Search Results - "Pacchioni, Alejandra M."

Extended methamphetamine self-administration in rats results in a selective reduction of dopamine transporter levels in the prefrontal cortex and dorsal striatum not accompanied by marked monoaminergic depletion by Schwendt, Marek, Rocha, Angelica, See, Ronald E, Pacchioni, Alejandra M, McGinty, Jacqueline F, Kalivas, Peter W

“…Chronic abuse of methamphetamine leads to cognitive dysfunction and high rates of relapse, paralleled by significant changes of brain dopamine and serotonin…”
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Neuronal pentraxins modulate cocaine-induced neuroadaptations by Pacchioni, Alejandra M, Vallone, Joseph, Worley, Paul F, Kalivas, Peter W

“…Neuronal pentraxins (NPs) function in the extracellular matrix to bind alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. Three NPs…”
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Long-Term Consequences of Methamphetamine Exposure in Young Adults Are Exacerbated in Glial Cell Line-Derived Neurotrophic Factor Heterozygous Mice by Boger, Heather A, Middaugh, Lawrence D, Patrick, Kennerly S, Ramamoorthy, Sammanda, Denehy, Emily D, Zhu, Haojie, Pacchioni, Alejandra M, Granholm, Ann-Charlotte, McGinty, Jacqueline F

“…Methamphetamine abuse in young adults has long-term deleterious effects on brain function that are associated with damage to monoaminergic neurons…”
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Exposure to glyphosate during pregnancy induces neurobehavioral alterations and downregulation of Wnt5a-CaMKII pathway by Coullery, Romina, Pacchioni, Alejandra M., Rosso, Silvana B.

“…•Gestational exposure to glyphosate induces neurobehavioural changes in rat pups.•Prenatal exposure to glyphosate leads to long-term motor and cognitive…”
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Social Isolation in Male Rats During Adolescence Inhibits the Wnt/β-Catenin Pathway in the Prefrontal Cortex and Enhances Anxiety and Cocaine-Induced Plasticity in Adulthood by Cuesta, Santiago, Funes, Alejandrina, Pacchioni, Alejandra M.

“…In adult animals, it is well established that stress has a proactive effect on psychostimulant responses. However, whether only a short period of stress during…”
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Levels and patterns of substance use among school-attending adolescents in Rosario (Santa Fe-Argentina) during 2016, 2018, and 2019 by Biolatto, Silvana, Konjuh, Cintia, Drogo, Claudia, Pacchioni, Alejandra M

“…Psychoactive substance (PS) use is a public health problem that affects society in general and particularly adolescents. Therefore, knowing adolescents' levels…”
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Role of Wnt/β‐catenin pathway in the nucleus accumbens in long‐term cocaine‐induced neuroplasticity: a possible novel target for addiction treatment by Cuesta, Santiago, Batuecas, Jorgelina, Severin, Maria J., Funes, Alejandrina, Rosso, Silvana B., Pacchioni, Alejandra M.

“…Cocaine addiction is a chronic relapsing disorder characterized by the loss of control over drug‐seeking and taking, and continued drug use regardless of…”
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Dorsal striatum mediation of cocaine-seeking after withdrawal from short or long daily access cocaine self-administration in rats by Pacchioni, Alejandra M., Gabriele, Amanda, See, Ronald E.

“…▶ Prolonged use of cocaine leads to neuroadaptations in the dorsolateral caudate/putamen. ▶ The current study investigated the role of the dlCPu in…”
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Dopamine and glutamate release in the dorsolateral caudate putamen following withdrawal from cocaine self-administration in rats by Gabriele, Amanda, Pacchioni, Alejandra M., See, Ronald E.

“…Evidence suggests that cocaine addiction may involve progressive neuroadaptive changes in the dorsolateral caudate putamen (dlCPu). While cocaine seeking…”
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Wnt/β‐catenin pathway in the prefrontal cortex is required for cocaine‐induced neuroadaptations by Cuesta, Santiago, Severin, Maria J., Batuecas, Jorgelina, Rosso, Silvana B., Pacchioni, Alejandra M.

“…Behavioral sensitization is a progressive and enduring enhancement of the motor stimulant effects elicited by repeated administration of drugs of abuse. It can…”
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A Glutamate-Dopamine Interaction in the Persistent Enhanced Response to Amphetamine in Nucleus Accumbens Core but not Shell Following a Single Restraint Stress by PACCHIONI, Alejandra M, CADOR, Martine, BREGONZIO, Claudia, CANCELA, Liliana M

“…The administration of psychostimulant drugs or stress can elicit a sensitized response to the stimulating and reinforcing properties of the drug. We previously…”
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Integrin expression is altered after acute and chronic cocaine by Wiggins, Armina T., Pacchioni, Alejandra M., Kalivas, Peter W.

“…Cocaine addiction is associated with an increase in actin cycling and alterations in dendritic spines in the nucleus accumbens. Both actin polymerization and…”
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P-glycoprotein inhibition potentiates the behavioural and neurochemical actions of risperidone in rats by Pacchioni, Alejandra M., Gabriele, Amanda, Donovan, Jennifer L., Lindsay DeVane, C., See, Ronald E.

“…Antipsychotic drugs are the mainstay pharmacotherapy for schizophrenia and related psychiatric disorders. While the metabolic pathways of antipsychotic drugs…”
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Nrf2 gene deletion fails to alter psychostimulant-induced behavior or neurotoxicity by Pacchioni, Alejandra M, Vallone, Joseph, Melendez, Roberto I, Shih, Andy, Murphy, Timothy H, Kalivas, Peter W

“…Abstract The transcription factor NF-E2-related factor (Nrf2) regulates the induction of phase 2 detoxifying enzymes by oxidative stress, including synthesis…”
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The Role of AMPAR Trafficking Mediated by Neuronal Pentraxins in Cocaine-induced Neuroadaptations by Pacchioni, Alejandra M, Kalivas, Peter W

“…Glutamate AMPA receptors (AMPAR) in the nucleus accumbens have an important role in cocaine-induced neuroadaptations. Neuronal pentraxins function in the…”
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Social Isolation in Male Rats During Adolescence Inhibits the Wnt/[beta]-Catenin Pathway in the Prefrontal Cortex and Enhances Anxiety and Cocaine-Induced Plasticity in Adulthood by Cuesta, Santiago, Funes, Alejandrina, Pacchioni, Alejandra M

“…In adult animals, it is well established that stress has a proactive effect on psychostimulant responses. However, whether only a short period of stress during…”
Get full text

Role of Wnt/[beta]-catenin pathway in the nucleus accumbens in long-term cocaine-induced neuroplasticity: a possible novel target for addiction treatment by Cuesta, Santiago, Batuecas, Jorgelina, Severin, Maria J, Funes, Alejandrina, Rosso, Silvana B, Pacchioni, Alejandra M

“…Cocaine addiction is a chronic relapsing disorder characterized by the loss of control over drug-seeking and taking, and continued drug use regardless of…”
Get full text

Wnt/[beta]-catenin pathway in the prefrontal cortex is required for cocaine-induced neuroadaptations by Cuesta, Santiago, Severin, Maria J, Batuecas, Jorgelina, Rosso, Silvana B, Pacchioni, Alejandra M

“…Behavioral sensitization is a progressive and enduring enhancement of the motor stimulant effects elicited by repeated administration of drugs of abuse. It can…”
Get full text