Search Results - "Padera, R. F."

BIBW2992, an irreversible EGFR HER2 inhibitor highly effective in preclinical lung cancer models by Li, D, Ambrogio, L, Shimamura, T, Kubo, S, Takahashi, M, Chirieac, L R, Padera, R F, Shapiro, G I, Baum, A, Himmelsbach, F, Rettig, W J, Meyerson, M, Solca, F, Greulich, H, Wong, K-K

“…Genetic alterations in the kinase domain of the epidermal growth factor receptor ( EGFR ) in non-small cell lung cancer (NSCLC) patients are associated with…”
Get full text

Integration of engineered cartilage by Obradovic, B, Martin, I, Padera, R.F, Treppo, S, Freed, L.E, Vunjak-Novakovic, G

“…The structure and function of cartilaginous constructs, engineered in vitro using bovine articular chondrocytes, biodegradable scaffolds and bioreactors, can…”
Get full text

In vitro generation of osteochondral composites by Schaefer, D, Martin, I, Shastri, P, Padera, R.F, Langer, R, Freed, L.E, Vunjak-Novakovic, G

“…Osteochondral repair involves the regeneration of articular cartilage and underlying bone, and the development of a well-defined tissue-to-tissue interface. We…”
Get full text

Dilatation of the ascending aorta in patients with congenitally bicuspid aortic valves by Robicsek, F, Padera, Jr, R F, Thubrikar, M J

“…The cause of ascending aortic dilatation occurring in patients with congenitally bicuspid aortic valves was investigated. Flow patterns through human aortic…”
Get full text

Adjacent tissues (cartilage, bone) affect the functional integration of engineered calf cartilage in vitro by Tognana, E., Chen, F., Padera, R.F., Leddy, H.A., Christensen, S.E., Guilak, F., Vunjak-Novakovic, G., Freed, L.E.

“…An in vitro model was used to test the hypothesis that culture time and adjacent tissue structure and composition affected chondrogenesis and integrative…”
Get full text

TIM‐1 Signaling Is Required for Maintenance and Induction of Regulatory B Cells by Yeung, M. Y., Ding, Q., Brooks, C. R., Xiao, S., Workman, C. J., Vignali, D. A. A., Ueno, T., Padera, R. F., Kuchroo, V. K., Najafian, N., Rothstein, D. M.

“…Apart from their role in humoral immunity, B cells can exhibit IL‐10‐dependent regulatory activity (Bregs). These regulatory subpopulations have been shown to…”
Get full text

In vitro differentiation of chick embryo bone marrow stromal cells into cartilaginous and bone-like tissues by Martin, I, Padera, R F, Vunjak-Novakovic, G, Freed, L E

“…Bone marrow stromal cells, progenitor cells involved in repair of bone and cartilage, can potentially provide a source for autologous skeletal tissue…”
Get more information

Systemic delivery of human growth hormone using genetically modified tissue-engineered microvascular networks: prolonged delivery and endothelial survival with inclusion of nonendothelial cells by Sieminski, A L, Padera, R F, Blunk, T, Gooch, K J

“…Endothelial cells have the potential to provide efficient long-term delivery of therapeutic proteins to the circulation if a sufficient number of genetically…”
Get more information

A novel biotinylated degradable polymer for cell-interactive applications by Cannizzaro, Scott M., Padera, Robert F., Langer, Robert, Rogers, Rick A., Black, Fiona E., Davies, Martyn C., Tendler, Saul J. B., Shakesheff, Kevin M.

“…We describe the development of a novel biodegradable polymer designed to present bioactive motifs at the surfaces of materials of any architecture. The polymer…”
Get full text

An integrated experimental-computational approach for the study of engineered cartilage constructs subjected to combined regimens of hydrostatic pressure and interstitial perfusion by Moretti, M, Freed, L E, Padera, R F, Laganà, K, Boschetti, F, Raimondi, M T

Get more information

In vivo evaluation of tetrahedral amorphous carbon by LaVan, David A., Padera, Robert F., Friedmann, Thomas A., Sullivan, John P., Langer, Robert, Kohane, Daniel S.

“…The in vivo behavior and tissue reaction to tetrahedral amorphous carbon (ta-C) has been evaluated for periods of up to 6 months in SV129 mice. Two sample…”
Get full text

Time course of membrane microarchitecture-driven neovascularization by Padera, Robert F., Colton, Clark K.

“…The host response to a microporous material that induces neovascularization at the material-tissue interface was studied in terms of the number and types of…”
Get full text

A preliminary report on the biocompatibility of photopolymerizable semi-interpenetrating anhydride networks by Shastri, Venkatram Prasad, Padera, Robert F., Tarcha, Peter, Langer, Robert

“…A new family of poly(anhydrides) (PA) has been developed which can be cured photochemically to produce degradable networks. These degradable anhydride networks…”
Get full text

The biocompatibility of mesoporous silicates by Hudson, Sarah P, Padera, Robert F, Langer, Robert, Kohane, Daniel S

“…Abstract Micro- and nano-mesoporous silicate particles are considered potential drug delivery systems because of their ordered pore structures, large surface…”
Get full text

Histocompatibility of photocrosslinked polyanhydrides: A novel in situ forming orthopaedic biomaterial by Poshusta, Amy K., Burdick, Jason A., Mortisen, Derek J., Padera, Robert F., Ruehlman, Dana, Yaszemski, Michael J., Anseth, Kristi S.

“…Cell–polymer interactions in subcutaneous and bony tissue were examined for a novel class of in situ forming and surface eroding polyanhydride networks…”
Get full text

Surface-mediated bone tissue morphogenesis from tunable nanolayered implant coatings by Shah, Nisarg J, Hyder, Md Nasim, Moskowitz, Joshua S, Quadir, Mohiuddin A, Morton, Stephen W, Seeherman, Howard J, Padera, Robert F, Spector, Myron, Hammond, Paula T

“…The functional success of a biomedical implant critically depends on its stable bonding with the host tissue. Aseptic implant loosening accounts for more than…”
Get more information

Bronchial and Peripheral Murine Lung Carcinomas Induced by T790M-L858R Mutant EGFR Respond to HKI-272 and Rapamycin Combination Therapy by Li, Danan, Shimamura, Takeshi, Ji, Hongbin, Chen, Liang, Haringsma, Henry J., McNamara, Kate, Liang, Mei-Chih, Perera, Samanthi A., Zaghlul, Sara, Borgman, Christa L., Kubo, Shigeto, Takahashi, Masaya, Sun, Yanping, Chirieac, Lucian R., Padera, Robert F., Lindeman, Neal I., Jänne, Pasi A., Thomas, Roman K., Meyerson, Matthew L., Eck, Michael J., Engelman, Jeffrey A., Shapiro, Geoffrey I., Wong, Kwok-Kin

“…The EGFR T790M mutation has been identified in tumors from lung cancer patients that eventually develop resistance to erlotinib. In this study, we generated a…”
Get full text

A51 EXPERIMENTAL MODELS OF PULMONARY HYPERTENSION: Deficiency Of Mmp-8 Exacerbates Hypoxia-Induced Pulmonary Hypertension by Haeger, C Mallarino, Coronata, A F, Chrobak, I M, Polverino, F, Vitali, S H, Padera, R F, Owen, C A, Fredenburgh, L E

Get full text

A53 RESPIRATORY FAILURE: RISK FACTORS AND OUTCOMES IN ARDS: Interstitial Lung Abnormalities And Acute Respiratory Distress Syndrome by Putman, R K, Hunninghake, G M, Barragan-Bradford, D, Dieffenbach, P B, Adams, U, McKeon, A, Hatabu, H, Nishino, M, Padera, R F, Fredenburgh, L, Baron, R M, Englert, J A

Get full text

Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms by Wolach, Ofir, Sellar, Rob S, Martinod, Kimberly, Cherpokova, Deya, McConkey, Marie, Chappell, Ryan J, Silver, Alexander J, Adams, Dylan, Castellano, Cecilia A, Schneider, Rebekka K, Padera, Robert F, DeAngelo, Daniel J, Wadleigh, Martha, Steensma, David P, Galinsky, Ilene, Stone, Richard M, Genovese, Giulio, McCarroll, Steven A, Iliadou, Bozenna, Hultman, Christina, Neuberg, Donna, Mullally, Ann, Wagner, Denisa D, Ebert, Benjamin L

“…Thrombosis is a major cause of morbidity and mortality in Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs), clonal disorders of…”
Get more information