Search Results - "Padanilam, Babu J."

Regulation of necrotic cell death: p53, PARP1 and cyclophilin D-overlapping pathways of regulated necrosis? by Ying, Yuan, Padanilam, Babu J.

“…In contrast to apoptosis and autophagy, necrotic cell death was considered to be a random, passive cell death without definable mediators. However, this dogma…”
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Defective Mitochondrial Fatty Acid Oxidation and Lipotoxicity in Kidney Diseases by Jang, Hee-Seong, Noh, Mi Ra, Kim, Jinu, Padanilam, Babu J

“…The kidney is a highly metabolic organ and uses high levels of ATP to maintain electrolyte and acid-base homeostasis and reabsorb nutrients. Energy depletion…”
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Targeted deletion of p53 in the proximal tubule prevents ischemic renal injury by Ying, Yuan, Kim, Jinu, Westphal, Sherry N, Long, Kelly E, Padanilam, Babu J

“…The contribution of p53 to kidney dysfunction, inflammation, and tubular cell death, hallmark features of ischemic renal injury (IRI), remains undefined. Here,…”
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Loss of SAV1 in Kidney Proximal Tubule Induces Maladaptive Repair after Ischemia and Reperfusion Injury by Moon, Daeun, Padanilam, Babu J, Park, Kwon Moo, Kim, Jinu

“…Kidney ischemia and reperfusion injury (IRI) is a significant contributor to acute kidney injury (AKI), characterized by tubular injury and kidney dysfunction…”
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TIGAR regulates glycolysis in ischemic kidney proximal tubules by Kim, Jinu, Devalaraja-Narashimha, Kishor, Padanilam, Babu J

“…Tp53-induced glycolysis and apoptosis regulator (TIGAR) activation blocks glycolytic ATP synthesis by inhibiting phosphofructokinase-1 activity. Our data…”
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Proximal tubule cyclophilin D regulates fatty acid oxidation in cisplatin-induced acute kidney injury by Jang, Hee-Seong, Noh, Mi Ra, Jung, Eui-Man, Kim, Woo-Yang, Southekal, Siddesh, Guda, Chittibabu, Foster, Kirk W, Oupicky, David, Ferrer, Fernando A, Padanilam, Babu J

“…Regardless of the etiology, acute kidney injury involves aspects of mitochondrial dysfunction and ATP depletion. Fatty acid oxidation is the preferred energy…”
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Renal Sympathetic Nerve-Derived Signaling in Acute and Chronic kidney Diseases by Noh, Mi Ra, Jang, Hee-Seong, Kim, Jinu, Padanilam, Babu J

“…The kidney is innervated by afferent sensory and efferent sympathetic nerve fibers. Norepinephrine (NE) is the primary neurotransmitter for post-ganglionic…”
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Cell death induced by acute renal injury: a perspective on the contributions of apoptosis and necrosis by Padanilam, Babu J

“…In humans and experimental models of renal ischemia, tubular cells in various nephron segments undergo necrotic and/or apoptotic cell death. Various factors,…”
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Poly(ADP-ribose) polymerase 1 activation is required for cisplatin nephrotoxicity by Kim, Jinu, Long, Kelly E, Tang, Kang, Padanilam, Babu J

“…Apoptosis, necrosis, and inflammation are hallmarks of cisplatin nephrotoxicity; however, the role and mechanisms of necrosis and inflammation remains…”
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The Presence of Testis Determines Aristolochic Acid-Induced Nephrotoxicity in Mice by Li, Wei-Long, Padanilam, Babu J, Kim, Jinu

“…Aristolochic acid (AA) is notorious for inducing nephrotoxicity, but the influence of sex on AA-induced kidney injury was not clear. This study sought to…”
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Loss of poly(ADP-ribose) polymerase 1 attenuates renal fibrosis and inflammation during unilateral ureteral obstruction by Kim, Jinu, Padanilam, Babu J

“…Poly(ADP-ribose) polymerase 1 (PARP1) contributes to necrotic cell death and inflammation in several disease models; however, the role of PARP1 in fibrogenesis…”
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PARP-1 Inhibits Glycolysis in Ischemic Kidneys by DEVALARAJA-NARASHIMHA, Kishor, PADANILAM, Babu J

“…After ischemic renal injury (IRI), selective damage occurs in the S(3) segments of the proximal tubules as a result of inhibition of glycolysis, but the…”
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Cyclophilin D gene ablation protects mice from ischemic renal injury by Devalaraja-Narashimha, Kishor, Diener, Alicia M, Padanilam, Babu J

“…Increased oxidative stress and intracellular calcium levels and mitochondrial overloading of calcium during ischemic renal injury (IRI) favor mitochondrial…”
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PARP1 deficiency exacerbates diet-induced obesity in mice by Devalaraja-Narashimha, Kishor, Padanilam, Babu J

“…Poly (ADP-ribose) polymerase-1 (PARP1) regulates gene expression as a transcriptional cofactor and protein functions via poly (ADP-ribosyl)ation. This study…”
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Activation of Yes-Associated Protein Is Indispensable for Transformation of Kidney Fibroblasts into Myofibroblasts during Repeated Administration of Cisplatin by Yu, Jia-Bin, Padanilam, Babu J, Kim, Jinu

“…Cisplatin is a potent chemotherapy medication that is used to treat various types of cancer. However, it can cause nephrotoxic side effects, which lead to…”
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Renal Nerves Drive Interstitial Fibrogenesis in Obstructive Nephropathy by KIM, Jinu, PADANILAM, Babu J

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Repeated Administration of Cisplatin Transforms Kidney Fibroblasts through G2/M Arrest and Cellular Senescence by Yu, Jia-Bin, Lee, Dong-Sun, Padanilam, Babu J, Kim, Jinu

“…Cisplatin is a potent chemotherapeutic used for the treatment of many types of cancer, but it has nephrotoxic side effects leading to acute kidney injury and…”
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Smooth muscle‐generated methylglyoxal impairs endothelial cell‐mediated vasodilatation of cerebral microvessels in type 1 diabetic rats by Alomar, Fadhel, Singh, Jaipaul, Jang, Hee‐Seong, Rozanzki, George J, Shao, Chun Hong, Padanilam, Babu J, Mayhan, William G, Bidasee, Keshore R

“…Background and Purpose Endothelial cell‐mediated vasodilatation of cerebral arterioles is impaired in individuals with Type 1 diabetes (T1D). This defect…”
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Epoxyeicosatrienoic acid activation moderates endothelial mesenchymal transition to reduce obstructive nephropathy by Padanilam, Babu J

“…Fibrosis is the hallmark of end-stage organ disease and accounts for 45% of deaths around the world. Fibrosis is a key component in the progression of chronic…”
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Renal sympathetic nerve activation via α2-adrenergic receptors in chronic kidney disease progression by Jang, Hee-Seong, Kim, Jinu, Padanilam, Babu J

“…Chronic kidney disease (CKD) is increasing worldwide without an effective therapeutic strategy. Sympathetic nerve activation is implicated in CKD progression,…”
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