Search Results - "Pack, Allan I"

Symptom Subtypes of Obstructive Sleep Apnea Predict Incidence of Cardiovascular Outcomes by Mazzotti, Diego R, Keenan, Brendan T, Lim, Diane C, Gottlieb, Daniel J, Kim, Jinyoung, Pack, Allan I

“…Symptom subtypes have been described in clinical and population samples of patients with obstructive sleep apnea (OSA). It is unclear whether these subtypes…”
Get full text

Metrics of sleep apnea severity: beyond the apnea-hypopnea index by Malhotra, Atul, Ayappa, Indu, Ayas, Najib, Collop, Nancy, Kirsch, Douglas, Mcardle, Nigel, Mehra, Reena, Pack, Allan I, Punjabi, Naresh, White, David P, Gottlieb, Daniel J

“…Abstract Obstructive sleep apnea (OSA) is thought to affect almost 1 billion people worldwide. OSA has well established cardiovascular and neurocognitive…”
Get full text

Obstructive Sleep Apnea: Update and Future by Lim, Diane C, Pack, Allan I

“…Obstructive sleep apnea (OSA) is a worldwide disease whose prevalence is increasing as obesity rates increase. The link between obesity and OSA is likely to be…”
Get full text

The neurobiological basis of sleep: Insights from Drosophila by Ly, Sarah, Pack, Allan I., Naidoo, Nirinjini

“…•Drosophila sleep is regulated by multiple neurotransmitters and intracellular signaling pathways in the brain.•Many of the identified regulators of Drosophila…”
Get full text

The different clinical faces of obstructive sleep apnoea: a cluster analysis by LICHUAN YE, PIEN, Grace W, RATCLIFFE, Sarah J, BJÖRNSDOTTIR, Erla, ARNARDOTTIR, Erna Sif, PACK, Allan I, BENEDIKTSDOTTIR, Bryndis, GISLASON, Thorarinn

“…Although commonly observed in clinical practice, the heterogeneity of obstructive sleep apnoea (OSA) clinical presentation has not been formally characterised…”
Get full text

Randomized clinical trials of cardiovascular disease in obstructive sleep apnea: understanding and overcoming bias by Pack, Allan I, Magalang, Ulysses J, Singh, Bhajan, Kuna, Samuel T, Keenan, Brendan T, Maislin, Greg

“…Abstract Three recent randomized control trials (RCTs) found that treatment of obstructive sleep apnea (OSA) with continuous positive airway pressure (CPAP)…”
Get full text

Tongue fat and its relationship to obstructive sleep apnea by Kim, Andrew M, Keenan, Brendan T, Jackson, Nicholas, Chan, Eugenia L, Staley, Bethany, Poptani, Harish, Torigian, Drew A, Pack, Allan I, Schwab, Richard J

“…The objective of this study was to determine whether tongue fat is increased in obese sleep apneics compared to obese subjects without sleep apnea. We…”
Get full text

Genetic Basis of Chronotype in Humans: Insights From Three Landmark GWAS by Kalmbach, David A., Schneider, Logan D., Cheung, Joseph, Bertrand, Sarah J., Kariharan, Thiruchelvam, Pack, Allan I., Gehrman, Philip R.

“…Abstract Study Objectives: Chronotype, or diurnal preference, refers to behavioral manifestations of the endogenous circadian system that governs preferred…”
Get full text

CPAP, Weight Loss, or Both for Obstructive Sleep Apnea by Chirinos, Julio A, Gurubhagavatula, Indira, Teff, Karen, Rader, Daniel J, Wadden, Thomas A, Townsend, Raymond, Foster, Gary D, Maislin, Greg, Saif, Hassam, Broderick, Preston, Chittams, Jesse, Hanlon, Alexandra L, Pack, Allan I

“…In this study, continuous positive airway pressure plus weight loss was no better than either one alone in reducing C-reactive protein levels in patients with…”
Get full text

Risk factors for sleep-disordered breathing in pregnancy by Pien, Grace W, Pack, Allan I, Jackson, Nicholas, Maislin, Greg, Macones, George A, Schwab, Richard J

“…Symptoms of sleep-disordered breathing (SDB) are common among pregnant women, and several studies link SDB symptoms with gestational hypertension and…”
Get more information

Molecular Signatures of Obstructive Sleep Apnea in Adults : A Review and Perspective by ARNARDOTTIR, Erna S, MACKIEWICZ, Miroslaw, GISLASON, Thorarinn, TEFF, Karen L, PACK, Allan I

“…The consequences of obstructive sleep apnea (OSA) are largely mediated by chronic intermittent hypoxia and sleep fragmentation. The primary molecular domains…”
Get full text

Aging in mice reduces the ability to sustain sleep/wake states by Wimmer, Mathieu E, Rising, Justin, Galante, Raymond J, Wyner, Abraham, Pack, Allan I, Abel, Ted

“…One of the most significant problems facing older individuals is difficulty staying asleep at night and awake during the day. Understanding the mechanisms by…”
Get full text

Definition of excessive daytime sleepiness in the general population: Feeling sleepy relates better to sleep‐related symptoms and quality of life than the Epworth Sleepiness Scale score. Results from an epidemiological study by Thorarinsdottir, Elin H., Bjornsdottir, Erla, Benediktsdottir, Bryndis, Janson, Christer, Gislason, Thorarinn, Aspelund, Thor, Kuna, Samuel T., Pack, Allan I., Arnardottir, Erna S.

“…Many different subjective tools are being used to measure excessive daytime sleepiness (EDS) but the most widely used is the Epworth Sleepiness Scale (ESS)…”
Get full text

Continuous positive airway pressure and adverse cardiovascular events in obstructive sleep apnea: are participants of randomized trials representative of sleep clinic patients? by Reynor, Ayesha, McArdle, Nigel, Shenoy, Bindiya, Dhaliwal, Satvinder S, Rea, Siobhan C, Walsh, Jennifer, Eastwood, Peter R, Maddison, Kathleen, Hillman, David R, Ling, Ivan, Keenan, Brendan T, Maislin, Greg, Magalang, Ulysses, Pack, Allan I, Mazzotti, Diego R, Lee, Chi-Hang, Singh, Bhajan

“…Abstract Study Objectives Randomized controlled trials (RCTs) have shown no reduction in adverse cardiovascular (CV) events in patients randomized to…”
Get full text

Performance of an automated polysomnography scoring system versus computer-assisted manual scoring by Malhotra, Atul, Younes, Magdy, Kuna, Samuel T, Benca, Ruth, Kushida, Clete A, Walsh, James, Hanlon, Alexandra, Staley, Bethany, Pack, Allan I, Pien, Grace W

“…Manual scoring of polysomnograms (PSG) is labor intensive and has considerable variance between scorers. Automation of scoring could reduce cost and improve…”
Get full text

Gut microbiome: Role in insulin resistance in obstructive sleep apnea by Pack, Allan I.

Get full text

Relationship between hours of CPAP use and achieving normal levels of Sleepiness and daily functioning by WEAVER, Terri E, MAISLIN, Greg, DINGES, David F, BLOXHAM, Thomas, GEORGE, Charles F. P, GREENBERG, Harly, KADER, Gihan, MAHOWALD, Mark, YOUNGER, Joel, PACK, Allan L

“…Evidence suggests that, to maintain treatment effects, nasal continuous positive airway pressure (CPAP) therapy for obstructive sleep apnea (OSA) needs to be…”
Get full text

Heart rate variability during wakefulness as a marker of obstructive sleep apnea severity by Qin, Hua, Keenan, Brendan T, Mazzotti, Diego R, Vaquerizo-Villar, Fernando, Kraemer, Jan F, Wessel, Niels, Tufik, Sergio, Bittencourt, Lia, Cistulli, Peter A, de Chazal, Philip, Sutherland, Kate, Singh, Bhajan, Pack, Allan I, Chen, Ning-Hung, Fietze, Ingo, Gislason, Thorarinn, Holfinger, Steven, Magalang, Ulysses J, Penzel, Thomas

“…Abstract Study Objectives Patients with obstructive sleep apnea (OSA) exhibit heterogeneous heart rate variability (HRV) during wakefulness and sleep. We…”
Get full text

Different components of excessive daytime sleepiness and the change with positive airway pressure treatment in patients with obstructive sleep apnea: Results from the Icelandic Sleep Apnea Cohort (ISAC) by Thorarinsdottir, Elin H., Janson, Christer, Aspelund, Thor, Benediktsdottir, Bryndis, Júlíusson, Sigurður, Gislason, Thorarinn, Kuna, Samuel T., Pack, Allan I., Keenan, Brendan T.

“…Summary Excessive daytime sleepiness includes both an inability to stay awake during the day and a general feeling of sleepiness. We describe different…”
Get full text

Heart Failure and Sleep-Disordered Breathing — The Plot Thickens by Magalang, Ulysses J, Pack, Allan I

“…Central sleep apnea occurring within the cyclic breathing pattern of Cheyne–Stokes respiration has been reported to be common in patients with heart failure. 1…”
Get full text