Search Results - "Packiriswamy, Nandakumar"

Oncolytic measles virus therapy enhances tumor antigen-specific T-cell responses in patients with multiple myeloma by Packiriswamy, Nandakumar, Upreti, Deepak, Zhou, Yumei, Khan, Rehan, Miller, Amber, Diaz, Rosa M., Rooney, Cliona M., Dispenzieri, Angela, Peng, Kah-Whye, Russell, Stephen J.

“…Oncolytic virus therapy leads to immunogenic death of virus-infected tumor cells and this has been shown in preclinical models to enhance the cytotoxic…”
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Boosting of SARS-CoV-2 immunity in nonhuman primates using an oral rhabdoviral vaccine by Peng, Kah-Whye, Carey, Timothy, Lech, Patrycja, Vandergaast, Rianna, Muñoz-Alía, Miguel Á., Packiriswamy, Nandakumar, Gnanadurai, Clement, Krotova, Karina, Tesfay, Mulu, Ziegler, Christopher, Haselton, Michelle, Sevola, Kara, Lathrum, Chase, Reiter, Samantha, Narjari, Riya, Balakrishnan, Baskar, Suksanpaisan, Lukkana, Sakuma, Toshie, Recker, Jordan, Zhang, Lianwen, Waniger, Scott, Russell, Luke, Petro, Christopher D., Kyratsous, Christos A., Baum, Alina, Janecek, Jody L., Lee, Rachael M., Ramachandran, Sabarinathan, Graham, Melanie L., Russell, Stephen J.

“…An orally active vaccine capable of boosting SARS-CoV-2 immune responses in previously infected or vaccinated individuals would help efforts to achieve and…”
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Poly(I:C) Priming Exacerbates Cecal Ligation and Puncture-Induced Polymicrobial Sepsis in Mice by Sharma, Deepika, Malik, Ankit, Packiriswamy, Nandakumar, Steury, Michael D., Parameswaran, Narayanan

“…Sepsis continues to be a major healthcare issue with one of the highest mortality rates in intensive care units. Toll-like receptors are pattern recognition…”
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Oxidative stress-induced mitochondrial dysfunction in a normal colon epithelial cell line by Packiriswamy, Nandakumar, Coulson, Kari F, Holcombe, Susan J, Sordillo, Lorraine M

“…AIM To determine how a normal human colon cell line reacts to microbial challenge as a way to study oxidative stress-induced responses associated with…”
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Surface-modified measles vaccines encoding oligomeric, prefusion-stabilized SARS-CoV-2 spike glycoproteins boost neutralizing antibody responses to Omicron and historical variants, independent of measles seropositivity by Muñoz-Alía, Miguel Á, Nace, Rebecca A, Balakrishnan, Baskar, Zhang, Lianwen, Packiriswamy, Nandakumar, Singh, Gagandeep, Warang, Prajakta, Mena, Ignacio, Narjari, Riya, Vandergaast, Rianna, Peng, Kah-Whye, García-Sastre, Adolfo, Schotsaert, Michael, Russell, Stephen J

“…Serum titers of SARS-CoV-2-neutralizing antibodies (nAbs) correlate well with protection from symptomatic COVID-19 but decay rapidly in the months following…”
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Apoptosis of Endothelial Cells by 13-HPODE Contributes to Impairment of Endothelial Barrier Integrity by Ryman, Valerie E., Sordillo, Lorraine M., Packiriswamy, Nandakumar

“…Inflammation is an essential host response during bacterial infections such as bovine mastitis. Endothelial cells are critical for an appropriate inflammatory…”
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A phase I oncolytic virus trial with vesicular stomatitis virus expressing human interferon beta and tyrosinase related protein 1 administered intratumorally and intravenously in uveal melanoma: safety, efficacy, and T cell responses by Smith, Katherine E R, Peng, Kah-Whye, Pulido, Jose S, Weisbrod, Adam J, Strand, Carrie A, Allred, Jacob B, Newsom, Alysha N, Zhang, Lianwen, Packiriswamy, Nandakumar, Kottke, Timothy, Tonne, Jason M, Moore, Madelyn, Montane, Heather N, Kottschade, Lisa A, McWilliams, Robert R, Dudek, Arkadiusz Z, Yan, Yiyi, Dimou, Anastasios, Markovic, Svetomir N, Federspiel, Mark J, Vile, Richard G, Dronca, Roxana S, Block, Matthew S

“…Metastatic uveal melanoma (MUM) has a poor prognosis and treatment options are limited. These patients do not typically experience durable responses to immune…”
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Distinct Signature of Oxylipid Mediators of Inflammation during Infection and Asymptomatic Colonization by E. coli in the Urinary Bladder by Sordillo, Lorraine M., Mobley, Harry L. T., Smith, Sara N., Gandy, Jeff, Packiriswamy, Nandakumar, Subashchandrabose, Sargurunathan

“…Urinary tract infection (UTI) is an extremely common infectious disease. Uropathogenic Escherichia coli (UPEC) is the predominant etiological agent of UTI…”
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422 Safety and efficacy of neoadjuvant intravesical oncolytic MV-NIS in patients with urothelial carcinoma by Miest, Tanner, Leibovich, Bradley, Bardot, Stephen, Young, Paul, Boorjian, Stephen, Gonzalgo, Mark, Herrera-Hernandez, Loren, Tollefson, Matthew, Karnes, Jeffrey, Nichols, Paige, Kroeninger, Tessa, Graham, Rachel, Lahana, Carole, Reckner, Monica, Newsom, Alysha, Packiriswamy, Nandakumar, Anoka, Janice, Peng, Kah Whye, Wiegert, Erol, Bexon, Alice, Naik, Shruthi

“…BackgroundBladder cancer is a leading cause of cancer death in the United States.1 The histology in > 90% of cases is urothelial carcinoma (UC). Tumors may…”
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In Vivo Generation of Functional CD19 CAR-T Cells Using a Serum-Stable CD3-Targeted Lentiviral Vector by Krotova, Karina, Nenavath, Gopal Naik, Packiriswamy, Nandakumar, Vandergaast, Rianna, Moy, Melissa, Ziegler, Christopher, Muñoz Alía, Miguel A, Peng, Kah-Whye, Russell, Stephen

“…The high cost and complexity of CAR-T therapy has spurred efforts to generate CAR-T cells directly within patients via systemic infusion of serum-stable…”
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Oncolytic α-herpesvirus and myeloid-tropic cytomegalovirus cooperatively enhance systemic antitumor responses by Jiang, Haifei, Nace, Rebecca, Ariail, Emily, Ma, Yejun, McGlinch, Erin, Ferguson, Coryn, Fernandez Carrasco, Talia, Packiriswamy, Nandakumar, Zhang, Lianwen, Peng, Kah Whye, Russell, Stephen J

“…Oncolytic virotherapy aims to activate host antitumor immunity. In responsive tumors, intratumorally injected herpes simplex viruses (HSVs) have been shown to…”
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Role of endothelial cells in bovine mammary gland health and disease by Ryman, Valerie E, Packiriswamy, Nandakumar, Sordillo, Lorraine M

“…The bovine mammary gland is a dynamic and complex organ composed of various cell types that work together for the purpose of milk synthesis and secretion. A…”
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G-protein-coupled receptor kinases in inflammation and disease by Packiriswamy, N, Parameswaran, N

“…G-protein-coupled receptor kinases (GRKs) are serine/threonine protein kinases originally discovered for their role in G-protein-coupled receptor (GPCR)…”
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Critical involvement of GPCR kinase-5 in E.coli induced pneumonia (INC7P.427) by Packiriswamy, Nandakumar, Steury, Michael, Parameswaran, Narayanan

“…Abstract G-protein coupled receptor kinases are serine/threonine kinases involved in a range of pathophysiological processes including inflammation. We…”
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GPCR kinase‐6 inhibits neutrophil infiltration but mediates bacterial killing during lung bacterial infection (145.5) by Parameswaran, Narayanan, Packiriswamy, Nandakumar, Lee, Taehyung

“…GPCR kinases (GRKs) are serine/threonine kinases known to be critical players in desensitization of GPCRs. Recent studies have implicated GRKs in a number of…”
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T cell responses to tumor associated antigens in multiple myeloma patients treated with MV-NIS, an oncolytic measles virus by Packiriswamy, Nandakumar, Upreti, Deepak, Zhou, Yumei, Dispenzieri, Angela, Peng, Kah Whye, Russell, Stephen J.

“…Abstract only 218 Background: Evidence from mouse studies shows that Oncolytic viral mode of tumor cell killing can boost the cytotoxic T lymphocyte response…”
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T Cell Responses to Tumor Associated Antigens in Multiple Myeloma Patients Treated with MV-NIS, an Oncolytic Measles Virus by Packiriswamy, Nandakumar, Upreti, Deepak, Zhou, Yumei, Dispenzieri, Angela, Peng, Kah-Whye, Russell, Stephen J.

“…Introduction: Oncolytic virus therapy leads to immunogenic death of virus infected tumor cells. Evidence from mouse studies shows that this mode of tumor cell…”
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Assessment of heavy metal concentrations and associated resistant bacterial communities in bulk and rhizosphere soil of Avicennia marina of Pichavaram mangrove, India by Balakrishnan, Baskar, Sahu, Biraja Kumar, Kothilmozhian Ranishree, Jayappriyan, Lourduraj, Arockia Vasanthi, Nithyanandam, Marimuthu, Packiriswamy, Nandakumar, Panchatcharam, Prabakaran

“…Heavy metals are known to pose a potential threat to terrestrial and aquatic flora and fauna. Due to increasing human influence, heavy metal concentrations are…”
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Nonhematopoietic β-Arrestin-1 Inhibits Inflammation in a Murine Model of Polymicrobial Sepsis by Sharma, Deepika, Packiriswamy, Nandakumar, Malik, Ankit, Lucas, Peter C, Parameswaran, Narayanan

“…β-Arrestin-1 (βArr1), a scaffolding protein critical in G-protein coupled receptor desensitization has more recently been found to be important in the…”
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Safety and efficacy of neoadjuvant intravesical oncolytic MV-NIS in patients with urothelial carcinoma by Naik, Shruthi, Leibovich, Bradley C., Miest, Tanner, Bardot, Stephen, Young, Paul R, Boorjian, Stephen A., Gonzalgo, Mark L., Herrera Hernandez, Loren, Tollefson, Matthew K., Karnes, Jeffrey, Nichols, Paige, Kroeninger, Tessa, Graham, Rachel, Reckner, Monica, Newsom, Alysha, Packiriswamy, Nandakumar, Peng, Kah Whye, Wiegert, Erol, Bexon, Alice Susannah

“…Abstract only 509 Background: Bladder cancer is a leading cause of cancer death in the United States. The histology in > 90% of cases is urothelial carcinoma…”
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