Search Results - "Pacal, Marek"

Induction of the ganglion cell differentiation program in human retinal progenitors before cell cycle exit by Pacal, Marek, Bremner, Rod

“…Background: Despite the disease relevance, understanding of human retinal development lags behind that of other species. We compared the kinetics of gene…”
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Mapping differentiation kinetics in the mouse retina reveals an extensive period of cell cycle protein expression in post-mitotic newborn neurons by Pacal, Marek, Bremner, Rod

“…Background: Knowledge of gene expression kinetics around neuronal cell birth is required to dissect mechanisms underlying progenitor fate. Here, we timed cell…”
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Division and apoptosis of E2f-deficient retinal progenitors by Chen, Danian, Pacal, Marek, Wenzel, Pamela, Knoepfler, Paul S., Leone, Gustavo, Bremner, Rod

“…E2f transcription factors The in vivo function of E2f transcription factors has been a matter of debate. They are generally thought to be essential for cell…”
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Rb-mediated neuronal differentiation through cell-cycle-independent regulation of E2f3a by Chen, Danian, Opavsky, Rene, Pacal, Marek, Tanimoto, Naoyuki, Wenzel, Pamela, Seeliger, Mathias W, Leone, Gustavo, Bremner, Rod

“…It has long been known that loss of the retinoblastoma protein (Rb) perturbs neural differentiation, but the underlying mechanism has never been solved. Rb…”
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Insights from animal models on the origins and progression of retinoblastoma by Pacal, Marek, Bremner, Rod

“…The RB gene was discovered 20 years ago because of its role in the childhood eye cancer retinoblastoma. However, surprisingly little progress was made in…”
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Chx10 Is Required to Block Photoreceptor Differentiation but Is Dispensable for Progenitor Proliferation in the Postnatal Retina by Livne-bar, Izzy, Pacal, Marek, Cheung, Melissa C., Hankin, Mark, Trogadis, Judy, Chen, Danian, Dorval, Kimberley M., Bremner, Rod

“…In the Chx10-null ocular retardation ($or^{J}$) mouse, retinal progenitor cell (RPC) proliferation is impaired, and bipolar neurons, a late born cell type,…”
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Noninvasive, in vivo assessment of mouse retinal structure using optical coherence tomography by Fischer, M Dominik, Huber, Gesine, Beck, Susanne C, Tanimoto, Naoyuki, Muehlfriedel, Regine, Fahl, Edda, Grimm, Christian, Wenzel, Andreas, Remé, Charlotte E, van de Pavert, Serge A, Wijnholds, Jan, Pacal, Marek, Bremner, Rod, Seeliger, Mathias W

“…Optical coherence tomography (OCT) is a novel method of retinal in vivo imaging. In this study, we assessed the potential of OCT to yield histology-analogue…”
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Induction of the ganglion cell differentiation program in human retinal progenitors before cell cycle exit by Pacal, Marek, Bremner, Rod

“…Background: Despite the disease relevance, understanding of human retinal development lags behind that of other species. We compared the kinetics of gene…”
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Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity by Pearson, Joel D., Huang, Katherine, Pacal, Marek, McCurdy, Sean R., Lu, Suying, Aubry, Arthur, Yu, Tao, Wadosky, Kristine M., Zhang, Letian, Wang, Tao, Gregorieff, Alex, Ahmad, Mohammad, Dimaras, Helen, Langille, Ellen, Cole, Susan P.C., Monnier, Philippe P., Lok, Benjamin H., Tsao, Ming-Sound, Akeno, Nagako, Schramek, Daniel, Wikenheiser-Brokamp, Kathryn A., Knudsen, Erik S., Witkiewicz, Agnieszka K., Wrana, Jeffrey L., Goodrich, David W., Bremner, Rod

“…Cancer heterogeneity impacts therapeutic response, driving efforts to discover over-arching rules that supersede variability. Here, we define pan-cancer binary…”
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Hypophosphorylated pRb knock‐in mice exhibit hallmarks of aging and vitamin C‐preventable diabetes by Jiang, Zhe, Li, Huiqin, Schroer, Stephanie A, Voisin, Veronique, Ju, YoungJun, Pacal, Marek, Erdmann, Natalie, Shi, Wei, Chung, Philip E D, Deng, Tao, Chen, Nien‐Jung, Ciavarra, Giovanni, Datti, Alessandro, Mak, Tak W, Harrington, Lea, Dick, Frederick A, Bader, Gary D, Bremner, Rod, Woo, Minna, Zacksenhaus, Eldad

“…Despite extensive analysis of pRB phosphorylation in vitro , how this modification influences development and homeostasis in vivo is unclear. Here, we show…”
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Progenitor division and cell autonomous neurosecretion are required for rod photoreceptor sublaminar positioning by Gurdita, Akshay, Pham Truong, Victor Q B, Dolati, Parnian, Juric, Matey, Tachibana, Nobuhiko, Liu, Zhongda C, Ortín-Martínez, Arturo, Ibrahimi, Mostafa, Pokrajac, Nenad T, Comanita, Lacrimioara, Pacal, Marek, Huang, Mengjia, Sugita, Shuzo, Bremner, Rod, Wallace, Valerie A

“…Migration is essential for the laminar stratification and connectivity of neurons in the central nervous system. In the retina, photoreceptors (PRs) migrate to…”
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Division and apoptosis in the E2f-deficient retina by Chen, Danian, Pacal, Marek, Wenzel, Pamela, Knoepfler, Paul S., Leone, Gustavo, Bremner, Rod

“…E2fs 1-3, also known as activating E2fs, are viewed broadly as critical positive cell cycle regulators. They induce transcription and can drive cells out of…”
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Coordinating cell cycle exit and differentiation in the mammalian retina and its dependence on Rb by Pacal, Marek

“…Cell cycle exit ("birth") of retinal progenitor cells (RPCs) is considered a watershed that is preceded by changing levels of cell cycle regulators, and…”
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Abstract 1092: Alterations of the retinoblastoma gene in stage III breast cancers by Berge, Elisabet O., Knappskog, Stian, Geisler, Stephanie, Staalesen, Vidar, Puntervoll, Pål, Pacal, Marek, Børresen-Dale, Anne-Lise, Lillehaug, Johan R., Lønning, Per E.

“…Abstract We report the novel finding of point mutations affecting the RB1 gene in breast cancer tissue. Analyzing 73 locally advanced (stage III) breast…”
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Direct and indirect effects of hedgehog pathway activation in the mammalian retina by Yu, Chuan, Mazerolle, Chantal J., Thurig, Sherry, Wang, Yaping, Pacal, Marek, Bremner, Rod, Wallace, Valerie A.

“…The morphogen Sonic hedgehog (Shh) is expressed by the projection neurons of the retina, retinal ganglion cells (RGCs) and promotes retinal precursor cell…”
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Protection from infection with severe acute respiratory syndrome coronavirus in a Chinese hamster model by equine neutralizing F(ab')2 by Luo, Deyan, Ni, Bing, Zhao, Guangyu, Jia, Zhengcai, Zhou, Lili, Pacal, Marek, Zhang, Liangyan, Zhang, Songle, Xing, Li, Lin, Zhihua, Wang, Li, Li, Jintao, Liang, Yunfei, Shi, Xinfu, Zhao, Tingting, Zou, Liyun, Wu, Yuzhang, Wang, Xiliang

“…To warrant potential clinical testing, the equine anti-severe acute respiratory syndrome coronavirus (SARS-CoV) F(ab')(2) requires evaluation in as many animal…”
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The RB protein family in retinal development and retinoblastoma: new insights from new mouse models by Bremner, Rod, Chen, Danian, Pacal, Marek, Livne-Bar, Izhar, Agochiya, Mahima

“…The Rb gene was isolated almost 20 years ago, but fundamental questions regarding its role in retinal development and retinoblastoma remain. What is the normal…”
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Coordinating cell cycle exit and differentiation in the mammalian retina and its dependence on Rb by Pacal, Marek

“…Cell cycle exit ("birth") of retinal progenitor cells (RPCs) is considered a watershed that is preceded by changing levels of cell cycle regulators, and…”
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Inhibition of severe acute respiratory syndrome-associated coronavirus infection by equine neutralizing antibody in golden Syrian hamsters by Zhao, Guangyu, Ni, Bing, Jiang, Haiyan, Luo, Deyan, Pacal, Marek, Zhou, Lili, Zhang, Liangyan, Xing, Li, Jia, Zhengcai, Lin, Zhihua, Wang, Li, Li, Jintao, Liang, Yunfei, Shi, Xinfu, Zhao, Tingting, Zhou, Liyun, Wu, Yuzhang, Wang, Xiliang

“…Equine anti-severe acute respiratory syndrome-associated coronavirus F(ab')(2) has been verified to protect mice from infection with severe acute respiratory…”
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Escherichia coli mRNAs with strong Shine/Dalgarno sequences also contain 5 ′ end sequences complementary to domain # 17 on the 16S ribosomal RNA by Golshani, Ashkan, Krogan, Nevan J., Xu, John, Pacal, Marek, Yang, Xiao-Chum, Ivanov, Ivaylo, Providenti, Miguel A., Ganoza, M.Clelia, Ivanov, Ivan G., AbouHaidar, Mounir G.

“…A well-established feature of the translation initiation region, which attracts the ribosomes to the prokaryotic mRNAs, is a purine rich area called…”
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