Search Results - "Paculova, Hana"

Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex by Ekumi, Kingsley M, Paculova, Hana, Lenasi, Tina, Pospichalova, Vendula, Bösken, Christian A, Rybarikova, Jana, Bryja, Vitezslav, Geyer, Matthias, Blazek, Dalibor, Barboric, Matjaz

“…The Cdk12/CycK complex promotes expression of a subset of RNA polymerase II genes, including those of the DNA damage response. CDK12 is among only nine genes…”
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Reversible phosphorylation of cyclin T1 promotes assembly and stability of P-TEFb by Huang, Fang, Nguyen, Trang Tt, Echeverria, Ignacia, Rakesh, Ramachandran, Cary, Daniele C, Paculova, Hana, Sali, Andrej, Weiss, Arthur, Peterlin, Boris Matija, Fujinaga, Koh

“…The positive transcription elongation factor b (P-TEFb) is a critical coactivator for transcription of most cellular and viral genes, including those of HIV…”
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Non-Coding RNA Signatures of B-Cell Acute Lymphoblastic Leukemia by Rodriguez, Princess D, Paculova, Hana, Kogut, Sophie, Heath, Jessica, Schjerven, Hilde, Frietze, Seth

“…Non-coding RNAs (ncRNAs) comprise a diverse class of non-protein coding transcripts that regulate critical cellular processes associated with cancer. Advances…”
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The emerging roles of CDK12 in tumorigenesis by Paculová, Hana, Kohoutek, Jiří

“…Cyclin-dependent kinases (CDKs) are key regulators of both cell cycle progression and transcription. Since dysregulation of CDKs is a frequently occurring…”
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BRCA1 or CDK12 loss sensitizes cells to CHK1 inhibitors by Paculová, Hana, Kramara, Juraj, Šimečková, Šárka, Fedr, Radek, Souček, Karel, Hylse, Ondřej, Paruch, Kamil, Svoboda, Marek, Mistrík, Martin, Kohoutek, Jiří

“…A broad spectrum of tumors develop resistance to classic chemotherapy, necessitating the discovery of new therapies. One successful strategy exploits the…”
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Polychlorinated environmental toxicants affect sphingolipid metabolism during neurogenesis in vitro by Slováčková, Jana, Slavík, Josef, Kulich, Pavel, Večeřa, Josef, Kováč, Ondrej, Paculová, Hana, Straková, Nicol, Fedr, Radek, Silva, João Pedro, Carvalho, Félix, Machala, Miroslav, Procházková, Jiřina

“…[Display omitted] Sphingolipids (SLs) are important signaling molecules and functional components of cellular membranes. Although SLs are known as crucial…”
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Hypoxia/Hif1α prevents premature neuronal differentiation of neural stem cells through the activation of Hes1 by Večeřa, Josef, Procházková, Jiřina, Šumberová, Veronika, Pánská, Veronika, Paculová, Hana, Lánová, Martina Kohutková, Mašek, Jan, Bohačiaková, Dáša, Andersson, Emma Rachel, Pacherník, Jiří

“…•Hypoxia inducible factor 1α (Hif1α) is stabilized in mouse embryonic neuroepithelium.•Hif1α is transcriptionally active and activates neural repressor…”
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Functional Roles of Bromodomain Proteins in Cancer by Boyson, Samuel P, Gao, Cong, Quinn, Kathleen, Boyd, Joseph, Paculova, Hana, Frietze, Seth, Glass, Karen C

“…Histone acetylation is generally associated with an open chromatin configuration that facilitates many cellular processes including gene transcription, DNA…”
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Abstract A09: Targeting chemoresistant ovarian malignancies to cytostatic drugs and PARP inhibitors by inhibition of CDK12 kinase activity by Kohoutek, Jiri, Svoboda, Marek, Vrabel, David, Paculova, Hana, Dzimkova, Marta

“…Ovarian cancer ranks fifth in cancer deaths among women in the USA. After surgery, women are subjected to a combined treatment with platinum-based drugs…”
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Ikaros Regulates microRNA Networks in Acute Lymphoblastic Leukemia by Kogut, Sophie, Paculova, Hana, Rodriguez, Princess, Boyd, Joseph, Richman, Alyssa, Palaria, Amrita, Schjerven, Hilde, Frietze, Seth

“…The hematopoietic transcription factor Ikaros (IKZF1) regulates normal B cell development and functions as a tumor suppressor in precursor B cell acute…”
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Hypoxia/Hif1 α prevents premature neuronal di fferentiation of neural stem cells through the activation of Hes1 by Vecera, J, Prochazkova, J, Sumberova, V, Panska, V, Paculova, H, Lanova, MK, Masek, J, Bohaciakova, D, Andersson, ER, Pachernik, J

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Abstract MIP-043: OVARIAN CARCINOMA CDK12 MUTATIONS IMPAIR GENE-SPECIFIC POL II ELONGATION AND FAITHFUL REPAIR OF DNA DOUBLE STRAND BREAKS by Ekumi, Kingsley M., Paculova, Hana, Lenasi, Tina, Pospichalova, Vendula, Bösken, Christian A., Rybarikova, Jana, Bryja, Vitezslav, Geyer, Matthias, Blazek, Dalibor, Barboric, Matjaz

“…The Cdk12/CycK complex is a novel transcription elongation-associated kinase that promotes expression of a subset of RNA polymerase II (Pol II) genes,…”
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Abstract AS21: Ovarian carcinoma CDK12 mutations misregulate DNA repair genes via deficient formation and function of the Cdk12/CycK complex by Ekumi, Kingsley M., Paculova, Hana, Pospichalova, Vendula, Bosken, Christian A., Bryja, Vitezslav, Geyer, Matthias, Blazek, Dalibor, Barboric, Matjaz

“…The Cdk12/CycK complex promotes gene expression by phosphorylating the C-terminal domain of RNA polymerase II. In previous work we found that CDK12/CycK…”
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