Search Results - "Pacoma, Reynand"
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Tau overexpression exacerbates neuropathology after repeated mild head impacts in male mice
Published in Neurobiology of disease (01-02-2020)“…Repeated mild traumatic brain injury (rmTBI) can lead to development of chronic traumatic encephalopathy (CTE), which is characterized by progressive…”
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Discovery of a Small-Molecule Modulator of Glycosaminoglycan Sulfation
Published in ACS chemical biology (15-12-2017)“…Glycosaminoglycans (GAGs) play critical roles in diverse processes ranging from viral infection to neuroregeneration. Their regiospecific sulfation patterns,…”
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Enhanced proteolytic clearance of plasma Aβ by peripherally administered neprilysin does not result in reduced levels of brain Aβ in mice
Published in The Journal of neuroscience (06-02-2013)“…Accumulation of β-amyloid (Aβ) in the brain is believed to contribute to the pathology of Alzheimer's Disease (AD). Aβ levels are controlled by the production…”
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Discovery of inhibitors of the channel-activating protease prostasin (CAP1/PRSS8) utilizing structure-based design
Published in Bioorganic & medicinal chemistry (15-11-2008)“…Structure-based design was utilized to guide the early stage optimization of a substrate-like inhibitor to afford potent peptidomimetic inhibitors of the…”
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