Search Results - "Pádua, Rodrigo Maia de"

Machine Learning-Based Virtual Screening of Antibacterial Agents against Methicillin-Susceptible and Resistant Staphylococcus aureus by Fernandes, Philipe Oliveira, Dias, Anna Letícia Teotonio, dos Santos Júnior, Valtair Severino, Sá Magalhães Serafim, Mateus, Sousa, Yamara Viana, Monteiro, Gustavo Claro, Coutinho, Isabel Duarte, Valli, Marilia, Verzola, Marina Mol Sena Andrade, Ottoni, Flaviano Melo, Pádua, Rodrigo Maia de, Oda, Fernando Bombarda, dos Santos, André Gonzaga, Andricopulo, Adriano Defini, da Silva Bolzani, Vanderlan, Mota, Bruno Eduardo Fernandes, Alves, Ricardo José, de Oliveira, Renata Barbosa, Kronenberger, Thales, Maltarollo, Vinícius Gonçalves

“…The application of computer-aided drug discovery (CADD) approaches has enabled the discovery of new antimicrobial therapeutic agents in the past. The high…”
Get full text

Semisynthetic Cardenolides Acting as Antiviral Inhibitors of Influenza A Virus Replication by Preventing Polymerase Complex Formation by Boff, Laurita, Schreiber, André, da Rocha Matos, Aline, Del Sarto, Juliana, Brunotte, Linda, Munkert, Jennifer, Melo Ottoni, Flaviano, Silva Ramos, Gabriela, Kreis, Wolfgang, Castro Braga, Fernão, José Alves, Ricardo, Maia de Pádua, Rodrigo, Maria Oliveira Simões, Cláudia, Ludwig, Stephan

“…Influenza virus infections represent a major public health issue by causing annual epidemics and occasional pandemics that affect thousands of people…”
Get full text

Natural Products and Derivatives as Potential Zika virus Inhibitors: A Comprehensive Review by Pereira, Rosângela Santos, Santos, Françoise Camila Pereira, Campana, Priscilla Rodrigues Valadares, Costa, Vivian Vasconcelos, de Pádua, Rodrigo Maia, Souza, Daniele G, Teixeira, Mauro Martins, Braga, Fernão Castro

“…(ZIKV) is an arbovirus whose infection in humans can lead to severe outcomes. This article reviews studies reporting the anti-ZIKV activity of natural products…”
Get full text

Elucidation of the mechanism of anti-herpes action of two novel semisynthetic cardenolide derivatives by Boff, Laurita, Schneider, Naira Fernanda Zanchett, Munkert, Jennifer, Ottoni, Flaviano Melo, Ramos, Gabriela Silva, Kreis, Wolfgang, Braga, Fernão Castro, Alves, Ricardo José, de Pádua, Rodrigo Maia, Simões, Cláudia Maria Oliveira

“…Human herpesviruses are among the most prevalent pathogens worldwide and have become an important public health issue. Recurrent infections and the emergence…”
Get full text

Effects of Lipophilicity and Structural Features on the Antiherpes Activity of Digitalis Cardenolides and Derivatives by Pádua, Rodrigo Maia, Kratz, Jadel Müller, Munkert, Jennifer, Bertol, Jéssica Wildgrube, Rigotto, Caroline, Schuster, Daniela, Maltarollo, Vinícius Gonçalves, Kreis, Wolfgang, Simões, Cláudia Maria Oliveira, Braga, Fernão Castro

“…There is growing interest in exploring Digitalis cardenolides as potential antiviral agents. Hence, we herein investigated the influence of structural features…”
Get full text

Cytotoxicity of glucoevatromonoside alone and in combination with chemotherapy drugs and their effects on Na+,K+-ATPase and ion channels on lung cancer cells by Schneider, Naira Fernanda Zanchett, Menegaz, Danusa, Dagostin, Andre Luiz Andreotti, Persich, Lara, Rocha, Sayonarah C., Ramos, Ana Carolina Pacheco, Cortes, Vanessa Faria, Fontes, Carlos Frederico Leite, de Pádua, Rodrigo Maia, Munkert, Jennifer, Kreis, Wolfgang, Braga, Fernão Castro, Barbosa, Leandro A., Silva, Fátima Regina Mena Barreto, Simões, Cláudia Maria Oliveira

“…Cardiac glycosides (CGs) are useful drugs to treat cardiac illnesses and have potent cytotoxic and anticancer effects in cultured cells and animal models…”
Get full text

Anti‐Zika Virus Activity of Plant Extracts Containing Polyphenols and Triterpenes on Vero CCL‐81 and Human Neuroblastoma SH‐SY5Y Cells by Santos Pereira, Rosângela, Vasconcelos Costa, Vivian, Luiz Menezes Gomes, Gabriel, Rodrigues Valadares Campana, Priscilla, Maia de Pádua, Rodrigo, Barbosa, Milton, Oki, Yumi, Heiden, Gustavo, Fernandes, Geraldo Wilson, Menezes de Oliveira, Djalma, Souza, Daniele G., Martins Teixeira, Mauro, Castro Braga, Fernão

“…Zika virus (ZIKV) infection is a global threat associated to neurological disorders in adults and microcephaly in children born to infected mothers. No vaccine…”
Get full text

Ketamine can be produced by Pochonia chlamydosporia: an old molecule and a new anthelmintic? by Ferreira, Sebastiao Rodrigo, Machado, Alan Rodrigues T, Furtado, Luís Fernando, Gomes, Jose Hugo de S, de Almeida, Raquel M, de Oliveira Mendes, Thiago, Maciel, Valentina N, Barbosa, Fernando Sergio, Carvalho, Lorendane M, Bueno, Lilian Lacerda, Bartholomeu, Daniella Castanheira, de Araújo, Jackson Victor, Rabelo, Elida M L, de Pádua, Rodrigo Maia, Pimenta, Lucia Pinheiro Santos, Fujiwara, Ricardo Toshio

“…Infection by nematodes is a problem for human health, livestock, and agriculture, as it causes deficits in host health, increases production costs, and incurs…”
Get full text

Quantitative Chemical Composition, Anti-Oxidant Activity, and Inhibition of TNF Release by THP-1 Cells Induced by Extracts of Echinodorus macrophyllus and Echinodorus grandiflorus by Rocha, Marina Pereira, da Silva, Lyandra Maciel Cabral, Silva, Laura Paulino Maia, Gomes, José Hugo de Sousa, Pádua, Rodrigo Maia de, Batista, João Aguiar Nogueira, Sena, Marcelo Martins, Campana, Priscilla Rodrigues Valadares, Braga, Fernão Castro

“…This study investigated the similarities between and , plant species that are traditionally used in Brazil to treat rheumatism and arthritis, whose…”
Get full text

Strychnos pseudoquina and Its Purified Compounds Present an Effective In Vitro Antileishmanial Activity by Lopes, Amanda de Santana, de Andrade, Pedro Henrique Rocha, Lage, Paula Sousa, Chávez Fumagalli, Miguel Angel, Valadares, Diogo Garcia, Duarte, Mariana Costa, Pagliara Lage, Daniela, Costa, Lourena Emanuele, Martins, Vivian Tamietti, Ribeiro, Tatiana Gomes, Filho, José Dias de Souza, Tavares, Carlos Alberto Pereira, Pádua, Rodrigo Maia de, Leite, João Paulo Viana, Coelho, Eduardo Antonio Ferraz

“…The development of new and cost-effective alternative therapeutic strategies to treat leishmaniasis has become a high priority. In the present study, the…”
Get full text

TNF-α inhibition, antioxidant effects and chemical analysis of extracts and fraction from Brazilian guaraná seed powder by Machado, Kamilla Nunes, Paula Barbosa, Antony de, de Freitas, Aline Alves, Alvarenga, Luana Farah, Pádua, Rodrigo Maia de, Gomes Faraco, André Augusto, Braga, Fernão Castro, Vianna-Soares, Cristina Duarte, Castilho, Rachel Oliveira

“…•Fractionation of seed powder guaraná result a fraction highly active.•Identification of type-A procyanidin trimer by LC-ESI-MS.•High inhibition of TNF-α…”
Get full text

Definition of chemical markers for Hancornia speciosa Gomes by chemometric analysis based on the chemical composition of extracts, their vasorelaxant effect and α-glucosidase inhibition by Pereira, Ana Bárbara D., Gomes, José Hugo de Sousa, Pereira, Aline Carvalho, Pádua, Rodrigo Maia de, Côrtes, Steyner F., Sena, Marcelo Martins, Braga, Fernão Castro

“…ETHNOPHARMACOLOGICAL RELEVANCEHancornia speciosa Gomes (Apocynaceae) is a tree found in the Brazilian savannah, traditionally used to treat several diseases,…”
Get full text

Photoconverting nets affect plant growth and levels of antiviral glucoevatromonoside and total cardenolides in Digitalis mariana ssp. heywoodii (P. Silva and M. Silva) Hinz by Marafeli, Érica Alves Marques, Chibli, Lucas Apolinário, Rocha, João Pedro Miranda, Assis, Rafael Marlon Alves de, Pinto, José Eduardo Brasil Pereira, Pádua, Rodrigo Maia de, Kreis, Wolfgang, Munkert, Jennifer, Braga, Fernão Castro, Bertolucci, Suzan Kelly Vilela

“…Digitalis mariana ssp. heywoodii (P. Silva & M. Silva) Hinz is an important source of bioactive cardenolides, including the promising antiviral agent…”
Get full text

Potential anti-herpes and cytotoxic action of novel semisynthetic digitoxigenin-derivatives by Boff, Laurita, Munkert, Jennifer, Ottoni, Flaviano Melo, Zanchett Schneider, Naira Fernanda, Ramos, Gabriela Silva, Kreis, Wolfgang, Fernandes de Andrade, Saulo, Dias de Souza Filho, José, Braga, Fernão Castro, Alves, Ricardo José, Maia de Pádua, Rodrigo, Oliveira Simões, Cláudia Maria

“…In recent years, new therapeutic possibilities were proposed for cardiac glycosides traditionally used to treat heart diseases, such as anticancer and…”
Get full text

A rapid simultaneous determination of methylxanthines and proanthocyanidins in Brazilian guaraná (Paullinia cupana Kunth.) by Machado, Kamilla Nunes, Freitas, Aline Alves de, Cunha, Luzia Helena, Faraco, André Augusto Gomes, Pádua, Rodrigo Maia de, Braga, Fernão Castro, Vianna-Soares, Cristina Duarte, Castilho, Rachel Oliveira

“…•The developed RP-HPLC-UV/PDA method simultaneously quantifies 7 chemical markers.•Caffeine is the major compound and all other, including tannins, are minor…”
Get full text

Exploring the bioactivity potential of Leonotis nepetifolia: phytochemical composition, antimicrobial and antileishmanial activities of extracts from different anatomical parts by de Oliveira, Diego Pinto, de Almeida, Letícia, Marques, Marcos José, de Carvalho, Roberta Ribeiro, Dias, Amanda Latércia Tranches, da Silva, Geraldo Alves, de Pádua, Rodrigo Maia, Braga, Fernão Castro, da Silva, Marcelo Aparecido

“…Leonotis nepetifolia (L.) Br. (Lamiaceae) is an African shrub popularly known as 'cordão-de-frade' in Brazil, traditionally used to treat infectious diseases,…”
Get full text

Investigation of the cytotoxic activity of two novel digitoxigenin analogues on H460 lung cancer cells by Boff, Laurita, Persich, Lara, Brambila, Paula, Ottoni, Flaviano Melo, Munkert, Jennifer, Ramos, Gabriela Silva, Soares Viana, Adhônis Rodrigues, Kreis, Wolfgang, Braga, Fernão Castro, Alves, Ricardo José, Maia de Pádua, Rodrigo, Schneider, Naira Fernanda Zanchett, Oliveira Simões, Cláudia Maria

“…Cardiac glycosides (CGs) are natural compounds traditionally used for the treatment of heart disorders, and recently new therapeutic possibilities were…”
Get full text

Encapsulation of trans-aconitic acid in mucoadhesive microspheres prolongs the anti-inflammatory effect in LPS-induced acute arthritis by Pinto de Oliveira, Diego, Guimarães Augusto, Gabriela, Vieira Batista, Nathália, de Oliveira, Vivian Louise S., Santos Ferreira, Diêgo, Castro e Souza, Mateus Araújo, Fernandes, Christian, Almeida Amaral, Flávio, Martins Teixeira, Mauro, Maia de Pádua, Rodrigo, Oliveira, Mônica Cristina, Castro Braga, Fernão

“…trans-Aconitic acid (TAA) is the main constituent of the leaves from the medicinal plant Echinodorus grandiflorus, used to treat different inflammatory…”
Get full text

Antiherpes activity of glucoevatromonoside, a cardenolide isolated from a Brazilian cultivar of Digitalis lanata by Bertol, Jéssica Wildgrube, Rigotto, Caroline, de Pádua, Rodrigo Maia, Kreis, Wolfgang, Barardi, Célia Regina Monte, Braga, Fernão Castro, Simões, Cláudia Maria Oliveira

“…Cardiac glycosides, known ligands of the sodium pump, are widely used in the treatment of heart failure, such as digoxin and digitoxin. Besides this important…”
Get full text

Cytotoxicity of AMANTADIG – a semisynthetic digitoxigenin derivative – alone and in combination with docetaxel in human hormone-refractory prostate cancer cells and its effect on Na+/K+-ATPase inhibition by Silva, Izabella Thaís, Munkert, Jennifer, Nolte, Elke, Schneider, Naira Fernanda Zanchett, Rocha, Sayonarah Carvalho, Ramos, Ana Carolina Pacheco, Kreis, Wolfgang, Braga, Fernão Castro, de Pádua, Rodrigo Maia, Taranto, Alex G., Cortes, Vanessa, Barbosa, Leandro Augusto, Wach, Sven, Taubert, Helge, Simões, Cláudia Maria Oliveira

“…[Display omitted] •Combination of AMANTADIG and docetaxel showed synergistic effects in prostate cancer.•Combination of AMANTADIG and docetaxel induced G2/M…”
Get full text