountain spotted fever, the most severe SFG…”
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Personalization of the Microbiota of Donor Human Milk with Mother's Own Milk by Cacho, Nicole T, Harrison, Natalie A, Parker, Leslie A, Padgett, Kaylie A, Lemas, Dominick J, Marcial, Guillermo E, Li, Nan, Carr, Laura E, Neu, Josef, Lorca, Graciela L

“…The American Academy of Pediatrics recommends that extremely preterm infants receive mother's own milk (MOM) when available or pasteurized donor breast milk…”
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Phylogeography of Borrelia spirochetes in Ixodes pacificus and Ixodes spinipalpis ticks highlights differential acarological risk of tick-borne disease transmission in northern versus southern California by Rose, Ian, Yoshimizu, Melissa Hardstone, Bonilla, Denise L, Fedorova, Natalia, Lane, Robert S, Padgett, Kerry A

“…The common human-biting tick, Ixodes pacificus, is the primary vector of the Lyme disease spirochete, Borrelia burgdorferi sensu stricto (ss) in western North…”
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Isolation of Borrelia miyamotoi and other Borreliae using a modified BSK medium by Replogle, Adam J., Sexton, Christopher, Young, John, Kingry, Luke C., Schriefer, Martin E., Dolan, Marc, Johnson, Tammi L., Connally, Neeta P., Padgett, Kerry A., Petersen, Jeannine M.

“…Borrelia spirochetes are the causative agents of Lyme borreliosis (LB) and relapsing fever (RF). Despite the steady rise in infections and the identification…”
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How stress influences the immune response by Padgett, David A., Glaser, Ronald

“…In response to a stressor, physiological changes are set into motion to help an individual cope with the stressor. However, chronic activation of these stress…”
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