Search Results - "Pacini, Maria Florencia"
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Immunization With Lipopolysaccharide-Activated Dendritic Cells Generates a Specific CD8+ T Cell Response That Confers Partial Protection Against Infection With Trypanosoma cruzi
Published in Frontiers in cellular and infection microbiology (07-07-2022)“…Lipopolysaccharide (LPS) induces the activation of dendritic cells (DCs) throughout the engagement of toll-like receptor 4. LPS-activated DCs show increased…”
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Assessment of a combined treatment with a therapeutic vaccine and benznidazole for the Trypanosoma cruzi chronic infection
Published in Acta tropica (01-05-2022)“…•A new vaccine formulation named TSNt-ISPA was developed against T. cruzi infection.•A therapeutic vaccine treatment was assessed in two chronic infection…”
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Nasal immunization with a L. lactis-derived trans-sialidase antigen plus c-di-AMP protects against acute oral T. cruzi infection
Published in Vaccine (01-04-2022)“…•Mucosal vaccine strategy can protect against T. cruzi infection.•TS antigen plus c-di-AMP trigger systemic and mucosal TS-specific antibodies.•TS antigen plus…”
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Chagas disease reactivation in rheumatologic patients: association with immunosuppressive therapy and humoral response
Published in Clinical rheumatology (01-07-2021)“…Evidence for Chagas disease reactivation (CDR) in rheumatologic patients under rheumatologic treatments (RTs) is scarce. To screen and follow-up patients with…”
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Intranasal Trans-Sialidase Vaccine Mitigates Acute and Chronic Pathology in a Preclinical Oral Chagas Disease Model
Published in Vaccines (Basel) (01-10-2024)“…Chagas disease, caused by , leads to severe complications in 30% of infected individuals, including acute myocarditis and chronic fibrosing cardiomyopathy…”
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The high identity of the Trypanosoma cruzi Group-I of trans-sialidases points them as promising vaccine immunogens
Published in Proteins, structure, function, and bioinformatics (01-10-2023)“…Trans-sialidase (TS) superfamily of proteins comprises eight subgroups, being the proteins of Group-I (TS-GI) promising immunogens in vaccine approaches…”
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Systemic inflammatory Th1 cytokines during Trypanosoma cruzi infection disrupt the typical anatomical cell distribution and phenotypic/functional characteristics of various cell subsets within the thymus
Published in Microbes and infection (01-07-2024)“…The thymus plays a crucial role in T cell differentiation, a complex process influenced by various factors such as antigens, the microenvironment and thymic…”
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Activation of PPARγ reduces N-acetyl-cysteine -induced hypercorticoidism by down-regulating MC2R expression into adrenal glands
Published in Free radical biology & medicine (20-08-2020)“…We previously demonstrated that oral supplementation with antioxidants induced hyperactivity of hypothalamus-pituitary-adrenal (HPA) axis, attested by…”
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