Search Results - "Pablo, Juan Lorenzo"
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Scanning mutagenesis of the voltage-gated sodium channel NaV1.2 using base editing
Published in Cell reports (Cambridge) (27-06-2023)“…It is challenging to apply traditional mutational scanning to voltage-gated sodium channels (NaVs) and functionally annotate the large number of coding…”
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2
Charting a TRP to Novel Therapeutic Destinations for Kidney Diseases
Published in Trends in pharmacological sciences (Regular ed.) (01-12-2019)“…Ion channels are critical to kidney function, and their dysregulation leads to several distinct kidney diseases. Of the diversity of ion channels in kidney…”
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3
TRPC5 Channel Inhibition Protects Podocytes in Puromycin-Aminonucleoside Induced Nephrosis Models
Published in Frontiers in medicine (21-09-2021)“…Podocyte injury and the appearance of proteinuria are key features of several progressive kidney diseases. Genetic deletion or selective inhibition of TRPC5…”
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4
Progress in ciliary ion channel physiology
Published in The Journal of general physiology (01-01-2017)“…Mammalian cilia are ubiquitous appendages found on the apical surface of cells. Primary and motile cilia are distinct in both morphology and function. Most…”
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5
Analysis of the antibody structure based on high-resolution crystallographic studies
Published in New biotechnology (01-09-2011)“…High-resolution structures of liganded and unliganded antibody molecules were analyzed in terms of the interaction between the antibody with ligand, between…”
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6
Scanning mutagenesis of the voltage-gated sodium channel Na V 1.2 using base editing
Published in Cell reports (Cambridge) (25-06-2024)Get full text
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7
Scanning mutagenesis of the voltage-gated sodium channel NaV1.2 using base editing
Published in Cell reports (Cambridge) (25-06-2024)Get full text
Journal Article -
8
A High-Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury
Published in Cell reports. Medicine (17-11-2020)“…Drug repurposing has the advantage of identifying potential treatments on a shortened timescale. In response to the pandemic spread of SARS-CoV-2, we took…”
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9
Gasdermin D pore structure reveals preferential release of mature interleukin-1
Published in Nature (London) (27-05-2021)“…As organelles of the innate immune system, inflammasomes activate caspase-1 and other inflammatory caspases that cleave gasdermin D (GSDMD). Caspase-1 also…”
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10
Mechanisms of Protein Trafficking and Quality Control in the Kidney and Beyond
Published in Annual review of physiology (10-02-2023)“…Numerous trafficking and quality control pathways evolved to handle the diversity of proteins made by eukaryotic cells. However, at every step along the…”
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11
FGF14 is a regulator of KCNQ2/3 channels
Published in Proceedings of the National Academy of Sciences - PNAS (03-01-2017)“…KCNQ2/3 (Kv7.2/7.3) channels and voltage-gated sodium channels (VGSCs) are enriched in the axon initial segment (AIS) where they bind to ankyrin-G and…”
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12
Polarized localization of voltage-gated Na⁺ channels is regulated by concerted FGF13 and FGF14 action
Published in Proceedings of the National Academy of Sciences - PNAS (10-05-2016)“…Clustering of voltage-gated sodium channels (VGSCs) within the neuronal axon initial segment (AIS) is critical for efficient action potential initiation…”
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13
Design, synthesis and characterization of novel N-heterocyclic-1-benzyl-1H-benzo[d]imidazole-2-amines as selective TRPC5 inhibitors leading to the identification of the selective compound, AC1903
Published in Bioorganic & medicinal chemistry letters (15-01-2019)“…[Display omitted] The transient receptor potential cation channel 5 (TRPC5) has been previously shown to affect podocyte survival in the kidney. As such,…”
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14
Pore Formation Mechanism of Human Gasdermin D
Published in Biophysical journal (07-02-2020)Get full text
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15
FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity
Published in Cell metabolism (02-05-2023)“…Cellular exposure to free fatty acids (FFAs) is implicated in the pathogenesis of obesity-associated diseases. However, there are no scalable approaches to…”
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Further Exploration of the Benzimidazole Scaffold as TRPC5 Inhibitors: Identification of 1‐Alkyl‐2‐(pyrrolidin‐1‐yl)‐1H‐benzo[d]imidazoles as Potent and Selective Inhibitors
Published in ChemMedChem (19-07-2022)“…The transient receptor potential cation channel 5 (TRPC5) plays an important role in numerous cellular processes. Due to this, it has gained considerable…”
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17
Molecular basis of TMED9 oligomerization and entrapment of misfolded protein cargo in the early secretory pathway
Published in Science advances (20-09-2024)“…Intracellular accumulation of misfolded proteins causes serious human proteinopathies. The transmembrane emp24 domain 9 (TMED9) cargo receptor promotes a…”
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18
Scanning mutagenesis of the voltage-gated sodium channel Na V 1.2 using base editing
Published in Cell reports (Cambridge) (27-06-2023)“…It is challenging to apply traditional mutational scanning to voltage-gated sodium channels (Na s) and functionally annotate the large number of coding…”
Get full text
Journal Article -
19
Divide, multitask, and conquer: Coordination in channel regulation
Published in Channels (Austin, Tex.) (04-07-2017)Get full text
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20
The Diversity of FHF-mediated Ion Channel Regulation
Published 01-01-2015“…Fibroblast growth factor homologous factors (FHFs) are noncanonical members of the fibroblast growth factor family (FGFs, FGF11-FGF14) that bind directly to…”
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Dissertation