Search Results - "Pacholczyk, Marcin"

Styrylquinazoline derivatives as ABL inhibitors selective for different DFG orientations by Malarz, Katarzyna, Mularski, Jacek, Pacholczyk, Marcin, Musiol, Robert

“…Among tyrosine kinase inhibitors, quinazoline-based compounds represent a large and well-known group of multi-target agents. Our previous studies have shown…”
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Mathematical modeling of regulatory networks of intracellular processes – Aims and selected methods by Kardynska, Malgorzata, Kogut, Daria, Pacholczyk, Marcin, Smieja, Jaroslaw

“…Regulatory networks structure and signaling pathways dynamics are uncovered in time- and resource consuming experimental work. However, it is increasingly…”
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Increased EGFRvIII Epitope Accessibility after Tyrosine Kinase Inhibitor Treatment of Glioblastoma Cells Creates More Opportunities for Immunotherapy by Tręda, Cezary, Włodarczyk, Aneta, Pacholczyk, Marcin, Rutkowska, Adrianna, Stoczyńska-Fidelus, Ewelina, Kierasińska, Amelia, Rieske, Piotr

“…The number of glioblastoma (GB) cases is increasing every year, and the currently available therapies remain ineffective. A prospective antigen for GB therapy…”
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EMQIT: a machine learning approach for energy based PWM matrix quality improvement by Smolinska, Karolina, Pacholczyk, Marcin

“…Transcription factor binding affinities to DNA play a key role for the gene regulation. Learning the specificity of the mechanisms of binding TFs to DNA is…”
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Neuromedin U secreted by colorectal cancer cells promotes a tumour-supporting microenvironment by Przygodzka, Patrycja, Soboska, Kamila, Sochacka, Ewelina, Pacholczyk, Marcin, Braun, Marcin, Kassassir, Hassan, Papiewska-Pająk, Izabela, Kielbik, Michal, Boncela, Joanna

“…Neuromedin U (NMU) was identified as one of the hub genes closely related to colorectal cancer (CRC) progression and was recently shown to be a motility…”
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A Possible Role for Arylsulfatase G in Dermatan Sulfate Metabolism by Poterala-Hejmo, Aleksandra, Golda, Adam, Pacholczyk, Marcin, Student, Sebastian, Tylki-Szymańska, Anna, Lalik, Anna

“…Perturbations of glycosaminoglycan metabolism lead to mucopolysaccharidoses (MPS)-lysosomal storage diseases. One type of MPS (type VI) is associated with a…”
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Neuromedin U induces an invasive phenotype in CRC cells expressing the NMUR2 receptor by Przygodzka, Patrycja, Sochacka, Ewelina, Soboska, Kamila, Pacholczyk, Marcin, Papiewska-Pająk, Izabela, Przygodzki, Tomasz, Płociński, Przemysław, Ballet, Steven, De Prins, An, Boncela, Joanna

“…Successful colorectal cancer (CRC) therapy often depends on the accurate identification of primary tumours with invasive potential. There is still a lack of…”
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PDBrt: A free database of complexes with measured drug-target residence time [version 2; peer review: 1 approved, 1 approved with reservations] by Ługowska, Magdalena, Pacholczyk, Marcin

“…Background: Difficulties in translating the in vitro potency determined by cellular assays into in vivo efficacy in living organisms complicates the design and…”
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PDBrt: A free database of complexes with measured drug-target residence time [version 1; peer review: 1 approved with reservations] by Ługowska, Magdalena, Pacholczyk, Marcin

“…Background: Difficulties in translating the in vitro potency determined by cellular assays into in vivo efficacy in living organisms complicates the design and…”
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Terpyridines as promising antitumor agents: an overview of their discovery and development by Musiol, Robert, Malecki, Patryk, Pacholczyk, Marcin, Mularski, Jacek

“…The fused aromatic system of terpyridines makes them good, innocent ligands for various metals. The resulting complexes have been extensively studied for both…”
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The p53 stabilizing agent CP-31398 and multi-kinase inhibitors. Designing, synthesizing and screening of styrylquinazoline series by Mularski, Jacek, Malarz, Katarzyna, Pacholczyk, Marcin, Musiol, Robert

“…Quinazoline derivatives constitute a large family of small-molecule inhibitors of tyrosine kinases. In the current study, the p53 protein reactivator CP-31398…”
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Interaction of new tri-, tetra-, and pentacyclic azaphenothiazine derivatives with calf thymus DNA: Spectroscopic and molecular docking studies by Sochacka, Jolanta, Pacholczyk, Marcin, Jeleń, Małgorzata, Morak-Młodawska, Beata, Pluta, Krystian

“…[Display omitted] •Three selected multicyclic azaphenothiazines AZA bind to calf thymus DNA.•The UV–VIS spectral profiles suggest partial intercalation to…”
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The Landscape of the Anti-Kinase Activity of the IDH1 Inhibitors by Malarz, Katarzyna, Mularski, Jacek, Pacholczyk, Marcin, Musiol, Robert

“…Isocitrate dehydrogenases constitute a class of enzymes that are crucial for cellular metabolism. The overexpression or mutation of isocitrate dehydrogenases…”
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Cyclic trans -phosphorylation in a homodimer as the predominant mechanism of EGFRvIII action and regulation by Stec, Wojciech, Rosiak, Kamila, Treda, Cezary, Smolarz, Maciej, Peciak, Joanna, Pacholczyk, Marcin, Lenart, Anna, Grzela, Dawid, Stoczynska-Fidelus, Ewelina, Rieske, Piotr

“…Despite intensive research no therapies targeted against the oncogenic EGFRvIII are present in the clinic. One of the reasons is the elusive nature of the…”
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Exploring the landscape of protein-ligand interaction energy using probabilistic approach by Pacholczyk, Marcin, Kimmel, Marek

“…Analysis of protein/small molecule interactions is crucial in the discovery of new drug candidates and lead structure optimization. Small biomolecules…”
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Different mutational characteristics of TSG in cell lines and surgical specimens by Stoczynska-Fidelus, Ewelina, Bienkowski, Michal, Pacholczyk, Marcin, Winiecka-Klimek, Marta, Banaszczyk, Mateusz, Zieba, Jolanta, Bieniek, Grzegorz, Piaskowski, Sylwester, Rieske, Piotr

“…One of the most crucial concerns of cancer research pertains to the differences between the neoplastic cells in tumor specimens in vivo and their counterparts…”
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PIN3 duplication may be partially responsible for TP53haploinsufficiency by Winiecka-Klimek, Marta, Szybka, Malgorzata, Rieske, Piotr, Piaskowski, Sylwester, Bienkowski, Michal, Walczak, Maciej, Pacholczyk, Marcin, Rostkowski, Michal, Zieba, Jolanta, Banaszczyk, Mateusz, Hulas-Bigoszewska, Krystyna, Peciak, Joanna, Pawliczak, Rafal, Stoczynska-Fidelus, Ewelina

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PIN3 duplication may be partially responsible for TP53 haploinsufficiency by Winiecka-Klimek, Marta, Szybka, Malgorzata, Rieske, Piotr, Piaskowski, Sylwester, Bienkowski, Michal, Walczak, Maciej, Pacholczyk, Marcin, Rostkowski, Michal, Zieba, Jolanta, Banaszczyk, Mateusz, Hulas-Bigoszewska, Krystyna, Peciak, Joanna, Pawliczak, Rafal, Stoczynska-Fidelus, Ewelina

“…Previously we have suggested that cancer cells develop a mechanism(s) which allows for either: silencing of the wild-type TP53 transcription, degradation of…”
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Analysis of differences in amino acid substitution patterns, using multilevel G-tests by Pacholczyk, Marcin, Kimmel, Marek

“…In this paper, a new algorithm is presented, which makes possible multilevel comparison of BLOSUM protein substitution matrices based on data from different…”
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Virtual Urban Space Simulator - - Gliwice, Poland City Centre Example in the Context of COVID-19 pandemic by Galuszka, Adam, Probierz, Eryka, Bereska, Damian, Pacholczyk, Marcin, Bajer, Ewa, Smieja, Jaroslaw, Skowronski, Kamil, Szydlowka, Aleksandra, Solarz, Piotr, Kania, Lukasz, Cholewa, Maciej, Woronow, Pawel

“…Virtual environments (VE) are commonly used in learning or training in many different areas. We are focused on the problem when a group of artificial agents…”
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