Search Results - "Pacak, Karel"

New Perspectives on Pheochromocytoma and Paraganglioma: Toward a Molecular Classification by Crona, Joakim, Taïeb, David, Pacak, Karel

“…Abstract A molecular biology–based taxonomy has been proposed for pheochromocytoma and paraganglioma (PPGL). Data from the Cancer Genome Atlas revealed…”
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Pheochromocytoma: The First Metabolic Endocrine Cancer by Jochmanova, Ivana, Pacak, Karel

“…Dysregulated metabolism is one of the key characteristics of cancer cells. The most prominent alterations are present during regulation of cell respiration,…”
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Mitochondrial Complex II: At the Crossroads by Bezawork-Geleta, Ayenachew, Rohlena, Jakub, Dong, Lanfeng, Pacak, Karel, Neuzil, Jiri

“…Mitochondrial complex II (CII), also called succinate dehydrogenase (SDH), is a central purveyor of the reprogramming of metabolic and respiratory adaptation…”
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Molecular imaging and radionuclide therapy of pheochromocytoma and paraganglioma in the era of genomic characterization of disease subgroups by Taïeb, David, Jha, Abhishek, Treglia, Giorgio, Pacak, Karel

“…In recent years, advancement in genetics has profoundly helped to gain a more comprehensive molecular, pathogenic, and prognostic picture of pheochromocytomas…”
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Personalized Management of Pheochromocytoma and Paraganglioma by Nölting, Svenja, Bechmann, Nicole, Taieb, David, Beuschlein, Felix, Fassnacht, Martin, Kroiss, Matthias, Eisenhofer, Graeme, Grossman, Ashley, Pacak, Karel

“…Pheochromocytomas/paragangliomas are characterized by a unique molecular landscape that allows their assignment to clusters based on underlying genetic…”
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Emerging Treatments for Advanced/Metastatic Pheochromocytoma and Paraganglioma by Ilanchezhian, Maran, Jha, Abhishek, Pacak, Karel, Del Rivero, Jaydira

“…Opinion statement The incidence of metastatic pheochromocytoma (PHEO) and paraganglioma (PGL) may occur in as many as 35% of patients particularly with PGL and…”
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Genomic Landscape of Pheochromocytoma and Paraganglioma by Jochmanova, Ivana, Pacak, Karel

“…Recent comprehensive molecular analysis allowed the identification of unique molecular signatures in pheochromocytomas (PHEOs) and paragangliomas (PGLs). Here…”
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Pheochromocytoma and paraganglioma: Diagnosis, genetics, management, and treatment by Martucci, Victoria L, Pacak, Karel, MD, PhD, DSc

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Update of Pheochromocytoma Syndromes: Genetics, Biochemical Evaluation, and Imaging by Alrezk, Rami, Suarez, Andres, Tena, Isabel, Pacak, Karel

“…Pheochromocytomas and paragangliomas (PCCs/PGLs) are rare commonly benign neuroendocrine tumors that share pathology features and clinical behavior in many…”
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Genetics, diagnosis, management and future directions of research of phaeochromocytoma and paraganglioma: a position statement and consensus of the Working Group on Endocrine Hypertension of the European Society of Hypertension by Lenders, Jacques W.M., Kerstens, Michiel N., Amar, Laurence, Prejbisz, Aleksander, Robledo, Mercedes, Taieb, David, Pacak, Karel, Crona, Joakim, Zelinka, Tomáš, Mannelli, Massimo, Deutschbein, Timo, Timmers, Henri J.L.M., Castinetti, Frederic, Dralle, Henning, Widimský, Jřri, Gimenez-Roqueplo, Anne-Paule, Eisenhofer, Graeme

“…Phaeochromocytoma and paraganglioma (PPGL) are chromaffin cell tumours that require timely diagnosis because of their potentially serious cardiovascular and…”
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Mapping of human brown adipose tissue in lean and obese young men by Leitner, Brooks P., Huang, Shan, Brychta, Robert J., Duckworth, Courtney J., Baskin, Alison S., McGehee, Suzanne, Tal, Ilan, Dieckmann, William, Gupta, Garima, Kolodny, Gerald M., Pacak, Karel, Herscovitch, Peter, Cypess, Aaron M., Chen, Kong Y.

“…Human brown adipose tissue (BAT) can be activated to increase glucose uptake and energy expenditure, making it a potential target for treating obesity and…”
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Pheochromocytoma and Paraganglioma: An Endocrine Society Clinical Practice Guideline by Lenders, Jacques W. M, Duh, Quan-Yang, Eisenhofer, Graeme, Gimenez-Roqueplo, Anne-Paule, Grebe, Stefan K. G, Murad, Mohammad Hassan, Naruse, Mitsuhide, Pacak, Karel, Young, William F

“…Objective: The aim was to formulate clinical practice guidelines for pheochromocytoma and paraganglioma (PPGL). Participants: The Task Force included a chair…”
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European Association of Nuclear Medicine Practice Guideline/Society of Nuclear Medicine and Molecular Imaging Procedure Standard 2019 for radionuclide imaging of phaeochromocytoma and paraganglioma by Taïeb, David, Hicks, Rodney J., Hindié, Elif, Guillet, Benjamin A., Avram, Anca, Ghedini, Pietro, Timmers, Henri J., Scott, Aaron T., Elojeimy, Saeed, Rubello, Domenico, Virgolini, Irène J., Fanti, Stefano, Balogova, Sona, Pandit-Taskar, Neeta, Pacak, Karel

“…Purpose Diverse radionuclide imaging techniques are available for the diagnosis, staging, and follow-up of phaeochromocytoma and paraganglioma (PPGL). Beyond…”
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Molecular Imaging of Gastroenteropancreatic Neuroendocrine Tumors: Current Status and Future Directions by Deroose, Christophe M, Hindié, Elif, Kebebew, Electron, Goichot, Bernard, Pacak, Karel, Taïeb, David, Imperiale, Alessio

“…Through diagnostic imaging and peptide receptor radionuclide therapy, nuclear medicine has earned a major role in gastroenteropancreatic neuroendocrine tumors…”
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Current Management of Pheochromocytoma/Paraganglioma: A Guide for the Practicing Clinician in the Era of Precision Medicine by Nölting, Svenja, Ullrich, Martin, Pietzsch, Jens, Ziegler, Christian G., Eisenhofer, Graeme, Grossman, Ashley, Pacak, Karel

“…Pheochromocytomas and paragangliomas (PCC/PGLs) are rare, mostly catecholamine-producing neuroendocrine tumors of the adrenal gland (PCCs) or the extra-adrenal…”
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Superiority of [68Ga]-DOTATATE PET/CT to Other Functional Imaging Modalities in the Localization of SDHB-Associated Metastatic Pheochromocytoma and Paraganglioma by Janssen, Ingo, Blanchet, Elise M, Adams, Karen, Chen, Clara C, Millo, Corina M, Herscovitch, Peter, Taieb, David, Kebebew, Electron, Lehnert, Hendrik, Fojo, Antonio T, Pacak, Karel

“…Patients with succinate dehydrogenase subunit B(SDHB) mutation-related pheochromocytoma/paraganglioma (PHEO/PGL) are at a higher risk for metastatic disease…”
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Genetic Determinants of Pheochromocytoma and Paraganglioma Imaging Phenotypes by Taïeb, David, Pacak, Karel

“…Parallel to the application of new PET radiopharmaceuticals for pheochromocytoma and paraganglioma (collectively named PPGLs) imaging, several studies have…”
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Phaeochromocytoma — advances through science, collaboration and spreading the word by Pacak, Karel, Eisenhofer, Graeme, Tischler, Arthur S.

“…The first International Symposium on Phaeochromocytoma in 2005 was followed by considerable progress in the field, largely owing to the many collaborations and…”
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Somatic HIF2A Gain-of-Function Mutations in Paraganglioma with Polycythemia by Zhuang, Zhengping, Yang, Chunzhang, Lorenzo, Felipe, Merino, Maria, Fojo, Tito, Kebebew, Electron, Popovic, Vera, Stratakis, Constantine A, Prchal, Josef T, Pacak, Karel

“…Two patients with paraganglioma (one of whom also had somatostatinoma) were found to have mutations in HIF2A that altered HIF-2α turnover and led to excess…”
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Irisin and FGF21 Are Cold-Induced Endocrine Activators of Brown Fat Function in Humans by Lee, Paul, Linderman, Joyce D., Smith, Sheila, Brychta, Robert J., Wang, Juan, Idelson, Christopher, Perron, Rachel M., Werner, Charlotte D., Phan, Giao Q., Kammula, Udai S., Kebebew, Electron, Pacak, Karel, Chen, Kong Y., Celi, Francesco S.

“…Rediscovery of cold-activated brown adipose tissue (BAT) in humans has boosted research interest in identifying BAT activators for metabolic benefits. Of…”
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