Search Results - "Pachter, Joel S."

Extracellular vesicles: mediators and biomarkers of pathology along CNS barriers by Ramirez, Servio H, Andrews, Allison M, Paul, Debayon, Pachter, Joel S

“…Extracellular vesicles (EVs) are heterogeneous, nano-sized vesicles that are shed into the blood and other body fluids, which disperse a variety of bioactive…”
Get full text

The primary macrophage chemokine, CCL2, is not necessary after a peripheral nerve injury for macrophage recruitment and activation or for conditioning lesion enhanced peripheral regeneration by Talsma, Aaron D, Niemi, Jon P, Pachter, Joel S, Zigmond, Richard E

“…Peripheral nerve injuries stimulate the regenerative capacity of injured neurons through a neuroimmune phenomenon termed the conditioning lesion (CL) response…”
Get full text

Appearance of claudin-5 + leukocyte subtypes in the blood and CNS during progression of EAE by Krajewski, Dylan, Paul, Debayon, Ge, Shujun, Jellison, Evan, Pachter, Joel S

“…Tight junctions (TJs) are membrane specializations characteristic of barrier-forming membranes, which function to seal the aqueous pathway between endothelial…”
Get full text

Caveolin-1 regulates expression of junction-associated proteins in brain microvascular endothelial cells by Song, Li, Ge, Shujun, Pachter, Joel S.

“…Recent evidence from this laboratory indicated that reduced expression of caveolin-1 accompanied the diminished expression of tight junction (TJ)–associated…”
Get full text

Human ESC-Derived MSCs Outperform Bone Marrow MSCs in the Treatment of an EAE Model of Multiple Sclerosis by Wang, Xiaofang, Kimbrel, Erin A., Ijichi, Kumiko, Paul, Debayon, Lazorchak, Adam S., Chu, Jianlin, Kouris, Nicholas A., Yavanian, Gregory J., Lu, Shi-Jiang, Pachter, Joel S., Crocker, Stephen J., Lanza, Robert, Xu, Ren-He

“…Current therapies for multiple sclerosis (MS) are largely palliative, not curative. Mesenchymal stem cells (MSCs) harbor regenerative and immunosuppressive…”
Get full text

Appearance of claudin-5 + leukocytes in the central nervous system during neuroinflammation: a novel role for endothelial-derived extracellular vesicles by Paul, Debayon, Baena, Valentina, Ge, Shujun, Jiang, Xi, Jellison, Evan R, Kiprono, Timothy, Agalliu, Dritan, Pachter, Joel S

“…The mechanism of leukocyte transendothelial migration (TEM) across the highly restrictive blood-brain barrier (BBB) remains enigmatic, with paracellular TEM…”
Get full text

Proteomic interrogation of the meninges reveals the molecular identities of structural components and regional distinctions along the CNS axis by Santorella, Elise, Balsbaugh, Jeremy L, Ge, Shujun, Saboori, Parisa, Baker, David, Pachter, Joel S

“…Abstract The meninges surround the brain and spinal cord, affording physical protection while also serving as a niche of neuroimmune activity. Though…”
Get full text

Endothelial cell heterogeneity of blood-brain barrier gene expression along the cerebral microvasculature by Macdonald, Jennifer A., Murugesan, Nivetha, Pachter, Joel S.

“…The blood‐brain barrier (BBB) refers to the network of microvessels that selectively restricts the passage of substances between the circulation and the…”
Get full text

Spatiotemporal resolution of spinal meningeal and parenchymal inflammation during experimental autoimmune encephalomyelitis by Shrestha, Bandana, Jiang, Xi, Ge, Shujun, Paul, Debayon, Chianchiano, Peter, Pachter, Joel S.

“…Experimental autoimmune encephalomyelitis (EAE) induced by active immunization of C57BL/6 mice with peptide from myelin oligodendrocyte protein (MOG35–55), is…”
Get full text

Systemic TLR2 tolerance enhances central nervous system remyelination by Wasko, Nicholas J, Kulak, Meghan Horne, Paul, Debayon, Nicaise, Alexandra M, Yeung, Stephen T, Nichols, Frank C, Khanna, Kamal M, Crocker, Stephen, Pachter, Joel S, Clark, Robert B

“…Multiple sclerosis (MS) is a central nervous system (CNS) autoimmune disease characterized by both inflammatory demyelination and impaired remyelination…”
Get full text

The CCL2 synthesis inhibitor bindarit targets cells of the neurovascular unit, and suppresses experimental autoimmune encephalomyelitis by Ge, Shujun, Shrestha, Bandana, Paul, Debayon, Keating, Carolyn, Cone, Robert, Guglielmotti, Angelo, Pachter, Joel S

“…Production of the chemokine CCL2 by cells of the neurovascular unit (NVU) drives critical aspects of neuroinflammation. Suppression of CCL2 therefore holds…”
Get full text

Human ES-derived MSCs correct TNF-α-mediated alterations in a blood-brain barrier model by Ge, Shujun, Jiang, Xi, Paul, Debayon, Song, Li, Wang, Xiaofang, Pachter, Joel S

“…Immune cell trafficking into the CNS is considered to contribute to pathogenesis in MS and its animal model, EAE. Disruption of the blood-brain barrier (BBB)…”
Get full text

The Blood-Brain Barrier and Its Role in Immune Privilege in the Central Nervous System by PACHTER, JOEL S, DE VRIES, HELGA E, FABRY, ZSUZSA

“…The blood-brain barrier (BBB) provides both anatomical and physiological protection for the central nervous system (CNS), strictly regulating the entry of many…”
Get full text

Where is the blood-brain barrier ... really? by Ge, Shujun, Song, Li, Pachter, Joel S.

“…Few terms in the biomedical lexicon are as widely recognized as the phrase blood–brain barrier (BBB). Indeed, it immediately conjures up a “barricade” between…”
Get full text

Isolation and culture of microvascular endothelial cells from murine spinal cord by Ge, Shujun, Pachter, Joel S.

“…The isolation and culture of spinal cord microvascular endothelial cells (SCMEC), which form the blood–spinal cord barrier (BSCB), is described. Though…”
Get full text

Transcellular transport of CCL2 across brain microvascular endothelial cells by Ge, Shujun, Song, Li, Serwanski, David R, Kuziel, William A, Pachter, Joel S

“…The means by which the chemokine CCL2 produced in the brain parenchyma can recruit leukocytes lying behind the highly impervious endothelium of the blood-brain…”
Get full text

Monocyte chemoattractant protein-1 alters expression of tight junction-associated proteins in brain microvascular endothelial cells by Song, Li, Pachter, Joel S

“…The chemokine monocyte chemoattractant protein (MCP-1) is recognized to mediate extravasation of mononuclear leukocytes into the brain during a variety of…”
Get full text

Altered ATP7A expression and other compensatory responses in a murine model of Menkes disease by Niciu, Mark J, Ma, Xin-Ming, El Meskini, Rajaâ, Pachter, Joel S, Mains, Richard E, Eipper, Betty A

“…Abstract Mutations in the copper-transporter ATP7A lead to severe neurodegeneration in the mottled brindled hemizygous male (MoBr/y ) mouse and human patients…”
Get full text

Astrocyte- and Endothelial-Targeted CCL2 Conditional Knockout Mice: Critical Tools for Studying the Pathogenesis of Neuroinflammation by Ge, Shujun, Murugesan, Nivetha, Pachter, Joel S.

“…While the expression of the C–C chemokine ligand 2 (CCL2) in the central nervous system (CNS) is associated with numerous neuroinflammatory conditions, the…”
Get full text

Caveolin-1 Knockdown by Small Interfering RNA Suppresses Responses to the Chemokine Monocyte Chemoattractant Protein-1 by Human Astrocytes by Ge, Shujun, Pachter, Joel S.

“…Astrocytes regulate the integrity of the blood-brain barrier and influence inflammatory processes in the central nervous system. The pro-inflammatory chemokine…”
Get full text