Search Results - "Pablo, Juan Lorenzo"

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    Scanning mutagenesis of the voltage-gated sodium channel NaV1.2 using base editing by Pablo, Juan Lorenzo B., Cornett, Savannah L., Wang, Lei A., Jo, Sooyeon, Brünger, Tobias, Budnik, Nikita, Hegde, Mudra, DeKeyser, Jean-Marc, Thompson, Christopher H., Doench, John G., Lal, Dennis, George, Alfred L., Pan, Jen Q.

    Published in Cell reports (Cambridge) (27-06-2023)
    “…It is challenging to apply traditional mutational scanning to voltage-gated sodium channels (NaVs) and functionally annotate the large number of coding…”
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    Journal Article
  2. 2

    Charting a TRP to Novel Therapeutic Destinations for Kidney Diseases by Pablo, Juan Lorenzo, Greka, Anna

    “…Ion channels are critical to kidney function, and their dysregulation leads to several distinct kidney diseases. Of the diversity of ion channels in kidney…”
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    Journal Article
  3. 3

    TRPC5 Channel Inhibition Protects Podocytes in Puromycin-Aminonucleoside Induced Nephrosis Models by Zhou, Yiming, Kim, Choah, Pablo, Juan Lorenzo B, Zhang, Fan, Jung, Ji Yong, Xiao, Li, Bazua-Valenti, Silvana, Emani, Maheswarareddy, Hopkins, Corey R, Weins, Astrid, Greka, Anna

    Published in Frontiers in medicine (21-09-2021)
    “…Podocyte injury and the appearance of proteinuria are key features of several progressive kidney diseases. Genetic deletion or selective inhibition of TRPC5…”
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    Journal Article
  4. 4

    Progress in ciliary ion channel physiology by Pablo, Juan Lorenzo, DeCaen, Paul G, Clapham, David E

    Published in The Journal of general physiology (01-01-2017)
    “…Mammalian cilia are ubiquitous appendages found on the apical surface of cells. Primary and motile cilia are distinct in both morphology and function. Most…”
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    Journal Article
  5. 5

    Analysis of the antibody structure based on high-resolution crystallographic studies by Narciso, Jo Erika T., Uy, Iris Diana C., Cabang, April B., Chavez, Jenina Faye C., Pablo, Juan Lorenzo B., Padilla-Concepcion, Gisela P., Padlan, Eduardo A.

    Published in New biotechnology (01-09-2011)
    “…High-resolution structures of liganded and unliganded antibody molecules were analyzed in terms of the interaction between the antibody with ligand, between…”
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    Journal Article
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    Gasdermin D pore structure reveals preferential release of mature interleukin-1 by Xia, Shiyu, Zhang, Zhibin, Magupalli, Venkat Giri, Pablo, Juan Lorenzo, Dong, Ying, Vora, Setu M., Wang, Longfei, Fu, Tian-Min, Jacobson, Matthew P., Greka, Anna, Lieberman, Judy, Ruan, Jianbin, Wu, Hao

    Published in Nature (London) (27-05-2021)
    “…As organelles of the innate immune system, inflammasomes activate caspase-1 and other inflammatory caspases that cleave gasdermin D (GSDMD). Caspase-1 also…”
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    Journal Article
  10. 10

    Mechanisms of Protein Trafficking and Quality Control in the Kidney and Beyond by Shaw, Jillian L, Pablo, Juan Lorenzo, Greka, Anna

    Published in Annual review of physiology (10-02-2023)
    “…Numerous trafficking and quality control pathways evolved to handle the diversity of proteins made by eukaryotic cells. However, at every step along the…”
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    Journal Article
  11. 11

    FGF14 is a regulator of KCNQ2/3 channels by Pablo, Juan Lorenzo, Pitt, Geoffrey S.

    “…KCNQ2/3 (Kv7.2/7.3) channels and voltage-gated sodium channels (VGSCs) are enriched in the axon initial segment (AIS) where they bind to ankyrin-G and…”
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    Journal Article
  12. 12

    Polarized localization of voltage-gated Na⁺ channels is regulated by concerted FGF13 and FGF14 action by Pablo, Juan Lorenzo, Wang, Chaojian, Presby, Matthew M., Pitt, Geoffrey S.

    “…Clustering of voltage-gated sodium channels (VGSCs) within the neuronal axon initial segment (AIS) is critical for efficient action potential initiation…”
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    Journal Article
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    Scanning mutagenesis of the voltage-gated sodium channel Na V 1.2 using base editing by Pablo, Juan Lorenzo B, Cornett, Savannah L, Wang, Lei A, Jo, Sooyeon, Brünger, Tobias, Budnik, Nikita, Hegde, Mudra, DeKeyser, Jean-Marc, Thompson, Christopher H, Doench, John G, Lal, Dennis, George, Jr, Alfred L, Pan, Jen Q

    Published in Cell reports (Cambridge) (27-06-2023)
    “…It is challenging to apply traditional mutational scanning to voltage-gated sodium channels (Na s) and functionally annotate the large number of coding…”
    Get full text
    Journal Article
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    The Diversity of FHF-mediated Ion Channel Regulation by Pablo, Juan Lorenzo B

    Published 01-01-2015
    “…Fibroblast growth factor homologous factors (FHFs) are noncanonical members of the fibroblast growth factor family (FGFs, FGF11-FGF14) that bind directly to…”
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    Dissertation