Search Results - "Pacanowska, Dolores Gonzalez"

Pharmacophore Identification and Structure–Activity Relationship Analysis of a Series of Substituted Azaindoles as Inhibitors of Trypanosoma brucei by Ferrins, Lori, Diaz, Rosario, Cordon-Obras, Carlos, Rojas-Barros, Domingo, Quotadamo, Antonio, Oehme, Daniel P., Ceballos-Pérez, Gloria, Swaminathan, Uma, Pérez-Moreno, Guiomar, Bosch-Navarrete, Cristina, García-Hernández, Raquel, Gomez-Liñan, Claudia, Saura, Andreu, Ruiz-Perez, Luis Miguel, Gamarro, Francisco, Martinez-Martinez, Maria Santos, Manzano, Pilar, González-Pacanowska, Dolores, Navarro, Miguel, Pollastri, Michael P.

“…Human African trypanosomiasis is among the World Health Organization’s designated neglected tropical diseases. Repurposing strategies are often employed in…”
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Strasseriolides A–D, A Family of Antiplasmodial Macrolides Isolated from the Fungus Strasseria geniculata CF-247251 by Annang, Frederick, Pérez-Moreno, Guiomar, González-Menéndez, Víctor, Lacret, Rodney, Pérez-Victoria, Ignacio, Martín, Jesús, Cantizani, Juan, de Pedro, Nuria, Choquesillo-Lazarte, Duane, Ruiz-Pérez, Luis M, González-Pacanowska, Dolores, Genilloud, Olga, Vicente, Francisca, Reyes, Fernando

“…A novel family of four potent antimalarial macrolides, strasseriolides A–D (1–4), has been isolated from cultures of Strasseria geniculata CF-247251, a fungal…”
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Inosine triphosphate pyrophosphatase from Trypanosoma brucei cleanses cytosolic pools from deaminated nucleotides by Vidal, Antonio E., Yagüe-Capilla, Miriam, Martínez-Arribas, Blanca, García-Caballero, Daniel, Ruiz-Pérez, Luis M., González-Pacanowska, Dolores

“…Inosine triphosphate pyrophosphatases (ITPases) are ubiquitous house-cleaning enzymes that specifically recognize deaminated purine nucleotides and catalyze…”
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MDN-0104, an Antiplasmodial Betaine Lipid from Heterospora chenopodii by Martín, Jesús, Crespo, Gloria, González-Menéndez, Víctor, Pérez-Moreno, Guiomar, Sánchez-Carrasco, Paula, Pérez-Victoria, Ignacio, Ruiz-Pérez, Luis M, González-Pacanowska, Dolores, Vicente, Francisca, Genilloud, Olga, Bills, Gerald F, Reyes, Fernando

“…Bioassay-guided fractionation of the crude fermentation extract of Heterospora chenopodii led to the isolation of a novel monoacylglyceryltrimethylhomoserine…”
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Strasseriolides display in vitro and in vivo activity against trypanosomal parasites and cause morphological and size defects in Trypanosoma cruzi by Bosch-Navarrete, Cristina, Pérez-Moreno, Guiomar, Annang, Frederick, Diaz-Gonzalez, Rosario, García-Hernández, Raquel, Rocha, Hedy, Gamarro, Francisco, Cordón-Obras, Carlos, Navarro, Miguel, Rodriguez, Ana, Genilloud, Olga, Reyes, Fernando, Vicente, Francisca, Ruiz-Pérez, Luis M, González-Pacanowska, Dolores

“…Neglected diseases caused by kinetoplastid parasites are a health burden in tropical and subtropical countries. The need to create safe and effective medicines…”
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A nuclear orthologue of the dNTP triphosphohydrolase SAMHD1 controls dNTP homeostasis and genomic stability in Trypanosoma brucei by Antequera-Parrilla, Pablo, Castillo-Acosta, Víctor M., Bosch-Navarrete, Cristina, Ruiz-Pérez, Luis Miguel, González-Pacanowska, Dolores

“…Maintenance of dNTPs pools in Trypanosoma brucei is dependent on both biosynthetic and degradation pathways that together ensure correct cellular homeostasis…”
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Repurposing the Open Global Health Library for the discovery of novel Mpro destabilizers with scope as broad-spectrum antivirals by Castillo, Francisco, Ramírez, David, Ramos, María C, Martinez-Arribas, Blanca, Domingo-Contreras, Elisabeth, Mackenzie, Thomas A, Peña-Varas, Carlos, Lindemann, Sven, Montero, Fernando, Annang, Fredderick, Vicente, Francisca, Genilloud, Olga, González-Pacanowska, Dolores, Fernandez-Godino, Rosario

“…The SARS coronavirus 2 (SARS-CoV-2) epidemic remains globally active. The emergence of new variants of interest and variants of concern (VoCs), which are…”
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MDN-0185, an Antiplasmodial Polycyclic Xanthone Isolated from Micromonospora sp. CA-256353 by Annang, Frederick, Pérez-Victoria, Ignacio, Pérez-Moreno, Guiomar, Domingo, Elizabeth, González, Ignacio, Tormo, José Rubén, Martín, Jesús, Ruiz-Pérez, Luis M, Genilloud, Olga, González-Pacanowska, Dolores, Vicente, Francisca, Reyes, Fernando

“…A potent antiplasmodial polycyclic xanthone, MDN-0185 (1), was isolated from an unidentified species of the genus Micromonospora. The planar structure of 1 was…”
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Preclinical evaluation of strasseriolides A–D, potent antiplasmodial macrolides isolated from Strasseria geniculata CF-247,251 by Annang, Frederick, Pérez-Moreno, Guiomar, Díaz, Caridad, González-Menéndez, Victor, de Pedro Montejo, Nuria, del Palacio, José Pérez, Sánchez, Paula, Tanghe, Scott, Rodriguez, Ana, Pérez-Victoria, Ignacio, Cantizani, Juan, Ruiz-Pérez, Luis M, Genilloud, Olga, Reyes, Fernando, Vicente, Francisca, González-Pacanowska, Dolores

“…Abstract Background Malaria is a global health problem for which novel therapeutic compounds are needed. To this end, a recently published novel family of…”
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Discovery of New Compounds Active against Plasmodium falciparum by High Throughput Screening of Microbial Natural Products by Pérez-Moreno, Guiomar, Cantizani, Juan, Sánchez-Carrasco, Paula, Ruiz-Pérez, Luis Miguel, Martín, Jesús, El Aouad, Noureddine, Pérez-Victoria, Ignacio, Tormo, José Rubén, González-Menendez, Víctor, González, Ignacio, de Pedro, Nuria, Reyes, Fernando, Genilloud, Olga, Vicente, Francisca, González-Pacanowska, Dolores

“…Due to the low structural diversity within the set of antimalarial drugs currently available in the clinic and the increasing number of cases of resistance,…”
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Insights into the role of endonuclease V in RNA metabolism in Trypanosoma brucei by García-Caballero, Daniel, Pérez-Moreno, Guiomar, Estévez, Antonio M., Ruíz-Pérez, Luis Miguel, Vidal, Antonio E., González-Pacanowska, Dolores

“…Inosine may arise in DNA as a result of oxidative deamination of adenine or misincorporation of deoxyinosine triphosphate during replication. On the other…”
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Validation of Plasmodium falciparum dUTPase as the target of 5'-tritylated deoxyuridine analogues with anti-malarial activity by Pérez-Moreno, Guiomar, Sánchez-Carrasco, Paula, Ruiz-Pérez, Luis Miguel, Johansson, Nils Gunnar, Müller, Sylke, Baragaña, Beatriz, Hampton, Shahienaz Emma, Gilbert, Ian Hugh, Kaiser, Marcel, Sarkar, Sandipan, Pandurangan, Thiyagamurthy, Kumar, Vijeesh, González-Pacanowska, Dolores

“…Malaria remains as a major global problem, being one of the infectious diseases that engender highest mortality across the world. Due to the appearance of…”
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Establishment of a screening platform based on human coronavirus OC43 for the identification of microbial natural products with antiviral activity by Martínez-Arribas, Blanca, Annang, Frederick, Díaz-González, Rosario, Pérez-Moreno, Guiomar, Martín, Jesús, Mackenzie, Thomas A, Castillo, Francisco, Reyes, Fernando, Genilloud, Olga, Ruiz-Pérez, Luis Miguel, Vicente, Francisca, Ramos, María C, González-Pacanowska, Dolores

“…The COVID-19 pandemic has revealed the lack of effective treatments against betacoronaviruses and the urgent need for new broad-spectrum antivirals. Natural…”
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Carbohydrate-Binding Non-Peptidic Pradimicins for the Treatment of Acute Sleeping Sickness in Murine Models by Castillo-Acosta, Víctor M, Ruiz-Pérez, Luis M, Etxebarria, Juan, Reichardt, Niels C, Navarro, Miguel, Igarashi, Yasuhiro, Liekens, Sandra, Balzarini, Jan, González-Pacanowska, Dolores

“…Current treatments available for African sleeping sickness or human African trypanosomiasis (HAT) are limited, with poor efficacy and unacceptable safety…”
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Synthesis and Evaluation of α‑Thymidine Analogues as Novel Antimalarials by Cui, Huaqing, Carrero-Lérida, Juana, Silva, Ana P. G, Whittingham, Jean L, Brannigan, James A, Ruiz-Pérez, Luis M, Read, Kevin D, Wilson, Keith S, González-Pacanowska, Dolores, Gilbert, Ian H

“…Plasmodium falciparum thymidylate kinase (PfTMPK) is a key enzyme in pyrimidine nucleotide biosynthesis. 3-Trifluoromethyl-4-chloro-phenyl-urea-α-thymidine has…”
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Antiparasitic Meroterpenoids Isolated from Memnoniella dichroa CF-080171 by Annang, Frederick Boye, Pérez-Moreno, Guiomar, Bosch-Navarrete, Cristina, González-Menéndez, Victor, Martín, Jesús, Mackenzie, Thomas A, Ramos, Maria C, Ruiz-Pérez, Luis M, Genilloud, Olga, González-Pacanowska, Dolores, Vicente, Francisca, Reyes, Fernando

“…is a fungal genus from which a wide range of diverse biologically active compounds have been isolated. A CF-080171 extract was identified to exhibit potent…”
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A Mitochondrial Orthologue of the dNTP Triphosphohydrolase SAMHD1 Is Essential and Controls Pyrimidine Homeostasis in Trypanosoma brucei by Yagüe-Capilla, Miriam, Castillo-Acosta, Víctor M, Bosch-Navarrete, Cristina, Ruiz-Pérez, Luis Miguel, González-Pacanowska, Dolores

“…The maintenance of deoxyribonucleotide triphosphate (dNTP) homeostasis through synthesis and degradation is critical for accurate genomic and mitochondrial DNA…”
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Trypanosoma brucei gambiense adaptation to different mammalian sera is associated with VSG expression site plasticity by Cordon-Obras, Carlos, Cano, Jorge, González-Pacanowska, Dolores, Benito, Agustin, Navarro, Miguel, Bart, Jean-Mathieu

“…Trypanosoma brucei gambiense infection is widely considered an anthroponosis, although it has also been found in wild and domestic animals. Thus, fauna could…”
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New Compounds with Bioisosteric Replacement of Classic Choline Kinase Inhibitors Show Potent Antiplasmodial Activity by Aguilar-Troyano, Francisco José, Torretta, Archimede, Rubbini, Gianluca, Fasiolo, Alberto, Luque-Navarro, Pilar María, Carrasco-Jimenez, María Paz, Pérez-Moreno, Guiomar, Bosch-Navarrete, Cristina, González-Pacanowska, Dolores, Parisini, Emilio, Lopez-Cara, Luisa Carlota

“…In the fight against Malaria, new strategies need to be developed to avoid resistance of the parasite to pharmaceutics and other prevention barriers. Recently,…”
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Evaluation of a class of isatinoids identified from a high-throughput screen of human kinase inhibitors as anti-Sleeping Sickness agents by Klug, Dana M, Diaz-Gonzalez, Rosario, Pérez-Moreno, Guiomar, Ceballos-Pérez, Gloria, García-Hernández, Raquel, Gomez-Pérez, Veronica, Ruiz-Pérez, Luis Miguel, Rojas-Barros, Domingo I, Gamarro, Francisco, González-Pacanowska, Dolores, Martínez-Martínez, María S, Manzano, Pilar, Ferrins, Lori, Caffrey, Conor R, Navarro, Miguel, Pollastri, Michael P

“…New treatments are needed for neglected tropical diseases (NTDs) such as Human African trypanosomiasis (HAT), Chagas disease, and schistosomiasis. Through a…”
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