Search Results - "Paasinen, Aino"

Hypoxia Triggers the Intravasation of Clustered Circulating Tumor Cells by Donato, Cinzia, Kunz, Leo, Castro-Giner, Francesc, Paasinen-Sohns, Aino, Strittmatter, Karin, Szczerba, Barbara Maria, Scherrer, Ramona, Di Maggio, Nunzia, Heusermann, Wolf, Biehlmaier, Oliver, Beisel, Christian, Vetter, Marcus, Rochlitz, Christoph, Weber, Walter Paul, Banfi, Andrea, Schroeder, Timm, Aceto, Nicola

“…Circulating tumor cells (CTCs) are shed from solid cancers in the form of single or clustered cells, and the latter display an extraordinary ability to…”
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Single-Center Experience with a Targeted Next Generation Sequencing Assay for Assessment of Relevant Somatic Alterations in Solid Tumors by Paasinen-Sohns, Aino, Koelzer, Viktor H, Frank, Angela, Schafroth, Julian, Gisler, Aline, Sachs, Melanie, Graber, Anne, Rothschild, Sacha I, Wicki, Andreas, Cathomas, Gieri, Mertz, Kirsten D

“…Abstract Companion diagnostics rely on genomic testing of molecular alterations to enable effective cancer treatment. Here we report the clinical application…”
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DNA profiling of tumor buds in colorectal cancer indicates that they have the same mutation profile as the tumor from which they derive by Centeno, Irene, Paasinen Sohns, Aino, Flury, Miriam, Galván, José A., Zahnd, Stefan, Koelzer, Viktor H., Sokol, Lena, Dawson, Heather E., Lugli, Alessandro, Cathomas, Gieri, Zlobec, Inti

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An In Vivo CRISPR Screen Identifies Stepwise Genetic Dependencies of Metastatic Progression by Scheidmann, Manuel C, Castro-Giner, Francesc, Strittmatter, Karin, Krol, Ilona, Paasinen-Sohns, Aino, Scherrer, Ramona, Donato, Cinzia, Gkountela, Sofia, Szczerba, Barbara M, Diamantopoulou, Zoi, Muenst, Simone, Vlajnic, Tatjana, Kunz, Leo, Vetter, Marcus, Rochlitz, Christoph, Taylor, Verdon, Giachino, Claudio, Schroeder, Timm, Platt, Randall J, Aceto, Nicola

“…Blood-borne metastasis of breast cancer involves a series of tightly regulated sequential steps, including the growth of a primary tumor lesion, intravasation…”
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Ornithine decarboxylase activity is critical for cell transformation by Auvinen, Merja, Paasinen, Aino, Andersson, Leif C, Hölttä, Erkki

“…The enzyme ornithine decarboxylase is the key regulator of the synthesis of polyamines which are essential for cell proliferation. Expression of this enzyme is…”
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Colorectal Choriocarcinoma in a Patient with Probable Lynch Syndrome by Koelzer, Viktor H, Steuer, Karl, Gross, Ulrike Camenisch, Zimmermann, Dieter, Paasinen-Sohns, Aino, Mertz, Kirsten D, Cathomas, Gieri

“…Personalized therapy of colorectal cancer is influenced by morphological, molecular, and host-related factors. Here, we report the comprehensive…”
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Merkel cell polyomavirus large T antigen is detected in rare cases of nonmelanoma skin cancer by Mertz, Kirsten D., Paasinen, Aino, Arnold, Andreas, Baumann, Michèle, Offner, Felix, Willi, Niels, Cathomas, Gieri

“…Background Studies of Merkel cell polyomavirus (MCPyV) in nonmelanoma skin cancers (NMSC) other than Merkel cell carcinoma (MCC) produced controversial…”
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Cells transformed by ODC, c-Ha-ras and v-src exhibit MAP kinase/Erk-independent constitutive phosphorylation of Sos, Raf and c-Jun activation domain, and reduced PDGF receptor expression by PAASINEN-SOHNS, A, HÖLTTÄ, E

“…While it is known that the constitutive activity of a variety of signal transduction molecules leads to cell transformation, a key unresolved question is…”
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Trametinib after disease reactivation under dabrafenib in Erdheim-Chester disease with both BRAF and KRAS mutations by Nordmann, Thierry M., Juengling, Freimut D., Recher, Mike, Berger, Christoph T., Kalbermatten, Daniel, Wicki, Andreas, Paasinen-Sohns, Aino, Cathomas, Gieri, Tzankov, Alexandar, Daikeler, Thomas

“…Major advances have been made in understanding the pathogenesis of Erdheim-Chester disease (ECD) leading to novel treatment strategies. Targeted therapies such…”
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Combined Simplified Molecular Classification of Gastric Adenocarcinoma, Enhanced by Lymph Node Status: An Integrative Approach by Daun, Till, Nienhold, Ronny, Paasinen-Sohns, Aino, Frank, Angela, Sachs, Melanie, Zlobec, Inti, Cathomas, Gieri

“…Gastric adenocarcinoma (GAC) is a heterogeneous disease and at least two major studies have recently provided a molecular classification for this tumor: The…”
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Ornithine decarboxylase- and ras-induced cell transformations: reversal by protein tyrosine kinase inhibitors and role of pp130CAS by Auvinen, M, Paasinen-Sohns, A, Hirai, H, Andersson, L C, Hölttä, E

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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p72(syk) protein tyrosine kinase: An early transducer of slgG-triggered apoptotic signalling in human follicular lymphoma cells by Eray, Mine, Liwszyc, Guillermo E, Paasinen-Sohns, Aino, Stahls, Anders

“…Cross-linking of B cell antigen receptor (sIg) elicits different biological responses, including cell activation, proliferation, differentiation, anergy and…”
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Chaotic neovascularization induced by aggressive fibrosarcoma cells overexpressing S-adenosylmethionine decarboxylase by Paasinen-Sohns, Aino, Kääriäinen, Essi, Yin, Miao, Järvinen, Kristiina, Nummela, Pirjo, Hölttä, Erkki

“…S-adenosylmethionine decarboxylase is a key enzyme in the biosynthesis of polyamines essential for cell proliferation. Overexpression of S-adenosylmethionine…”
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Pathologie: Die Zukunft hat schon begonnen: Next Generation Sequencing in der Pathologie by Mertz, Kirsten D., Paasinen Sohns, Aino, Cathomas, Gieri

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Pathologie: Le séquençage de nouvelle génération en pathologie: l’avenir est en marche by Mertz, Kirsten D., Paasinen Sohns, Aino, Cathomas, Gieri

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Human ornithine decarboxylase-overproducing NIH3T3 cells induce rapidly growing, highly vascularized tumors in nude mice by AUVINEN, M, LAINE, A, PAASINEN-SOHNS, A, KANGAS, A, KANGAS, L, SAKSELA, O, ANDERSSON, L. C, HÖLTTÄ, E

“…Overexpression of human ornithine decarboxylase (ODC) under the control of strong promoters induces morphological transformation of immortalized NIH3T3 and…”
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Ornithine decarboxylase-induced cellular transformation: the involvement of protein tyrosine kinase(s) and pp130 by Hölttä, E, Auvinen, M, Paasinen, A, Kangas, A, Andersson, L C

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Domains in Middle-T Antigen That Cooperate in Polyomavirus-Mediated Oncogenic Transformation by Pérez, Leonor, Urich, Marc, Paasinen, Aino, Senften, Mathias, Meili, Ruedi, Ballmer-Hofer, Kurt

“…Middle-T antigen is the oncogenic protein of Polyomavirus and associates with several cellular enzymes involved in signal transduction, e,g., Src tyrosine…”
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c-Jun Activation-Dependent Tumorigenic Transformation Induced Paradoxically by Overexpression or Block of S-Adenosylmethionine Decarboxylase by Paasinen-Sohns, Aino, Kielosto, Mari, Kääriäinen, Essi, Eloranta, Terho, Laine, Aire, Jänne, Olli A., Birrer, Michael J., Hölttä, Erkki

“…All mammalian cells absolutely require polyamines (putrescine, spermidine, and spermine) for growth. Here we show that the overexpression of cDNA for…”
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Loss of p27Kip1 from cyclin e/cyclin-dependent kinase (CDK) 2 but not from cyclin D1/CDK4 complexes in cells transformed by polyamine biosynthetic enzymes by RAVANKO, Kirsi, JÄRVINEN, Kristiina, PAASINEN-SOHNS, Aino, HÖLTTÄ, Erkki

“…Cancer cells are known to display up-regulation of ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (AdoMetDC), the key enzymes in the…”
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