Search Results - "Pádua, Rodrigo M"

The Cyclitol L-(+)-Bornesitol as an Active Marker for the Cardiovascular Activity of the Brazilian Medicinal Plant Hancornia speciosa by Moreira, Luciana N., Silva, Grazielle C., Câmara, Diógenes V., Pádua, Rodrigo M., Lemos, Virgínia S., Braga, Fernão C., Cortes, Steyner F.

“…The cyclitol bornesitol is the main constituent of the leaves from the antihypertensive medicinal plant Hancornia speciosa. This study aimed to investigate the…”
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Inhibition of the sphingosine‐1‐phosphate pathway promotes the resolution of neutrophilic inflammation by Perez, Denise A., Galvão, Izabela, Athayde, Rayssa M., Rezende, Barbara M., Vago, Juliana P., Silva, Julia D., Reis, Alesandra C., Ribeiro, Lucas S., Gomes, José H. S., Pádua, Rodrigo M., Braga, Fernão C., Sousa, Lirlândia P., Teixeira, Mauro M., Pinho, Vanessa

“…Sphingosine‐1‐phosphate (S1P) is an important sphingolipid derived from plasma membrane and has a known role in productive phase of inflammation, but its role…”
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Determination of l-(+)-bornesitol, the hypotensive constituent of Hancornia speciosa, in rat plasma by LC-MS/MS and its application on a pharmacokinetic study by Moreira, Luciana N., Feltrin, Clarissa, Gonçalves, José E., de Castro, Whocely V., Simões, Cláudia M.O., de Pádua, Rodrigo M., Cortes, Steyner F., Braga, Fernão C.

“…[Display omitted] •An UPLC-ESI-MS/MS method was developed to quantify bornesitol in rat plasma.•Pharmacokinetic of bornesitol was evaluated after intravenous…”
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Cytotoxic effects of the cardenolide convallatoxin and its Na,K-ATPase regulation by Schneider, Naira Fernanda Zanchett, Silva, Izabella Thais, Persich, Lara, de Carvalho, Annelise, Rocha, Sayonarah C., Marostica, Lucas, Ramos, Ana Carolina Pacheco, Taranto, Alex G., Pádua, Rodrigo M., Kreis, Wolfgang, Barbosa, Leandro A., Braga, Fernão C., Simões, Cláudia M. O.

“…Cardenolides are cardiac glycosides, mostly obtained from natural sources. They are well known for their inhibitory action on the Na,K-ATPase, an effect that…”
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Cardiac Glycoside Glucoevatromonoside Induces Cancer Type-Specific Cell Death by Schneider, Naira F Z, Cerella, Claudia, Lee, Jin-Young, Mazumder, Aloran, Kim, Kyung Rok, de Carvalho, Annelise, Munkert, Jennifer, Pádua, Rodrigo M, Kreis, Wolfgang, Kim, Kyu-Won, Christov, Christo, Dicato, Mario, Kim, Hyun-Jung, Han, Byung Woo, Braga, Fernão C, Simões, Cláudia M O, Diederich, Marc

“…Cardiac glycosides (CGs) are natural compounds used traditionally to treat congestive heart diseases. Recent investigations repositioned CGs as potential…”
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Cytotoxic and cytostatic effects of digitoxigenin monodigitoxoside (DGX) in human lung cancer cells and its link to Na,K-ATPase by Schneider, Naira Fernanda Zanchett, Persich, Lara, Rocha, Sayonarah C., Ramos, Ana Carolina Pacheco, Cortes, Vanessa Faria, Silva, Izabella Thaís, Munkert, Jennifer, Pádua, Rodrigo M., Kreis, Wolfgang, Taranto, Alex G., Barbosa, Leandro A., Braga, Fernão C., Simões, Cláudia M.O.

“…[Display omitted] •DGX potently inhibits the growth of NSCLC cells.•DGX strongly induced cytotoxic effects on H460 cells.•DGX induced cytostatic effects on…”
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Inhibition of cell proliferation, invasion and migration by the cardenolides digitoxigenin monodigitoxoside and convallatoxin in human lung cancer cell line by Schneider, Naira F. Z., Geller, Fabiana C., Persich, Lara, Marostica, Lucas L., Pádua, Rodrigo M., Kreis, Wolfgang, Braga, Fernão C., Simões, Cláudia M. O.

“…Cardiac glycosides consist of a large family of naturally derived compounds that are clinically used to treat congestive heart failure, and also present…”
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New 99mTc-Labeled Digitoxigenin Derivative for Cancer Cell Identification by Munkert, Jennifer, Gomes, Eliza R, Marostica, Lucas L, Cota, Betânia B, Lopes, Cristina L. M, Andrade, Saulo F, Filho, José D. de Souza, Alves, Ricardo J, Oliveira, Monica C, Braga, Fernão C, Simões, Cláudia M. O, Pádua, Rodrigo M, de Barros, André L. B

“…In recent years, cardiac glycosides (CGs) have been investigated as potential antiviral and anticancer drugs. Digitoxigenin (DIG) and other CGs have been shown…”
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Future directions for the discovery of natural product-derived immunomodulating drugs: an IUPHAR positional review by Wainwright, Cherry L., Teixeira, Mauro M., Adelson, David L., Braga, Fernão C., Buenz, Eric J., Campana, Priscilla R.V., David, Bruno, Glaser, Keith B., Harata-Lee, Yuka, Howes, Melanie-Jayne R., Izzo, Angelo A., Maffia, Pasquale, Mayer, Alejandro M.S., Mazars, Claire, Newman, David J., Nic Lughadha, Eimear, Pádua, Rodrigo M., Pimenta, Adriano M.C., Parra, John A.A., Qu, Zhipeng, Shen, Hanyuan, Spedding, Michael, Wolfender, Jean-Luc

“…Drug discovery from natural sources is going through a renaissance, having spent many decades in the shadow of synthetic molecule drug discovery, despite the…”
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Synthesis and cytotoxicity evaluation of glycosidic derivatives of lawsone against breast cancer cell lines by Ottoni, Flaviano M., Gomes, Eliza R., Pádua, Rodrigo M., Oliveira, Mônica C., Silva, Izabella T., Alves, Ricardo J.

“…[Display omitted] •Glycosylation of lawsone enhances its antitumor activity.•Glucosyl triazole of lawsone displays submicromolar IC50 against SKBR-3 breast…”
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(3,3″)-Linked Biflavanones from Ouratea spectabilis and Their Effects on the Release of Proinflammatory Cytokines in THP‑1 Cells by Rocha, Marina P, Campana, Priscilla R. V, Pádua, Rodrigo M, Souza Filho, José D, Ferreira, Daneel, Braga, Fernão C

“…Ouratea spectabilis is an arborous species traditionally used in Brazil as an anti-inflammatory agent. Four new (3,3″)-linked biflavanone O-methyl ethers,…”
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Bioguided chemical characterization of pequi (Caryocar brasiliense) fruit peels towards an anti-diabetic activity by Caldeira, Alisson S.P., Mbiakop, Ulrich C., Pádua, Rodrigo M., van de Venter, Maryna, Matsabisa, Motlalepula G., Campana, Priscilla R.V., Cortes, Steyner F., Braga, Fernão C.

“…•The antidiabetic potential of Caryocar brasiliense fruit peel extract was assessed.•Bioactive fractions were identified by cytokines and digestive enzymes…”
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Oral sub-chronic treatment with Terminalia phaeocarpa Eichler (Combretaceae) reduces liver PTP1B activity in a murine model of diabetes by Mbiakop, Ulrich C., Gomes, José H.S., Pádua, Rodrigo M., Lemos, Virgínia S., Braga, Fernão C., Cortes, Steyner F.

“…The endemic Brazilian medicinal plants of the genus Terminalia (Combretaceae), popularly known as capitão, comprising the similar species Terminalia phaeocarpa…”
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In Vitro TNF-α Inhibitory Activity of Brazilian Plants and Anti-Inflammatory Effect of Stryphnodendron adstringens in an Acute Arthritis Model by Amaral, Flávio A., Teixeira, Mauro Martins, Castilho, Rachel O., Braga, Fernão Castro, Dias, Ana Carolina F., Boff, Daiane, Oliveira, Thiago Henrique C., Oliveira, Vívian Louise S. de, Pádua, Rodrigo Maia de, Azevedo, Elaine Patrícia C., Corrêa, Olívia, Henriques, Bárbara O., Souza, Danielle Glória

“…Stryphnodendron species, popularly named “barbatimão,” are traditionally used in Brazil as anti-inflammatory agents. This study aimed to investigate the effect…”
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New 99m Tc-Labeled Digitoxigenin Derivative for Cancer Cell Identification by Munkert, Jennifer, Gomes, Eliza R, Marostica, Lucas L, Cota, Betânia B, Lopes, Cristina L M, Andrade, Saulo F, Filho, José D de Souza, Alves, Ricardo J, Oliveira, Monica C, Braga, Fernão C, Simões, Cláudia M O, Pádua, Rodrigo M, de Barros, André L B

“…In recent years, cardiac glycosides (CGs) have been investigated as potential antiviral and anticancer drugs. Digitoxigenin (DIG) and other CGs have been shown…”
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Purification and characterization of malonyl-coenzyme A: 21-hydroxypregnane 21- O-malonyltransferase ( Dp21MaT) from leaves of Digitalis purpurea L by Kuate, Serge Philibert, Pádua, Rodrigo M., Eisenbeiss, Wilhelm F., Kreis, Wolfgang

“…Malonyl-coenzyme A: 21-Hydroxypregnane 21- O-malonyltransferase catalyzing the transfer of a malonyl moiety to the 21-hydroxy group of 21-hydroxypregnanes has…”
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Synthesis of a putative substrate for malonyl-coenzyme A: 21-hydroxypregnane 21- O-malonyltransferase and development of an HPLC method for the quantification of the enzyme reaction by Kuate, Serge Philibert, Pádua, Rodrigo M., Poumale, Hervé Martial P., Kreis, Wolfgang

“…The butenolide ring is the main common characteristic of all cardenolides. Its formation is supposed to be initiated by the transfer of a malonyl moiety from…”
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A simple chemical method for synthesizing malonyl hemiesters of 21-hydroxypregnanes, potential intermediates in cardenolide biosynthesis by Pádua, Rodrigo M., Waibel, Reiner, Kuate, Serge Philibert, Schebitz, Pia K., Hahn, Stefanie, Gmeiner, Peter, Kreis, Wolfgang

“…A simple and versatile method for the chemical synthesis of 21-hydroxypregnane 21- O-malonyl hemiesters which may be important intermediates of cardenolide…”
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Biotransformation of digitoxigenin by Fusarium ciliatum by Pádua, Rodrigo M., Oliveira, Alaíde B., Souza Filho, José D., Vieira, Géssy J., Takahashi, Jacqueline A., Braga, Fernão C.

“…The biotransformation of digitoxigenin (1) by Fusarium ciliatum was investigated. The cardenolide 1 was obtained by the acid hydrolysis of digitoxin and the…”
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In Vitro TNF-[alpha] Inhibitory Activity of Brazilian Plants and Anti-Inflammatory Effect of Stryphnodendron adstringens in an Acute Arthritis Model by Henriques, Barbara O, Correa, Olivia, Azevedo, Elaine Patricia C, Padua, Rodrigo M, de Oliveira, Vivian Louise S, Oliveira, Thiago Henrique C, Boff, Daiane, Dias, Ana Carolina F, de Souza, Danielle G, Amaral, Flavio A, Teixeira, Mauro M, Castilho, Rachel O, Braga, Fernao C

“…Stryphnodendron species, popularly named "barbatimão," are traditionally used in Brazil as anti-inflammatory agents. This study aimed to investigate the effect…”
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