Search Results - "Pablos, M."

Hydroxytyrosol protects from aging process via AMPK and autophagy; a review of its effects on cancer, metabolic syndrome, osteoporosis, immune-mediated and neurodegenerative diseases by de Pablos, Rocío M., Espinosa-Oliva, Ana María, Hornedo-Ortega, Ruth, Cano, Mercedes, Arguelles, Sandro

“…[Display omitted] Aging is a complex process. It is considered a risk factor for several diseases such as cancer, neurodegenerative diseases, cardiovascular…”
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CCI soil moisture assessment with SMOS soil moisture and in situ data under different environmental conditions and spatial scales in Spain by González-Zamora, Á., Sánchez, N., Pablos, M., Martínez-Fernández, J.

“…In this research, the active, passive and combined Climate Change Initiative (CCI) Soil Moisture (SM) products were evaluated in comparison with in situ SM…”
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Chronic stress enhances microglia activation and exacerbates death of nigral dopaminergic neurons under conditions of inflammation by de Pablos, Rocío M, Herrera, Antonio J, Espinosa-Oliva, Ana M, Sarmiento, Manuel, Muñoz, Mario F, Machado, Alberto, Venero, José L

“…Parkinson's disease is an irreversible neurodegenerative disease linked to progressive movement disorders and is accompanied by an inflammatory reaction that…”
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Galectin-3, a rising star in modulating microglia activation under conditions of neurodegeneration by García-Revilla, Juan, Boza-Serrano, Antonio, Espinosa-Oliva, Ana M., Soto, Manuel Sarmiento, Deierborg, Tomas, Ruiz, Rocío, de Pablos, Rocío M., Burguillos, Miguel Angel, Venero, Jose L.

“…The advent of high-throughput single-cell transcriptomic analysis of microglia has revealed different phenotypes that are inherently associated with disease…”
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Chronic stress as a risk factor for Alzheimer's disease by Machado, Alberto, Herrera, Antonio J, de Pablos, Rocío M, Espinosa-Oliva, Ana María, Sarmiento, Manuel, Ayala, Antonio, Venero, José Luis, Santiago, Martiniano, Villarán, Ruth F, Delgado-Cortés, María José, Argüelles, Sandro, Cano, Josefina

“…This review aims to point out that chronic stress is able to accelerate the appearance of Alzheimer's disease (AD), proposing the former as a risk factor for…”
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Phenolic Compounds Characteristic of the Mediterranean Diet in Mitigating Microglia-Mediated Neuroinflammation by Hornedo-Ortega, Ruth, Cerezo, Ana B, de Pablos, Rocío M, Krisa, Stéphanie, Richard, Tristan, García-Parrilla, M Carmen, Troncoso, Ana M

“…Neuroinflammation is a pathological feature of quite a number of Central Nervous System diseases such as Alzheimer and Parkinson's disease among others. The…”
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Metformin, besides exhibiting strong in vivo anti-inflammatory properties, increases mptp-induced damage to the nigrostriatal dopaminergic system by Ismaiel, Afrah A.K., Espinosa-Oliva, Ana M., Santiago, Martiniano, García-Quintanilla, Albert, Oliva-Martín, María J., Herrera, Antonio J., Venero, José L., de Pablos, Rocío M.

“…Metformin is a widely used oral antidiabetic drug with known anti-inflammatory properties due to its action on AMPK protein. This drug has shown a protective…”
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Peripheral Inflammation Enhances Microglia Response and Nigral Dopaminergic Cell Death in an in vivo MPTP Model of Parkinson's Disease by García-Domínguez, Irene, Veselá, Karolina, García-Revilla, Juan, Carrillo-Jiménez, Alejandro, Roca-Ceballos, María Angustias, Santiago, Marti, de Pablos, Rocío M, Venero, José L

“…The impact of systemic inflammation in nigral dopaminergic cell loss remains unclear. Here, we have investigated the role of peripheral inflammation induced by…”
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Effect assessment of reclaimed water and carbamazepine exposure on the thyroid axis of X. laevis: Apical and histological effects by Pablos, M.V., Beltrán, E.M., Jiménez, M.A., García-Hortigüela, P., Fernández, A., González-Doncel, M., Fernández, C.

“…There is increasing environmental concern about the constant presence of pharmaceuticals and personal care products (PPCPs) in surface water, generally…”
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Dopaminergic neurons lacking Caspase-3 avoid apoptosis but undergo necrosis after MPTP treatment inducing a Galectin-3-dependent selective microglial phagocytic response by García-Revilla, Juan, Ruiz, Rocío, Espinosa-Oliva, Ana M., Santiago, Marti, García-Domínguez, Irene, Camprubí-Ferrer, Lluís, Bachiller, Sara, Deierborg, Tomas, Joseph, Bertrand, de Pablos, Rocío M., Rodríguez-Gómez, José A., Venero, José Luis

“…Parkinson’s Disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the Substantia nigra pars compacta…”
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Ulcerative colitis exacerbates lipopolysaccharide-induced damage to the nigral dopaminergic system: potential risk factor in Parkinson`s disease by Villarán, Ruth F, Espinosa-Oliva, Ana M, Sarmiento, Manuel, de Pablos, Rocío M, Argüelles, Sandro, Delgado-Cortés, María J, Sobrino, Verónica, van Rooijen, Nico, Venero, José L, Herrera, Antonio J, Cano, Josefina, Machado, Alberto

“…J. Neurochem. (2010) 114, 1687-1700. Peripheral inflammation could play a role in the origin and development of certain neurodegenerative disorders. To…”
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Extracellular Vesicles in Chagas Disease: A New Passenger for an Old Disease by de Pablos Torró, Luis M, Retana Moreira, Lissette, Osuna, Antonio

“…Extracellular vesicles (EVs) are small lipid vesicles released by prokaryotic and eukaryotic cells containing nucleic acids, proteins, and small metabolites…”
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Selective inhibition of HDAC6 regulates expression of the oncogenic driver EWSR1-FLI1 through the EWSR1 promoter in Ewing sarcoma by García-Domínguez, Daniel J., Hajji, Nabil, Sánchez-Molina, Sara, Figuerola-Bou, Elisabet, de Pablos, Rocío M., Espinosa-Oliva, Ana M., Andrés-León, Eduardo, Terrón-Camero, Laura Carmen, Flores-Campos, Rocío, Pascual-Pasto, Guillem, Robles, María José, Machado, Isidro, Llombart-Bosch, Antonio, Magagnoli, Giovanna, Scotlandi, Katia, Carcaboso, Ángel M., Mora, Jaume, de Álava, Enrique, Hontecillas-Prieto, Lourdes

“…Ewing sarcoma (EWS) is an aggressive bone and soft tissue tumor of children and young adults in which the principal driver is a fusion gene, EWSR1-FLI1 …”
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Neuromelanin activates proinflammatory microglia through a caspase-8-dependent mechanism by Viceconte, Nikenza, Burguillos, Miguel A, Herrera, Antonio J, De Pablos, Rocío M, Joseph, Bertrand, Venero, José L

“…We have uncovered a caspase-dependent (caspase-8/caspase-3/7) signaling governing microglia activation and associated neurotoxicity. Importantly, a profuse…”
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Inflammatory bowel disease induces pathological α‐synuclein aggregation in the human gut and brain by Espinosa‐Oliva, Ana M., Ruiz, Rocío, Soto, Manuel Sarmiento, Boza‐Serrano, Antonio, Rodriguez‐Perez, Ana I., Roca‐Ceballos, María A., García‐Revilla, Juan, Santiago, Marti, Serres, Sébastien, Economopoulus, Vasiliki, Carvajal, Ana E., Vázquez‐Carretero, María D., García‐Miranda, Pablo, Klementieva, Oxana, Oliva‐Martín, María J., Deierborg, Tomas, Rivas, Eloy, Sibson, Nicola R., Labandeira‐García, José L., Machado, Alberto, Peral, María J., Herrera, Antonio J., Venero, José L., Pablos, Rocío M.

“…Aims According to Braak's hypothesis, it is plausible that Parkinson's disease (PD) originates in the enteric nervous system (ENS) and spreads to the brain…”
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Microglial Caspase-3 is essential for modulating hippocampal neurogenesis by Alonso Bellido, Isabel M., Posada-Pérez, Mercedes, Hernández-Rasco, Francisco, Vázquez-Reyes, Sandra, Cabanillas, María, Herrera, Antonio J., Bachiller, Sara, Soldán-Hidalgo, Jesús, Espinosa-Oliva, Ana M., Joseph, Bertrand, de Pablos, Rocío M., Venero, José L., Ruiz, Rocío

“…•Microglial Caspase-3 has a fundamental role in the maintenance of hippocampal microglia.•Microglia associated to neurogenic niches display a phenotype…”
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Divergent Effects of Metformin on an Inflammatory Model of Parkinson's Disease by Tayara, Khadija, Espinosa-Oliva, Ana M, García-Domínguez, Irene, Ismaiel, Afrah Abdul, Boza-Serrano, Antonio, Deierborg, Tomas, Machado, Alberto, Herrera, Antonio J, Venero, José L, de Pablos, Rocío M

“…The oral antidiabetic drug metformin is known to exhibit anti-inflammatory properties through activation of AMP kinase, thus protecting various brain tissues…”
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Gene expression responses for detecting sublethal effects of xenobiotics and whole effluents on a Xenopus laevis embryo assay by San Segundo, Laura, Martini, Federica, Pablos, M. Victoria

“…In the present study, the authors investigated the effects of bisphenol A, chlorpyrifos, methylparaben, and 2 effluent samples from wastewater treatment plants…”
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Hydroxytyrosol Decreases LPS- and α-Synuclein-Induced Microglial Activation In Vitro by Gallardo-Fernández, Marta, Hornedo-Ortega, Ruth, Alonso-Bellido, Isabel M, Rodríguez-Gómez, José A, Troncoso, Ana M, García-Parrilla, M Carmen, Venero, José L, Espinosa-Oliva, Ana M, Pablos, Rocío M de

“…Neuroinflammation is a common feature shared by neurodegenerative disorders, such as Parkinson's disease (PD), and seems to play a key role in their…”
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Gal3 Plays a Deleterious Role in a Mouse Model of Endotoxemia by Fernández-Martín, Juan Carlos, Espinosa-Oliva, Ana María, García-Domínguez, Irene, Rosado-Sánchez, Isaac, Pacheco, Yolanda M, Moyano, Rosario, Monterde, José G, Venero, José Luis, de Pablos, Rocío M

“…Lipopolysaccharide (LPS)-induced endotoxemia induces an acute systemic inflammatory response that mimics some important features of sepsis, the disease with…”
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