Search Results - "Pace, B S"

Osteoporosis treatment disparities: a 6-year aggregate analysis from national survey data by Cunningham, T. D., Di Pace, B. S., Ullal, J.

“…Summary We studied factors to determine the receipt of osteoporosis treatment in individuals with osteoporosis. Treatment was associated with age, gender,…”
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Fetal hemoglobin induction by the histone deacetylase inhibitor, scriptaid by Johnson, J, Hunter, R, McElveen, R, Qian, X H, Baliga, B S, Pace, B S

“…Many different classes of drugs induce fetal hemoglobin (HbF) including histone deacetylase (HDAC) inhibitors such as butyrate and trichostatin A. Although…”
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Beta globin gene inhibition by antisense RNA transcripts by XU, L, FERRY, A. E, MONTEIRO, C, PACE, B. S

“…Sickle cell disease is caused by a mutation in the beta globin gene leading to hemoglobin S (Hb S) production. Several approaches have been explored to prevent…”
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Erk pathway inhibitor U0126 induces gamma-globin expression in erythroid cells by McElveen, R L, Lou, T F, Reese, K, Xia, S, Baliga, B S, Pace, B S

“…Fetal hemoglobin (HbF) induction is an effective approach to improve clinical symptoms in sickle cell disease. Understanding molecular mechanisms for…”
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Selective inhibition of beta-globin RNA transcripts by antisense RNA molecules by Pace, B S, Qian, X, Ofori-Acquah, S F

“…Inhibition of beta-globin gene expression by antisense nucleic acids is a potentially powerful therapeutic strategy for sickle cell disease. To develop…”
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In Vivo Search for Butyrate Responsive Sequences Using Transgenic Mice Carrying Aγ Gene Promoter Mutants by Pace, Betty S., Li, Qiliang, Stamatoyannopoulos, George

“…We describe an in vivo approach, in transgenic mice, aimed to identify promoter elements responsible for the induction of γ globin expression by butyrate…”
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Transgenic mouse model of pharmacologic induction of fetal hemoglobin: studies using a new ribonucleotide reductase inhibitor, Didox by Pace, B S, Elford, H L, Stamatoyannopoulos, G

“…Evaluation of pharmacologic agents that stimulate fetal hemoglobin production has been done mainly in baboons and macaques. We investigated whether results in…”
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HIV-1 Tat protein-mediated transactivation of the HIV-1 long terminal repeat promoter is potentiated by a novel nuclear Tat-interacting protein of 110 kDa, Tip110 by Liu, Ying, Li, Jinliang, Kim, Byung Oh, Pace, Betty S, He, Johnny J

“…Human immunodeficiency virus type 1 (HIV-1) gene expression and replication is highly dependent on and modulated by interactions between viral and host…”
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Short-chain fatty acid derivatives stimulate cell proliferation and induce STAT-5 activation by Boosalis, Michael S., Bandyopadhyay, Ram, Bresnick, Emery H., Pace, Betty S., Van DeMark, Karyn, Zhang, Baohua, Faller, Douglas V., Perrine, Susan P.

“…Current chemotherapeutic and butyrate therapeutics that induce fetal hemoglobin expression generally also suppress erythropoiesis, limiting the production of…”
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Effects of N‐acetylcysteine on dense cell formation in sickle cell disease by Pace, Betty S., Shartava, Archil, Pack‐Mabien, Ardie, Mulekar, Mudhari, Ardia, Alfredo, Goodman, Steven R.

“…The extent to which dense and irreversible sickle cells (ISCs) contribute to vaso‐occlusive episodes in sickle cell disease remains unclear. N‐Acetylcysteine…”
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Stat3β Inhibits γ-Globin Gene Expression in Erythroid Cells by Foley, Heather A., Ofori-Acquah, Solomon F., Yoshimura, Akihiko, Critz, Stuart, Baliga, B. Surendra, Pace, Betty S.

“…We demonstrated previously γ-globin gene inhibition in K562 cells and primary erythroid progenitors treated with interleukin-6. Although several cis-acting…”
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Ethanol exposure induces neonatal neurodegeneration by enhancing CB1R Exon1 histone H4K8 acetylation and up-regulating CB1R function causing neurobehavioral abnormalities in adult mice by Subbanna, Shivakumar, Nagre, Nagaraja N, Umapathy, Nagavedi S, Pace, Betty S, Basavarajappa, Balapal S

“…Ethanol exposure to rodents during postnatal day 7 (P7), which is comparable to the third trimester of human pregnancy, induces long-term potentiation and…”
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Globin gene silencing in primary erythroid cultures. An inhibitory role for interleukin-6 by Ferry, A E, Baliga, S B, Monteiro, C, Pace, B S

“…There are numerous similarities between the erythroid and megakaryocytic lineages which suggest that commitment to either lineage occurs relatively late in…”
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Butyrate-inducible elements in the human γ-globin promoter by Pace, Betty S., Chen, Ying-Ru, Thompson, Amy, Goodman, Steven R.

“…Several agents including hydroxyurea, erythropoietin and butyric acid have been shown to reactivate γ gene expression during adult stage development by unknown…”
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Mechanism for fetal hemoglobin induction by hydroxyurea in sickle cell erythroid progenitors by Baliga, B. Surendra, Pace, Betty S., Chen, Hsueh‐Hua, Shah, Arvind K., Yang, Yih‐Ming

“…Hydroxyurea (HU) is a widely used cytotoxic agent that is known to induce fetal hemoglobin (HbF) production and is presently used to ameliorate the severity of…”
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Abrogation of IL-3 requirements and stimulation of hematopoietic cell proliferation in vitro and in vivo by carboxylic acids by Boosalis, M S, Ikuta, T, Pace, B S, da Fonseca, S, White, G L, Faller, D V, Perrine, S P

“…Short-chain fatty acids, such as butyrate and propionate, induce fetal globin gene expression and are under clinical investigation in the…”
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The HDAC inhibitors trichostatin A and suberoylanilide hydroxamic acid exhibit multiple modalities of benefit for the vascular pathobiology of sickle transgenic mice by Hebbel, Robert P., Vercellotti, Gregory M., Pace, Betty S., Solovey, Anna N., Kollander, Rahn, Abanonu, Chine F., Nguyen, Julia, Vineyard, Julie V., Belcher, John D., Abdulla, Fuad, Osifuye, Shadé, Eaton, John W., Kelm, Robert J., Slungaard, Arne

“…The vascular pathobiology of sickle cell anemia involves inflammation, coagulation, vascular stasis, reperfusion injury, iron-based oxidative biochemistry,…”
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Utility of recorded guided imagery and relaxing music in reducing patient pain and anxiety, and surgeon anxiety, during cutaneous surgical procedures: A single-blinded randomized controlled trial by Alam, Murad, MD, MSCI, MBA, Roongpisuthipong, Wanjarus, MD, Kim, Natalie A., MD, Goyal, Amita, MD, Swary, Jillian H., MD, Brindise, Renata T., DO, Iyengar, Sanjana, MD, Pace, Natalie, BS, West, Dennis P., PhD, Polavarapu, Mahesh, MD, Yoo, Simon, MD

“…Background Guided imagery and music can reportedly reduce pain and anxiety during surgery, but no comparative study has been performed for cutaneous surgery…”
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Short-chain fatty acid derivatives induce fetal globin expression and erythropoiesis in vivo by Pace, Betty S., White, Gary L., Dover, George J., Boosalis, Michael S., Faller, Douglas V., Perrine, Susan P.

“…Orally bioactive compounds that induce γ globin gene expression at tolerable doses are needed for optimal treatment of the β-hemoglobinopathies. Short-chain…”
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p38 MAP kinase activation mediates γ-globin gene induction in erythroid progenitors by Pace, Betty S, Qian, Xin-hua, Sangerman, Jose, Ofori-Acquah, Solomon F, Baliga, B.Surendra, Han, Jiahuai, Critz, Stuart D

“…Our goal was to determine the role of p38 mitogen-activated protein kinase (MAPK) signaling in fetal hemoglobin (HbF) induction. Two histone deacetylase…”
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