Search Results - "Pacifici, Maurizio"

Retinoid roles and action in skeletal development and growth provide the rationale for an ongoing heterotopic ossification prevention trial by Pacifici, Maurizio

“…The majority of skeletal elements develop via endochondral ossification. This process starts with formation of mesenchymal cell condensations at prescribed…”
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The pathogenic roles of heparan sulfate deficiency in hereditary multiple exostoses by Pacifici, Maurizio

“…Heparan sulfate (HS) is an essential component of cell surface and matrix proteoglycans (HS-PGs) that include syndecans and perlecan. Because of their unique…”
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SOX9 keeps growth plates and articular cartilage healthy by inhibiting chondrocyte dedifferentiation/osteoblastic redifferentiation by Hasee, Abdul, Kc, Ranjan, Angelozzi, Marco, de Charleroy, Charles, Rux, Danielle, Tower, Robert J., Yao, Lutian, da Silva, Renata Pellegrino, Pacifici, Maurizio, Qin, Ling, Lefebvre, Véronique

“…Cartilage is essential throughout vertebrate life. It starts developing in embryos when osteochondroprogenitor cells commit to chondrogenesis, activate a…”
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Common mutations in ALK2/ACVR1, a multi-faceted receptor, have roles in distinct pediatric musculoskeletal and neural orphan disorders by Pacifici, Maurizio, Shore, Eileen M

“…Graphical abstract…”
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Cell origin, volume and arrangement are drivers of articular cartilage formation, morphogenesis and response to injury in mouse limbs by Decker, Rebekah S., Um, Hyo-Bin, Dyment, Nathaniel A., Cottingham, Naiga, Usami, Yu, Enomoto-Iwamoto, Motomi, Kronenberg, Mark S., Maye, Peter, Rowe, David W., Koyama, Eiki, Pacifici, Maurizio

“…Limb synovial joints are composed of distinct tissues, but it is unclear which progenitors produce those tissues and how articular cartilage acquires its…”
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Activin A promotes the development of acquired heterotopic ossification and is an effective target for disease attenuation in mice by Mundy, Christina, Yao, Lutian, Sinha, Sayantani, Chung, Juliet, Rux, Danielle, Catheline, Sarah E, Koyama, Eiki, Qin, Ling, Pacifici, Maurizio

“…Heterotopic ossification (HO) is a common, potentially debilitating pathology that is instigated by inflammation caused by tissue damage or other insults,…”
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Comment on 'Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity' by Pacifici, Maurizio, Shore, Eileen M

“…We are writing to communicate our concerns regarding the recently published study by Lees-Shepard et al. (2018)…”
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Activin A marks a novel progenitor cell population during fracture healing and reveals a therapeutic strategy by Yao, Lutian, Lu, Jiawei, Zhong, Leilei, Wei, Yulong, Gui, Tao, Wang, Luqiang, Ahn, Jaimo, Boerckel, Joel D, Rux, Danielle, Mundy, Christina, Qin, Ling, Pacifici, Maurizio

“…Insufficient bone fracture repair represents a major clinical and societal burden and novel strategies are needed to address it. Our data reveal that the TGF-β…”
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Elevated inflammatory gene expression in intervertebral disc tissues in mice with ADAM8 inactivated by Zhang, Yejia, Tian, Zuozhen, Gerard, David, Yao, Lutian, Shofer, Frances S., Cs-Szabo, Gabriella, Qin, Ling, Pacifici, Maurizio, Enomoto-Iwamoto, Motomi

“…We found ADAM8 enzymatic activity elevated in degenerative human intervertebral disc (IVD). Here, we examined the discs in ADAM8-inactivation mice that carry a…”
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Joints in the appendicular skeleton: Developmental mechanisms and evolutionary influences by Rux, Danielle, Decker, Rebekah S, Koyama, Eiki, Pacifici, Maurizio

“…The joints are a diverse group of skeletal structures, and their genesis, morphogenesis, and acquisition of specialized tissues have intrigued biologists for…”
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Periarticular Mesenchymal Progenitors Initiate and Contribute to Secondary Ossification Center Formation During Mouse Long Bone Development by Tong, Wei, Tower, Robert J., Chen, Chider, Wang, Luqiang, Zhong, Leilei, Wei, Yulong, Sun, Hao, Cao, Gaoyuan, Jia, Haoruo, Pacifici, Maurizio, Koyama, Eiki, Enomoto‐Iwamoto, Motomi, Qin, Ling

“…Long bone development involves the embryonic formation of a primary ossification center (POC) in the incipient diaphysis followed by postnatal development of a…”
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Retinoid Agonists in the Targeting of Heterotopic Ossification by Pignolo, Robert J, Pacifici, Maurizio

“…Retinoids are metabolic derivatives of vitamin A and regulate the function of many tissues and organs both prenatally and postnatally. Active retinoids, such…”
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Pathogenesis of MHE: Recent advances and prospects for therapies by Pacifici, Maurizio, PhD

“…Multiple hereditary exostoses (MHE) is a congenital autosomal-dominant disorder caused by mutations in the Golgi-associated heparan sulfate (HS)-synthesizing…”
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Roles of Ihh signaling in chondroprogenitor function in postnatal condylar cartilage by Kurio, Naito, Saunders, Cheri, Bechtold, Till E., Salhab, Imad, Nah, Hyun-Duck, Sinha, Sayantani, Billings, Paul C., Pacifici, Maurizio, Koyama, Eiki

“…Condylar articular cartilage in mouse temporomandibular joint develops from progenitor cells near the articulating surface that proliferate, undergo…”
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Identification and characterization of a novel heparan sulfate-binding domain in Activin A longest variants and implications for function by Yang, Evan, Mundy, Christina, Rappaport, Eric F, Pacifici, Maurizio, Billings, Paul C

“…Activins regulate numerous processes including inflammation and are synthesized as precursors consisting of a long N-terminal pro-region and a mature protein…”
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A distinct cohort of progenitor cells participates in synovial joint and articular cartilage formation during mouse limb skeletogenesis by Koyama, Eiki, Shibukawa, Yoshihiro, Nagayama, Motohiko, Sugito, Hiroki, Young, Blanche, Yuasa, Takahito, Okabe, Takahiro, Ochiai, Takanaga, Kamiya, Nobuhiko, Rountree, Ryan B., Kingsley, David M., Iwamoto, Masahiro, Enomoto-Iwamoto, Motomi, Pacifici, Maurizio

“…The origin, roles and fate of progenitor cells forming synovial joints during limb skeletogenesis remain largely unclear. Here we produced prenatal and…”
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Perichondrium phenotype and border function are regulated by Ext1 and heparan sulfate in developing long bones: A mechanism likely deranged in Hereditary Multiple Exostoses by Huegel, Julianne, Mundy, Christina, Sgariglia, Federica, Nygren, Patrik, Billings, Paul C., Yamaguchi, Yu, Koyama, Eiki, Pacifici, Maurizio

“…During limb skeletogenesis the cartilaginous long bone anlagen and their growth plates become delimited by perichondrium with which they interact functionally…”
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Unsuspected osteochondroma-like outgrowths in the cranial base of Hereditary Multiple Exostoses patients and modeling and treatment with a BMP antagonist in mice by Sinha, Sayantani, Mundy, Christina, Bechtold, Till, Sgariglia, Federica, Ibrahim, Mazen M, Billings, Paul C, Carroll, Kristen, Koyama, Eiki, Jones, Kevin B, Pacifici, Maurizio

“…Hereditary Multiple Exostoses (HME) is a rare pediatric disorder caused by loss-of-function mutations in the genes encoding the heparan sulfate…”
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Heparan sulfate in skeletal development, growth, and pathology: The case of hereditary multiple exostoses by Huegel, Julianne, Sgariglia, Federica, Enomoto‐Iwamoto, Motomi, Koyama, Eiki, Dormans, John P., Pacifici, Maurizio

“…Heparan sulfate (HS) is an essential component of cell surface and matrix‐associated proteoglycans. Due to their sulfation patterns, the HS chains interact…”
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Mechanisms of synovial joint and articular cartilage formation: Recent advances, but many lingering mysteries by Pacifici, Maurizio, Koyama, Eiki, Iwamoto, Masahiro

“…Synovial joints are elegant, critically important, and deceptively simple biomechanical structures. They are comprised of articular cartilage that covers each…”
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