Search Results - "Padakanti, Prashanth K."

C. Elegans Fatty Acid Two-Hydroxylase Regulates Intestinal Homeostasis by Affecting Heptadecenoic Acid Production by Li, Yuanbao, Wang, Chunxia, Huang, Yikai, Fu, Rong, Zheng, Hanxi, Zhu, Yi, Shi, Xiaoruo, Padakanti, Prashanth K., Tu, Zhude, Su, Xiong, Zhang, Huimin

“…Abstract Background/Aims: The hydroxylation of fatty acids at the C-2 position is the first step of fatty acid α-oxidation and generates sphingolipids…”
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Synthesis and biological characterization of a promising F-18 PET tracer for vesicular acetylcholine transporter by Tu, Zhude, Zhang, Xiang, Jin, Hongjun, Yue, Xuyi, Padakanti, Prashanth K., Yu, Lihai, Liu, Hui, Flores, Hubert P., Kaneshige, Kota, Parsons, Stanley M., Perlmutter, Joel S.

“…[Display omitted] Nine fluorine-containing vesicular acetylcholine transporter (VAChT) inhibitors were synthesized and screened as potential PET tracers for…”
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Radiosynthesis and in vivo evaluation of [11C]MP-10 as a PET probe for imaging PDE10A in rodent and non-human primate brain by Tu, Zhude, Fan, Jinda, Li, Shihong, Jones, Lynne A., Cui, Jinquan, Padakanti, Prashanth K., Xu, Jinbin, Zeng, Dexing, Shoghi, Kooresh I., Perlmutter, Joel S., Mach, Robert H.

“…Structure and microPET image of [11C]MP-10. 2-((4-(1-[11C]Methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl)-quinoline (MP-10), a specific PDE10A…”
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Heteroaromatic and Aniline Derivatives of Piperidines As Potent Ligands for Vesicular Acetylcholine Transporter by Li, Junfeng, Zhang, Xiang, Zhang, Zhanbin, Padakanti, Prashanth K, Jin, Hongjun, Cui, Jinquan, Li, Aixiao, Zeng, Dexing, Rath, Nigam P, Flores, Hubert, Perlmutter, Joel S, Parsons, Stanley M, Tu, Zhude

“…To identify suitable lipophilic compounds having high potency and selectivity for vesicular acetylcholine transporter (VAChT), a heteroaromatic ring or a…”
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Radiosyntheses and in vivo evaluation of carbon-11 PET tracers for PDE10A in the brain of rodent and nonhuman primate by Fan, Jinda, Zhang, Xiang, Li, Junfeng, Jin, Hongjun, Padakanti, Prashanth K., Jones, Lynne A., Flores, Hubert P., Su, Yi, Perlmutter, Joel S., Tu, Zhude

“…The radiosyntheses and in vivo evaluation of four carbon-11 labeled quinoline group-containing radioligands are reported here. Radiolabeling of [11C]1–4 was…”
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Radiosynthesis and in Vivo Evaluation of Two PET Radioligands for Imaging α-Synuclein by Zhang, Xiang, Jin, Hongjun, Padakanti, Prashanth K, Li, Junfeng, Yang, Hao, Fan, Jinda, Mach, Robert H, Kotzbauer, Paul, Tu, Zhude

“…Two α-synuclein ligands, 3-methoxy-7-nitro-10 -phenothiazine ( , = 32.1 ± 1.3 nM) and 3-(2-fluoroethoxy)-7-nitro-10 -phenothiazine ( , = 49.0 ± 4.9 nM), were…”
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Automated synthesis of [11C]L-glutamine on Synthra HCN plus synthesis module by Padakanti, Prashanth K., Li, Shihong, Schmitz, Alexander, Mankoff, David, Mach, Robert H., Lee, Hsiaoju S.

“…Background L-Glutamine (L-Gln) is the most abundant amino acid present in the human body and is involved in numerous metabolic pathways. Glutaminolysis is the…”
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Copper Loading of Preformed Nanoparticles for PET-Imaging Applications by Lu, Hoang D, Wang, Leon Z, Wilson, Brian K, McManus, Simon A, Jumai’an, Jenny, Padakanti, Prashanth K, Alavi, Abass, Mach, Robert H, Prud’homme, Robert K

“…Nanoparticles (NP) are promising contrast agents for positron emission tomography (PET) radionuclide imaging that can increase signal intensity by localizing…”
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Synthesis and in vitro evaluation of α-synuclein ligands by Yu, Lihai, Cui, Jinquan, Padakanti, Prashanth K., Engel, Laura, Bagchi, Devika P., Kotzbauer, Paul T., Tu, Zhude

“…Accumulation of misfolded α-synuclein in Lewy bodies and Lewy neurites is the pathological hallmark of Parkinson’s disease (PD). To identify ligands having…”
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Preclinical Evaluation of the Novel Monoclonal Antibody H6-11 for Prostate Cancer Imaging by Jin, Hongjun, Xu, Mai, Padakanti, Prashanth K, Liu, Yongjian, Lapi, Suzanne, Tu, Zhude

“…The biological properties of the novel monoclonal antibody (mAb) H6-11 and its potential utility for oncological imaging studies were evaluated using in vitro…”
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Syntheses and Radiosyntheses of Two Carbon-11 Labeled Potent and Selective Radioligands for Imaging Vesicular Acetylcholine Transporter by Padakanti, Prashanth K., Zhang, Xiang, Li, Junfeng, Parsons, Stanley M., Perlmutter, Joel S., Tu, Zhude

“…Purpose The vesicular acetylcholine transporter (VAChT) is a specific biomarker for imaging presynaptic cholinergic neurons. The syntheses and C-11 labeling of…”
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Synthesis and in Vitro Biological Evaluation of Carbonyl Group-Containing Analogues for σ1 Receptors by Wang, Wei, Cui, Jinquan, Lu, Xiaoxia, Padakanti, Prashanth K, Xu, Jinbin, Parsons, Stanley M, Luedtke, Robert R, Rath, Nigam P, Tu, Zhude

“…To identify the ligands for σ1 receptors that are potent and selective, analogues of prezamicol and trozamicol scaffolds of carbonyl-containing vesicular…”
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In Vitro and In Vivo Characterization of Two C-11-Labeled PET Tracers for Vesicular Acetylcholine Transporter by Padakanti, Prashanth K., Zhang, Xiang, Jin, Hongjun, Cui, Jinquan, Wang, Ruike, Li, Junfeng, Flores, Hubert P., Parsons, Stanley M., Perlmutter, Joel S., Tu, Zhude

“…Purpose The vesicular acetylcholine transporter (VAChT) is a specific biomarker for imaging presynaptic cholinergic neurons. Herein, two potent and selective…”
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Kinetics of Nanoparticle Radiolabeling of Metalloporphyrin with 64 Cu for Positron Emission Tomography (PET) Imaging by Wang, Leon Z., Lim, Tristan L., Padakanti, Prashanth K., Carlin, Sean D., Alavi, Abass, Mach, Robert H., Prud’homme, Robert K.

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Abstract 318: Preclinical evaluation of monoclonal antibody H6-11 for prostate cancer imaging by Jin, Hongjun, Xu, Mai, Padakanti, Prashanth K., Tu, Zhude

“…Altered post-translational modification (PTM) of glycosylations to various nuclear and cytosolic proteins is a universal feature of cancer cells and these…”
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Synthesis and in Vitro Biological Evaluation of Carbonyl Group-Containing Analogues for σ 1 Receptors by Wang, Wei, Cui, Jinquan, Lu, Xiaoxia, Padakanti, Prashanth K., Xu, Jinbin, Parsons, Stanley M., Luedtke, Robert R., Rath, Nigam P., Tu, Zhude

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Kinetics of Nanoparticle Radiolabeling of Metalloporphyrin with 64Cu for Positron Emission Tomography (PET) Imaging by Wang, Leon Z, Lim, Tristan L, Padakanti, Prashanth K, Carlin, Sean D, Alavi, Abass, Mach, Robert H, Prud’homme, Robert K

“…Porphyrins are a unique class of biocompatible molecules with strong light absorption and rich coordination chemistry, leading to their use as chelating agents…”
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Radiosynthesis and in vivo evaluation of [11C]MP-10 as a PET probe for imaging PDE10A in rodent and nonhuman primate brain by Tu, Zhude, Fan, Jinda, Li, Shihong, Jones, Lynne A., Cui, Jinquan, Padakanti, Prashanth K., Xu, Jinbin, Zeng, Dexing, Shoghi, Kooresh I., Perlmutter, Joel S., Mach, Robert H.

“…2-((4-(1-[ 11 C]methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl)-quinoline (MP-10), a specific PDE10A inhibitor (IC 50 = 0.18 nM with 100-fold…”
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Radiosynthesis and in Vivo Evaluation of Two PET Radioligands for Imaging [alpha]-Synuclein by Zhang, Xiang, Jin, Hongjun, Padakanti, Prashanth K, Li, Junfeng, Yang, Hao, Fan, Jinda, Mach, Robert H, Kotzbauer, Paul, Tu, Zhude

“…Two α-synuclein ligands, 3-methoxy-7-nitro-10H-phenothiazine (2a, Ki = 32.1 ± 1.3 nM) and 3-(2-fluoroethoxy)-7-nitro-10H-phenothiazine (2b, Ki = 49.0 ± 4.9…”
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Synthesis of tetrahydropyrimidine-based acyl transfer catalysts and their application to enantioselective O- and C-acylations by Padakanti, Prashanth K

“…Structural variation of several types of amidine-based catalysts was explored, including variation of steric, electronic and other parameters. Enantioselective…”
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