Association of Serum Caffeine Concentrations with Blood Lipids in Caffeine-Drug Users and Nonusers: Results of German National Health Surveys from 1984 to 1999

Association of Serum Caffeine Concentrations with Blood Lipids in Caffeine-Drug Users and Nonusers: Results of German National Health Surveys from 1984 to 1999

Previous studies regarding effects of caffeine on lipids focused mainly on coffee consumption, the real association of serum caffeine concentrations with blood lipids is unclear. 814 caffeine-drug users had taken any caffeine/caffeine-containing pharmaceutical products and 623 nonusers without any d...

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Bibliographic Details
Published in:European journal of epidemiology Vol. 20; no. 4; pp. 311 - 316
Main Authors: Du, Yong, Melchert, Hans-Ulrich, Knopf, Hildtraud, Braemer-Hauth, Marianne, Gerding, Barbara, Pabel, Ellen
Format: Journal Article
Language:English
Published: Dordrecht Springer 01-04-2005
Springer Nature B.V
Subjects:
Adolescent
Adult
Aged
Biological and medical sciences
Blood
Blood lipids
Caffeine
Caffeine - administration & dosage
Caffeine - blood
Cardiovascular diseases
Cardiovascular Epidemiology
Cholesterols
Coffee
Correlation analysis
Drug and alcohol surveys
Epidemiology
Female
Females
Germany
Health Surveys
Humans
Immunoenzyme Techniques
Lipids
Lipids - blood
Male
Medical sciences
Men
Middle Aged
Miscellaneous
Pharmaceutical Preparations
Population Surveillance
Public health. Hygiene
Public health. Hygiene-occupational medicine
Regression analysis
Serum cholesterol
Tea
Womens health
Europe
Germany
Human
CNS stimulant
National health survey
Psychotropic
Metabolic diseases
Lipids
Concentration
Epidemiology
Blood
Respiratory analeptic
Association
Lipemia
Cardiovascular risk
Serum
Xanthine derivatives
Blood lipids
Dyslipemia
Public health
Germany
Caffeine
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Summary:Previous studies regarding effects of caffeine on lipids focused mainly on coffee consumption, the real association of serum caffeine concentrations with blood lipids is unclear. 814 caffeine-drug users had taken any caffeine/caffeine-containing pharmaceutical products and 623 nonusers without any drug use in the last seven days before the medical interview were identified from German National Health Surveys from 1984 to 1999. Serum caffeine concentrations were measured by using EIA for caffeine-drug users and nonusers in the same laboratory. Blood lipids were measured routinely for all survey participants. The association of caffeine concentrations with blood lipids was established by means of partial correlation analysis and regression analysis. After controlling for influence factors, caffeine concentrations were closely positively related to triglycerides in caffeine-drug users (male: r = 0.245, p < 0.001; female: r = 0.117, p = 0.018) and related to HDL-C in female nonusers (r = 0.245, p < 0.001). No associations were found between caffeine concentrations and total cholesterol and LDL-C levels in any groups of our study. Acute intake of caffeine might increase triglycerides levels especially in men while chronic intake of caffeine might be weakly but positively associated with HDL-C concentrations in women. The effects of caffeine on the pathogenesis of cardiovascular diseases should be further confirmed through epidemiological studies.
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ISSN:0393-2990
1573-7284
DOI:10.1007/s10654-004-7536-x